10 research outputs found
Rapid quality control of potato chips using near and mid-infrared spectroscopy
- Author
- Publication venue
- Publication date
- 02/04/2007
- Field of study
Potato chips are the most important product among all the snack industry. Quality of potato chips is monitored by their moisture content and fat content. Traditional methods are reliable, but also time consuming and expensive. The feasibility of developing a methodology for a reliable, sensitive and fast quantification of moisture and fat in potato chips by using infrared spectroscopy combined with multivariate analysis was investigated
Commercial potato chips (16) were obtained from a local market. Samples were grinded and their spectra collected using an integrating sphere (NIR) or attenuated total reflectance (MIR). Calibration models were developed to predict the content of fat and moisture in an independent set of samples. The total fat content ranged from 18% to 45% and the moisture content ranged from 1.2% to 4%. The correlation coefficients (r) obtained for the prediction model of moisture were >0.97 and standard error of cross validation (SECV) 0.96 and SECV values of 1.29% and 1.65% for NIR and MIR, respectively. Classification models developed based on Soft Independent Modeling of Class Analogy were able to differentiate the potato chips according to type of oil in which the potatoes were fried. The MIR spectroscopy was able to identify samples containing -trans fats at 965 cm-1. A fast, simple and accurate method to evaluate potato chip quality was developed by infrared spectroscopy, providing the industry a convenient technique for routine analysis of the product
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H
- Aamodt Anne H
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J
- Adeoye Abiodun M
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D
- Anderson Christopher D
- Anderson Christopher D
- Aparicio Hugo J
- Arenillas Juan Francisco
- Armasu Sebastian M
- Armstrong Nicole D
- Arnett Donna K
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K
- Bammler Theo K
- Bartz Traci M
- Bastarache Lisa
- Beiser Alexa S
- Beiser Alexa S
- Bell Steven
- Benavente Oscar R
- Benn Marianne
- Bennett David A
- Berr Claudine
- Bevan Steve
- Bis Joshua C
- Bis Joshua C
- Bis Joshua C
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K
- Brody Jennifer A
- Brouwers Paul JAM
- Brown Robert D
- Brumpton Ben M
- Brumpton Ben M
- Buring Julie E
- Bustamante Mariana
- Butterworth Adam S
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L
- Caso Valeria
- Castillo Jose
- Chasman Daniel I
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul IW
- de Cid Rafael
- de Cid Rafael
- de Jager Phil L
- de Jager Phil L
- de Jager Phil L
- de Kort Paul L
- de Laat Karlijn F
- de Laat Karlijn F
- de Leeuw Frank-Erik
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran Hossein
- Deleuze Jean-Francois
- Delgado Pilar
- Delgado Pilar
- Delgado-Mederos Raquel
- den Heijer Tom
- den Hoed Marcel
- DeStefano Anita L
- Dhar Rajat
- Diaz-Navarro Rosa
- Dichgans Martin
- Dorr Marcus
- Duan Qing
- Ellekjaer Hanne
- Endres Matthias
- Engelter Stefan T
- Engstrom Gunnar
- Esko Tonu
- Esko Tonu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Fakunle Adekunle G
- Falcone Guido J
- Fernandez-Cadenas Israel
- Ferreira Leslie E
- Ferreira Leslie E
- Fongang Bernard
- Ford Ian
- Fornage Myriam
- Franca Paulo HC
- Frantz Stefan
- Frazer Kelly A
- Freijo Marimar
- Frikke-Schmidt Ruth
- Fritsche Lars G
- Furie Karen L
- Gabrielsen Maiken E
- Gabrielsen Maiken E
- Gallego-Fabrega Cristina
- Gallego-Fabrega Cristina
- Gasca Natalie C
- Gasca Natalie C
- Geerlings Mirjam I
- Geerlings Mirjam I
- Geerlings Mirjam I
- Georgakis Marios K
- Germain Marine
- Ghanbari Mohsen
- Gieger Christian
- Giese Anne-Katrin
- Giese Anne-Katrin
- Giulianini Franco
- Gons Rob AR
- Gordon William
- Gottesman Rebecca F
- Gottesman Rebecca F
- Gottesman Rebecca F
- Grabe Hans J
- Gravel Simon
- Gretarsdottir Solveig
- Grewal Raji P
- Gudnason Vilmundur
- Gudnason Vilmundur
- Guo Yu
- Gurpreet Wander S
- Gustafsson Stefan
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler Jeffrey
- Haessler Jeffrey
- Haeusler Karl Georg
- Hagen Knut
- Hamsten Anders
- Hansen John-Bjarne
- Harris Tamara B
- Hassan Ahamad
- Hata Jun
- Havulinna Aki S
- He Jing
- He Yunye
- Heath Alicia K
- Heath Alicia K
- Heckbert Susan R
- Heit John A
- Heitsch Laura
- Heuch Ingrid
- Heuschmann Peter Ulrich
- Hill Michael
- Ho Yuk-Lam
- Holliday Elizabeth G
- Hopewell Jemma C
- Howard George
- Howson Joanna MM
- Hozawa Atsushi
- Hsu Fang-Chi
- Huffman Jennifer E
- Hveem Kristian
- Hveem Kristian
- Hyacinth Hyacinth I
- Ibanez Laura
- Ibrahim Manal
- Ikram Mohammad A
- Ikram Mohammad K
- Ilinca Andreea
- Ingelsson Erik
- Ingelsson Martin
- Inouye Michael
- Irvin Marguerite R
- Irvin Marguerite R
- Irvin Marguerite R
- Iwasaki Motoki
- Jackson Rebecca D
- Jackson Rebecca D
- Jacob Mina A
- Jee Yon Ho
- Jenkins Carolyn
- Jensen Gorm B
- Jeon Christina E
- Jern Christina
- Jian Xueqiu
- Jimenez-Conde Jordi
- Johnson Andrew D
- Johnson Julie A
- Jood Katarina
- Jousilahti Pekka
- Judy Renae L
- Jukema J Wouter
- Jung Keum Ji
- Jurgenson Tuuli
- Kabrhel Christopher
- Kaffashian Sara
- Kalra Lalit
- Kamanu Frederick K
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup Pia R
- Kanai Masahiro
- Kappelle L Jaap
- Keene Keith L
- Kim Bong-Jo
- Kim Bong-Jo
- Kim Jihye
- Kim Young Jin
- Kinnunen Janne
- Kissela Brett M
- Kitazono Takanari
- Kittner Steven J
- Kjartansson Olafur
- Kleindorfer Dawn O
- Kleinschnitz Christoph
- Kleinschnitz Christoph
- Kloss Manja
- Knol Maria J
- Koido Masaru
- Komolafe Morenikeji
- Konuma Takahiro
- Kooperberg Charles
- Kooperberg Charles
- Kooperberg Charles
- Korv Janika
- Koudstaal Peter J
- Kraft Peter
- Krebs Kristi
- Kristoffersen Espen S
- Krupinski Jerzy
- Kubo Michiaki
- Kumar Amit
- Labovitz Daniel L
- Lacaze Paul
- Lange Leslie A
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Launer Lenore J
- Laurie Cathy C
- Le Grand Quentin
- Le Grand Quentin
- Le Grand Quentin
- Lee Jin-Moo
- Lee Keon-Joo
- Lee Tsong-Hai
- Lemmens Robin
- Lemmons Robin
- Leonard Hampton L
- Lepik Kaido
- Levi Christopher R
- Lewis Adam J
- Lewis Cathryn M
- Leys Didier
- Li Jiang
- Li Liming
- Li Linxin
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin Wei-Yu
- Lind Lars
- Lindgren Arne G
- Lindgren Cecilia M
- Lindstrom Sara
- Linkohr Birgit
- Lioutas Vasileios
- Liu Yong Mei
- Lledos Miquel
- Llucia-Carol Laia
- Longstreth WT
- Lopez Oscar L
- Lopez-Cancio Elena
- Lorentzen Erik
- Luijckx Gert-Jan
- Lv Jun
- MacDonald James
- Magi Reedik
- Magnusson Patrik K
- Maguire Jane
- Makoto Hirata
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S
- Marston Nicholas A
- Marti-Fabregas Joan
- Martinez-Majander Nicolas
- Martinsen Amy E
- Matsuda Koichi
- Mayerhofer Ernst
- McArdle Patrick F
- McCauley Bryan M
- McDonough Caitrin W
- McKnight Barbara
- Meitinger Thomas
- Melander Olle
- Menon Vilas
- Menon Vilas
- Meschia James F
- Metspalu Andres
- Milani Lili
- Millan Monica
- Millwood Iona Y
- Minegishi Naoko
- Mishra Aniket
- Mitchell Braxton D
- Molina Carlos A
- Montaner Joan
- Montellano Felipe A
- Morange Pierre-Emmanuel
- Morisaki Takayuki
- Morris Andrew P
- Mosley Thomas H
- Muino Elena
- Muller-Nurasyid Martina
- Munoz-Narbona Lucia
- Murakami Yoishinori
- Nagai Akiko
- Nagai Akiko
- Nalls Mike A
- Namba Shinichi
- Nederkoorn Paul J
- Nederkoorn Paul J
- Nelis Mari
- Nielsen Jonas B
- Nielsen Jonas B
- Niiranen Teemu J
- Ninomiya Toshiharu
- Nordestgaard Borge G
- Nordestgaard Borge G
- Norrving Bo
- Nygaard Marianne
- O'Donnell Chris J
- O'Donnell Martin J
- Obach Victor
- Obiako Reginald
- Ogbole Godwin
- Ogishima Soichi
- Okada Yukinori
- Olalere Abimbola
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Osaigbovo Godwin
- Ovbiagele Bruce
- Owolabi Lukman
- Owolabi Mayowa O
- Pankow James S
- Pankratz Nathan
- Parati Eugenio A
- Pare Guillaume
- Parodi Livia
- Pattee Jack W
- Peddareddygari Leema Reddy
- Pedersen Linda M
- Pedersen Nancy L
- Pera Joanna
- Perola Markus
- Peters Annette
- Peto Richard
- Pezzini Alessandro
- Pileggi Silvana
- Posner Daniel C
- Pozarickij Alfred
- Prasad Kameshwar
- Prats-Sanchez Luis
- Psaty Bruce M
- Pulit Sara L
- Putaala Jukka
- Puurunen Marja K
- Rabionet Raquel
- Rannikmae Kristiina
- Reiner Alexander
- Reiner Alexander P
- Rexrode Kathryn M
- Riaz Moeen
- Riba-Llena Iolanda
- Ribases Marta
- Ribo Marc
- Rice Kenneth
- Rich Stephen S
- Ridker Paul M
- Rissanen Ina L
- Rolfs Arndt
- Romero Jose R
- Roquer Jaume
- Rosand Jonathan
- Rosendaal Frits R
- Roshchupkin Gennady V
- Ross Owen A
- Rost Natalia S
- Rothwell Peter M
- Rotter Jerome I
- Rudd Anthony G
- Ruff Christian T
- Ruigrok Ynte M
- Rundek Tatjana
- Rutten-Jacobs Loes
- Sabatine Marc S
- Sacco Ralph L
- Saillour-Glenisson Florence
- Sakaue Saori
- Sale Michele M
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera Dharambir K
- Sapkota Bishwa R
- Sarfo Fred S
- Sargurupremraj Muralidharan
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarju Ralhan
- Sarnowski Chloe
- Sasaki Makoto
- Satizabal Claudia L
- Satoh Mamoru
- Sattar Naveed
- Sawada Norie
- Schmidt Carsten O
- Schmidt Dan
- Schmidt Reinhold
- Schminke Ulf
- Schnohr Peter
- Schnohr Peter
- Segura Tomas
- Serrano-Heras Gemma
- Seshadri Sudha
- Sharma Pankaj
- Shi Mingyang
- Shimizu Atsushi
- Shiroma Eric J
- Sibolt Gerli
- Sigurdsson Asgeir
- Sigurdsson Sigurdur
- Simonsick Eleanor M
- Skogholt Anne H
- Sloane Kelly L
- Slowik Agnieszka
- Smith Albert
- Smith Erin N
- Smith Nicholas L
- Sobrino Tomas
- Sobue Kenji
- Soderholm Martin
- Soriano-Tarraga Carolina
- Srinivasasainagendra Vinodh
- Stanne Tara M
- Stefansson Kari
- Stevens Becky
- Stine O Colin
- Stott David J
- Strauch Konstantin
- Strbian Daniel
- Suchon Pierre
- Sudlow Cathie LM
- Sumoy Lauro
- Sun Yan V
- Sung Yun Ju
- Sutoh Yoichi
- Takai Takako
- Tanaka Hideo
- Tang Weihong
- Tanislav Christian
- Tanno Kozo
- Tatlisumak Turgut
- Taylor Kent D
- Taylor Kent D
- Teumer Alexander
- Thijs Vincent NS
- Thomas Laurent F
- Thomassen Jesper Qvist
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tiainen Marjaana
- Tiedt Steffen
- Tiwari Hemant K
- Tomppo Liisa
- Torres-Aguila Nuria P
- Touze Emmanuel
- Traylor Matthew
- Tregouet David-Alexandre
- Trompet Stella
- Tsugane Shoichiro
- Tuladhar Anil Man
- Turman Constance
- Turnbull Iain
- Tybjaerg-Hansen Anne
- Tzourio Christophe
- Uitterlinden Andre G
- Ungethum Kathrin
- Uvere Ezinne
- Valdimarsson Einar M
- van der Laan Sander W
- van der Lee Sven J
- van Dijk Ewoud J
- van Dijk Ewoud J
- van Dijk Gert W
- van Duijn Cornelia M
- van Hylckama Vlieg Astrid
- van Norden Anouk GW
- van Oostenbrugge Robert J
- van Rooij Frank GW
- van Setten Jessica
- van Setten Jessica
- van Vugt Marion
- van Vugt Marion
- Vaura Felix C
- Verma Shefali S
- Verma Shefali S
- Vermeer Sarah E
- Vibo Riina
- Visser Marieke C
- Vives-Bauza Cristofol
- Volker Uwe
- Volzke Henry
- Vonk Jet MJ
- Wahab Kolawole
- Wakai Kenji
- Walters Matthew
- Walters Robin G
- Wang Chen
- Wang Lu
- Wang Ruiqi
- Wareham Nicholas J
- Wassertheil-Smoller Sylvia
- Weir David
- Wennberg Patrik
- Wermer Marieke JH
- Wiggins Kerri L
- Willer Cristen J
- Williams Stephen R
- Wilson James G
- Wilson Peter WF
- Winsvold Bendik Slagsvold
- Wolfe Charles DA
- Wong Quenna
- Woo Daniel
- Worrall Bradford B
- Xu Huichun
- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries
Rapid and Simultaneous Determination of Lycopene and β-Carotene Contents in Tomato Juice by Infrared Spectroscopy
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
O profissional da inclusão escolar
- Author
- Ana Dorziat
- CORAGGIO José Luis
- CORAZZA Sandra M.
- CORREIA Luís de Miranda
- DELEUZE Gilles
- FERREIRA Maria Cecília Carareto
- FORQUIN Jean-Claude
- FREIRE Sofia
- GÓES Maria Cecília Rafael de
- MINAYO Maria Cecilia de Souza
- MORGADO José
- MORIN Edgar
- NIZA Sérgio
- SANTOS Maria Cristina A. S. C.
- SHIROMA Eneida Oto
- SIMÃO Elisa
- SIMÃO Elisa
- SIMÃO Elisa
- SOUZA Regina Maria
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- 't Hart Leen M
- Abecasis Goncalo
- Adair L.S.
- Adams H.H.H.
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer Singh
- Akiyama Masato
- Al-Mulla F.
- Allison Matthew A.
- Andersen Mette korre
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett D.K.
- Asselbergs F.W.
- Assimes Themistocles
- Attia J.
- Auton Adam
- Banas B.
- Bandinelli S.
- Bartell Eric
- Bennett D.A.
- Bergler T.
- Berndt Sonja I.
- Bharadwaj D.
- Bhaskar Seema
- Bielak Lawrence F.
- Biino G.
- Bin Wei W.
- Bisgaard H.
- Boehnke Michael
- Boerwinkle E.
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma D.I.
- Borja J.B.
- Bork-Jensen Jette
- Bouchard C.
- Bowden D.W.
- Bradfield J.P.
- Bradford Y.
- Brandslund I.
- Braund P.S.
- Brody J.A.
- Brumpton B.
- Burgdorf K.S.
- Buring J.E.
- Böger C.A.
- Bønnelykke K.
- Børglum A.D.
- Cade B.E.
- Cai H.
- Cai Q.
- Campbell Archie
- Catamo E.
- Caulfield M.J.
- Cañadas-Garre Marisa
- Chai J.F.
- Chai X.
- Chambers J.C.
- Chandak G.R.
- Chang L.C.
- Chang Y.C.
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi N.
- Chen C.H.
- Chen Shyh-Huei
- Chen Y.D.I.
- Chen Z.
- Cheng C.Y.
- Chesi A.
- Cho Yoon Shin
- Choi S.H.
- Christofidou P.
- Christophersen I.E.
- Chung R.H.
- Ciullo M.
- Cocca M.
- Cole J.W.
- Collins F.S.
- Concas M.P.
- Cooper R.S.
- Couture C.
- Croteau-Chonka Damien
- Cruz M.
- Cucca F.
- Cuellar-Partida Gabriel
- Cupples L.A.
- Cutler M.J.
- Damrauer S.M.
- Danning R.
- Dantoft T.M.
- Daw E.W.
- de Borst G.J.
- de Groot L.C.P.G.M.
- De Jager P.L.
- de Kleijn D.P.V.
- Dedoussis G.V.
- Degenhard F.
- Delgado G.E.
- Delitala A.
- Deloukas Panos
- Demirkan A.
- den Hollander A.I.
- Deng X.
- Devineni P.
- Dietl A.
- Dimitriou M.
- Dimitrov L.
- Dorajoo R.
- Du S.
- Easton D.F.
- Ekici A.B.
- Elders P.J.M.
- Eliasen Anders U.
- Eliassen A.H.
- Ellinor P.T.
- Elmståhl S.
- Engmann J.E.
- Erdmann J.
- Esko Tõnu
- Evans M.K.
- Fairhurst-Hunter Z.
- Farmaki A.E.
- Fatkin D.
- Faul J.D.
- Feenstra B.
- Feitosa M.F.
- Fernandez-Lopez J.C.
- Ferreira Teresa
- Ferrucci L.
- Ford I.
- Forer L.
- Fornage M.
- Francescatto M.
- Franke A.
- Franks P.W.
- Frayling Timothy M.
- Freedman B.I.
- Freitag-Wolf S.
- Fuchsberger C.
- Galesloot Tessel E
- Gao Y.
- Gao Z.
- Gasparini P.
- Geller F.
- Giannakopoulou O.
- Gieger C.
- Girotto G.
- Giulianini F.
- Gjesing A.P.
- Goddard M.E.
- Goel A.
- Golightly Y.M.
- Gonzalez-Villalpando C.
- Gordon S.D.
- Gordon-Larsen P.
- Gorski M.
- Graff Marielisa
- Graham Sarah E.
- Grallert H.
- Grant S.F.A.
- Grarup N.
- Griffiths L.
- Grove J.
- Gudnason V.
- Guo X.
- Gustafsson S.
- Haessler J.
- Haiman C.
- Hakonarson H.
- Hansen T.
- Hansen T.F.
- Hartman C.A.
- Hattersley A.T.
- Havulinna A.S.
- Haworth S.J.
- Hayward C.
- He J.
- Heard-Costa N.
- Hebbar P.
- Heckbert S.R.
- Heid Iris M.
- Heng C.K.
- Hengstenberg C.
- Hewitt A.W.
- Highland Heather H.
- Hindy G.
- Hirschhorn Joel N.
- Hishigaki H.
- Ho Y.L.A.
- Hofer E.
- Holliday E.
- Horn K.
- Hornsby W.E.
- Hottenga J.J.
- Hoyng C.B.
- Huang H.
- Huang J.
- Huang P.L.
- Huang W.
- Huerta-Chagoya A.
- Huffman J.E.
- Hung Y.J.
- Hunt S.C.
- Huo S.
- Hveem K.
- Hwang M.Y.
- Hyppönen E.
- Iacono W.G.
- Ichihara S.
- Iha H.
- Ikeda D.D.
- Ikram M.A.
- Isasi C.R.
- Isono M.
- Jackson A.U.
- Jackson R.D.
- Janaka de Silva H.
- Jansen I.E.
- Jarvelin M.R.
- Ji Yingjie
- Jiang Yunxuan
- Jin Z.B.
- Johansson I.
- Jonas J.B.
- Jonsson A.
- Joshi P.K.
- Jousilahti P.
- Jukema J.W.
- Justice Anne E.
- Jäger S.
- Jöckel K.H.
- Jørgensen T.
- Kalafati I.P.
- Kamatani Y.
- Kanai M.
- Kang K.D.
- Kanoni S.
- Kaprio J.
- Karaderi Tugce
- Kardia S.L.R.
- Karpe F.
- Kasturiratne A.
- Kato N.
- Katsuya T.
- Kawaguchi T.
- Kee F.
- Kember R.L.
- Kentistou K.A.
- Kessler T.
- Khera A.V.
- Khor C.C.
- Kiemeney L.A.L.M.
- Kim B.J.
- Kim E.K.
- Kim H.L.
- Kim H.N.
- Kim Y.J.
- Kirchhof P.
- Kivimaki M.
- Kleber M.E.
- Knol M.J.
- Koh W.P.
- Koistinen H.A.
- Kolovou G.D.
- Kooner J.S.
- Kooperberg C.
- Kovacs P.
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- Salomaa V.
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- Smith J.G.
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- Stefansson Kari
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- Strachan D.P.
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- Sun Yan V.
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- Tai E. Shyong
- Takeuchi F.
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- Thorsteinsdottir Unnur
- Timmers P.R.H.J.
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- Tuomi T.
- Tuomilehto J.
- Turman C.
- Tusié-Luna M.T.
- Tönjes A.
- Uitterlinden A.G.
- Universitat Autònoma de Barcelona
- Vaccargiu S.
- van Dam R.M.
- van der Harst P.
- van der Laan S.W.
- van der Most P.J.
- Van der Velde N.
- van Duijn C.M.
- van Klinken J.B.
- van Schoor N.M.
- van Setten J.
- Vedantam Sailaja
- Verma S.S.
- Verweij N.
- Veturi Y.
- Vidal P.M.
- Visscher PM.
- Vitart V.
- Vollenweider P.
- Vonk Judith M.
- Vrieze Scott
- Völker U.
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- Walker M.
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- Wang C.
- Wang C.A.
- Wang L.
- Wang Y.X.
- Wang Z.
- Wareham N.J.
- Warren H.R.
- Watanabe R.M.
- Watkins Hugh
- Weir D.R.
- Werge T.M.
- Wickremasinghe A.R.
- Widen E.
- Wielscher M.
- Wiggins K.L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold B.S.
- Wong A.
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Y.
- Wuttke M.
- Xia R.
- Xie T.
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto K.
- Yang J.
- Yang Jian
- Yao J.
- Yengo Loic
- Yin Xianyong
- Yokota Mitsuhiro
- Young H.
- Young Kristin L.
- Yousri N.A.
- Yu L.
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng L.
- Zhang W.
- Zhang X.
- Zhao J.H.
- Zhao W.
- Zheng Wei
- Zhou W.
- Zhu Xiaofeng
- Zimmermann M.E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John-Anker
- Álvarez Marcus
- Åsvold B.O.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
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- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- 'The Nature Conservancy'
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart Leen M
- 23andMe Research Team
- Abecasis Goncalo R
- Adair Linda S
- Adams Hieab HH
- Aguilar-Salinas Carlos A
- Ahluwalia Tarunveer S
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A
- Alvarez Marcus
- Andersen Mette K
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A
- Bergler Tobias
- Berndt Sonja I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L
- Boomsma Dorret I
- Borja Judith B
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brumpton Ben
- Burgdorf Kristoffer S
- Buring Julie E
- Böger Carsten A
- Bønnelykke Klaus
- Børglum Anders D
- Cade Brian E
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C
- Chandak Giriraj R
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen J
- Chasman Daniel I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W
- Collins Francis S
- Concas Maria Pina
- Cooper Richard S
- Couture Christian
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L Adrienne
- Cutler Michael J
- Damrauer Scott M
- Danning Rebecca
- Dantoft Thomas M
- Daw E Warwick
- de Borst Gert J
- de Groot Lisette CPGM
- De Jager Philip L
- de Kleijn Dominique PV
- Dedoussis George V
- Degenhard Frauke
- Delgado Graciela E
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F
- Ekici Arif B
- Elders Petra JM
- Eliasen Anders U
- Eliassen A Heather
- Ellinor Patrick T
- Elmståhl Sölve
- eMERGE (Electronic Medical Records and Genomics Network)
- Engmann Jorgen E
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D
- Feenstra Bjarke
- Feitosa Mary F
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freedman Barry I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P
- Goddard Michael E
- Goel Anuj
- Golightly Yvonne M
- Gonzalez-Villalpando Clicerio
- Gordon Scott D
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E
- Grallert Harald
- Grant Struan FA
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F
- Hansen Torben
- Hartman Catharina A
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon J
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R
- Heid Iris M
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W
- Highland Heather H
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam A
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E
- Hottenga Jouke-Jan
- Hoyng Carel B
- Huang Hongyan
- Huang Jie
- Huang Paul L
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E
- Hung Yi-Jen
- Hunt Steven C
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Isasi Carmen R
- Isono Masato
- Jackson Anne U
- Jackson Rebecca D
- Janaka de Silva H
- Jansen Iris E
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B
- Jonsson Anna
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon LR
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L
- Kentistou Katherine A
- Kessler Thorsten
- Khera Amit V
- Khor Chiea Chuen
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- Smith J Gustav
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- Understanding Society Scientific Group
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- Wang Lihua
- Wang Ya Xing
- Wang Zhe
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- Wong Tien-Yin
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- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L
- Yousri Noha A
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E
- Zmuda Joseph M
- Zoledziewska Magdalena
- Zonderman Alan B
- Zwart John-Anker
- Åsvold Bjørn Olav
- Publication venue
- Nature
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H.
- Aamodt Anne H.
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J.
- Adeoye Abiodun M.
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D.
- Anderson Christopher D.
- Anderson Christopher D.
- Aparicio Hugo J.
- Arenillas Juan Francisco
- Armasu Sebastian M.
- Armstrong Nicole D.
- Arnett Donna K.
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K.
- Bammler Theo K.
- Bartz Traci M.
- Bastarache Lisa
- Beiser Alexa S.
- Beiser Alexa S.
- Bell Steven
- Benavente Oscar R.
- Benn Marianne
- Bennett David A.
- Berr Claudine
- Bevan Steve
- Bis Joshua C.
- Bis Joshua C.
- Bis Joshua C.
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B.
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K.
- Brody Jennifer A.
- Brouwers Paul J. A. M.
- Brown Robert D., Jr.
- Brumpton Ben M.
- Brumpton Ben M.
- Buring Julie E.
- Bustamante Mariana
- Butterworth Adam S.
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L.
- Caso Valeria
- Castillo Jose
- Chasman Daniel I.
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R.
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W.
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M.
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul I. W.
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- Debette Stephanie
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- Delgado Pilar
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- den Heijer Tom
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- Dichgans Martin
- Dorr Marcus
- Duan Qing
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- Esko Tonu
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- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B.
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Asvold Bjorn Olav
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja, I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Boger Carsten A.
- Bollepalli Sailalitha
- Bonnelykke Klaus
- Bonnycastle Lori L.
- Boomsma Dorret, I
- Borglum Anders D.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben
- Burgdorf Kristoffer S.
- Buring Julie E.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Canadas-Garre Marisa
- Catamo Eulalia
- Caulfield Mark J.
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen J.
- Chasman Daniel, I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P., V
- de Silva H. Janaka
- Dedoussis George, V
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke, I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmstahl Solve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tonu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry, I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F.
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hypponen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Jager Susanne
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Jockel Karl-Heinz
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Jorgensen Torben
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Kahonen Mika
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karhus Line L.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit, V
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kottgen Anna
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimaki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian'an
- Lubitz Steven A.
- Lull Kreete
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikainen Leo-Pekka
- Machado Moara
- Mackey David A.
- Magi Reedik
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Marz Winfried
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark, I
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellstrom Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mollehave Line T.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher S.
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Nothen Markus M.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- Pahkala Katja
- Pajukanta Paivi
- Palmer Colin N. A.
- Pandit Anita
- Parna Katri
- Parra Esteban J.
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte, V
- Peyser Patricia A.
- Pitkanen Niina
- Polasek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits R.
- Rotter Jerome, I
- Rudan Igor
- Rueger Sina
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Borge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderic K. C.
- Smit Roelof A. J.
- Smith Albert, V
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorrain E.
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan, V
- t' Hart Leen M.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divyasripriyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
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- Thanaraj Thangavel A.
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- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
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- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
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- Tusie-Luna Maria-Teresa
- Uitterlinden Andre G.
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- Vedantam Sailaja
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- Vitart Veronique
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- Vollenweider Peter
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- Vrieze Scott
- Wacher-Rodarte Niels H.
- Walker Mark
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- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
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- Watkins Hugh
- Wei Wen Bin
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- Winsvold Bendik S.
- Wong Andrew
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- Woo Jeong-Taek
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- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loic
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
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- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study