Effect of disorder with long-range correlation on transport in graphene nanoribbon

Transport in disordered armchair graphene nanoribbons (AGR) with long-range correlation between quantum wire contact is investigated by transfer matrix combined with Landauer's formula. Metal-insulator transition is induced by disorder in neutral AGR. Thereinto, the conductance is one conductance quantum for metallic phase and exponentially decays otherwise when the length of AGR is infinity and far longer than its width. Similar to the case of long-range disorder, the conductance of neutral AGR first increases and then decreases while the conductance of doped AGR monotonically decreases, as the disorder strength increases. In the presence of strong disorder, the conductivity depends monotonically and non-monotonically on the aspect ratio for heavily doped and slightly doped AGR respectively.Comment: 6 pages, 8 figures; J. Phys: Condensed Matter (May 2012

Study of Interplanetary Magnetic Field with Ground State Alignment

We demonstrate a new way of studying interplanetary magnetic field -- Ground State Alignment (GSA). Instead of sending thousands of space probes, GSA allows magnetic mapping with any ground telescope facilities equipped with spectropolarimeter. The polarization of spectral lines that are pumped by the anisotropic radiation from the Sun is influenced by the magnetic realignment, which happens for magnetic field (<1G). As a result, the linear polarization becomes an excellent tracer of the embedded magnetic field. The method is illustrated by our synthetic observations of the Jupiter's Io and comet Halley. Polarization at each point was constructed according to the local magnetic field detected by spacecrafts. Both spatial and temporal variations of turbulent magnetic field can be traced with this technique as well. The influence of magnetic field on the polarization of scattered light is discussed in detail. For remote regions like the IBEX ribbons discovered at the boundary of interstellar medium, GSA provides a unique diagnostics of magnetic field.Comment: 11 pages, 19 figures, published in Astrophysics and Space Scienc

Mass changes of southern and northern inylchek glacier, Central Tian Shan, kyrgyzstan, during ∼1975 and 2007 derived from remote sensing data

Glacier melt is an essential source of freshwater for the arid regions surrounding the Tian Shan. However, the knowledge about glacier volume and mass changes over the last decades is limited. In the present study, glacier area, glacier dynamics and mass changes are investigated for the period ∼1975-2007 for Southern Inylchek Glacier (SIG) and Northern Inylchek Glacier (NIG), the largest glacier system in Central Tian Shan separated by the regularly draining Lake Merzbacher. The area of NIG increased by 2.0 ± 0.1 km2 (∼1.3%) in the period ∼1975-2007. In contrast, SIG has shrunk continuously in all investigated periods since ∼1975. Velocities of SIG in the central part of the ablation region reached ∼100-120 m a-1 in 2002/2003, which was slightly higher than the average velocity in 2010/2011. The central part of SIG flows mainly towards Lake Merzbacher rather than towards its terminus. The measured velocities at the distal part of the terminus downstream of Lake Merzbacher were below the uncertainty, indicating very low flow with even stagnant parts. Geodetic glacier mass balances have been calculated using multioral digital elevation models from KH-9 Hexagon (representing the year 1975), SRTM3 (1999), ALOS PRISM (2006) and SPOT-5 high-resolution geometrical (HRG) data (2007). In general, a continuous mass loss for both SIG and NIG could be observed between ∼1975 and 2007. SIG lost mass at a rate of 0.43 ± 0.10 m w.e. a-1 and NIG at a rate of 0.25 ± 0.10 m w.e. ag-1 within the period ∼1975-1999. For the period 1999-2007, the highest mass loss of 0.57 ± 0.46 m w.e. ag-1 was found for NIG, whilst SIG showed a potential moderate mass loss of 0.28 ± 0.46 m w.e. a-1. Both glaciers showed a small retreat during this period. Between ∼1975 and 1999, we identified a thickening at the front of NIG with a maximum surface elevation increase of about 150 m as a consequence of a surge event. In contrast significant thinning (>0.5 m a-1) and comparatively high velocities close to the dam of Lake Merzbacher were observed for SIG, indicating that Lake Merzbacher enhances glacier mass loss.Publisher PDFPeer reviewe

Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer

Using antibody/aptamer-drug conjugates can be a promising method for decreasing toxicity, while increasing the efficiency of chemotherapy.In this study, the antitumor agent Doxorubicin (Dox) was incorporated into the modified DNA aptamer TLS11a-GC, which specifically targets LH86, a human hepatocellular carcinoma cell line. Cell viability tests demonstrated that the TLS11a-GC-Dox conjugates exhibited both potency and target specificity. Importantly, intercalating Dox into the modified aptamer inhibited nonspecific uptake of membrane-permeable Dox to the non-target cell line. Since the conjugates are selective for cells that express higher amounts of target proteins, both criteria noted above are met, making TLS11a-GC-Dox conjugates potential candidates for targeted delivery to liver cancer cells.Considering the large number of available aptamers that have specific targets for a wide variety of cancer cells, this novel aptamer-drug intercalation method will have promising implications for chemotherapeutics in general

Solar forcing for CMIP6 (v3.2)

This paper describes the recommended solar forcing dataset for CMIP6 and highlights changes with respect to CMIP5. The solar forcing is provided for radiative properties, namely total solar irradiance (TSI), solar spectral irradiance (SSI), and the F10.7 index as well as particle forcing, including geomagnetic indices Ap and Kp, and ionization rates to account for effects of solar protons, electrons, and galactic cosmic rays. This is the first time that a recommendation for solar-driven particle forcing has been provided for a CMIP exercise. The solar forcing datasets are provided at daily and monthly resolution separately for the CMIP6 preindustrial control, historical (1850–2014), and future (2015–2300) simulations. For the preindustrial control simulation, both constant and time-varying solar forcing components are provided, with the latter including variability on 11-year and shorter timescales but no long-term changes. For the future, we provide a realistic scenario of what solar behavior could be, as well as an additional extreme Maunder-minimum-like sensitivity scenario. This paper describes the forcing datasets and also provides detailed recommendations as to their implementation in current climate models. For the historical simulations, the TSI and SSI time series are defined as the average of two solar irradiance models that are adapted to CMIP6 needs: an empirical one (NRLTSI2–NRLSSI2) and a semi-empirical one (SATIRE). A new and lower TSI value is recommended: the contemporary solar-cycle average is now 1361.0 W m−2. The slight negative trend in TSI over the three most recent solar cycles in the CMIP6 dataset leads to only a small global radiative forcing of −0.04 W m−2. In the 200–400 nm wavelength range, which is important for ozone photochemistry, the CMIP6 solar forcing dataset shows a larger solar-cycle variability contribution to TSI than in CMIP5 (50 % compared to 35 %). We compare the climatic effects of the CMIP6 solar forcing dataset to its CMIP5 predecessor by using time-slice experiments of two chemistry–climate models and a reference radiative transfer model. The differences in the long-term mean SSI in the CMIP6 dataset, compared to CMIP5, impact on climatological stratospheric conditions (lower shortwave heating rates of −0.35 K day−1 at the stratopause), cooler stratospheric temperatures (−1.5 K in the upper stratosphere), lower ozone abundances in the lower stratosphere (−3 %), and higher ozone abundances (+1.5 % in the upper stratosphere and lower mesosphere). Between the maximum and minimum phases of the 11-year solar cycle, there is an increase in shortwave heating rates (+0.2 K day−1 at the stratopause), temperatures ( ∼  1 K at the stratopause), and ozone (+2.5 % in the upper stratosphere) in the tropical upper stratosphere using the CMIP6 forcing dataset. This solar-cycle response is slightly larger, but not statistically significantly different from that for the CMIP5 forcing dataset. CMIP6 models with a well-resolved shortwave radiation scheme are encouraged to prescribe SSI changes and include solar-induced stratospheric ozone variations, in order to better represent solar climate variability compared to models that only prescribe TSI and/or exclude the solar-ozone response. We show that monthly-mean solar-induced ozone variations are implicitly included in the SPARC/CCMI CMIP6 Ozone Database for historical simulations, which is derived from transient chemistry–climate model simulations and has been developed for climate models that do not calculate ozone interactively. CMIP6 models without chemistry that perform a preindustrial control simulation with time-varying solar forcing will need to use a modified version of the SPARC/CCMI Ozone Database that includes solar variability. CMIP6 models with interactive chemistry are also encouraged to use the particle forcing datasets, which will allow the potential long-term effects of particles to be addressed for the first time. The consideration of particle forcing has been shown to significantly improve the representation of reactive nitrogen and ozone variability in the polar middle atmosphere, eventually resulting in further improvements in the representation of solar climate variability in global models

Silencing of PTK7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis via Mitochondrial Pathway

Protein tyrosine kinase-7 (PTK7) is a catalytically inactive receptor tyrosine kinase (RTK). PTK7 is upregulated in many common human cancers, including colon cancer, lung cancer, gastric cancer and acute myeloid leukemia. The reason for this up-regulation is not yet known. To explore the functional role of PTK7, the expression of PTK7 in HCT 116 cells was examined using small interference (siRNA)-mediated gene silencing. Following transfection, the siRNA successfully suppressed PTK7 mRNA and protein expression. Knocking down of PTK7 in HCT 116 cells inhibited cell proliferation compared to control groups and induced apoptosis. Furthermore, this apoptosis was characterized by decreased mitochondrial membrane potential and activation of caspase-9 and -10. Addition of a caspase-10 inhibitor totally blocked this apoptosis, suggesting that caspase-10 may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria. These observations may indicate a role for PTK7 in cell proliferation and cell apoptosis and may provide a potential therapeutic pathway for the treatment of a variety of cancers

The Mass of β Pictoris C from β Pictoris b Orbital Motion

Aims. We aim to demonstrate that the presence and mass of an exoplanet can now be effectively derived from the astrometry of another exoplanet. Methods. We combined previous astrometry of β Pictoris b with a new set of observations from the GRAVITY interferometer. The orbital motion of β Pictoris b is fit using Markov chain Monte Carlo simulations in Jacobi coordinates. The inner planet, β Pictoris c, was also reobserved at a separation of 96 mas, confirming the previous orbital estimations. Results. From the astrometry of planet b only, we can (i) detect the presence of β Pictoris c and (ii) constrain its mass to 10.04-3.10+4.53 MJup. If one adds the astrometry of β Pictoris c, the mass is narrowed down to 9.15-1.06+1.08 MJup. The inclusion of radial velocity measurements does not affect the orbital parameters significantly, but it does slightly decrease the mass estimate to 8.89-0.75+0.75 MJup. With a semimajor axis of 2.68 ± 0.02 au, a period of 1221 ± 15 days, and an eccentricity of 0.32 ± 0.02, the orbital parameters of β Pictoris c are now constrained as precisely as those of β Pictoris b. The orbital configuration is compatible with a high-order mean-motion resonance (7:1). The impact of the resonance on the planets\u27 dynamics would then be negligible with respect to the secular perturbations, which might have played an important role in the eccentricity excitation of the outer planet