Combined effect of gene-gene interaction on the among the function of thyroid gland and the degree of its enlargement in patients of autoimmune thyroiditis and thyroid adenoma in the inhabitants of Northern Bukovina

Sheremet M. I. Combined effect of gene-gene interaction on the among the function of thyroid gland and the degree of its enlargement in patients of autoimmune thyroiditis and thyroid adenoma in the inhabitants of Northern Bukovina. Journal of Education, Health and Sport. 2017;7(9):606-620. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1000955 http://ojs.ukw.edu.pl/index.php/johs/article/view/4936 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2017. Revised: 10.09.2017. Accepted: 10.09.2017. COMBINED EFFECT OF GENE-GENE INTERACTION ON THE AMONG THE FUNCTION OF THYROID GLAND AND THE DEGREE OF ITS ENLARGEMENT IN PATIENTS OF AUTOIMMUNE THYROIDITIS AND THYROID ADENOMA IN THE INHABITANTS OF NORTHERN BUKOVINA M. I. Sheremet Surgery Department №1, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine, Е-mail: [email protected] Abstract Was a comprehensive analysis of combined influence of the gene polymorphisms associated with various links in the regulation of apoptosis (BCL-2, CTLA-4 and APO-1 / Fas) on the development of nodular goiter on the background of autoimmune thyroiditis and thyroid adenoma in the surveyed population with regard to changes in the functional activity of the thyroid gland and the degree of the thyroid gland enlargement has been performed. For this purpose, we used the method of Multifactor Dimensions Reduction 3.0.2 – MDR by calculating the prediction potentials. Established that graphic models of gene-gene interaction with the highest cross-validation consistency created by Multifactor Dimensions Reduction 3.0.2 – MDR method, showed complex "synergistic or independent" impact of polymorphic loci of the CTLA-4 (+ 49G / A), Fas (-1377G / A) and Bcl-2 (63291411A> G) genes on the onset of the change of thyroid function and degree of hyperplasia in the population of residents of Northern Bukovina. Key words: nodular goiter, autoimmune thyroiditis, thyroid adenoma, APO-1 / FAS, CTLA-4 and BCL-2 genes interaction

Comparative concept similarity over Minspaces: Axiomatisation and Tableaux Calculus

We study the logic of comparative concept similarity \CSL introduced by Sheremet, Tishkovsky, Wolter and Zakharyaschev to capture a form of qualitative similarity comparison. In this logic we can formulate assertions of the form " objects A are more similar to B than to C". The semantics of this logic is defined by structures equipped by distance functions evaluating the similarity degree of objects. We consider here the particular case of the semantics induced by \emph{minspaces}, the latter being distance spaces where the minimum of a set of distances always exists. It turns out that the semantics over arbitrary minspaces can be equivalently specified in terms of preferential structures, typical of conditional logics. We first give a direct axiomatisation of this logic over Minspaces. We next define a decision procedure in the form of a tableaux calculus. Both the calculus and the axiomatisation take advantage of the reformulation of the semantics in terms of preferential structures.Comment: 25 page

Research of caspase-dependent mechanisms of apoptosis induction and the activity of peroxidation and antioxidant defense in the thyroid tissue of patients with nodular forms of goiter combined with autoimmune thyroiditis and thyroid adenoma depending on the allelic status of Bcl-2 (rs17759659), CTLA-4 (rs231775), APO-1 / Fas (rs2234767) genes

Sheremet M. I. Research of caspase-dependent mechanisms of apoptosis induction and the activity of peroxidation and antioxidant defense in the thyroid tissue of patients with nodular forms of goiter combined with autoimmune thyroiditis and thyroid adenoma depending on the allelic status of Bcl-2 (rs17759659), CTLA-4 (rs231775), APO-1 / Fas (rs2234767) genes. Journal of Education, Health and Sport. 2017;7(5):610-627. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.815595 http://ojs.ukw.edu.pl/index.php/johs/article/view/4557 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.05.2017. Revised: 23.05.2017. Accepted: 31.05.2017. RESEARCH OF CASPASE-DEPENDENT MECHANISMS OF APOPTOSIS INDUCTION AND THE ACTIVITY OF PEROXIDATION AND ANTIOXIDANT DEFENSE IN THE THYROID TISSUE OF PATIENTS WITH NODULAR FORMS OF GOITER COMBINED WITH AUTOIMMUNE THYROIDITIS AND THYROID ADENOMA DEPENDING ON THE ALLELIC STATUS OF Bcl-2 (rs17759659), CTLA-4 (rs231775), APO-1 / Fas (rs2234767) GENES M. I. Sheremet Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» PhD, Associated Professor of Surgery Department №1, Phone / fax (+38 0372) 55-37-54, e-mail: [email protected] Abstract The aim of the work is to analyze the mechanisms of caspase-dependent apoptosis and pro- and antioxidant activity in the thyroid tissue homogenate in patients with in patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma considering the polymorphic variants of BCL-2 (rs17759659), CTLA-4 (rs231775), APO-1 / Fas (rs2234767) genes. Methods of research: We investigated pro- and antioxidant activity and the activity of caspases 3 and 8in 5% of thyroid tissue homogenates. The BCL-2 (rs17759659), CTLA-4 (rs231775), Fas (rs2234767) genes polymorphism were studied by Real-Time Polymerase Chain Reaction in 95 patients with nodular goiter on the background of autoimmune thyroiditis, 30 patients with thyroid adenoma and 25 healthy individuals. Results: We have not found any pronounced dependence of the processes oxidative modification of proteins and antioxidant protection nor the activity of caspasess-8 and 3 in the thyroid tissue on the genotypes of BCL-2 (rs17759659) and APO-1/Fas (rs2234767) genes. However, it should be noted that in homozygous carriers of A-allele of the BCL-2 (rs17759659) gene the activity of effector caspase-3 is higher than that in the control group. The imbalance between the activity of peroxidation and antioxidant defense in patients with nodular goiter on the background of autoimmune thyroiditis and thyroid adenoma is associated with the promoter of the CTLA-4 (rs231775) and APO-1 / Fas (rs2234767) genes and is characterized by an increasing degree of oxidative modification of proteins in the altered thyroid tissue alongside with a lower capacity of the antioxidant protection system enzymes. Key words: nodular goiter on the background of autoimmune thyroiditis, thyroid gland, caspases, pro - and antioxidant status, genetic association

Mixed convection of silica-molybdenum disulphide/water hybrid nanoliquid over a rough sphere

A steady combined convective motion over a rough sphere with hybrid nanoparticles is analyzed. We have considered silica (SiO2) and molybdenum disulphide (MoS2) nanoadditives which are added in H2O to form MoS2–SiO2/H2O hybrid nanoliquid. The partial differential equations describing the boundary layer flow characteristics are reduced into non-dimensional form with appropriate non-similar reduction. It should be noted that the governing equations have been written using the conservation laws of mass, momentum and energy. These considered equations allow simulating the analyzed phenomenon using numerical techniques. Implicit finite difference approximation and technique of Quasilinearization are utilized to work out the dimensionless control equations. The influence of various physical characteristics included in this challenge, such as the velocity fields and temperature patterns, is investigated. The study of border gradients is performed, which deals with the skin friction and energy transport strength. The plots of computational outcomes are considered, which ascertain that velocity distribution reduces, whilst coefficient of friction at the surface, energy transport strength and temperature distribution augment for enhancing values of hybrid nanofluid. For enhancing magnitude of combined convection parameter, dimensionless velocity distribution, surface drag coefficient and energy transport strength enhance, while temperature distribution diminishes. High impact of hybrid nanofluid on energy transport strength and the surface friction compared to the host liquid and mono nanofluid in presence/absence of surface roughness is shown. Velocity distribution enhances for rising values of velocity ratio parameter. Enhancing values of frequency parameter rise the friction at the surface and energy transport strength. It is also examined that the hybrid nanofluid has a maximum temperature for the blade-shaped nanoparticles and has a low temperature for the spherical-shaped nanoparticles

Nonlinear mixed convective flow over a moving yawed cylinder driven by buoyancy

The fluid flow over a yawed cylinder is useful in understanding practical significance for undersea applications, for example, managing transference and/or separation of the boundary layer above submerged blocks and in suppressing recirculating bubbles. The present analysis examines nonlinear mixed convection flow past a moving yawed cylinder with diffusion of liquid hydrogen. The coupled nonlinear control relations and the border restrictions pertinent to the present flow problem are nondimensionalized by using nonsimilar reduction. Further, implicit finite difference schemes and Quasilinearization methods are employed to solve the nondimensional governing equations. Impact of several nondimensional parameters of the analysis on the dimensionless velocity, temperature and species concentration patterns and also on Nusselt number, Sherwood number and friction parameter defined at the cylinder shell is analyzed through numerical results presented in various graphs. Velocity profiles can be enhanced, and the coefficients of friction at the surface can be reduced, for increasing values of velocity ratio parameters along chordwise as well as spanwise directions. Species concentration profile is reduced, while the Sherwood number is enhanced, for growth of the Schmidt number and yaw angles. Furthermore, for an increasing value of yaw angle, skin-friction coefficient in chordwise direction diminishes in opposing buoyancy flow case, whereas the results exhibit the opposite trend in assisting buoyancy flow case. Moreover, very importantly, for increasing magnitude of nonlinear convection characteristic, the liquid velocity and surface friction enhance in spanwise direction. Further, for increasing magnitude of combined convection characteristics, velocity profiles and coefficient of friction at the surface enhance in both spanwise and chordwise directions. Moreover, we have observed that there is no deviation for zero yaw angle in Nusselt number and Sherwood number

Analysis of the barotropic model of the subtropical gyre in the ocean for finite Reynolds numbers. Part II.

This paper is a continuation of Part I of the suggested study of the barotropic model of the subtropical gyre for finite Reynolds numbers. The statement of the problem, the motivation of the analysis, and the description of the general properties of the solution are presented in Part I (Kamenkovich et al., 1995). Here, in Part II of the study, the detailed investigations of the peculiarities of the solution are offered. The most striking feature of the solution is the formation of a recirculation gyre in the northwest corner of the basin. To study the gyre structure for various Reynolds numbers the time-averaged fields of the stream function, and that of the relative and potential vorticity are thoroughly examined. The role of the eddies, appeared within the boundary layer, in the transfer of positive vorticity from the west coast is clarified. The analysis of the energy characteristics of the system is presented and the vorticity balance both integral and regional (within a closed streamline) is elucidated. Finally, the consistent discussion of the process of the formation of the recirculation gyre for different Reynolds numbers is suggested

On the Shoaling of Solitary Waves in the Presence of Short Random Waves

Overhead video from a small number of laboratory tests conducted by Kaihatu et al. at the Tsunami Wave Basin at Oregon State University shows that the breaking point of a shoaling solitary wave shifts to deeper water if random waves are present. The analysis of the laboratory data collected confirms that solitary waves indeed tend to break earlier in the presence of random wave field, and suggests that the effect is the result of the radiation stresses gradient induced by the random wave fields. A theoretical approach based on the forced KdV equation is shown to successfully predict the shoaling process of the solitary wave. An ensemble of tests simulated using a state-of-the-art nonhydrostatic model is used to test the statistical significance of the process. The results of this study point to a potentially significant oceanographic process that has so far been ignored and suggest that systematic research into the interaction between tsunami waves and the swell background could increase the accuracy of tsunami forecasting. © 2015 American Meteorological Society

Eigenanalysis of the two-dimensional wind-driven ocean circulation problem

A barotropic model of the wind-driven circulation in the subtropical region of the ocean is considered. A no-slip condition is specified at the coasts and slip at the fluid boundaries. Solutions are governed by two parameters: inertial boundary-layer width; and viscous boundary-layer width. Numerical computations indicate the existence of a wedge-shaped region in this two-dimensional parameter space, where three steady solutions coexist. The structure of the steady solution can be of three types: boundary-layer, recirculation and basin-filling-gyre. Compared to the case with slip conditions (Ierley and Sheremet, 1995) in the no-slip case the wedge-shaped region is displaced to higher Reynolds numbers. Linear stability analysis of solutions reveals several classes of perturbations: basin modes of Rossby waves, modes associated with the recirculation gyre, wall-trapped modes and a “resonant” mode. For a standard subtropical gyre wind forcing, as the Reynolds number increases, the wall-trapped mode is the first one destabilized. The resonant mode associated with disturbances on the southern side of the recirculation gyre is amplified only at larger Reynolds number, nonetheless this mode ultimately provides a stronger coupling between the mean circulation and Rossby basin modes than do the wall-trapped modes