Islam and Evolution

"This book attempts to equip the reader with a holistic and accessible account of Islam and evolution. It guides the reader through the different variables that have played a part in the ongoing dialogue between Muslim creationists and evolutionists. This work views the discussion through the lens of al-Ghazālī (1058-1111), a widely-known and well-respected Islamic intellectual from the medieval period. By understanding al-Ghazālī as an Ash’arite theologian, a particular strand of Sunni theology, his metaphysical and hermeneutic ideas are taken to explore if and how much Neo-Darwinian evolution can be accepted. It is shown that his ideas can be used to reach an alignment between Islam and Neo-Darwinian evolution. This book offers a detailed examination that seeks to offer clarity if not agreement in the midst of an intense intellectual conflict and polarity amongst Muslims. As such, it will be of great interest to scholars of Science and Religion, Theology, Philosophy of Religion, Islamic Studies, and Religious Studies more generally.

Damage detection using self-sensing composites

The primary aim of this research programme was to enable damage detection in glass fibre reinforced composites using the reinforcing fibres as the sensing element. In other words, E-glass fibres were used as light guides to detect the fracture of individual fibres, when loaded in tension. This was achieved by monitoring the transmitted light intensity through the reinforcing glass fibres. Two types of glass fibres and matrices were evaluated. In the case of glass fibres, E-glass and custom-made small-diameter (12 µm) optical fibre (SDOF) were used. Three types of low refractive index resin systems with specified failure strains were also used. The basic technology involved illuminating one end of the fibre bundle or composite with a white light or laser source and the opposite end was imaged using a high-speed CCD camera. Acoustic emission monitoring of fibre bundles revealed that there were two types of failures occurring in a bundle, a lower amplitude of the acoustic emission signal (AES) related to the inter-fibre friction and a high amplitude of the AES to fibre fractures. This characteristic was also confirmed by a Weibull statistical analysis where it was demonstrated that a two parameter distribution was present corresponding to two different flaw distributions. In the case of self-sensing composites, it was found that the specific failure modes in the composites (matrix failure, fibre fracture, debonding) generate their characteristic amplitudes of the AES and frequencies. These failure modes were recorded and correlated to the tensile test data. It was demonstrated that the attenuation of transmitted light can be related to the fracture of fibres in the bundle or a composite test specimen. It was found that the image analysis routines were capable of identifying and tracking the survival or fracture of each fibre in the bundle or composite. The results obtained from mechanical loading, acoustic emission and images analysis were cross-correlated

Effects on ALT normalization in the first month of treatment by Sofosbuvir/Ribavirin therapy versus Sofosbuvir/Daclatasvir therapy in HCV infected individuals

Objective: To evaluate the effects on ALT normalization in first month by SOFOS/RIB therapy versus SOFOS/DAC therapy in HCV infected individuals in Pakistan Study Design: Cross sectional comparative study Material and Methods: In a cross sectional analysis in a total of 200 Hepatitis c infected patients, sex, H/O diabetes mellitus, prior interferon therapy, decrease in hemoglobin >2 gm/dl in 1st month and rise in serum bilirubin in 1st month were the qualitative variables and the quantitative variables were age, weight, baseline hemoglobin, baseline bilirubin at week 4 of treatment. The statistical relation of the mentioned variables was checked using SPSS version 15 on the basis of data collected. Results: Out of total 200 patients, 47% (94) were males, 53% (106) were females, 28% (56) patients were diabetic & 44.5% (89) patients had history of prior interferon therapy, 28.5% (57) patients were having low hemoglobin levels before starting above mentioned treatment. Both the groups completed the treatments A & B for 24 &12 weeks respectively & collected data showed the superiority of treatment B to treatment A as no decrease in hemoglobin (p=0.000), & no rise in serum bilirubin(p=0.000) during 1st month of treatment while ,serum bilirubin was 93 % in treatment B and 73 % in treatment A. Conclusion: The results concluded that treatment B (Sofosbuvir / Daclatasvir for 12 weeks) is superior anti hepatitis C therapy as compared to the treatment A (Sofosbuvir / Ribavirin for 24 weeks) in order to achieve ALT normalization in first month of therapy in Pakistani population. Ribavirin should be avoided to prevent hemolytic anemia as well. Keywords: Hepatitis C, Alkaline Phosphatas

Depression, Anxiety And Stress Among Medical And Allied Health Sciences Students At Sargodha Medical College

Abstract Objective: This study attempts to determine the frequency of depression, anxiety and stress and associated factors among medical and allied health sciences students of Sargodha Medical College.  Methods: The nature of the study is cross-sectional, among 350 (175 each) medical and allied health sciences students of Sargodha Medical College. The students were recruited using convenient sampling. Socio-demographic information was recorded and depression, anxiety and stress were assessed using the depression, anxiety and stress scale (DASS-21). Statistical Package for Social Sciences (SPSS) version 24.0 was used for data entry and analysis. Results: The study shows that nearly half of medical students (53.1%) had depression, 69.7% had anxiety and 44% had stress; while among allied health sciences students, 60.6% were depressed, 73.7% had anxiety and 45.1% had reported stress. The mean depression score among medical students was 12.19 ± 9.98 and 13.29 ± 11.12 among allied health sciences students (p≤0.332). Conclusion: Based on the results, it is recommended that various methods should be adapted and prioritized for enhancing the mental health of the students to support and improve academic learning among students.

Ferula asafoetida Linn. is effective for early functional recovery following mechanically induced insult to the sciatic nerve of a mouse model

Purpose: To evaluate the effect of Ferula asafoetida (oleo gum resin powder) on sensory and motor functions retrieval on an induced sciatic nerve injury in a mouse model.Methods: A mechanical crush was inserted in the sciatic nerve of all the experimental mice after acclimatization. The mice were allocated to four groups; one normal chow group (control, n = 7) and three Ferula asafoetida chow groups (each n = 7) of different doses (50, 100 and 200 mg/kg). Muscle grip strength, muscle mass, and sciatic functional index were measured to evaluate the motor function regain, while sensory function regain was assessed by hot plate test. Oxidative stress and glycemic levels were measured by biochemical assays.Results: The findings of this study indicate that Ferula asafoetida 200 mg/kg has a highly significant (p≤ 0.001) ameliorating effect in terms of improved grip strength (77.7 ± 5.4 % for 200 mg/kg vs. 46 ± 5.1 % for control), reversal of SFI towards normal ( -34 ± 8.1 for 200 mg/kg group vs. –61 ± 6.1 for control), decrease in paw withdrawal latency (7.10 ± 0.06 s for 200 mg/kg group vs. 15 ± 0.5 s for control) on day 12 post-injury, as well as restoration of skeletal muscle mass towards normal. Interestingly, F. asafoetida chow 50 mg/kg and 100 mg/kg groups also impacted significant (p < 0.01) improvement in the ameliorative effect. However, the differences among all treatment groups in ameliorating recovery were not significant (p > 0.05). Moreover, comparatively improved (p < 0.0001) total antioxidant capacity along with reduced total oxidant status (p = 0.01) in the Ferula asafoetida chow (200 mg/kg) group, indicate the antioxidative effect of this plant. Furthermore, the treated mice (200 mg/kg) also expressedan improved glycemic level (p = 0.0005).Conclusion: Ferula asafoetida supplementation helps to accelerate both sensory and motor function retrieval following sciatic nerve injury. This  improvement is thought to be correlated with the antioxidant capacity of the plant. However, further investigations are required to identify the therapeutic principles responsible for the observed actions. Keywords: Sciatic nerve injury, Ferula asafoetida, Function recovery, Oxidative stress, Biochemical analysi

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO