Metástasis musculares del adenocarcinoma renal

El carcinoma renal puede producir metástasis, siendo las más frecuentes en pulmón, hígado, esqueleto y encéfalo. Las metástasis aisladas en el músculo esquelético son muy raras, existiendo alrededor de veinte casos publicados en la literatura. Presentamos dos casos de metástasis de carcinoma renal, localizadas en el músculo esquelético. Es importante el diagnóstico diferencial de estas metástasis con los sarcomas de partes blandas, ya que su tratamiento y pronóstico son muy diferentes.The renal cell carcinoma can produce metastatic, the most common are in lung, liver, bones and encephalon. The isolated metastatic in muscle are unusual, there are only twenty cases published, most of them isolated cases. We present two cases of metastatic of renal cell carcinoma isolated in skeletal muscle. It is very important the differential diagnosis of this kind of lesions with soft tissue sarcomas because treatment and prognosis are very different

Application of a novel statistical model for quantitative proteomics by labeling to the study of VEGF-induced angiogenesis in vascular endothelial cells

Comunicaciones a congreso

Parallel Online Time Warping for Real-Time Audio-to-Score Alignment in Multi-core Systems

[EN] The Audio-to-Score framework consists of two separate stages: pre- processing and alignment. The alignment is commonly solved through offline Dynamic Time Warping (DTW), which is a method to find the path over the distortion matrix with the minimum cost to determine the relation between the performance and the musical score times. In this work we propose a par- allel online DTW solution based on a client-server architecture. The current version of the application has been implemented for multi-core architectures (x86, x64 and ARM), thus covering either powerful systems or mobile devices. An extensive experimentation has been conducted in order to validate the software. The experiments also show that our framework allows to achieve a good score alignment within the real-time window by using parallel computing techniques.This work has been partially supported by Spanish Ministry of Science and Innovation and FEDER under Projects TEC2012-38142-C04-01, TEC2012-38142-C04-03, TEC2012-38142-C04-04, TEC2015-67387-C4-1-R, TEC2015-67387-C4-3-R, TEC2015-67387-C4-4-R, the European Union FEDER (CAPAP-H5 network TIN2014-53522-REDT), and the Generalitat Valenciana under Grant PROMETEOII/2014/003.Alonso-Jordá, P.; Cortina, R.; Rodríguez-Serrano, F.; Vera-Candeas, P.; Alonso-González, M.; Ranilla, J. (2017). Parallel Online Time Warping for Real-Time Audio-to-Score Alignment in Multi-core Systems. The Journal of Supercomputing. 73(1):126-138. https://doi.org/10.1007/s11227-016-1647-5S126138731Joder C, Essid S, Richard G (2011) A conditional random field framework for robust and scalable audio-to-score matching. 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In: Proceedings of the international computer music conference (ICMC), pp 129–132Simon I, Morris D, Basu S (2008) MySong: automatic accompaniment generation for vocal melodies. In: Proceedings of the SIGCHI conference on human factors in computing systems. ACM, New York, pp 725–734Rodriguez-Serrano FJ, Duan Z, Vera-Candeas P, Pardo B, Carabias-Orti JJ (2015) Online score-informed source separation with adaptive instrument models. J New Music Res Lond 44(2):83–96Arzt A, Widmer G, Dixon S (2008) Automatic page turning for musicians via real-time machine listening. In: Proceedings of the 18th European conference on artificial intelligence. IOS Press, Amsterdam, pp 241–245Carabias-Orti JJ, Rodriguez-Serrano FJ, Vera-Candeas P, Canadas-Quesada FJ, Ruiz-Reyes N (2015) An audio to score alignment framework using spectral factorization and dynamic time warping. In: 16th International Society for music information retrieval conference, pp 742–748Rodríguez-Serrano FJ, Menéndez-Canal J, Vidal A, Cañadas-Quesada FJ, Cortina R (2015) A DTW based score following method for score-informed sound source separation. In: Proceedings of the 12th sound and music computing conference 2015 (SMC-15), Ireland, pp 491–496Carabias-Ortí JJ, Rodríguez-Serrano FJ, Vera-Candeas P, Cañadas-Quesada FJ, Ruíz-Reyes N (2013) Constrained non-negative sparse coding using learnt instrument templates for realtime music transcription. Eng Appl Artif Intell 26(7):1671–1680Raphael C (2006) Aligning music audio with symbolic scores using a hybrid graphical model. Mach Learn 65:389–409Schreck-Ensemble (2001–2004) ComParser 1.42. http://home.hku.nl/~pieter.suurmond/SOFT/CMP/doc/cmp.html . Accessed Sept 2015Itakura F (1975) Minimum prediction residual principle applied to speech recognition. IEEE Trans Acoust Speech Signal Process 23:52–72Dannenberg R, Hu N (2003) Polyphonic audio matching for score following and intelligent audio editors. In: Proceedings of the international computer music conference. International Computer Music Association, San Francisco, pp 27–34Mueller M, Kurth F, Roeder T (2004) Towards an efficient algorithm for automatic score-to-audio synchronization. In: Proceedings of the 5th international conference on music information retrieval, Barcelona, SpainMueller M, Mattes H, Kurth F (2006) An efficient multiscale approach to audio synchronization. In: Proceedings of the 7th international conference on music information retrieval, Victoria, CanadaKaprykowsky H, Rodet X (2006) Globally optimal short-time dynamic time warping applications to score to audio alignment. In: IEEE ICASSP, Toulouse, France, pp 249–252Fremerey C, Müller M, Clausen M (2010) Handling repeats and jumps in score-performance synchronization. In: Proceedings of ISMIR, pp 243–248Arzt A, Widmer G (2010) Towards effective any-time music tracking. In: Proceedings of starting AI researchers symposium (STAIRS), Lisbon, Portugal, pp 24–3

Spectroscopic observations of the δ Scorpii binary during its recent periastron passage

The bright star δ Sco has been considered a typical B0-type object for many years. Spectra of the star published prior to 1990 showed no evidence of emission, but only of short-term line profile variations attributed to nonradial pulsations. Speckle interferometric observations show that δ Sco is a binary system with a highlyeccentric orbit and a period of ~10.6 years. Weak emission in the Hα line was detected in its spectrum for the rst time during a periastron passage in 1990. Shortly before the next periastron passage in the summer of 2000, the binary entered a strong Hα emission and enhanced mass-loss phase. We monitored the spectroscopic development of the Be outburst from July 2000 through March 2001. In this paper we present results from our spectroscopy, refine elements of the binary orbit, and discuss possible mechanisms for the mass loss.Fabregat Llueca, Juan, [email protected] ; Blay Serrano, Pedro Jose, [email protected]

HReMAS: Hybrid Real-time Musical Alignment System

[EN] This paper presents a real-time audio-to-score alignment system for musical applications. The aim of these systems is to synchronize a live musical performance with its symbolic representation in a music sheet. We have used as a base our previous real-time alignment system by enhancing it with a traceback stage, a stage used in offline alignment to improve the accuracy of the aligned note. This stage introduces some delay, what forces to assume a trade-off between output delay and alignment accuracy that must be considered in the design of this type of hybrid techniques. We have also improved our former system to execute faster in order to minimize this delay. Other interesting improvements, like identification of silence frames, have also been incorporated to our proposed system.This work has been supported by the "Ministerio de Economia y Competitividad" of Spain and FEDER under Projects TEC2015-67387-C4-{1,2,3}-R.Cabañas-Molero, P.; Cortina-Parajón, R.; Combarro, EF.; Alonso-Jordá, P.; Bris-Peñalver, FJ. (2019). HReMAS: Hybrid Real-time Musical Alignment System. The Journal of Supercomputing. 75(3):1001-1013. https://doi.org/10.1007/s11227-018-2265-1S10011013753Alonso P, Cortina R, Rodríguez-Serrano FJ, Vera-Candeas P, Alonso-González M, Ranilla J (2017) Parallel online time warping for real-time audio-to-score alignment in multi-core systems. J Supercomput 73(1):126–138Alonso P, Vera-Candeas P, Cortina R, Ranilla J (2017) An efficient musical accompaniment parallel system for mobile devices. J Supercomput 73(1):343–353Arzt A (2016) Flexible and robust music tracking. Ph.D. thesis, Johannes Kepler University Linz, Linz, ÖsterreichArzt A, Widmer G, Dixon S (2008) Automatic page turning for musicians via real-time machine listening. In: Proceedings of the 18th European Conference on Artificial Intelligence (ECAI), Amsterdam, pp 241–245Carabias-Orti J, Rodríguez-Serrano F, Vera-Candeas P, Ruiz-Reyes N, Cañadas-Quesada F (2015) An audio to score alignment framework using spectral factorization and dynamic time warping. In: Proceedings of ISMIR, pp 742–748Cont A (2006) Realtime audio to score alignment for polyphonic music instruments, using sparse non-negative constraints and hierarchical HMMs. In: 2006 IEEE International Conference on Acoustics Speech and Signal Processing Proceedings, vol 5. pp V–VCont A, Schwarz D, Schnell N, Raphael C (2007) Evaluation of real-time audio-to-score alignment. In: International Symposium on Music Information Retrieval (ISMIR), ViennaDannenberg RB, Raphael C (2006) Music score alignment and computer accompaniment. Commun ACM 49(8):38–43Devaney J, Ellis D (2009) Handling asynchrony in audio-score alignment. In: Proceedings of the International Computer Music Conference Computer Music Association. pp 29–32Dixon S (2005) An on-line time warping algorithm for tracking musical performances. In: Proceedings of the International Joint Conference on Artificial Intelligence (IJCAI). pp 1727–1728Duan Z, Pardo B (2011) Soundprism: an online system for score-informed source separation of music audio. IEEE J Sel Top Signal Process 5(6):1205–1215Ewert S, Muller M, Grosche P (2009) High resolution audio synchronization using chroma onset features. In: IEEE International Conference on Acoustics, Speech and Signal Processing, 2009 (ICASSP 2009). pp 1869–1872Hu N, Dannenberg R, Tzanetakis G (2003) Polyphonic audio matching and alignment for music retrieval. In: 2003 IEEE Workshop on Applications of Signal Processing to Audio and Acoustics. pp 185–188Kaprykowsky H, Rodet X (2006) Globally optimal short-time dynamic time warping, application to score to audio alignment. In: Proceedings of the International Conference on Acoustics, Speech and Signal Processing, vol 5. pp. V–VLi B, Duan Z (2016) An approach to score following for piano performances with the sustained effect. IEEE/ACM Trans Audio Speech Lang Process 24(12):2425–2438Miron M, Carabias-Orti JJ, Bosch JJ, Gómez E, Janer J (2016) Score-informed source separation for multichannel orchestral recordings. J Electr Comput Eng 2016(8363507):1–19Muñoz-Montoro A, Cabañas-Molero P, Bris-Peñalver F, Combarro E, Cortina R, Alonso P (2017) Discovering the composition of audio files by audio-to-midi alignment. In: Proceedings of the 17th International Conference on Computational and Mathematical Methods in Science and Engineering. pp 1522–1529Orio N, Schwarz D (2001) Alignment of monophonic and polyphonic music to a score. In: Proceedings of the International Computer Music Conference (ICMC), pp 155–158Pätynen J, Pulkki V, Lokki T (2008) Anechoic recording system for symphony orchestra. Acta Acust United Acust 94(6):856–865Raphael C (2010) Music plus one and machine learning. In: Proceedings of the 27th International Conference on Machine Learning (ICML), pp 21–28Rodriguez-Serrano FJ, Carabias-Orti JJ, Vera-Candeas P, Martinez-Munoz D (2016) Tempo driven audio-to-score alignment using spectral decomposition and online dynamic time warping. ACM Trans Intell Syst Technol 8(2):22:1–22:2

Scarce population genetic differentiation but substantial spatiotemporal phenotypic variation of water‑use efficiency in Pinus sylvestris at its western distribution range

Water and carbon fluxes in forests are largely related to leaf gas exchange physiology varying across spatiotemporal scales and modulated by plant responses to environmental cues. We quantified the relevance of genetic and phenotypic variation of intrinsic water-use efficiency (WUEi, ratio of net photosynthesis to stomatal conductance of water) in Pinus sylvestris L. growing in the Iberian Peninsula as inferred from tree-ring carbon isotopes. Inter-population genetic variation, evaluated in a provenance trial comprising Spanish and German populations, was low and relevant only at continental scale. In contrast, phenotypic variation, evaluated in natural stands (at spatial level) and by tree-ring chronologies (at temporal inter-annual level), was important and ten- and threefold larger than the population genetic variance, respectively. These results points to preponderance of plastic responses dominating variability in WUEi for this species. Spatial phenotypic variation in WUEi correlated negatively with soil depth (r = − 0.66; p < 0.01), while temporal phenotypic variation was mainly driven by summer precipitation. At the spatial level, WUEi could be scaled-up to ecosystem-level WUE derived from remote sensing data by accounting for soil water-holding capacity (r = 0.63; p < 0.01). This outcome demonstrates a direct influence of the variation of leaf-level WUEi on ecosystem water and carbon balance differentiation. Our findings highlight the contrasting importance of genetic variation (negligible) and plastic responses in WUEi (large, with changes of up to 33% among sites) on determining carbon and water budgets at stand and ecosystem scales in a widespread conifer such as Pinus sylvestris.This work was supported by the Spanish Government [MINECO Grant Number AGL2015-68274-C3-3-R] and the Russian Science Foundation (Project Number 14-14-00219-P, mathematical approach). We acknowledge P. Sopeña and M.J. Pau for technical assistance and V. Muñoz, M. Sala and A. Teixidó for field sampling

Geographic miss: a cause of treatment failure in radio-oncology applied to intracoronary radiation therapy

BACKGROUND: A recognized limitation of endovascular beta-radiation therapy is the development of new stenosis at the edges of the irradiated area. The combination of injury and low-dose radiation may be the precursor of this phenomenon. We translated the radio-oncological concept of "geographic miss" to define cases in which the radiation source did not fully cover the injured area. The aims of the study were to determine the incidence and causes of geographic miss and evaluate the impact of this inadequate treatment on the outcome of patients treated with intracoronary beta-radiation. METHODS AND RESULTS: We analyzed 50 consecutive patients treated with beta-radiation after percutaneous coronary intervention. The prescribed dose ranged between 12 and 20 Gy at 2 mm from the source axis. By means of quantitative coronary angiography, the irradiated segment (IRS) and both edges were studied before and after intervention and at 6-month follow-up. Edges that were injured during the procedure constituted the geographic miss edges. Twenty-two edges were injured during the intervention, mainly because of procedural complications that extended the treatment beyond the margins of the IRS. Late loss was significantly higher in geographic miss edges than in IRSs and uninjured edges (0.84+/-0.6 versus 0.15+/-0.4 and 0.09+/-0.4 mm, respectively; P<0.0001). Similarly, restenosis rate was significantly higher in the injured edges (10% within IRS, 40.9% in geographic miss edges, and 1.9% in uninjured edges; P<0.001). CONCLUSIONS: These data support the hypothesis that the combination of injury and low-dose beta-radiation induces deleterious outcome

Caracterización de ganaderos y unidades de producción pecuaria beneficiarios del programa de estímulos a la productividad ganadera (PROGAN) en México

The PROGAN has been criticized, just like other agriculturalsupport governmental programs, because it does not start with adiagnosis of the real situation that cattle production has and,therefore, does not take into consideration the differences betweenproducers, an important aspect in the design of public policies.The objective of this research was to characterize economicallyand productively the livestock producers that integrate the registryof PROGAN beneficiaries in México, in order to clarify theconditions in which extensive livestock production is carried out,and allowing in the long term a differentiation of policies. Thestudy was based on 977 surveys, and the analysis methodologyused was Factor Analysis, which as a statistical technique fordata reduction turned out to be efficient in identifying six factorswhich were used to adjust the sample and characterize it in fourtypes of producers with different levels of economic and productivedevelopment.El PROGAN ha sido criticado, al igual que otros programas deapoyo gubernamental, por no partir de un diagnóstico de la situaciónreal que guarda la ganadería bovina y, por tanto, notomar en consideración las diferencias entre los productores, aspectoimportante en el diseño de políticas públicas. El objetivode esta investigación fue caracterizar económica y productivamentea los ganaderos que integran el padrón de beneficiariosdel PROGAN en México; a fin de esclarecer las condiciones enlas que se desempeña la actividad ganadera extensiva, permitiendoa futuro una diferenciación de políticas. El estudio se apoyóen 977 encuestas, y la metodología de análisis que se aplicó fue lade Análisis Factorial, que como técnica estadística de reducciónde datos resultó ser eficiente en la identificación de seis factores,que fueron utilizados para ponderar la muestra y caracterizarlaen cuatro tipos de productores con diferentes niveles de desarrolloeconómico y productivo

Diagnosis of an Intracoronary Thrombus With Intravascular Ultrasound

A60-year-old man was referred for coronary angiography because of exertional angina (Canadian Cardiovascular Society angina classification type II). Twelve years earlier, he had had a myocardial infarction with a venous bypass graft to the right coronary artery