Development of Millimeter-wave FMCW Vertical-looking Entomological Radar System

This work presents a frequency modulated continuous wave (FMCW) millimeter-wave vertical-looking radar (VLR) system. The proposed system operates at 34.5 GHz and can continuously detect targets flying at a maximum of 200m above the ground. In field tests, it measures the target's displacement direction, moving speed, mass and body shape. An Altera Stratix IV FPGA is utilized for signal processing of the FMCW radar signal. A cosecant squared pattern leaky wave antenna is suggested to detect the targets with constant power and reduce the data processing load in real time system

Parkinson\u27s disease and the gastrointestinal microbiome

Recently, there has been a surge in awareness of the gastrointestinal microbiome (GM) and its role in health and disease. Of particular note is an association between the GM and Parkinson’s disease (PD) and the realisation that the GM can act via a complex bidirectional communication between the gut and the brain. Compelling evidence suggests that a shift in GM composition may play an important role in the pathogenesis of PD by facilitating the characteristic ascending neurodegenerative spread of α-synuclein aggregates from the enteric nervous system to the brain. Here, we review evidence linking GM changes with PD, highlighting mechanisms supportive of pathological α-synuclein spread and intestinal inflammation in PD. We summarise existing patterns and correlations seen in clinical studies of the GM in PD, together with the impacts of non-motor symptoms, medications, lifestyle, diet and ageing on the GM. Roles of GM modulating therapies including probiotics and faecal microbiota transplantation are discussed. Encouragingly, alterations in the GM have repeatedly been observed in PD, supporting a biological link and highlighting it as a potential therapeutic target

Towards Green Metaverse Networking Technologies, Advancements and Future Directions

As the Metaverse is iteratively being defined, its potential to unleash the next wave of digital disruption and create real-life value becomes increasingly clear. With distinctive features of immersive experience, simultaneous interactivity, and user agency, the Metaverse has the capability to transform all walks of life. However, the enabling technologies of the Metaverse, i.e., digital twin, artificial intelligence, blockchain, and extended reality, are known to be energy-hungry, therefore raising concerns about the sustainability of its large-scale deployment and development. This article proposes Green Metaverse Networking for the first time to optimize energy efficiencies of all network components for Metaverse sustainable development. We first analyze energy consumption, efficiency, and sustainability of energy-intensive technologies in the Metaverse. Next, focusing on computation and networking, we present major advancements related to energy efficiency and their integration into the Metaverse. A case study of energy conservation by incorporating semantic communication and stochastic resource allocation in the Metaverse is presented. Finally, we outline the critical challenges of Metaverse sustainable development, thereby indicating potential directions of future research towards the green Metaverse

A WSN approach to unmanned aerial surveillance of traffic anomalies: Some challenges and potential solutions

Stationary CCTV cameras are often used to help monitor car movements and detect any anomalies - e.g., accidents, cars going faster than the allowed speed, driving under the influence of alcohol, etc. The height of the cameras can limit their effectiveness and the types of image processing algorithm which can be used. With advancements in the development of inexpensive aerial flying objects and wireless devices, these two technologies can be coupled to support enhanced surveillance. The flying objects can carry multiple cameras and be sent well above the ground to capture and feed video/image information back to a ground station. In addition, because of the height the objects can achieve, they can capture videos and images which could lend themselves more suitably for the application of a variety of video and image processing algorithms to assist analysts in detecting any anomalies. In this paper, we examine some main challenges of using flying objects for surveillance purposes and propose some potential solutions to these challenges. By doing so, we attempt to provide the basis for developing a framework to build a viable system for improved surveillance based on low-cost equipment. © 2013 IEEE.t.published_or_final_versio

Exploiting metallophilicity for the assembly of inorganic nanocrystals and conjugated organic molecules

The accurate engineering of interfaces between inorganic nanocrystals and semiconducting organic molecules is currently viewed as key for further developments in critical fields such as photovoltaics and photocatalysis. In this work, a new and unconventional source of interface interaction based on metal–metal bonds is presented. With this aim, an AuI organometallic gelator was exploited for the formation of hydrogel-like nanocomposites containing inorganic nanoparticles and conjugated organic molecules. Noteworthy, the establishment of metallophilic interactions at the interface between the two moieties greatly enhances interparticle coupling in the composites. Thus, we believe that this new hybrid system might represent a promising alternative in several fields, such as in the fabrication of improved light-harvesting devices.Peer ReviewedPostprint (author's final draft

Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis

Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related death, especially in China. In addition, the prognosis of late stage patients is extremely poor. However, the biological significance of the long non-coding RNA lnc-ATB and its potential role in ESCC remain to be documented. In this study, we investigated the role of lnc-ATB and the underlying mechanism promoting its oncogenic activity in ESCC. Expression of lnc-ATB was higher in ESCC tissues and cell lines than that in normal counterparts. Upregulated lnc-ATB served as an independent prognosis predictor of ESCC patients. Moreover, loss-of-function assays in ESCC cells showed that knockdown of lnc-ATB inhibited cell proliferation and migration both in vitroand in vivo. Mechanistic investigation indicated that lnc-ATB exerted oncogenic activities via regulating Kindlin-2, as the anti-migration role of lnc-ATB silence was attenuated by ectopic expression of Kindlin-2. Further analysis showed that lnc-ATB functions as a molecular sponge for miR-200b and Kindlin-2. Dysregulated miR-200b/Kindlin-2 signaling mediated the oncogenic activity of lnc-ATB in ESCC. Our results suggest that lnc-ATB predicts poor prognosis and may serve as a potential therapeutic target for ESCC patients

Prevalence of malnutrition and associated factors among children aged 6–24 months under poverty alleviation policy in Shanxi province, China: A cross-sectional study

Introduction: Child malnutrition continues to be a major public health issue, accounting for 54% of all child mortality globally. This study aimed to determine the prevalence of childhood malnutrition and its associated risk factors as well as to explore the best developmental strategy among infants and young children (IYC). Methodology: This cross-sectional study was conducted six months after the distribution of nutritious YingYangBao (YYB). It involved children aged 6–24 months in Shaanxi Province, China. Data were collected via interviews with parents of IYC, followed by measurements of the children’s height and weight. Data were analyzed using EpiInfo software and SPSSv.26, which encompassed descriptive statistics, Pearson Chi-square, and multivariate logistic regression analysis. Ethics approval and parents’ informed consent were attained prior to the study. Result: A total of 3431 data were analyzed in the study. The prevalence of stunting was highest among IYC between 12 and 18 months (3.9%). Prevalence of underweight (0.5%) and wasting (1.5%) were highest among IYC aged 18–24 months while the prevalence of overweight was highest among IYC aged 6–12months (9.0%). Significant associating risk factors of malnutrition were IYC from Northern Shaanxi (aOR = 2.24; 95% CI:1.68–2.98) and mothers with parity ≥3 (aOR = 1.52; 95%CI:1.10–2.10). IYC with a higher educated father (aOR = 0.79; 95%CI:0.66–0.95), YYB intervention (aOR = 0.77; 95%CI:0.65–0.90), correct supplementary food time (aOR = 0.84; 95%CI:0.71–1.00) and separate supplementary food preparation (aOR = 0.79; 95% CI:0.66–0.95) were significantly associated with lower risk of malnutrition. Conclusion: Even though the prevalence of stunting, underweight, and wasting were relatively low (<5%), there is still a need to strengthen existing policies on child nutrition

Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms

Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC) utilize its tetratricopeptide repeat (TPR) domain to interact with over 10 different cargos. Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos. We determined the structures of human KLC1 and KLC2 tetratricopeptide repeat (TPR) domains using X-ray crystallography and investigated the different mechanisms by which KLCs interact with their cargos. Using isothermal titration calorimetry, we attributed the specific interaction between KLC1 and JNK-interacting protein 1 (JIP1) cargo to residue N343 in the fourth TRP repeat. Structurally, the N343 residue is adjacent to other asparagines and lysines, creating a positively charged polar patch within the groove of the TPR domain. Whereas, KLC2 with the corresponding residue S328 did not interact with JIP1. Based on these finding, we propose that N343 of KLC1 can form “a carboxylate clamp” with its neighboring asparagine to interact with JIP1, similar to that of HSP70/HSP90 organizing protein-1's (HOP1) interaction with heat shock proteins. For the binding of cargos shared by KLC1 and KLC2, we propose a different site located within the groove but not involving N343. We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4. Together, these results provide structural insights into possible mechanisms of interaction between KLC TPR domains and various cargo proteins