On a scale-invariant Fermi gas in a time-dependent harmonic potential

We investigate a scale-invariant two-component Fermi gas in a time-dependent isotropic harmonic potential. The exact time evolution of the density distribution in position space in any spatial dimension is obtained. Two experimentally relevant examples, an abrupt change and a periodic modulation of the trapping frequency are solved. Small deviations from scale invariance and isotropy of the confinement are addressed within first order perturbation theory. We discuss the consequences for experiments with ultracold quantum gases such as the excitation of a tower of undamped breathing modes and a new alternative for measuring the Tan contact.Comment: 6+3 pages, 2 figures; revised and extended versio

Relevance of the salt-inducible kinase network for the development of high blood pressure and cardiac hypertrophy

Hypertension (high blood pressure) is a multifactorial condition that remains a big worldwide problem. 95% of all hypertensive people suffer from essential hypertension with unknown causes. This can cause different heart diseases such as cardiac hypertrophy (CH), a condition which can ultimately lead to heart failure. Salt intake has been suggested to be one of the factors promoting hypertension. The aims of this thesis were to elucidate the importance of salt-inducible kinase 1 (SIK1) in the development of high blood pressure (BP) and to identify salt-activated molecular pathways that could activate transcription factors and genes coupled with development of CH independently of high BP. SIK1 has been implicated in intracellular pathways that control cell sodium homeostasis and is also important for myocyte development. To investigate whether SIK1 is a potential regulator of BP, genotype-phenotype association studies between a genetic variation within SIK1 coding region (rs3746951) and BP in four population-based cohorts were performed. After performing a meta-analysis of the four studies the results revealed an association between the rs3746951 and lower systolic- and diastolic blood pressures. Rs3746951 was also associated with lower left ventricular mass. In studies performed in cultured vascular smooth muscle cells it was shown that rs3746951 was associated with higher SIK1 and Na+/K+ -ATPase activity. These results suggest that SIK1 affects BP. To explore the involvement of SIK1 in the development of CH, studies were performed in a mouse cardiac atrium cell line (HL-1). The overall results revealed that SIK1 mediated the effect of salt on transcription factors MEF2 and NFAT and on the genes associated with CH: Mhc Bnp and Ska. Studies performed on samples from human biopsies confirmed the association between SIK1 and hypertrophic genes. These results suggest that salt intake could trigger events that lead to increased expression levels of genes associated with CH, independently of increases in BP and that SIK1 is a mediator of this process. Since SIK1 can affect the transcription of genes that are associated with CH, the involvement of a hypertensive form of α-adducin and SIK isoforms in this process was examined. mRNA levels for SIK2, α-adducin, and several markers of CH were correlated in tissue biopsies obtained from human hearts. Evidence that SIK2 is critical for the development of CH in response to chronic high-salt diet was also obtained in mice with ablation of the Sik2 gene. Increases in heart size upon high salt diet, occurred only in Sik2+/+ but not in Sik2-/- mice. The presence of a hypertensive variant of α-adducin in Milan rats (before they become hypertensive) was associated with elevated transcription factors and genes associated with CH. Thus, we concluded that CH, triggered by salt intake or the presence of a genetic variant of α-adducin, requires SIK2 and is independent of elevated BP. Taken together, this thesis describes how the SIK network could affect BP regulation and independently of BP mediate the effect of salt on the development of CH

Кримінально-правові санкції у протидії злочинності: методологічні питання визначення та сутності

Попов С. В. Кримінально-правові санкції у протидії злочинності: методологічні питання визначення та сутності / С. В. Попов // Про злочини та покарання: еволюція кримінально-правової доктрини : матеріали Міжнар. наук.-практ. конф., присвяченої 250-річчю трактату Чезаре Беккаріа (м. Одеса, 13 черв. 2014 р.) / редкол. : С. В. Ківалов (голов. ред.), В. О. Туляков (заст. голов ред.), Є. Л. Стрельцов (заст. голов ред.), Д. О. Балобанова ; МОН України, НУ ОЮА, ПРЦ НАПрН України, Одес. відділ. ГО «Всеукр. асоц. кримін. права». — Одеса : Юрид. л-ра, 2014. - С. 337-343

Когнитивно-эволюционное исследование причин сходств и различий между генетическим кодом и лингвистическим кодом, а также отдельными семиотическими системами

This article focuses on the cognitive and evolutionary study of reasons for the isomorphism of the genetic and linguistic code, the subconscious development of semiotic systems in individuals following the model of a genetic code, and a more developed tool in the linguistic code.Prispevek je posvečen kognitivni in evolucijski raziskavi vzrokov za izomorfizem genetičnega in lingvističnega koda, podzavestnemu razvoju semiotičnih sistemov pri posameznikih po modelu genetičnega koda ter bolj razvitemu orodju v lingvističnem kodu

Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection

The peroxisomal proliferator-activated receptor γ (PPARγ) is a nuclear receptor that controls inflammation and immunity. Innate immune defense against bacterial infection appears to be compromised by PPARγ. The relevance of PPARγ in myeloid cells, that organize anti-bacterial immunity, for the outcome of immune responses against intracellular bacteria such as Listeria monocytogenes in vivo is unknown. We found that Listeria monocytogenes infection of macrophages rapidly led to increased expression of PPARγ. This prompted us to investigate whether PPARγ in myeloid cells influences innate immunity against Listeria monocytogenes infection by using transgenic mice with myeloid-cell specific ablation of PPARγ (LysMCre×PPARγflox/flox). Loss of PPARγ in myeloid cells results in enhanced innate immune defense against Listeria monocytogenes infection both, in vitro and in vivo. This increased resistance against infection was characterized by augmented levels of bactericidal factors and inflammatory cytokines: ROS, NO, IFNγ TNF IL-6 and IL-12. Moreover, myeloid cell-specific loss of PPARγ enhanced chemokine and adhesion molecule expression leading to improved recruitment of inflammatory Ly6Chi monocytes to sites of infection. Importantly, increased resistance against Listeria infection in the absence of PPARγ was not accompanied by enhanced immunopathology. Our results elucidate a yet unknown regulatory network in myeloid cells that is governed by PPARγ and restrains both listeriocidal activity and recruitment of inflammatory monocytes during Listeria infection, which may contribute to bacterial immune escape. Pharmacological interference with PPARγ activity in myeloid cells might represent a novel strategy to overcome intracellular bacterial infection

STAMPING TOOL FOR MANUFACTURE OF LARGE DIAMETER PIPES FROM TUBULAR BILLET WITH PRESS MOLDING

FIELD: technological processes, tool. SUBSTANCE: tool is arranged in the form of two symmetrically installed stamp holders and set of split pair inserts installed in contact with them along support surfaces, which are installed with the possibility of coupling and creation of internal shape-generating surface, support installed on the outer end of upper insert that is extreme according to travel, and limiting plate installed inside the mentioned upper insert and fixed in support with the help of bars with the possibility of control of its distance from the end of upper insert. At that longitudinal axis of limiting plate coincides with transverse axis of shape-generating surface of upper insert, and its length exceeds the distance between the walls of tubular billet. EFFECT: accuracy of tubular billet installation into stamping tool is increased, as well as quality of pipes press molding. 3 dwg.Изобретение относится к области обработки металлов давлением, в частности к штамповым инструментам для прессовой формовки. Инструмент выполнен в виде двух симметрично установленных штамподержателей и размещенного в контакте с ними по опорным поверхностям комплекта разъемных парных вкладышей, установленных с возможностью сопряжения и образования внутренней формообрзующей поверхности, упора, установленного на внешнем торце крайнего по ходу верхнего вкладыша, и ограничительной пластины, расположенной внутри упомянутого верхнего вкладыша и закрепленной на упоре при помощи штанг с возможностью регулирования ее расстояния от торца верхнего вкладыша. При этом продольная ось ограничительной пластины совпадает с поперечной осью формообразующей поверхности верхнего вкладыша, а ее длина превышает расстояние между стенками трубной заготовки. Повышается точность установки трубной заготовки в штамповый инструмент, а также качество прессовой формовки труб. 3 ил

Когнитивно‑эволюционная интерпретация концепции Б. Ф. Поршнева о физиологических предпосылках появления языка [Kognitivno-èvoljucionnaja interpretacija koncepcii B. F. Poršneva o fiziologičeskih predposylkah pojavlenija jazyka]

The paper is the cognitive and evolutionary interpretation of B.F. Porshnev’s concept on physiological prerequisites of the language origination. It represents the basic ideas of the cognitive and evolutionary concept as well as the essence of B.F. Porshnev’s theory being analyzed; truthlikeness degree and elusive linguistic value of the theory have been substantiated; and its cognitive and evolutionary study has been carried out.Članek je kognitivna in evolucijska interpretacija pogledov B. F. Poršnjeva na fiziološke predpostavke pojavitve jezika. Podane so kognitivne osnove in analizirano bistvo pogledov Poršnjeva, preverjeni sta stopnja in jezikovna vrednost njegovih pogledov ter nadalje izvedene kognitivne in evolucijske raziskave

The Retrieval of NURBS-surface by Genetic Algorithm on the Basis of Point Cloud

The approach to the geometrical modeling problem solution is described in this report. The approach is dedicated to the approximation of the cloud of points by a NURBS-curve or NURBS-surface and is based on the inheritance mechanism or on the so-called Genetic Algorithm. Genetic Algorithm is the heuristic search and optimization technique that mimics the process of natural evolution. The mechanisms of evolution seem well suited for some of the most pressing scientific problems in many fields. Therefore, the concept of evolution can be applied to solve different computational problems and NURBS-surface retrieval including. The efficiency of the approach is demonstrated by the retrieval of a human face and ship hull surface

The shortest path finding between two points on a polyhedral surface

The paper describes the approximate method of the shortest path finding between two points on a surface. This problem occurs when generating a cutting pattern after the form of the fabric tensile surface is found. The shortest path finding is reduced to the problem of finding the geodesic line on the surface. However, the numerical problem solution of the form finding of fabric tensile structure leads to the fact that the final surface is represented by an arbitrary polyhedron. There is no analytical problem solution of finding shortest paths in this case. The described method allows finding the shortest path on a surface of any regular polyhedron form