Resource Allocation in a MAC with and without security via Game Theoretic Learning

In this paper a $K$-user fading multiple access channel with and without security constraints is studied. First we consider a F-MAC without the security constraints. Under the assumption of individual CSI of users, we propose the problem of power allocation as a stochastic game when the receiver sends an ACK or a NACK depending on whether it was able to decode the message or not. We have used Multiplicative weight no-regret algorithm to obtain a Coarse Correlated Equilibrium (CCE). Then we consider the case when the users can decode ACK/NACK of each other. In this scenario we provide an algorithm to maximize the weighted sum-utility of all the users and obtain a Pareto optimal point. PP is socially optimal but may be unfair to individual users. Next we consider the case where the users can cooperate with each other so as to disagree with the policy which will be unfair to individual user. We then obtain a Nash bargaining solution, which in addition to being Pareto optimal, is also fair to each user. Next we study a $K$-user fading multiple access wiretap Channel with CSI of Eve available to the users. We use the previous algorithms to obtain a CCE, PP and a NBS. Next we consider the case where each user does not know the CSI of Eve but only its distribution. In that case we use secrecy outage as the criterion for the receiver to send an ACK or a NACK. Here also we use the previous algorithms to obtain a CCE, PP or a NBS. Finally we show that our algorithms can be extended to the case where a user can transmit at different rates. At the end we provide a few examples to compute different solutions and compare them under different CSI scenarios.Comment: 27 pages, 12 figures. Part of the paper was presented in 2016 IEEE Information theory and applicaitons (ITA) Workshop, San Diego, USA in Feb. 2016. Submitted to journa

EFFICACY OF ‘MADHUSIKTHADI LEPA’ IN PADADARI

Padadari is one of the commonest & most negligible diseases. It is observed that people are least bothered about their feet than their face. The feet bear the whole body weight. In India 80 % of population live in rural area. Most of them work in farms in wet soil and water also. So incidence of cracking the skin of the foot is very common. Poor people ignore this problem due to lack of consciousness about foot care or may be due to costly drugs. In Ayurveda, Padadari is described in Kshudra roga by Sushruta, Madhavanidana, Bhavaprakasha, Yogaratnakara etc. The signs, symptoms, pathogenesis and treatment of Padadari are mentioned in details which indicate that this disease was affecting the people since ancient times. It is mentioned that Padadari is caused due to Vataprakopaka hetu such as Aticankramana (i.e. excessive walking especially barefooted). In the initial stage of disease patient does not have any complaint. But as the disease progresses, it can lead to severe symptoms as acute pain, burning sensation, itching and even bleeding from cracks. Study was a small scale trial including 50 patients with a small duration of 11days. But after studying 15 patients for one more week (total 14 days), it was observed that 12 patients (80%) were totally symptom free. So we concluded that Madhusikthadi lepa gives better effects in long duration with proper Pathyapalana

TO ACCESS THE EFFECT OF PIPALLI CHOORNA AND SHATAVARI CHOORNA IN STANYAKSHAYA

Aim: To access the effect of Pipalli and Shatavari choorna with Shukhoshna godugdha in Stanyakshaya. Objective: Study of literature regarding Stanyakshaya and Pippli choorna. Observation on the effect of Pippali choorna with Godugdha on lactating mother and observe if any adverse effect.Method: Study Group: 60 patients were observed & treated, Study divided in two groups 30 patients in each group. In Group A (Trial Group) 30 patients are randomly selected in which Stanyakshaya will be treated with Pipplichoorna, 500 mg twice daily after meals with Sukhoshana Godugdha. In Group B (Control Group) 30 patients are Group of randomly selected in which Stanya Jananan drug Shatavarimool choorna 2 gm twice daily with Godugdha after meal. A follow up was done on each patient after every 7 days. Initially all the signs and symptoms were noted thoroughly. Change in signs and symptoms in each follow up were observed and noted in case paper. Follow up was done for 3 weeks during treatment and for 2 weeks after treatment. The total duration of treatment was 21 days.Results: Comparing all the symptoms before and after treatment had positive results of  treatment given to group B (Shatavari Choorna) showed slightly better results over treatment given to group A (Pippali choorna). The Statistical Analysis reveals that Shatavari Choorna with Shukhoshna godugdha in the management of Stanyakshaya is more effective than Pippalichoorna with Shukhoshna godugdha. Conclusion: Treatment given to group B (Shatavari Choorna) showed better results over treatment given to group A (Pippali choorna), we can conclude that treatment Shatavari Choorna given to group B is better for this disease Stanyakshaya

A Rare Case of Severe Aortic Regurgitation with Silent Ascending Aortic Dissection

Classically, ascending aortic dissection (AD) presents as sudden, severe chest pain that is tearing type and radiates to the back. Herein, we present a rare case of severe aortic regurgitation with silent ascending AD, which had no chest pain symptoms. The aortic valve apparatus probably masked this AD; therefore, it was not detected by echocardiography and during the surgery

Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study

Introduction: Acne is a multifactorial and common skin disease which can significantly affect the quality of life of sufferers. In this study, a topical herbal preparation traditionally used in Ayurvedic medicine was evaluated as a treatment for individuals with acne on their shoulders and backs. Methods: Study participants were randomly assigned either to treatment (Eladi Keram) or vehicle control (coconut oil) groups under double blind conditions and instructed on its daily home application. Standardised lesion counting and acne grading were conducted in accordance with US Food and Drug Administration guidelines and with reference to the Leeds Acne Grading Technique. Participants were assessed for severity of the condition at commencement and on day 28 of treatment. Results: The treatment group showed improvements of 42% (p < 0.005) on the Investigators Global Assessment scale, a 60% (p < 0.05) reduction in inflammatory lesions, a 59% (p < 0.05) reduction in non-inflammatory lesions, and a 59% (p < 0.005) reduction in combined lesion count. The control group showed no statistically significant changes for these criteria. Conclusion: This study is the first reported clinical evaluation of Eladi Keram as a treatment for acne and findings suggest that it could be effective in reducing inflammatory and non-inflammatory lesions, warranting further investigation by means of a larger scale clinical trial

Efect of maleated anhydride on mechanical properties of rice husk filler reinforced PLA Matrix Polymer Composite

Polylactic acid (PLA) formulated from corn starch has a bright potential to replace the non-renewable petroleum-based plastics. The combination of PLA and natural fbre has gained interest due to its unique performance, as reported in many researches and industries. Meanwhile, rice husk produced as the by-product of rice milling can be utilised, unless it is turned completely into waste. Therefore, in the present study, the rice husk powder (RHP) was used as a fller in the PLA, so to determine the infuence of the fller loading on the mechanical properties of the PLA composite. A coupling agent was selected for treatment from two options, i.e., maleic anhydride polypropylene (MAPP) and maleic anhydride polyethylene (MAPE), by applying the agents with various loading contents, such as 2, 4 and 6 wt%. The composite was fabricated by using the hot compression machine. Both the treated and untreated RHP–PLA composites were characterised via the tensile, fexural and impact strength tests. The increase in the RHP loading content led to the decrease in the tensile and fexural strengths. The applications of the coupling agents (MAPE and MAPP) did not improve the tensile and impact strengths, but the fexural strength was enhanced

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

A simple and convenient synthesis of 4,6- disubstituted 3-cyanopyridin-2(1<i>H</i>)-ones under solvent-free microwave conditions

885-887A rapid and efficient method for the preparation of 4,6- disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1, 3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods