Serum vitamin D is associated with improved lung function markers but not with prevalence of asthma, emphysema, and chronic bronchitis

Hypovitaminosis D has been linked to several non-bone diseases. Relation between 25-hydroxyvitamin D [25(OH)D] and lung function and lung diseases has received little attention at the global level. Cross-sectional data from three National Health and Nutrition Examination Surveys, 2007–2008, 2009–2010, and 2011–2012 were used to investigate the relationship between serum 25(OH)D concentrations and lung function makers [forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)] and lung diseases (asthma, emphysema, and chronic bronchitis) with multivariate regression models (n = 11,983; men, 6,010; women, 5,973). Serum 25(OH)D concentrations were directly associated with FVC and FEV1 (P for trend < 0.01). Individuals in the 4th quartile serum 25(OH)D had significantly higher FVC and FEV1 compared to those in the 1st quartile (P < 0.01). When data were stratified based on gender and smoking status, we found similar associations between serum 25(OH)D concentrations and lung function markers. There was no relation between serum 25(OH)D and prevalence of asthma, chronic bronchitis, and emphysema in US adults. Serum 25(OH)D concentration is associated with improved lung function markers but not with the prevalence of asthma, emphysema, and chronic bronchitis. Controlled studies are needed to determine if the vitamin D supplementation improves lung function in adults and in smokers.Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qata

Hollow spherical SiO2 micro-container encapsulation of LiCl for high-performance simultaneous heat reallocation and seawater desalination

Energy & fresh water have both become scarce resources in the modern era of human society. Sorption-based technology is environmentally friendly and energy-efficient and can be driven by low-grade energy to transfer energy and produce fresh water. Here, we report a solid sorbent fabricated by encapsulating a hygroscopic salt, lithium chloride (LiCl), inside micro-sized hollow-structured SiO2. This composite sorbent (LiCl@HS) exhibits 6 times faster water vapor sorption kinetics than pure LiCl and a water vapor sorption capacity of 1.7 kg kg-1 at a relative humidity (RH) of 50%, which is the highest ever reported for any solid sorbent in the literature. The low regeneration temperature (<80 °C) and good cycling stability ensure the feasibility of the composite sorbent for use in practical applications. The thermodynamic calculations reveal that the sorbent is able to continuously supply 20 °C temperature lift with a maximum coefficient of performance (COP) for cooling of 0.97 and COP for heating of 1.89 while simultaneously producing 9.05 kg potable water per kilogram sorbent daily using seawater as the source water and solar energy as the sole energy source. A homemade system is developed and its practical performance in providing seasonally switchable heating and cooling along with clean water production from source water with an impaired quality is successfully verified, indicating its great potential

Investigation of oscillation frequency and disorder induced dynamic phase transitions in a quenched-bond diluted Ising ferromagnet

Frequency evolutions of hysteresis loop area and hysteresis tools such as remanence and coercivity of a kinetic Ising model in the presence of quenched bond dilution are investigated in detail. The kinetic equation describing the time dependence of the magnetization is derived by means of effective-field theory with single-site correlations. It is found that the frequency dispersions of hysteresis loop area, remanence and coercivity strongly depend on the quenched bond randomness, as well as applied field amplitude and oscillation frequency. In addition, the shape of the hysteresis curves for a wide variety of Hamiltonian parameters is studied and some interesting behaviors are found. Finally, a comparison of our observations with those of recently published studies is represented and it is shown that there exists a qualitatively good agreement.Comment: 11 pages, 8 figure

Analysis of global manufacturing virtual networks in the aeronautical industry

The evolution of organizations that work in multinational environments has considerably altered their production strategies. One of the consequences has been the appearance of Global Manufacturing Virtual Networks (GMVNs), which include all kinds of enterprises and production centres and establish a new type of horizontal collaboration and relations between independent companies and even competitors who establish occasional collaborations on projects they could not take on individually. This paper analyses the causes behind the formation of such networks, their strategy, structure, dynamics and evolution, taking into account areas such as strategic intercompany alliances, synchronization of their value and supply chains, their information systems, the cultural aspects of the organizations in question and, finally, their convergence with another of the more relevant future trends in production: mass customization. The proposed model shall be applied to the aeronautical industry which is one of the industries which has developed the GMVN concept. The case study of the engine manufacturer Rolls Royce will provide a better understanding of the evolution of its strategic positioning, as well as the dynamic and fluent nature of its virtual relations. This will demonstrate its effectiveness by clarifying and putting these organizations in perspective and analyzing their evolution over the next few year

LoRa mesh-5G integrated network for trackside smart weather monitoring

Monitoring of trackside weather is a critical aspect of railway operations, mainly for safety and efficiency reasons. Unfortunately, current cellular networks, including the fourth-generation and fifth-generation (5G) cellular networks, do not provide ubiquitous coverage for rail lines mainly due to an unfavorable cost-benefit realization. In this paper, we propose a Long Range (LoRa) mesh-5G integrated network that tackles this problem by utilizing a 5G network for backhaul, computing and storage, and LoRa mesh to extend coverage. We design a LoRa mesh server that runs on a private cloud of the 5G network to manage the LoRa mesh network. We integrate edge computing into the network and design a cloud-edge-terminal collaborative architecture with three algorithms for timely significant-change updates, packet loss detection, and adaptive thresholds to reduce the packet rate and data volume of the network. We validate the design by implementing a proof-of-concept on the 5G testbed at the University of Glasgow. The experimental results demonstrate the feasibility of the network and the cloud-edge-terminal collaborative architecture

Differential Association of Gene Content Polymorphisms of Killer Cell Immunoglobulin-Like Receptors with Placental Malaria in HIV− and HIV+ Mothers

Pregnant women have abundant natural killer (NK) cells in their placenta, and NK cell function is regulated by polymorphisms of killer cell immunoglobulin-like receptors (KIRs). Previous studies report different roles of NK cells in the immune responses to placental malaria (PM) and human immunodeficiency virus (HIV-1) infections. Given these references, the aim of this study was to determine the association between KIR gene content polymorphism and PM infection in pregnant women of known HIV-1 status. Sixteen genes in the KIR family were analyzed in 688 pregnant Kenyan women. Gene content polymorphisms were assessed in relation to PM in HIV-1 negative and HIV-1 positive women, respectively. Results showed that in HIV-1 negative women, the presence of the individual genes KIR2DL1 and KIR2DL3 increased the odds of having PM, and the KIR2DL2/KIR2DL2 homozygotes were associated with protection from PM. However, the reverse relationship was observed in HIV-1 positive women, where the presence of individual KIR2DL3 was associated with protection from PM, and KIR2DL2/KIR2DL2 homozygotes increased the odds for susceptibility to PM. Further analysis of the HIV-1 positive women stratified by CD4 counts showed that this reverse association between KIR genes and PM remained only in the individuals with high CD4 cell counts but not in those with low CD4 cell counts. Collectively, these results suggest that inhibitory KIR2DL2 and KIR2DL3, which are alleles of the same locus, play a role in the inverse effects on PM and PM/HIV co-infection and the effect of KIR genes on PM in HIV positive women is dependent on high CD4 cell counts. In addition, analysis of linkage disequilibrium (LD) of the PM relevant KIR genes showed strong LD in women without PM regardless of their HIV status while LD was broken in those with PM, indicating possible selection pressure by malaria infection on the KIR genes

Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya

Background Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear. In this study, the drug resistance profile of current and previous first-line anti-malarials in Kenya was assessed within the context of drug policy change and scale-up of ITNs. National first-line treatment changed from chloroquine (CQ) to sulphadoxine-pyrimethamine (SP) in 1998 and to artemether-lumefantrine (AL) in 2004. ITN use was scaled-up in the Asembo, Gem and Karemo areas of western Kenya in 1997, 1999 and 2006, respectively. Methods Smear-positive samples (N = 253) collected from a 2007 cross-sectional survey among children in Asembo, Gem and Karemo were genotyped for mutations in pfcrt and pfmdr1 (CQ), dhfr and dhps (SP), and at pfmdr-N86 and the gene copy number in pfmdr1 (lumefantrine). Results were compared among the three geographic areas in 2007 and to retrospective molecular data from children in Asembo in 2001. Results In 2007, 69 and 85% of samples harboured the pfmdr1-86Y mutation and dhfr/dhps quintuple mutant, respectively, with no significant differences by study area. However, the prevalence of the pfcrt-76T mutation differed significantly among areas (p <0.02), between 76 and 94%, with the highest prevalence in Asembo. Several 2007 samples carried mutations at dhfr-164L, dhps-436A, or dhps-613T. From 2001 to 2007, there were significant increases in the pfcrt-76T mutation from 82 to 94% (p <0.03), dhfr/dhps quintuple mutant from 62 to 82% (p <0.03), and an increase in the septuple CQ and SP combined mutant haplotype, K 76 Y 86 I 51 R 59 N 108 G 437 E 540 , from 28 to 39%. The prevalence of the pfmdr1-86Y mutation remained unchanged. All samples were single copy for pfmdr1. Conclusions Molecular markers associated with lumefantrine resistance were not detected in 2007. More recent samples will be needed to detect any selective effects by AL. The prevalence of CQ and SP resistance markers increased from 2001 to 2007 in the absence of changes in transmission intensity. In 2007, only the prevalence of pfcrt-76T mutation differed among study areas of varying transmission intensity. Resistant parasites were most likely selected by sustained drug pressure from the continued use of CQ, SP, and mechanistically similar drugs, such as amodiaquine and cotrimoxazole. There was no clear evidence that differences in transmission intensity, as a result of ITN scale-up, influenced the prevalence of drug resistance molecular markers

High viscous oil–water two–phase flow: experiments & numerical simulations

An experimental study on highly viscous oil-water two-phase flow conducted in a 5.5 m long and 25.4 mm internal diameter (ID) pipeline is presented. Mineral oil with viscosity ranging from 3.5 Pa.s – 5.0 Pa.s and water were used as test fluid for this study. Experiments were conducted for superficial velocities of oil and water ranging from 0.06 to 0.55 m/s and 0.01 m/s to 1.0 m/s respectively. Axial pressure measurements were made from which the pressure gradients were calculated. Flow pattern determination was aided by high definition video recordings. Numerical simulation of experimental flow conditions is performed using a commercially available Computational Fluid Dynamics code. Results show that at high oil superficial velocities, Core Annular Flow (CAF) is the dominant flow pattern while Oil Plug in Water Flow (OPF) and Dispersed Oil in Water (DOW) flow patterns are dominant high water superficial velocities. Pressure Gradient results showed a general trend of reduction to a minimum as water superficial velocity increases before subsequently increasing on further increasing the superficial water velocity. The CFD results performed well in predicting the flow configurations observed in the experiments

Genetic diversity of Plasmodium falciparum parasite by microsatellite markers after scale-up of insecticide-treated bed nets in western Kenya

Background: An initial study of genetic diversity of Plasmodium falciparum in Asembo, western Kenya showed that the parasite maintained overall genetic stability 5 years after insecticide-treated bed net (ITN) introduction in 1997. This study investigates further the genetic diversity of P. falciparum 10 years after initial ITN introduction in the same study area and compares this with two other neighbouring areas, where ITNs were introduced in 1998 (Gem) and 2004 (Karemo). Methods: From a cross-sectional survey conducted in 2007, 235 smear-positive blood samples collected from children ≤15-year-old in the original study area and two comparison areas were genotyped employing eight neutral microsatellites. Differences in multiple infections, allele frequency, parasite genetic diversity and parasite population structure between the three areas were assessed. Further, molecular data reported previously (1996 and 2001) were compared to the 2007 results in the original study area Asembo. Results: Overall proportion of multiple infections (M A ) declined with time in the original study area Asembo (from 95.9 %-2001 to 87.7 %-2007). In the neighbouring areas, M A was lower in the site where ITNs were introduced in 1998 (Gem 83.7 %) compared to where they were introduced in 2004 (Karemo 96.7 %) in 2007. Overall mean allele count (M AC ~ 2.65) and overall unbiased heterozygosity (H e ~ 0.77) remained unchanged in 1996, 2001 and 2007 in Asembo and was the same level across the two neighbouring areas in 2007. Overall parasite population differentiation remained low over time and in the three areas at F ST < 0.04. Both pairwise and multilocus linkage disequilibrium showed limited to no significant association between alleles in Asembo (1996, 2001 and 2007) and between three areas. Conclusions: This study showed the P. falciparum high genetic diversity and parasite population resilience on samples collected 10 years apart and in different areas in western Kenya. The results highlight the need for long-term molecular monitoring after implementation and use of combined and intensive prevention and intervention measures in the region