Momentum, Rather Than Velocity, Is a More Effective Measure of Improvements in Division IA Football Player Performance

Speed, or the time to complete straight runs or agility drills, is commonly used to assess performance in collegiate American football players. However, it is common for players\u27 speeds to plateau by the second year of eligibility, whereas their body masses continue to increase. The purpose of this study was to track change in speed, body mass, and momentum (body mass · velocity), across Division 1 football players\u27 4-year careers (n = 512). Complete data were derived for the 40-yd sprint (n = 82), the proagility shuttle (n = 73), and the L drill (n = 73) from the same NCAA Division 1 team over a 15-year period. Significant changes were seen for velocity between year 1 and the next 3 playing years (p \u3c 0.05), with no differences between years 2 and 4, whereas body mass increased significantly across all playing years (p \u3c 0.05). Further momentum increased across all years for all tests (p \u3c 0.0001). These results indicate the importance of including changes in body mass when evaluating performances during sprints and change of direction drills. Our results also suggest that using sprint or agility drill times to evaluate playing potential across football players\u27 collegiate careers may be ineffective and can provide players with a false and disheartening picture of their improvements across their careers. Momentum, which incorporates training-induced increases in both speed and body mass, would be a more relevant and supportive measure of players\u27 improvements. In addition, the simple computation of this variable, using existing speed and body mass data, may be an important addition to the National Football League combine as a measure of playing potential in the professional game

May the four be with you: novel IR-subtraction methods to tackle NNLO calculations

In this manuscript, we summarise all discussions originated as a result of the WorkStop/ThinkStart 3.0: paving the way to alternative NNLO strategies that took place on 4.-6. November 2019 at the Galileo Galilei Institute for Theoretical Physics (GGI). We gratefully acknowledge the support of GGI and the COST Action CA16201 PARTICLEFACE. We wish to thank toW.M. Marroquin and M. Morandini for their help in organising the workshop. P. Banerjee acknowledges support by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 701647. A.L. Cherchiglia, B. Hiller and M.Sampaio acknowledge support from Fundacao para a Ciencia e Tecnologia (FCT) through the projects UID/FIS/04564/2020 and CERN/FIS-COM/0035/2019. The work of L. Cieri has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 754496. The work of F. Driencourt-Mangin, G. Rodrigo, G. Sborlini and W.J. Torres Bobadilla is supported by the Spanish Government (Agencia Estatal de Investigacion), ERDF funds from European Commission (Grant No. FPA2017-84445-P), Generalitat Valenciana (Grant No. PROMETEO/2017/053) and from the SpanishGovernment (FJCI-2017-32128). T. Engel acknowledges support by the Swiss National Science Foundation (SNF) under contract 200021_178967. C. Gnendiger, R. Pittau, A. Signer and D. Stockinger wish to thank B. Page for his help in establishing (2.60). The work of R. J. Hernandez-Pinto is supported by CONACyT through the Project No. A1-S-33202 (Ciencia Basica) and Sistema Nacional de Investigadores. G. Pelliccioli was supported by the Bundesministerium fur Bildung und Forschung (BMBF, German Federal Ministry for Education and Research) under contract no. 05H18WWCA1. J. Pires was supported by Fundacao para a Ciencia e Tecnologia (FCT, Portugal) through the contract UIDP/50007/2020 and project CERN/FIS-PAR/0024/2019. The work of R. Pittau has been supported by the SpanishGovernment grant PID2019-106087GB-C21 and by the Junta de Andalucia project P18-FR-4314 (fondos FEDER). M. Sampaio acknowledges a research grant from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico 303482/2017-6). C. Signorile-Signorile was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Grant no. 396021762 - TRR 257.In this manuscript, we report the outcome of the topical workshop: paving the way to alternative NNLO strategies (https://indico.ific.uv.es/e/WorkStop-ThinkStart_3.0), by presenting a discussion about different frameworks to perform precise higher-order computations for high-energy physics. These approaches implement novel strategies to deal with infrared and ultraviolet singularities in quantum field theories. A special emphasis is devoted to the local cancellation of these singularities, which can enhance the efficiency of computations and lead to discover novel mathematical properties in quantum field theories.European Commission 701647Portuguese Foundation for Science and Technology European Commission UID/FIS/04564/2020 CERN/FIS-COM/0035/2019European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 754496Spanish Government (Agencia Estatal de Investigacion)ERDF funds from European Commission FPA2017-84445-PGeneralitat Valenciana European Commission PROMETEO/2017/053Spanish Government European Commission FJCI-2017-32128 PID2019-106087GB-C21Swiss National Science Foundation (SNSF) 200021_178967Consejo Nacional de Ciencia y Tecnologia (CONACyT) A1-S-33202Sistema Nacional de InvestigadoresFederal Ministry of Education & Research (BMBF) 05H18WWCA1Portuguese Foundation for Science and Technology UIDP/50007/2020 CERN/FIS-PAR/0024/2019Junta de Andalucia P18-FR-4314Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 303482/2017-6German Research Foundation (DFG) 396021762 - TRR 257GGIEuropean Cooperation in Science and Technology (COST) CA16201 PARTICLEFAC

Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer

<p>Abstract</p> <p>Background</p> <p>Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theories, researchers remain unsure as to the definitive cause of endometriosis. Our objective was to test the validity of the theory of müllerianosis for endometriosis, that is the misplacing of primitive endometrial tissue along the migratory pathway of foetal organogenesis</p> <p>Methods</p> <p>We have collected at autopsy 36 human female foetuses at different gestational age. We have performed a morphological and immunohistochemical study (expression of oestrogen receptor and CA125) on the pelvic organs of the 36 foetuses included en-block and totally analyzed.</p> <p>Results</p> <p>In 4 out of 36 foetuses we found presence of misplaced endometrium in five different ectopic sites: in the recto-vaginal septum, in the proximity of the Douglas pouch, in the mesenchimal tissue close to the posterior wall of the uterus, in the rectal tube at the level of muscularis propria, and in the wall of the uterus. All these sites are common location of endometriosis in women.</p> <p>Conclusion</p> <p>We propose that a cause of endometriosis is the dislocation of primitive endometrial tissue outside the uterine cavity during organogenesis.</p

The ac stark shift and space-borne rubidium atomic clocks

open7sìDue to its small size, low weight, and low power consumption, the Rb atomic frequency standard (RAFS) is routinely the first choice for atomic timekeeping in space. Consequently, though the device has very good frequency stability (rivaling passive hydrogen masers), there is interest in uncovering the fundamental processes limiting its long-term performance, with the goal of improving the device for future space systems and missions. The ac Stark shift (i. e., light shift) is one of the more likely processes limiting the RAFS' long-term timekeeping ability, yet its manifestation in the RAFS remains poorly understood. In part, this comes from the fact that light-shift induced frequency fluctuations must be quantified in terms of the RAFS' light-shift coefficient and the output variations in the RAFS' rf-discharge lamp, which is a nonlinear inductively-couple plasma (ICP). Here, we analyze the light-shift effect for a family of 10 on-orbit Block-IIR GPS RAFS, examining decade-long records of their on-orbit frequency and rf-discharge lamp fluctuations. We find that the ICP's light intensity variations can take several forms: deterministic aging, jumps, ramps, and non-stationary noise, each of which affects the RAFS' frequency via the light shift. Correlating these light intensity changes with RAFS frequency changes, we estimate the light-shift coefficient, K-LS, for the family of RAFS: K-LS = -(1.9 +/- 0.3) x 10(-12) /%. The 16% family-wide variation in K-LS indicates that while each RAFS may have its own individual K-LS, the variance of K-LS among similarly designed RAFS can be relatively small. Combining K-LS with our estimate of the ICP light intensity's non-stationary noise, we find evidence that random-walk frequency noise in high-quality space-borne RAFS is strongly influenced by the RAFS' rf-discharge lamp via the light shift effect. Published by AIP Publishing.openFormichella, V.; Camparo, J.; Sesia, I.; Signorile, G.; Galleani, L.; Huang, M.; Tavella, P.Formichella, V.; Camparo, J.; Sesia, Ilaria; Signorile, Giovanna; Galleani, L.; Huang, M.; Tavella, Patrizi

Clubbing masculinities: Gender shifts in gay men's dance floor choreographies

This is an Author's Accepted Manuscript of an article published in Journal of Homosexuality, 58(5), 608-625, 2011 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/10.1080/00918369.2011.563660This article adopts an interdisciplinary approach to understanding the intersections of gender, sexuality, and dance. It examines the expressions of sexuality among gay males through culturally popular forms of club dancing. Drawing on political and musical history, I outline an account of how gay men's gendered choreographies changed throughout the 1970s, 80s, and 90s. Through a notion of “technologies of the body,” I situate these developments in relation to cultural levels of homophobia, exploring how masculine expressions are entangled with and regulated by musical structures. My driving hypothesis is that as perceptions of cultural homophobia decrease, popular choreographies of gay men's dance have become more feminine in expression. Exploring this idea in the context of the first decade of the new millennium, I present a case study of TigerHeat, one of the largest weekly gay dance club events in the United States

Demonstrator of Time Services based on European GNSS signals: the H2020 DEMETRA Project

During 2015-2016, a European Consortium of 15 partners from 8 different countries, developed the DEMETRA (DEMonstrator of EGNSS services based on Time Reference Architecture), a project funded by the European Union in the frame of the Horizon 2020 program. This project aims at developing and experimenting time dissemination services dedicated to specific users like traffic control, energy distribution, finance, telecommunication, and scientific institutions. Nine services have been developed. These services provide time dissemination with accuracy levels from millisecond to the sub-ns, and also additional services like certification, calibration, or integrity. Five of these services are based on the European GNSS. After a development phase (see PTTI 2016 presentation) the full DEMETRA system has been working during six months for demonstration. The paper will report about the experimentation results, showing performances and limits of the proposed time dissemination services, aiming to foster the exploitation of the European GNSS for timing applications

Endometriosis and Headache

Headache and endometriosis show some similarities in their clinical and epidemiological features that are probably due to the influence of female sexual hormones on both disorders. Epidemiological studies indicate that they are comorbid disorders. However, the nature of the comorbidity is not known with certainty, but a likely explanation may be common susceptibility genes. Another possibility is that, because they both are related to pain, increased pain sensitivity induced by one of the disorders may lead to a higher likelihood of developing the other, possibly mediated by nitrogen oxide or prostaglandins. A common link to the widespread use of estroprogestins may seem less probable. For physicians dealing with women with either of these disorders, awareness of the comorbidity may be helpful in the treatment of the patient

Genetic dissection of the relationships between grain yield components by genome-wide association mapping in a collection of tetraploid wheats

Increasing grain yield potential in wheat has been a major target of most breeding programs. Genetic advance has been frequently hindered by negative correlations among yield components that have been often observed in segregant populations and germplasm collections. A tetraploid wheat collection was evaluated in seven environments and genotyped with a 90K SNP assay to identify major and stable quantitative trait loci (QTL) for grain yield per spike (GYS), kernel number per spike (KNS) and thousand-kernel weight (TKW), and to analyse the genetic relationships between the yield components at QTL level. The genome-wide association analysis detected eight, eleven and ten QTL for KNS, TKW and GYS, respectively, significant in at least three environments or two environments and the mean across environments. Most of the QTL for TKW and KNS were found located in different marker intervals, indicating that they are genetically controlled independently by each other. Out of eight KNS QTL, three were associated to significant increases of GYS, while the increased grain number of five additional QTL was completely or partially compensated by decreases in grain weight, thus producing no or reduced effects on GYS. Similarly, four consistent and five suggestive TKW QTL resulted in visible increase of GYS, while seven additional QTL were associated to reduced effects in grain number and no effects on GYS. Our results showed that QTL analysis for detecting TKW or KNS alleles useful for improving grain yield potential should consider the pleiotropic effects of the QTL or the association to other QTLs

Strength Training for Arthritis Trial (START): design and rationale

Background Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, while all published treatment guidelines recommend muscle strengthening exercise to combat loss of muscle mass and strength in knee OA patients, previous strength training studies either used intensities or loads below recommended levels for healthy adults or were generally short, lasting only 6 to 24 weeks. The efficacy of high-intensity strength training in improving OA symptoms, slowing progression, and affecting the underlying mechanisms has not been examined due to the unsubstantiated belief that it might exacerbate symptoms. We hypothesize that in addition to short-term clinical benefits, combining greater duration with high-intensity strength training will alter thigh composition sufficiently to attain long-term reductions in knee-joint forces, lower pain levels, decrease inflammatory cytokines, and slow OA progression. Methods/Design This is an assessor-blind, randomized controlled trial. The study population consists of 372 older (age ≥ 55 yrs) ambulatory, community-dwelling persons with: (1) mild-to-moderate medial tibiofemoral OA (Kellgren-Lawrence (KL) = 2 or 3); (2) knee neutral or varus aligned knee ( -2° valgus ≤ angle ≤ 10° varus); (3) 20 kg.m-2 ≥ BMI ≤ 45 kg.m-2; and (3) no participation in a formal strength-training program for more than 30 minutes per week within the past 6 months. Participants are randomized to one of 3 groups: high-intensity strength training (75-90% 1Repetition Maximum (1RM)); low-intensity strength training (30-40%1RM); or healthy living education. The primary clinical aim is to compare the interventions’ effects on knee pain, and the primary mechanistic aim is to compare their effects on knee-joint compressive forces during walking, a mechanism that affects the OA disease pathway. Secondary aims will compare the interventions’ effects on additional clinical measures of disease severity (e.g., function, mobility); disease progression measured by x-ray; thigh muscle and fat volume, measured by computed tomography (CT); components of thigh muscle function, including hip abductor strength and quadriceps strength, and power; additional measures of knee-joint loading; inflammatory and OA biomarkers; and health-related quality of life. Discussion Test-retest reliability for the thigh CT scan was: total thigh volume, intra-class correlation coefficients (ICC) = 0.99; total fat volume, ICC = 0.99, and total muscle volume, ICC = 0.99. ICC for both isokinetic concentric knee flexion and extension strength was 0.93, and for hip-abductor concentric strength was 0.99. The reliability of our 1RM testing was: leg press, ICC = 0.95; leg curl, ICC = 0.99; and leg extension, ICC = 0.98. Results of this trial will provide critically needed guidance for clinicians in a variety of health professions who prescribe and oversee treatment and prevention of OA-related complications. Given the prevalence and impact of OA and the widespread availability of this intervention, assessing the efficacy of optimal strength training has the potential for immediate and vital clinical impact