The Ursinus Weekly, February 23, 1959

Freshmen women welcomed on Color Day, Thurs. Feb. 19 • Jackie Robbins is May queen • Faculty holds panel discussion this evening • WAA to present the shuffle on Fri., Feb. 27 • U.C. students take part in religious week • Senior class presents She forgot to remember on March 6 and 7 • T. Holcombe chosen king of Lorelei, Friday • U.C. students solve Time map puzzle • Chi Alpha presents Rev. Mr. H. Muensterman • Roberts receives degree • Editorial: Help us • Wisdom • U.C. mermaids swamp Beaver by 46-20 • Girl b-ballers romp in 1st 3 games of season • Courtmen lose two to PMC, Swarthmore • Badminton team wins 1st two • Grapplers lose 3rd & 4th matches • Silver opinion competition on campus begins • Letters to the editor • Religion? Science?https://digitalcommons.ursinus.edu/weekly/1378/thumbnail.jp

Effect of Absent Tactile Sensation on Multi-digit Coordination Underlying Hand Control

We investigated the effect of anesthesia, causing absent tactile sensation feedback, on multi-digit coordination underlying hand control. The purpose of the study is to expand our understanding on the essential role of tactile sensation feedback in the sensorimotor integration process by examining the motor coordination patterns during multi-digit forces production tasks. We hypothesized that absent tactile sensation feedback would interrupt the force sharing pattern at local and non-local digits. Twelve participants were utilized for data collection and statistical analysis (25.6 ± 4.1 years old, 6 males and 6 females), right-handed (according to their preferred hand use for writing and eating) and had no significant hand injury within the last five years. All participants performed a maximal voluntary contraction (MVC), ramp, and step task, pre- and post-anesthesia. In general, participants presented lower maximal force production in all MVC conditions after anesthesia, total MVC force was not distributed evenly among individual digits, and when sensory function of the MVC involved digits are uniformly absent or intact, force sharing pattern across the individual digits would be maintained. When the instructed finger (master finger) was index, other fingers (enslaved fingers) barely produced force. However, other enslaved fingers showed relatively higher forces when the master finger was ring or little finger. When required force level increased, performance error was increased accordingly. The findings from the current study confirmed our hypothesis that absent tactile sensation feedback (somatosensory feedback) will not only affect force production at local digits, but also at non-local digits as well

The Ursinus Weekly, December 15, 1958

MSGA-WSGA hold banquet to hear USNSA speaker • Radio station planned for U.C. campus • 21st Messiah captivates U.C. audience • Pi Nu Epsilon holds initiations for new members • Rev. Rowland gives talk on marriage • Dr. Heilemann contributes to physics magazine • Communist system in China was topic of Bishop Tsu\u27s speech here • Annual banquet-dance held this Wednesday • Debating Club announces opponents for season • Editorial: Who knows? • Snake and the glass • Frosh opinion • Lebanon Valley names Petersen to all-opponent • Wrestling team begins choosing wrestlers • Basketball team drops third straight contest • U.C. mermaids begin practice for season • Letters to the editor • On Christmas • Ursinus to host annual county science fair • Quinn water colors on display at Ursinus • Open houses held at women\u27s dormitories • Ruby photographs planned for after vacation • Drinkinghttps://digitalcommons.ursinus.edu/weekly/1374/thumbnail.jp

The Ursinus Weekly, February 16, 1959

Dr. Goncharoff discusses world youth at Forum Wed. • Seniors to present play by C. George • Curtain Club presents plays • French Club presents Mme. Helene Bordas • YM-YWCA plan for Spring semester • Music room • Freshmen women elected Wed. Feb. 11 to YWCA, WAA, WSGA • Annual Lorelei to be held at Sunnybrook Fri. • May queen to be elected • Editorial: Destruction • Student opinion • Prof\u27s opinion • Girls\u27 b-ball teams win season\u27s start • B-ball squad drops two close tilts • Ursinus whips E-town in wrestling match 30-6 • Letters to the editorhttps://digitalcommons.ursinus.edu/weekly/1377/thumbnail.jp

The Ursinus Weekly, November 24, 1958

Y holds seminar Nov. 19; Marriage problem is topic • Fireside chats to be held Dec. 3 at prof\u27s home • C. Carpenter has poem published in anthology • Administrative regulation • Mayes, Francis \u2762 representatives to MSGA • New pledges announced by Alpha Psi Omega • De Gaulle and France topic at second Forum of Fall semester • Who\u27s who honors 12 leading Ursinus seniors • Senior Ball to be held at Sunnybrook Dec. 5 • W.S.G.A. presents plaque to winning frosh team • Editorial: Thanksgiving • Letters to the editor • Review: Joan of Lorraine • Slightly allegorical • U.C. soccermen lose last three games; Finish 2-6-1 • Prospects for U.C. basketball team looking up • Varsity hockey finishes with 4-2-1; J.V. is 6-0-1 • Football squad drops two games 12-0, 34-6 • Sorority bids • American hist. students begin tour program • Fine art of datinghttps://digitalcommons.ursinus.edu/weekly/1372/thumbnail.jp

1961 Ruby Yearbook

A digitized copy of the 1961 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1064/thumbnail.jp

A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings

BACKGROUND: More than 35 million people in developing countries are living with HIV infection. An enormous global effort is now underway to bring antiretroviral treatment to at least 3 million of those infected. While drug prices have dropped considerably, the cost and technical complexity of laboratory tests essential for the management of HIV disease, such as CD4 cell counts, remain prohibitive. New, simple, and affordable methods for measuring CD4 cells that can be implemented in resource-scarce settings are urgently needed. METHODS AND FINDINGS: Here we describe the development of a prototype for a simple, rapid, and affordable method for counting CD4 lymphocytes. Microliter volumes of blood without further sample preparation are stained with fluorescent antibodies, captured on a membrane within a miniaturized flow cell and imaged through microscope optics with the type of charge-coupled device developed for digital camera technology. An associated computer algorithm converts the raw digital image into absolute CD4 counts and CD4 percentages in real time. The accuracy of this prototype system was validated through testing in the United States and Botswana, and showed close agreement with standard flow cytometry (r = 0.95) over a range of absolute CD4 counts, and the ability to discriminate clinically relevant CD4 count thresholds with high sensitivity and specificity. CONCLUSION: Advances in the adaptation of new technologies to biomedical detection systems, such as the one described here, promise to make complex diagnostics for HIV and other infectious diseases a practical global reality

The Lantern Vol. 27, No. 2, Spring 1959

• The Case for a Stratified Society • Education Courses • Some Thoughts for God\u27s Thinking Creatures • Sawdust to the Oats? • To Change the Things I Can... • Vignette • I Meet Goliath • Reverie and Reminiscence • On Flight • In Defense of Jazz • A Description • Line of Retreat • Alan Lomax and the American Folk Song • Dawn Stillness • Seasons • Two Poems • Despair • Too Late • Education • For All Practical Purposes He Was Bald • Contrast • I Belong to the Sea • Waves • Love • The Glory and the Dreamhttps://digitalcommons.ursinus.edu/lantern/1077/thumbnail.jp

How Much Remains Undetected? Probability of Molecular Detection of Human Plasmodia in the Field

BACKGROUND: In malaria endemic areas, most people are simultaneously infected with different parasite clones. Detection of individual clones is hampered when their densities fluctuate around the detection limit and, in case of P. falciparum, by sequestration during part of their life cycle. This has important implications for measures of levels of infection or for the outcome of clinical trials. This study aimed at measuring the detectability of individual P. falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI). METHODS: Samples were obtained in a repeated cross-sectional field survey in 1 to 4.5 years old children from Papua New Guinea, who were followed up in 2-monthly intervals over 16 months. At each follow-up visit, two consecutive blood samples were collected from each child at intervals of 24 hours. Samples were genotyped for the polymorphic markers msp2 for P. falciparum and msp1F3 and MS16 for P. vivax. Observed prevalence and mean MOI estimated from single samples per host were compared to combined data from sampling twice within 24 h. FINDINGS AND CONCLUSION: Estimated detectability was high in our data set (0.79 [95% CI 0.76-0.82] for P. falciparum and, depending on the marker, 0.61 [0.58-0.63] or 0.73 [0.71-0.75] for P. vivax). When genotyping data from sequential samples, collected 24 hours apart, were combined, the increase in measured prevalence was moderate, 6 to 9% of all infections were missed on a single day. The effect on observed MOI was more pronounced, 18 to 31% of all individual clones were not detected in a single bleed. Repeated sampling revealed little difference between detectability of P. falciparum and P. vivax

Inter-Allelic Prion Propagation Reveals Conformational Relationships among a Multitude of [PSI] Strains

Immense diversity of prion strains is observed, but its underlying mechanism is less clear. Three [PSI] prion strains—named VH, VK, and VL—were previously isolated in the wild-type yeast genetic background. Here we report the generation and characterization of eight new [PSI] isolates, obtained by propagating the wild-type strains with Sup35 proteins containing single amino-acid alterations. The VH strain splits into two distinct strains when propagated in each of the three genetic backgrounds, harboring respectively single mutations of N21L, R28P, and Gi47 (i.e. insertion of a glycine residue at position 47) on the Sup35 N-terminal prion-forming segment. The six new strains exhibit complex inter-conversion patterns, and one of them continuously mutates into another. However, when they are introduced back into the wild-type background, all 6 strains revert to the VH strain. We obtain two more [PSI] isolates by propagating VK and VL with the Gi47 and N21L backgrounds, respectively. The two isolates do not transmit to other mutant backgrounds but revert to their parental strains in the wild-type background. Our data indicate that a large number of [PSI] strains can be built on three basic Sup35 amyloid structures. It is proposed that the three basic structures differ by chain folding topologies, and sub-strains with the same topology differ in distinct ways by local structural adjustments. This “large number of variations on a small number of basic themes” may also be operative in generating strain diversities in other prion elements. It thus suggests a possible general scheme to classify a multitude of prion strains