Reactive Acoustics Manta Project

Exploration Multimodal Interactions and\ua0AcousticsThe aim was to create a surface that changes its form – and therefore acoustic character – in response to multi-modal input including sound, stereoscopic vision, multi-touch, and brainwaves. The sculpture was then built to utilize the rigging infrastructure and acoustically inert environment of Rensselaer Polytechnic Institute’s Experimental Media and Performing Arts Center. Manta explores variability and responsiveness in the surface itself, advancing acoustic systems beyond individual elements and corrective treatment. This allowed for the designers to perceive the movement of the reactive surface in reality,\ua0as the user adjusts the preferences of the acoustical environment, the Manta morphs in real time to accommodate the user's needs

A Library of Induced Pluripotent Stem Cells from Clinically Well-Characterized, Diverse Healthy Human Individuals

Abstract A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a powerful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype association studies, and drug response evaluation. We report generation and extensive characterization of a gender-balanced, racially/ethnically diverse library of hiPSC lines from forty clinically healthy human individuals who range in age from 22-61. The hiPSCs match the karyotype and short tandem repeat identity of their parental fibroblasts, and have a transcription profile characteristic of pluripotent stem cells. We provide whole genome sequencing data for one hiPSC clone from each individual, ancestry determination, and analysis of Mendelian disease genes and risks. We document similar physiology of cardiomyocytes differentiated from multiple independent hiPSC clones derived from two individuals. This extensive characterization makes this hiPSC library a unique and valuable resource for many studies on human biology. Competing Interest Statement The authors have declared no competing interest

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals

A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development, disease modeling, genotype-phenotype association studies, and drug response evaluation. We report generation and extensive characterization of a gender-balanced, racially/ethnically diverse library of hiPSC lines from 40 clinically healthy human individuals who range in age from 22 to 61 years. The hiPSCs match the karyotype and short tandem repeat identities of their parental fibroblasts, and have a transcription profile characteristic of pluripotent stem cells. We provide whole-genome sequencing data for one hiPSC clone from each individual, genomic ancestry determination, and analysis of mendelian disease genes and risks. We document similar transcriptomic profiles, single-cell RNA-sequencing-derived cell clusters, and physiology of cardiomyocytes differentiated from multiple independent hiPSC lines. This extensive characterization makes this hiPSC library a valuable resource for many studies on human biology. •A library of induced pluripotent stem cells from 40 healthy human subjects•Racially/ethnically diverse subjects of clinically well-characterized health•Whole-genome sequencing identifies variants of mild common phenotypes or incomplete penetrance•Similar physiology of cardiomyocytes from independent hiPSC clones and individuals In this resource, Schaniel et al. report the generation and characterization of a gender-balanced, racially/ethnically diverse library of hiPSC lines from 40 clinically well-characterized healthy human individuals. The authors provide whole-genome sequencing data, ancestry determination, and analysis of mendelian disease genes and risks. Furthermore, similar physiology of cardiomyocytes differentiated from independent hiPSC clones derived from two individuals is documented