A fully on-chip LDO voltage regulator with 37 dB PSRR at 1 MHz for remotely powered biomedical implants

This article presents a fully on-chip low-power LDO voltage regulator dedicated to remotely powered wireless cortical implants. This regulator is stable over the full range of alternating load current and provides fast load regulation achieved by applying a time-domain design methodology. Moreover, a new compensation technique is proposed and implemented to improve PSRR beyond the performance levels which can be obtained using the standard cascode compensation technique. Measurement results show that the regulator has a load regulation of 0.175 V/A, a line regulation of 0.024%, and a PSRR of 37 dB at 1MHz power carrier frequency. The output of the regulator settles within 10-bit accuracy of the nominal voltage (1.8 V) within 1.6μs, at full load transition. The total ground current including the bandgap reference circuit is 28μA and the active chip area measures 290μm×360μm in a 0.18μm CMOS technolog

Patlayıcı Etki Analizi Simülasyon Yazılımının Geliştirilmesi ve Basınç Dalgası Parametrelerinin Derin Öğrenme ile Tahmin Edilmesi

Bu çalışmadaki amaç patlama sonucunda meydana gelen yüksek basınç dalgasını modelleyen bir simülasyon yazılımı geliştirmek ve bu simülasyon yazılımından elde edilen veri setini kullanarak derin sinir ağı ile basınç dalgası parametrelerini tahmin etmektir. Geliştirilen simülasyon yazılımı ile askeri alanda gerçekleştirilecek ana unsuru patlayıcı olan faaliyetlerin insan ve yapılar üzerindeki çevresel etkileri ortaya konulmaktadır. Kullanıcı tarafından belirlenen patlayıcı tipi, patlayıcı ağırlığı ve mesafe parametreleri girilerek basınç dalgası parametreleri hesaplanmaktadır. Basınç dalgası parametreleri hesaplanırken yazılım üzerinde matematiksel model veya derin sinir ağı modeli seçimi yapılabilmektedir. Üç boyutlu gösterim alanı veya harita üzerinde seçilen konum üzerinde basınç etkileri, basınç etki alanları, insan ve yapılar üzerindeki etkileri gösterilmektedir. Ayrıca geliştirilen yazılım birçok amaç için kullanılabilecek niteliktedir. Bunlardan bazıları; (i) askeri alanda stratejik bilginin hızlı ve kolay bir şekilde sağlanması, (ii) ideal patlayıcı yükünün bulunması, (iii) terör faaliyetlerinde kullanılan patlayıcı yüklerinin çevresel etkilerinin analiz edilmesi ve önlemlerin alınması, (iv) askeri operasyonlarda kullanılan patlayıcıların insan ve yapılar üzerindeki etkilerin tahmin edilmesi, (v) askeri alanda gerçekleştirilecek operasyonlarda belirlenen hedefe atılacak patlayıcı yükünün optimum seviyede belirlenmesi. Geliştirilen 3 boyutlu simülasyon ortamının patlama sonrası meydana gelen aşırı basınç dalgası parametrelerini doğru bir şekilde tahmin ederek, insan ve yapılar üzerindeki etkilerini etkili bir şekilde simüle ettiği gözlenmiştir. Bunun yanı sıra, çalışmada basınç verisi Derin Sinir Ağı ile de tahmin edilmiştir. Yazılım tarafından oluşturulan sentetik veri setleri ile derin sinir ağı modelinin eğitim ve test işlemleri gerçekleştirilmiştir. Seçilen patlayıcı tipine göre oluşturulan derin sinir ağı modeli ile yarı küresel patlamalar sonucu ortaya çıkan blast dalgası (aşırı basınç dalgası) parametreleri başarılı bir şekilde tahmin edilmiştir

Robot-assisted laparoscopic pyeloplasty (RALP) in children with horseshoe kidneys: results of a multicentric study

This multicentric study aimed to report our experience with robot-assisted laparoscopic pyeloplasty (RALP) in children with horseshoe kidney (HSK). METHODS: The records of 14 patients (11 boys and 3 girls with an average age of 9 years), who underwent RALP for repair of pelvi-ureteric junction obstruction (PUJO) in HSK in five international pediatric urology units over a 5-year period, were retrospectively reviewed. A dismembered pyeloplasty with no division of isthmus was performed in all the cases. RESULTS: The average operative time including docking was 143.5 min (range 100-205). No conversions to laparoscopy or open surgery or intra-operative complications occurred. Patients were discharged on postoperative day 2 following catheter and drain removal. The JJ stent was removed at mean 33 days postoperatively. Overall success rate was 92.8%. As for postoperative complications, we recorded a urinary tract infection (UTI) and stent-related irritative symptoms, managed with medical therapy, in two patients (II Clavien) and an anastomotic stricture in one patient needing surgical revision with no further recurrence (IIIb Clavien). At follow-up, all the patients (one after redo-surgery) reported complete resolution of symptoms, improvement of hydronephrosis on ultrasound and no residual obstruction on diuretic renogram. CONCLUSIONS: Our experience suggested that RALP in HSK is safe, feasible and with good medium-term outcomes in expert hands. An accurate pre-operative planning associated with a standardized technique is key points to achieve good surgical and functional outcomes in these challenging cases. The da Vinci robot technology offers the advantages of MIS procedures and overcomes the technical challenges of laparoscopic approach

The Effectiveness of Learning Instruments of Speaking Containing Character Values toward Speaking Learning

This development research aimed at describing the effectiveness of learning instruments of speaking that were contained in character values. The objects of the study were a syllabus, lesson plan, textbook, and assessment. The subjects of the study were the lecturers of Speaking and the 2nd-semester students of IIA, IIB, and IIC in the academic year of 2015/2016. The data was collected through observation, questionnaire, and test. The data was analyzed by administering descriptive qualitative technique and descriptive statistics. The results of the study showed that the learning instruments was effective to be used in the teaching and learning process, to improve students understanding on the materials, to improve students speaking skill, and to shape characters such as religious, polite, communicative, open, democratic, respectful, responsible, curious, discipline, confident, cooperative, appreciate achievement, logic, critic, creative and innovative, and love reading. The results of the study indicated that the learning instruments of speaking contained of character values were effective so that it was feasible to be used by both lecturers and students of Indonesian Language and Literature Department, Language and Art Faculty of Ganesha University of Education

Informalidad y responsabilidad ambiental de los comerciantes de la asociación Mercado Los Incas, Independencia, 2019

El objetivo de la tesis ha sido determinar la relación de la informalidad con la responsabilidad ambiental de los comerciantes de la asociación mercado Los Incas. La teoría que fundamenta Weber, M. (1920), nos dice que la burocracia forma parte de la organización que está conformada por normas y reglamentos establecidos periódicamente. Si principal objetivo es la legislación propia de las entidades es decir que define cómo debe funcionar la organización. Estas series de normas y reglamentos son precisamente para cubrir en su totalidad las áreas de la organización, para así poder tomar medidas de prevención ante situaciones posibles y encuadrarlas dentro de un esquema definido, capaz de regular todo lo que ocurra dentro de la organización. Según Organización Internacional del Trabajo (2013). El sector informal está identificado como el conjunto o grupo de personas dedicadas a la elaboración de bienes o la prestación de servicios con propósito de generar y ganar ingresos para las personas que participan en esa actividad. Además, Domingos, J; Díaz A. y Sánchez A. (2014). De manera grupal se llegó al acuerdo de que la responsabilidad ambiental define el concepto como la obligación de aplicar, indemnizar, reparar todo el daño o el perjuicio causado o generado por el ser humano, como consecuencia de un acto u omisión que ha ocasionado un menoscabo o deterioro del medio ambiente. El tipo de investigación ha sido aplicada, la población estuvo conformada por 335 y la muestra ha sido 179 consumidores, el instrumento que se utilizó para la recopilación de datos fue un cuestionario de tipo Likert. De acuerdo a los resultados y análisis respectivos se concluye que la informalidad tiene una relación positiva media con la responsabilidad ambiental

Could conscious sedation with midazolam for dental procedures be an alternative to general anesthesia?

Aim: The aim of our study was to evaluate the likelihood that conscious sedation (CS) with intravenous midazolam could become an alternative modality to general anesthesia (GA) for dental procedures.Materials and Methods: In our study, 58 and 47 American Society of Anesthesiologists (ASA).1 pediatric patients, aged 2.12 (mean 6) years, underwent dental procedures and minor oral surgical procedures under GA and CS with intravenous midazolam, respectively. The two groups were evaluated in terms of vital signs, duration of the treatment procedure, patient behavior, and the treatment comfort experienced by the physicians.Results: The oxygen saturation level was significantly lower (GA: 99.0 } 0.30, CS: 98.4 } 1.02; P < 0.001) and the duration of the treatment procedure was significantly shorter (P < 0.001) in the sedation group compared with the GA group. The physicians encountered various difficulties during implementation of the treatment strategy in cases wherethey used CS. Minor oral surgical procedures and tooth extraction  processes requiring no saline irrigation, however, could be performed successfully under CS.Conclusions: In cases requiring multiple dental management issues, the sedation method was not found to be a useful alternative to GA.Key words: Conscious sedation, general anesthesia, pediatric dentistr

Inductive Power Link for a Wireless Cortical Implant with Biocompatible Packaging

This article presents an inductive power link for a cortical implant. The link includes a Class-E power amplifier, an inductive link, a matching network, and a rectifier. The coils of the inductive link are designed and optimized for a distance of 10mm (scalp thickness). The power amplifier is designed in order to allow closed loop power control by controlling the supply voltage. A new packaging topology is proposed in order to position the implant in the skull, without occupying much area, but still obtaining short distance between the remote powering coils. The package is fabricated using biocompatible materials such as PDMS and Parylene-C, and it includes the secondary coil, the matching network, and the rectifier. The power efficiency of the link is characterized for a wide range of load power (1-20mW) and found to be 8.1% for nominal load of 10mW. The matching network improves the power efficiency on the whole range, compared to the link without the matching network

Organización comercial y satisfacción al cliente en el mercado Los Incas, Independencia, 2019

El objetivo del trabajo de investigación ha sido determinar la relación entre organización comercial y satisfacción al cliente en el mercado Los Incas, Independencia, 2019. La teoría que fundamenta es, Taylor, F. (1903). La teoría Científica de la Administración, tiene un punto de vista que se enfoca en los planes de la organización y también se concentra en la organización formal. Su pensamiento de organización se encarga en el cambio de los métodos empíricos por un método científico y se enfoca en el periodo y desplazamiento. La finalidad de esta teoría es el crecimiento de la eficiencia empresarial a través del crecimiento de la fabricación. Los premios vienen a ser la retribución por el trabajo del empleado. Según Mera, K. (2014), la organización comercial es general por lo mismo que puede ser aplicado cualquier grupo o grupos con un conjunto particular de preferencias, estrategias, capacidades y demandas que organizan para poder lograr de manera colectiva el objetivo determinado para obtener un logro. Además, Prieto (2014): Define que satisfacción del cliente, es la forma en la cual el cliente pueda percibir el servicio o calidad de producto que le está ofreciendo el vendedor o comerciantes la condición en el cual los deseos se puedan mostrar al momento de adquirir un producto o servicio. El tipo de investigación ha sido aplicada, la población estuvo conformada por 335 consumidores, la muestra ha sido 179 consumidores con un muestreo probabilístico, el instrumento que se utilizó fue un cuestionario de tipo Likert. Los resultados que se han obtenido podemos decir que las variables tienen una correlación de positiva media de 0.675**, por lo tanto, se ha determinado que existe una relación positiva media entre la organización comercial y satisfacción al cliente