Transcultural adaptation and validation of the “Hip and Knee” questionnaire into Spanish

Journal Article; Research Support, Non-U.S. Gov't;BACKGROUND The purpose of the present study is to translate and validate the "Hip and Knee Outcomes Questionnaire", developed in English, into Spanish. The 'Hip and Knee Outcomes Questionnaire is a questionnaire planned to evaluate the impact in quality of life of any problem related to the human musculoskeletal system. 10 scientific associations developed it. METHODS The questionnaire underwent a validated translation/retro-translation process. Patients undergoing primary knee arthroplasty, before and six months postoperative, tested the final version in Spanish. Psychometric properties of feasibility, reliability, validity and sensitivity to change were assessed. Convergent validity with SF-36 and WOMAC questionnaires was evaluated. RESULTS 316 patients were included. Feasibility: a high number of missing items in questions 3, 4 and 5 were observed. The number of patients with a missing item was 171 (51.35%) in the preoperative visit and 139 (44.0%) at the postoperative. Internal validity: revision of coefficients in the item-rest correlation recommended removing question 6 during the preoperative visit (coefficient <0.20). Convergent validity: coefficients of correlation with WOMAC and SF-36 scales confirm the questionnaire's validity. Sensitivity to change: statistically significant differences were found between the mean scores of the first visit compared to the postoperative. CONCLUSION The proposed translation to Spanish of the 'Hip and Knee Questionnaire' is found to be reliable, valid and sensible to changes produced at the clinical practice of patients undergoing primary knee arthroplasty. However, some changes at the completion instructions are recommended. LEVEL OF EVIDENCE Level I. Prognostic study.Ye

Fórmulas para el coeficiente de arrastre y la ecuación Navier-Stokes fraccional

Se quiere encontrar la relación entre la ecuación de Navier-Stokes fraccional y las fórmulas para el coeficiente de arrastre, como las de Kármán-Schoenherr, Prandtl- Kármán, y Nikuradse. Los cambios de escala producen una renormalización para las ecuaciones de la capa límite, que contiene la hipótesis esencial de la delgadez de dicha capa, y da lugar a una descripción multifractal. Se obtiene una generalización del resultado experimental de Blasius para el factor de fricción. Si se reajustan las relaciones del número de rasgos del multifractal, se infieren las fórmulas, objeto de este estudio, y se las representa como un bi-multifractal, lo que permite un camino analítico para el número de Reynolds crítico y señala a la de Kármán-Schoenherr como la fórmula apropiada para el límite a la derecha de la subcapa viscosa. Los reajustes se traducen en matizar las aproximaciones de la relación entre los números de Euler y Reynolds, o bien en los decaimientos relativos del coeficiente de arrastre. Se aplican los resultados a la descripción de la capa límite turbulenta y a las interacciones entre corrientes y fondos (en ríos, desiertos y huracanes)

Transcultural adaptation and validation of the ' Hip and Knee ' questionnaire into Spanish

BACKGROUND: The purpose of the present study is to translate and validate the 'Hip and Knee Outcomes Questionnaire', developed in English, into Spanish. The 'Hip and Knee Outcomes Questionnaire is a questionnaire planned to evaluate the impact in quality of life of any problem related to the human musculoskeletal system. 10 scientific associations developed it. METHODS: The questionnaire underwent a validated translation/retro-translation process. Patients undergoing primary knee arthroplasty, before and six months postoperative, tested the final version in Spanish. Psychometric properties of feasibility, reliability, validity and sensitivity to change were assessed. Convergent validity with SF-36 and WOMAC questionnaires was evaluated. RESULTS: 316 patients were included. Feasibility: a high number of missing items in questions 3, 4 and 5 were observed. The number of patients with a missing item was 171 (51.35%) in the preoperative visit and 139 (44.0%) at the postoperative. Internal validity: revision of coefficients in the item-rest correlation recommended removing question 6 during the preoperative visit (coefficient <0.20). Convergent validity: coefficients of correlation with WOMAC and SF-36 scales confirm the questionnaire's validity. Sensitivity to change: statistically significant differences were found between the mean scores of the first visit compared to the postoperative. CONCLUSION: The proposed translation to Spanish of the 'Hip and Knee Questionnaire' is found to be reliable, valid and sensible to changes produced at the clinical practice of patients undergoing primary knee arthroplasty. However, some changes at the completion instructions are recommended. LEVEL OF EVIDENCE: Level I. Prognostic study

Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study

Background: Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease and evaluate the participants' level of knowledge between Latin American migrants attending a community-based screening campaign. Methods: Three community-based campaigns were performed in Alicante (Spain) in 2016, 2017 and 2018, including educational chats and blood tests for Trypanosoma cruzi serology. Participants completed a questionnaire assessing knowledge about the mechanisms of transmission, disease presentation, diagnosis, and treatment. People seropositive for T. cruzi underwent diagnostic confirmation by two different tests. Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios (aORs), adjusting for age, sex, and time in Spain. Results: A total of 596 participants were included in the study; 17% were aged under 18 years. Prevalence in adults was 11% [54/496; 95% confidence interval (CI): 8.3-14.5%] versus 0% among children. All but one case were in Bolivians. Diagnosis was independently associated with having been born in Bolivia (aOR: 102, 95% CI: 13-781) and a primary school-level education (aOR: 2.40, 95% CI: 1.14-5.06). Of 54 people diagnosed with Chagas disease (most of whom were asymptomatic), 42 (77.7%) returned to the clinic at least once, and 24 (44.4%) received treatment. Multivariable analysis showed that coming from Argentina (aOR: 13, 95% CI: 1.61-1188) or Bolivia (aOR: 1.90, 95% CI: 1.19-3.39) and having received information about Chagas disease in Spain (aOR: 4.63, 95% CI: 2.54-8.97) were associated with a good level of knowledge on the disease. Having primary level studies (aOR: 0.59, 95% CI: 0.34-0.98) and coming from Ecuador (aOR: 4.63, 95% CI: 2.52-847) were independently associated with a lower level of knowledge. Conclusions: Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected, asymptomatic individuals.This study was partially supported by the third call for research grants (J-M.R.-R.) from the Institute of Health and Biomedical Research of Alicante (ISABIAL)/FISABIO Foundation (III convocatoria de ayudas a proyectos de investigación del Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) – Fundación FISABIO) (UGP-16-158); and by the collaborative agreement between ISABIAL/Fundación FISABIO and Fundación Mundo Sano-Spain, in accordance with the Sponsorship Law. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Asymptomatic Strongyloidiasis among Latin American Migrants in Spain: A Community-Based Approach

Strongyloides stercoralis infection is frequently underdiagnosed since many infections remain asymptomatic. Aim: To estimate the prevalence and characteristics of asymptomatic S. stercoralis infection in Latin American migrants attending a community-based screening program for Chagas disease in Spain. Methodology: Three community-based Chagas disease screening campaigns were performed in Alicante (Spain) in 2016, 2017, and 2018. Serological testing for S. stercoralis infection was performed using a non-automatized IVD-ELISA detecting IgG (DRG Instruments GmbH, Marburg, Germany). Results: Of the 616 migrants from Central and South America who were screened, 601 were included in the study: 100 children and adolescents (<18 years of age) and 501 adults. Among the younger group, 6 participants tested positive (prevalence 6%, 95% confidence interval [CI] 2.5% to 13.1%), while 60 adults did so (prevalence 12%, 95% CI 9.3% to 15.3%). S. stercoralis infection was more common in men than in women (odds ratio adjusted [ORa] 2.28, 95% CI 1.289 to 4.03) and in those from Bolivia (ORa 2.03, 95% CI 1.15 to 3.59). Prevalence increased with age (ORa 1.02, 95% CI 0.99 to 1.05). In contrast, a university education had a protective effect (ORa 0.29, 95% CI 0.31 to 0.88). Forty-one (41/66; 62.1%) of the total cases of S. stercoralis infection were treated at the health care center. Positive stool samples were observed in 19.5% of the followed-up positive cases. Conclusion: Incorporating serological screening for S. stercoralis into community-based screening for Chagas disease is a useful intervention to detect asymptomatic S. stercoralis infection in Central and South American migrants and an opportunity to tackle neglected tropical diseases in a transversal way. The remaining challenge is to achieve patients' adherence to the medical follow-up.This study was partially supported by the 3rd call for research project grants for the Institute of Health and Biometric Research of Alicante (ISABIAL)/FISABIO Foundation (UGP-16-158), and by the collaboration agreement regulated under the Law of Patronage between ISABIAL/FISABIO and the Foundation Mundo Sano, Spain.S

L practicum (prácticas externas), en la etapa formativa universitaria y su impacto en la formación profesional. Estudio de caso: interacción formativa entre la Universidad de Murcia y la Universidad Católica de Córdoba (2008 -2015).

El objetivo del presente trabajo es analizar el impacto de la experiencia que en el marco de la Cooperación Interuniversitaria concretan la Universidad de Murcia (UMU) de España y la Universidad Católica de Córdoba (UCC) Argentina, a través de la realización del Practicum o prácticas curriculares externas, en la sede de la Facultad de Educación de la UCC desde el año 2007. Se considera que el Practicum es un espacio privilegiado para poner en práctica el acercamiento al mundo laboral. Este Programa, en Argentina responde a los objetivos de internacionalización de la Universidad de Murcia y la UCC, promoviendo la movilidad y formación de sus estudiantes. Este trabajo de investigación podrá transformarse en un insumo relevante para la etapa de evaluación interna en la que se encuentra actualmente la UCC.Fil: Sesma, Ana María. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Caelles Arán, Susana Ester. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Rangone, Claudia Inés. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Peces de la cuenca del río Mira : Pacífico colombo-ecuatoriano

ilustraciones, fotografías, mapasCon esta obra, docentes, investigadores, estudiantes y público en general podrán conocer e incrementar el conocimiento sobre peces dulciacuícolas con información relevante sobre distribución, biología y taxonomía de las especies de la zona. Aquí se documenta la ri-queza de especies con características biológicas relevantes, claves y otros elementos que permiten su comprensión biológica; amén de recomendaciones sobre el manejo de este recurso biótico que deben ser aprovechadas por las autoridades ambientales de ambos países para la toma de decisiones que afectan directamente la conservación de los peces y los ecosistemas acuáticos continentales de la cuenca del río Mira, poco conocida en Colombia y Ecuador. Es un gran honor presentar esta contribución, edición bellamente ilustrada y de gran utilidad para todos los interesados en este grupo. Su elaboración demandó un enorme esfuerzo técnico-científico por parte de los autores de los diversos capítulos tratados, quienes sintetizan en cada uno de estos el conocimiento de los de peces de agua dulce. Dejo entonces en sus manos este gran esfuerzo de investigación, digno de estudiar, dis- frutar y apreciar. (texto tomado de la fuente)PRESENTACIÓN -- INTRODUCCIÓN -- LA CUENCA BINACIONAL DEL RÍO MIRA -- Generalidades de la cuenca -- Las expediciones -- CLAVE ARTIFICIAL PARA ESPECIES -- LOS PECES -- LAS ESPECIES -- Orden Characiformes Familia Erythrinidae -- Hoplias malabaricus -- Familia Curimatidae -- Pseudocurimata lineopunctata -- Pseudocurimata patiae -- Familia Lebiasinidae -- Lebiasina narinensis -- Familia Ctenoluciidae --Ctenolucius beani -- Familia Characidae -- Eretmobrycon dahli -- Eretmobrycon miraensis -- Hyphessobrycon aff. chocoensis -- Pseudochalceus longianalis -- Roeboides occidentalis -- Familia Bryconidae -- Brycon argenteus -- Brycon sp -- Brycon oligolepis -- Brycon posadae -- Orden Gymnotiformes -- Familia Hypopomidae -- Brachyhypopomus occidentalis -- Familia Sternopygidae -- Sternopygus sp. -- Orden Siluriformes -- Familia Trichomycteridae -- Trichomycterus latidens -- Trichomycterus taenia -- Familia Astroblepidae -- Astroblepus chotae -- Astroblepus cirratus Astroblepus cyclopus -- Astroblepus grixalvii -- Astroblepus aff. longifilis -- Astroblepus mojicai -- Familia Loricariidae -- Chaetostoma marginatum -- Rineloricaria jubata -- Familia Heptapteridae -- Pimelodella eutaenia -- Pimelodella grisea -- Rhamdia guatemalensis -- Familia Pseudopimelodidae -- Cruciglanis sp. -- Orden Salmoniformes -- Familia Salmonidae -- Oncorhynchus mykiss -- Orden Syngnathiformes 108 Familia Syngnathidae 108 Pseudophallus starksii -- Orden Gobiiformes -- Familia Eleotridae -- Eleotris picta -- Gobiomorus maculatus -- Hemieleotris latifasciata -- Familia Oxudercidae -- Awaous transandeanus -- Sicydium rosenbergii -- Orden Pleuronectiformes -- Familia Achiridae -- Achirus mazatlanus -- Orden Cichliformes -- Familia Cichlidae -- Andinoacara biseriatus -- Mesoheros ornatus Oreochromis niloticus -- Orden Beloniformes -- Familia Belonidae -- Strongylura fluviatilis -- Orden Cyprinodontiformes -- Familia Poeciliidae -- Pseudopoecilia fria -- Poecilia caucana -- Orden Mugiliformes -- Familia Mugilidae -- Dajaus monticola -- AMENAZAS DE LA CUENCA -- AGRADECIMIENTOS -- REFERENCIAS -- GLOSARIO -- TABLAS -- ANEXO -- LISTA DE FIGURASPrimera edició

Vida cotidiana, Sociedad y Control Territorial en el Entorno Circumpirenaico Occidental: el Castillo Medieval de Irulegi (Valle de Aranguren, Navarra)

The Irulegi castle, located at the top of Mountain Irulegi or Peña de Lakidain (Aranguren, Valley), is one of the most outstanding examples of medieval castles within the Kingdom of Navarre. The castle was built for defensive purposes and to control the surrounding territory between the 11th and early 12th centuries, adn it was occupied unineterruptedly until the end of the 15th century. The materials presented in this article constitute a varied repertoire that includes typical elements of daily life related to food, farmig, crafts, warfare, and the use of leisure time, as well as material evidence of other activities such as religious activities and ostentation. This paper presents an overview of all of them to define the main features of the remains of the movable elements of this fortified settlement and their significance for the study of everyday life and medieval society from the reality of the materiality of a fortress.El castillo de Irulegi, localizado en la cima del monte Irulegi o Peña de Lakidain (Valle de Aranguren), es uno de los ejemplos más destacados del Reino de Navarra. El castillo se erigió con finalidades defensivas y de control del territorio circundante. Su inicio se encuentra entre el siglo XI y principios del XII, y muestra una ocupación ininterrumpida hasta finales del siglo XV. Los materiales que se presentan en este trabajo constituyen elementos propios de la vida cotidiana referentes a la alimentación, actividades agropecuarias, actividades artesanales y bélicas, o el empleo del tiempo de ocio, y que atestiguan, además, las evidencias materiales de otras actividades como las religiosas y de ostentación. Este trabajo presenta una visión de conjunto a fin de definir los principales rasgos de los restos de elementos muebles de este asentamiento fortificado y su trascendencia para el estudio de la vida cotidiana y la sociedad medieval desde la realidad de la materialidad de una fortaleza

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio