MOA-2015-BLG-337: A Planetary System with a Low-mass Brown Dwarf/Planetary Boundary Host, or a Brown Dwarf Binary

We report the discovery and the analysis of the short timescale binary-lens microlensing event, MOA-2015-BLG-337. The lens system could be a planetary system with a very low mass host, around the brown dwarf/planetary mass boundary, or a brown dwarf binary. We found two competing models that explain the observed light curves with companion/host mass ratios of q~0.01 and ~0.17, respectively. From the measurement of finite source effects in the best-fit planetary model, we find a relatively small angular Einstein radius of theta_E ~ 0.03 mas which favors a low mass lens. We conduct a Bayesian analysis to obtain the probability distribution of the lens properties. The results for the planetary models strongly depend on the minimum mass, M_min, in the assumed mass function. In summary, there are two solutions of the lens system: (1) a brown dwarf/planetary mass boundary object orbited by a super-Neptune (the planetary model with M_min=0.001 M_sun) and (2) a brown dwarf binary (the binary model). If the planetary models is correct, this system can be one of a new class of planetary system, having a low host mass and also a planetary mass ratio (q <0.03) between the host and its companion. The discovery of the event is important for the study of planetary formation in very low mass objects. In addition, it is important to consider all viable solutions in these kinds of ambiguous events in order for the future comprehensive statistical analyses of planetary/binary microlensing events.Comment: 17 pages, 7 figures, Accepted for publication in A

Glossary

We present the analysis of the binary gravitational microlensing event MOA-2015-BLG-020. The event has a fairly long timescale (about 63 days) and thus the light curve deviates significantly from the lensing model that is based on the rectilinear lens-source relative motion. This enables us to measure the microlensing parallax through the annual parallax effect. The microlensing parallax parameters constrained by the ground-based data are confirmed by the Spitzer observations through the satellite parallax method. By additionally measuring the angular Einstein radius from the analysis of the resolved caustic crossing, the physical parameters of the lens are determined. It is found that the binary lens is composed of two dwarf stars with masses $M_1 = 0.606 \pm 0.028M_\odot$ and $M_2 = 0.125 \pm 0.006M_\odot$ in the Galactic disk. Assuming the source star is at the same distance as the bulge red clump stars, we find the lens is at a distance $D_L = 2.44 \pm 0.10 kpc$. In the end, we provide a summary and short discussion of all published microlensing events in which the annual parallax effect is confirmed by other independent observations.Comment: 16 pages, 5 figure

OGLE-2017-BLG-0406: Spitzer microlens parallax reveals Saturn-mass planet orbiting M-dwarf host in the inner galactic disk

Funding: Work by Y.H. was supported by JSPS KAKENHI Grant Number 17J02146. DPB, AB, and CR were supported by NASA through grant NASA-80NSSC18K0274. Work by N.K. is supported by JSPS KAKENHI Grant Number JP18J00897. Work by AG was supported by AST-1516842 from the US NSF and by JPL grant 1500811. AG received support from the European Research Council under the European Unions Seventh Framework Programme (FP 7) ERC Grant Agreement n.[321035]. Work by C.H. was supported by the grants of the National Research Foundation of Korea (2017R1A4A1015178 and 2019R1A2C2085965). YT acknowledges the support of DFG priority program SPP 1992 ”Exploring the Diversity of Extrasolar Planets” (WA 1047/11-1).We report the discovery and analysis of the planetary microlensing event OGLE-2017-BLG-0406, which was observed both from the ground and by the Spitzer satellite in a solar orbit. At high magnification, the anomaly in the light curve was densely observed by ground-based-survey and follow-up groups, and it was found to be explained by a planetary lens with a planet/host mass ratio of q = 7.0 x 10-4 from the light-curve modeling. The ground-only and Spitzer-"only" data each provide very strong one-dimensional (1-D) constraints on the 2-D microlens parallax vector πE. When combined, these yield a precise measurement of πE, and so of the masses of the host Mhost = 0.56 ± 0.07 M⊙ and planet Mplanet = 0.41 ± 0.05 MJup. The system lies at a distance DL = 5.2 ± 0.5 kpc from the Sun toward the Galactic bulge, and the host is more likely to be a disk population star according to the kinematics of the lens. The projected separation of the planet from the host is a⊥ = 3.5 ± 0.3 au, i.e., just over twice the snow line. The Galactic-disk kinematics are established in part from a precise measurement of the source proper motion based on OGLE-IV data. By contrast, the Gaia proper-motion measurement of the source suffers from a catastrophic 10σ error.PostprintPeer reviewe

Traditional Chinese and western medicine for the prevention of deep venous thrombosis after lower extremity orthopedic surgery: a meta-analysis of randomized controlled trials

Abstract Background Chinese herbal medicine has traditionally been considered to promote blood circulation to remove obstruction in the channels and clear pathogenic heat to drain dampness effects. We conducted this meta-analysis to evaluate its benefits for the prevention of deep venous thrombosis (DVT) after lower extremity orthopedic surgery. Methods Relevant, published studies were identified using the following keywords: lower extremity orthopedic surgery, arthroplasty, joint replacement, fracture, traditional Chinese and western medicine, Chinese herbal medicine, deep venous thrombosis (DVT), and Venous thromboembolism (VTE). The following databases were used to identify the literature consisting of RCTs with a date of search of 31 May 2017: PubMed, Cochrane Library, Web of knowledge, the Chinese National Knowledge Infrastructure Database, the Chongqing VIP Database, the Chinese Biomedical Database, and the Wanfang Database (including three English and four Chinese databases). All relevant data were collected from studies meeting the inclusion criteria. The outcome variables were the incidence rate of DVT, activated partial thromboplastin time (APTT), prothrombin time (PT), and d-dimer; subcutaneous hematoma; and other reported outcomes. RevMan5.2. software was adopted for the meta-analysis. Results A total of 20 published studies (1862 cases) met the inclusion criteria. The experimental group, 910 patients (48.87%), received the Chinese herbal medicine or traditional Chinese and western medicine for prevention of DVT; the control group, 952 patients (51.13%), received the standard western treatment. The meta-analysis showed that traditional Chinese and western medicine therapy reduced the incidence rates of DVT significantly when compared with controls (risk ratio [RR] = 0.40; 95% CI, 0.30 to 0.54; P < 0.00001), and the d-dimer was lower in the experimental group (P = 0.01). Besides, the incidence rate of subcutaneous hematoma was lower in the experimental group (P < 0.0001). However, no significant difference was found in the PT (P = 0.98) and APTT (P = 0.75) in two groups. No serious adverse events were reported. Conclusion Traditional Chinese and western medicine therapy may be a safe, effective prevention modality for DVT after lower extremity orthopedic surgery. Further rigorously designed, randomized trials are warranted

Effect of Acupuncture on Chronic Pain with Depression: A Systematic Review

Background. Numerous studies suggested that chronic pain and depression were closely related and widespread in the population. When patients have symptoms of chronic pain and depression, the corresponding treatment will become difficult. Acupuncture, a unique therapeutic method of traditional Chinese medicine, has been reported to potentially serve as an alternative treatment for patients with comorbid chronic pain and depression by many research studies. Methods. A comprehensive search was conducted through the online database, including the Cochrane Library, PubMed, EMBASE, SinoMed, CNKI, and Wanfang database. Trials were RCTs published in the English or Chinese language, recruiting participants with chronic pain and depression comorbidity. The primary outcomes were the Visual Analogue Scale (VAS) and Hamilton Depression Scale (HAMD). Statistical analyses were conducted using Review Manager 5.3. Each trail was quality appraised with the five-point Jadad Score. Results. 7 eligible RCTs involving 535 patients were included. Better therapeutic effect and safety could be observed in the experimental group compared with the control group. There was a significant decrease in the VAS (mean difference (MD) = −0.68 (−1.24, −0.12), P=0.02) and HAMD (MD = −2.18 (−3.09, −1.26), P<0.00001) scores and the incidence of adverse events between two groups. Conclusion. In the treatment of chronic pain with depression, acupuncture could not only get better clinical efficacy, but also have higher security compared with medicine therapy, which can be used in patients with poorer response to the conventional medication or suffering from serious side effects

Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment

Abstract Background Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood. Methods Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological characters and molecular pathways were analyzed in each subtype to prospect the clinical applications and progression mechanisms of ULMS. Results Two distinct molecular subtypes of ULMS were defined based on different gene expression signatures. Subtype I ULMS recapitulated low-grade ULMS, the gene expression pattern of which resembled normal smooth muscle cells, characterized by overexpression of smooth muscle function genes such as LMOD1, SLMAP, MYLK, MYH11. In contrast, subtype II ULMS recapitulated high-grade ULMS with higher tumor weight and invasion rate, and was characterized by overexpression of genes involved in the pathway of epithelial to mesenchymal transition and tumorigenesis, such as CDK6, MAPK13 and HOXA1. Conclusions We identified two distinct molecular subtypes of ULMS responding differently to chemotherapy treatment. Our findings provide a better understanding of ULMS intrinsic molecular subtypes, and will potentially facilitate the development of subtype-specific diagnosis biomarkers and therapy strategies for these tumors

Additional file 1: Figure S1. of Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment

Delineation of two distinct molecular subtypes of ULMS. (A) Empirical cumulative distribution plots. (B) The increased area under the CDF curve along with increased number of molecular subtypes. (TIFF 215 kb

Additional file 2: Figure S2. of Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment

Heatmap of the top 500 genes over-expressed in distinct molecular subtypes. Based on SAM-seq result, the top 500 genes over-expressed in each subtype were selected to form the TOP500 genes. Hierarchical clustering of the TOP500 genes was performed by Cluster 3.0 using centroid linkage method. Each row denotes a gene and each column corresponds to a case of ULMS. Red, over-expressed genes; Green, down-expressed genes. (TIFF 2173 kb