El médico frente al aborto

Resumen: Este pequeño pero sustancioso libro –escrito desde el Derecho y la Medicina- aborda todos y cada uno de los principales temas que están vinculados con la cuestión, ya existente pero ahora enfatizada por la Corte, de la relación del médico con el aborto

Social behavioral changes in MPTP-treated monkey model of Parkinson's disease

International audienceParkinsonian patients experience not only the physical discomfort of motor disordersbut also the considerable psychological distress caused by cognitive deficits and behavioraldisorders. These two factors can result in a disruption of social relationships during thesymptomatic and even the presymptomatic motor states of the disease. However, it remainsdifficult, if not impossible, to evaluate social relationships in presymptomatic patients.The present study focused on the evaluation of social relationships within a group offemale long-tailed macaques during presymptomatic and symptomatic motor states inducedby Chronic Low-Dose (CLD) and then Chronic High-Dose (CHD) systemic administration of1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Dopaminergic denervation withinbasal ganglia and cortical areas was evaluated using Positron Emission Tomography (PET)scans with 18F-DOPA (6-[18F]-fluoro-L-3,4-dihydroxyphenylalanine) radiotracer.Interestingly, social behavioral changes could be identified in the presymptomaticmotor state before any motor and/or cognitive impairment occurred. Stronger effects wereobserved in subordinate animals compared to dominant animals. From baseline state to CLDpresymptomaticmotor state, the frequency of emitted affiliative and aggressive behaviorsincreased. From CLD-presymptomatic to CHD-presymptomatic motor states, the frequency ofthe three categories of social behaviors (aggressive, submissive and affiliative) decreased. Atthis time, quantitative data analysis in PET scans highlighted a dopaminergic denervation inthe insula and the posterior caudate nucleus. Finally, the frequency of the three categories ofsocial behaviors decreased during the stable-symptomatic motor state compared to baselineand presymptomatic motor states; this was also associated with motor and cognitive disordersand a dopaminergic denervation in all the evaluated cortical and subcortical structures