Post-operative treatment in breast cancer diagnosed patient

[Resumen] El cáncer, que es la causa más frecuente de muerte prematura y evitable en la Unión Europea, constituye un problema importante de salud pública. Dentro del colectivo femenino, uno de los cánceres más frecuentes y que más preocupan a la población es el cáncer de mama. En Europa se estima que 8 de cada 100 mujeres desarrollarán está enfermedad antes de los 75 años. La cirugía y la radioterapia pueden provocar alteraciones postquirúrgicas que a la larga disminuyen la calidad de vida de estas pacientes. Con este artículo se pretende realizar una búsqueda bibliográfica que clarifique las alteraciones postquirúrgicas en este tipo de paciente y el tratamiento fisioterápico que se emplea para tratarlas. Todos los estudios analizados indican la aparición de alteraciones glenohumerales en estos pacientes y los beneficios que el tratamiento de fisioterapia les acarrea, ningún estudio atestigua resultados contrarios. Si bien es cierto que no existe ningún estudio con la suficiente muestra para aclarar que tipo de pacientes (edad, condición física, tipo de cirugía, radioterapia recibida) presentan una incidencia mayor de estas alteraciones.[Abstract] Cancer is the most frequent cause of premature and avoidable death in the European Union, constitutes an important problem of public health. Within the feminine group, one of the most frequent cancers is the breast cancer. In Europe esteem that 8 of each 100 women will develop is disease before the 75 years. Surgery and radiotherapy can cause postsurgical alterations that diminish the quality of life of these patients. With this article it is tried to make a bibliographical search that clarify the postsurgical alterations in this type of patient and the physical therapy treatment used to treat them. All the analyzed studies indicate the appearance of shoulder alterations in these patients and the benefits that the physical therapy treatment carries to them, no study testifies opposite results. Although it is certain that any study with the sufficient sample does not exist to clarify wich type of patients (age, physical training conditions, type of surgery, radiotherapy recieved) presents a greater incidence of these alterations

Preliminary feasibility study for the use of an adsorption/bio-regeneration system for molinate removal from effluents

This work studies the feasibility of the use of a combined physical-biological remediation procedure for treatment of effluents contaminated with molinate, where the herbicide is removed through adsorption and biodegraded in a subsequent stage, with the regeneration of the adsorbent. In order to select the most adequate absorbent for molinate, different materials were tested, namely pine bark, activated carbon and resin Amberlite XAD-4. Activated carbon and resin Amberlite XAD-4 were the most efficient on the removal of molinate from solutions, although the activated carbon used proved not to be bio-regenerable. It was also observed that factors such as temperature, pH, and conductivity did not affect significantly molinate adsorption onto resin Amberlite XAD-4. Resin Amberlite XAD-4 was successfully bio-regenerated, being observed that biodegradation was mainly dependent on spontaneous desorption of the molinate. After bio-regeneration, the resin could be re-utilised as adsorbent

Diet of non-breeding leach’s storm-petrels ( Hydrobates leucorhous ) in the sub-polar frontal zone of the North Atlantic

In order to understand the drivers of the distribution and abundance of pelagic seabirds it is necessary to know what they eat, yet there remains little detailed, geo-referenced information on the diets of pelagic seabird. In particular, due to sampling difficulties, information is lacking for non-breeding stages, smaller species, such as storm-petrels, and remote oceanic areas, which may include important diversity hotspots. In this study, we aimed to characterize the trophic ecology of Leach’s storm-petrels foraging in the vicinity of the North Atlantic Current and Evlanov Seamount Marine Protected Area using a combination of survey methods. On a cruise undertaken in June 2017 to characterize the distribution and ecology of seabirds in the region, nineteen Leach’s storm-petrels were caught, sampled and released unharmed. Regurgitations and faecal samples were collected, as well as blood and feather tissues for stable isotope analyses. Of the 12 males, 6 females and 1 unsexed bird, 84% were in active flight feather moult, suggesting they were non-breeders. Prey species, assayed via molecular metabarcoding, were dominated by mesopelagic fish, principally lanternfishes (Myctophidae) and hatchetfishes (Sternoptychidae), but also included cephalopods and crustaceans. Additionally, almost half of the birds had microplastics in their regurgitates. Stable isotopic ratios did not differ significantly between sexes. Our results, combined with those of previous studies, suggest that within the oceanic North Atlantic, Leach’s storm-petrels feed at a similar trophic level to much larger seabirds, targeting mesopelagic fishes that are a key component of the North Atlantic pelagic food web

State of Knowledge in Tiller Dynamics

Persistence of sown pastures is a concern for pastoral production worldwide. Fundamentally, when a pasture does not persist the problem can be expressed in terms of inadequate new tiller production or excessive tiller death. However, the collection of data to build an understanding of sward dynamics at this level is time consuming. Tiller survival diagrams are presented for a range of temperate and tropical grass species including Lolium perenne, Lolium multiflorum, Festuca arundinacea, Festuca pratensis, Phleum pratense, Bromus willdenowii, Cynodon dactylon, Brachiaria brizantha, Panicum maximum, Chloris gayana and Paspalum notatum. It is shown that each grass has a unique perennation strategy and accordingly unique strengths and weaknesses that confer persistence or lack of persistence in different situations. There is also confusion in extension circles about the trade-off between tiller size and tiller density and how to detect a suboptimal tiller density. Grass swards respond to high herbage mass by increase of tiller size and reduction in tiller density, but reduction in tiller density is often mistaken for sward decline. A distinctionmust be made between size/density compensation and sward decline. Increased understanding of sward dynamics at this level should help in the evolution of management practices that improve persistence on a range of grassland types

Extended-spectrum β-lactamases from the North of Portugal in the boundaries to Spain: emergence of high resistance to 4th generation cephalosporins

During the past 15 years, emergence and dissemination of third-generation cephalosporins resistance in nosocomial Enterobacteriaceae became a serious problem worldwide, due to the production of extended-spectrum-β-lactamases (ESBLs). The aim of this study was to investigate among the presence of ESBL-producing enterobacteria among Portuguese clinical isolates nearby Spain, to investigate the antimicrobial susceptibility patterns and to compare the two countries. The β-lactamases genes, blaTEM, blaSHV and blaCTX-M were detected by molecular methods. Among the ESBL-producing isolates it was found extraordinary levels (98.9%) of resistance to the fourth-generation cephalosporin Cefepime. These findings point to the need of reevaluate the definition of ESBL.Nos últimos 15 anos, a emergência e disseminação da resistência das enterobactérias nosocomiais às cefalosporinas de teceira geração devido à produção de β-lactamases de espectro ampliado (ESBL) tem-se tornado uma preocupação a nível mundial. O objectivo deste estudo é determinar a presença de ESBL em isolados clínicos de enterobactérias, o perfil de susceptibilidade aos antimicrobianos e comparar a situação portuguesa com a espanhola. Os genes blaTEM, blaSHV e blaCTX-M das β-lactamases foram detectados por métodos moleculares. Nas estirpes portuguesas produtoras de ESBL foram detectados níveis preocupantes de resistência à Cefepima (4ª geração), 98,9%, levando-nos a questionar sobre a necessidade de redefinir ESBL

Variations in salivary function in a rodent model of pre-diabetes

Diabetes is a widespread disease representing an enormous part of the total health costs. An early diagnostic could be of extremely importance both for the understanding and prevention of this pathology. Saliva is a fluid with increasing interest as a source of biomarkers for disease diagnostic and saliva protein composition changes have already been reported for diabetic individuals. However, the studies were performed after the onset of the disease and it is unknown if salivary changes are present in the early stages of development of the disease or a characteristic of overt diabetes. Wistar rats have been selected for their glucose intolerance (GIR). GIR females were compared with Wistar females with normal glucose tolerance (control) for changes in saliva protein composition and salivary gland histology. Fasting glycemias were observed to be normal (<95 mg/dl) in GIR animals, indicating an absence of a diabetic state. However they presented an abnormal increase in glycemia after a glucose bolus. For salivary parameters a marked increase in total protein concentration and alpha-amylase activity occurred in GIR animals, comparatively to controls. After separation of salivary proteins by SDS PAGE differences between the experimental groups for some protein bands, with apparent molecular masses ranging from 20 to 55 kDa were observed. Different expression of alphaamylase at salivary gland duct level is also apparent for pre-diabetic animals. Although preliminary, these results suggest changes in saliva occurring before the onset of diabetes, reinforcing the interest of further investigation of saliva composition for the diagnostic of pre-diabetic condition, ultimately allowing an early intervention and eventually the prevention of disease development

Excited states of bromopyrimidines probed by vuv photoabsorption spectroscopy and theoretical calculations

Funding Information: Funding: J.P.‐d.‐S. acknowledges the Portuguese National Funding Agency FCT‐MCTES through PhD grant PD/BD/142768/2018, together with R.R., J.A., M.M. and F.F.d.S. through the researcher grant PTDC/FIS‐AQM/31215/2017 and AIL through the researcher grant PTDC/FIS‐ AQM/31281/2017. This work was also supported by Radiation Biology and Biophysics Doctoral Training Programme (RaBBiT, PD/00193/2012); UIDB/04378/2020 (UCIBIO); and UIDB/00068/2020 (CEFITEC). The research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020.We report absolute photoabsorption cross sections for gas‐phase 2‐ and 5‐ bromopyrimidine in the 3.7–10.8 eV energy range, in a joint theoretical and experimental study. The measurements were carried out using high‐resolution vacuum ultraviolet synchrotron radiation, with quantum chemical calculations performed through the nuclear ensemble approach in combination with time‐dependent density functional theory, along with additional Franck–Condon Herzberg–Teller calculations for the first absorption band (3.7–4.6 eV). The cross sections of both bromopyrimidines are very similar below 7.3 eV, deviating more substantially from each other at higher energies. In the 7.3–9.0 eV range where the maximum cross‐section is found, a single and broad band is observed for 5‐bromopyrimidine, while more discernible features appear in the case of 2‐bromopyrimidine. Several π* ← π transitions account for the most intense bands, while weaker ones are assigned to transitions involving the nitrogen and bromine lone pairs, the antibonding σ*Br orbital, and the lower‐lying Rydberg states. A detailed comparison with the available photo‐absorption data of bromobenzene is also reported. We have found significant differences regarding the main absorption band, which is more peaked in bromobenzene, becoming broader and shifting to higher energies in both bromopyrimidines. In addition, there is a significant suppression of vibrational structures and of Rydberg states in the pair of isomers, most noticeably for 2‐bromopyrimidine.publishersversionpublishe

Multi-target analysis of cytostatics in hospital effluents over a 9-month period

The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated.publishe

Bond strength of metallic or ceramic orthodontic brackets to enamel, acrylic, or porcelain surfaces

Bonding strategies within different brackets and dental materials are still a challenge concerning adhesion and dental surface damage. This study compared the shear and tensile bond strength of orthodontic ceramic and metallic brackets to enamel, acrylic, and ceramic surfaces after thermal cycling. Dental surfaces were divided into three groups: enamel, ceramic, and acrylic. Each group received stainless-steel and ceramic brackets. After thermal cycling, specimens were randomly divided into two subgroups considering tensile (TBS) or shear bond strength (SBS) test. After the mechanical testing, scanning electron and optical microscopy were performed, and the adhesive remnant index (ARI) was determined. The two-way ANOVA full factorial design was used to compare TBS, SBS, and ARI on the surface and bracket type (α = 0.05). There were significant differences in TBS, SBS, and ARI values per surface (p p = 0.009) and type of bracket (p = 0.025 and p = 0.001). The highest mean SBS values were recorded for a ceramic bracket bonded to an acrylic surface (8.4 ± 2.3 MPa). For TBS, a ceramic bracket bonded to acrylic showed the worst performance (5.2 ± 1.8 MPa) and the highest values were found on a metallic bracket bonded to enamel. The adhesion of metallic or ceramic brackets is enough for clinical practice although the damage of the enamel surface after debonding is irreversible and harmful for the aesthetic outcome of the teeth.This work was financed by the Conselho Nacional de Desenvolvimento Científico e Tecnológico in the subject of the project PVE/CAPES/CNPq 407035/2013-3, and by FCT (Portugal) on the projects “Development of High Performance Bioinspired Functionally Graded Materials for Oral Rehabilitation”, and NORTE-01-0145-FEDER-000018-HAMaBICo

Diet of mid-Atlantic Sowerby’s beaked whales Mesoplodon bidens

Copyright © 2011 Elsevier Ltd. All rights reserved.The first mid-Atlantic diet of Mesoplodon beaked whales is presented, from ten Sowerby's Mesoplodon bidens stranded in the Azores region between 2002 and 2009. This doubles the worldwide number of stomachs sampled, and reveals new feeding habits for this species. The mean number of prey items per stomach was 85±89 (range: 12–238), with fish accounting for 99.3% and cephalopods contributing less than 1% of total prey. Fish otoliths from 15 families and cephalopod lower mandibles from three families were identified, representing 22 taxa. The diet consisted mainly of small mid-water fish, the most numerous being Diaphus sp., Lampanyctus sp. and Melamphaidae species. Myctophids were present in all stranded individuals, followed by Diretmidae, Melamphaidae and Opisthoproctus soleatus, while the remaining fish species were scarce or single occurrences. Consistency of diet in four different years reveals a divergence from all previous records in continental areas, where mainly neritic and shelf-break benthopelagic fish species have been reported. Mid-Atlantic Sowerby's beaked whales' showed dietary plasticity, feeding on the most abundant mid-water groups occurring between 0 and750 m. Trophic level from prey numerical frequency was estimated at 4.4±0.46