6,550 research outputs found
Measurement of Dielectric Suppression of Bremsstrahlung
In 1953, Ter-Mikaelian predicted that the bremsstrahlung of low energy
photons in a medium is suppressed because of interactions between the produced
photon and the electrons in the medium. This suppression occurs because the
emission takes place over on a long distance scale, allowing for destructive
interference between different instantaneous photon emission amplitudes. We
present here measurements of bremsstrahlung cross sections of 200 keV to 20 MeV
photons produced by 8 and 25 GeV electrons in carbon and gold targets. Our data
shows that dielectric suppression occurs at the predicted level, reducing the
cross section up to 75 percent in our data.Comment: 11 pages, format is postscript file, gzip-ed, uuencode-e
Unexpected one-pot synthesis of highly conjugated pentacyclic diquinoid compounds
A new class of pentacyclic diquinoid compounds
has been synthesized with a facile one-pot reaction of
two molecules of 2-hydroxynaphthoquinone and 1-bromoalkanes
in the presence of ferrocene. These molecules were
isolated as enol tautomers that exhibit intramolecular hydrogen
bond and extended electronic conjugation as proved by the
intense absorption spectrum with a broad band between 400
and 600 nm. The spectroscopic and electrochemical characterization
of this new class of compounds has been performed.
One of the synthesized diquinoid derivatives showed a
significant cytotoxicity with IC50 values of 25−50 μM against
Cisplatin-Resistant SKOV3 and colon carcinoma SW480 cell
lines. The results of our study provide a valuable tool to a one-pot synthesis of highly conjugated polyquinones, analogous to
important biological systems, with significant antitumoral activity
New Variant of the Treatment of Acromion-Clavicular Dislocation With TightRope ® System in a Mini - Open Approach: A Preliminary Clinical Study
Background: Many different surgical techniques have been described to stabilize the acromion-clavicular (AC) dislocations. So far many of these procedures are performed only in arthroscopy.
Objectives: In this study, we describe a new technique that utilizes the tightrope with a mini-invasive open approach for the acute stabilization of the acromion-clavicular joint (ACJ) dislocation.
Patients and Methods: We set an prospective study aimed to verify the efficacy of this new surgical technique. We treated 28 patients with acute ACJ dislocation with ACJ TightRope ® System with dual mini access. We retrospectively reviewed the data of 34 patients treated with arthroscopic technique. They were considered as the control group.
Results: At 6 month’s follow-up, all the 28 patients showed a stable joint during clinical examination and obtained an average Constant score of 98.62/100, with a complete recovery of ROM and strength in abduction. The mean operation time was of 33.7 minutes. The mean recovery duration was 102.8 days. No significant difference was found between the experimental and control groups (P > 0.05).
Conclusions: Results of this trial suggest the effectiveness of this new mini-invasive surgical technique in producing clinical and functional recovery in patients with ACJ dislocations
Signaling about norms: socialization under strategic uncertainty
We consider a signaling model where adults possess information about the dominant social norm. Children want to conform to whatever norm is dominant but, lacking accurate information, take the observed behavior of their parent as representative. We show that this causes a signaling distortion in adult behavior, even in the absence of conflicts of interest. Parents adopt attitudes that encourage their children to behave in a socially safe way, i.e. the way that would be optimal under maximum uncertainty about the prevailing social norm. We discuss applications to sexual attitudes, collective reputation, and trust
Statistical properties of genealogical trees
We analyse the statistical properties of genealogical trees in a neutral
model of a closed population with sexual reproduction and non-overlapping
generations. By reconstructing the genealogy of an individual from the
population evolution, we measure the distribution of ancestors appearing more
than once in a given tree. After a transient time, the probability of
repetition follows, up to a rescaling, a stationary distribution which we
calculate both numerically and analytically. This distribution exhibits a
universal shape with a non-trivial power law which can be understood by an
exact, though simple, renormalization calculation. Some real data on human
genealogy illustrate the problem, which is relevant to the study of the real
degree of diversity in closed interbreeding communities.Comment: Accepted for publication in Phys. Rev. Let
Arago (1810): the first experimental result against the ether
95 years before Special Relativity was born, Arago attempted to detect the
absolute motion of the Earth by measuring the deflection of starlight passing
through a prism fixed to the Earth. The null result of this experiment gave
rise to the Fresnel's hypothesis of an ether partly dragged by a moving
substance. In the context of Einstein's Relativity, the sole frame which is
privileged in Arago's experiment is the proper frame of the prism, and the null
result only says that Snell's law is valid in that frame. We revisit the
history of this premature first evidence against the ether theory and calculate
the Fresnel's dragging coefficient by applying the Huygens' construction in the
frame of the prism. We expose the dissimilar treatment received by the ray and
the wave front as an unavoidable consequence of the classical notions of space
and time.Comment: 16 pages. To appear in European Journal of Physic
Bremsstrahlung Suppression due to the LPM and Dielectric Effects in a Variety of Materials
The cross section for bremsstrahlung from highly relativistic particles is
suppressed due to interference caused by multiple scattering in dense media,
and due to photon interactions with the electrons in all materials. We present
here a detailed study of bremsstrahlung production of 200 keV to 500 MeV
photons from 8 and 25 GeV electrons traversing a variety of target materials.
For most targets, we observe the expected suppressions to a good accuracy. We
observe that finite thickness effects are important for thin targets.Comment: 52 pages, 13 figures (incorporated in the revtex LaTeX file
Environment-Sensitive Epigenetics and the Heritability of Complex Diseases
Genome-wide association studies have thus far failed to explain the observed heritability of complex human diseases. This is referred to as the “missing heritability” problem. However, these analyses have usually neglected to consider a role for epigenetic variation, which has been associated with many human diseases. We extend models of epigenetic inheritance to investigate whether environment-sensitive epigenetic modifications of DNA might explain observed patterns of familial aggregation. We find that variation in epigenetic state and environmental state can result in highly heritable phenotypes through a combination of epigenetic and environmental inheritance. These two inheritance processes together can produce familial covariances significantly higher than those predicted by models of purely epigenetic inheritance and similar to those expected from genetic effects. The results suggest that epigenetic variation, inherited both directly and through shared environmental effects, may make a key contribution to the missing heritability
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