CREATIVE PLACEMAKING: A CASE STUDY EXPLORATION OF HOW CREATIVE ECONOMY STRATEGIES CAN PROVIDE POTENTIAL OPPORTUNITIES FOR REVITALIZATION IN DOWNTOWN CHICOPEE, MA

Chicopee, a former industrial center in western Massachusetts, is experiencing a stagnant economy, high vacancy and a steady loss of population. City of Chicopee wants to increase downtown visibility and bolster its economy by attracting in the area people constituent of creative class. This research represents an attempt to identify creative strategies to develop the neglected downtown of Chicopee. After more than a century of economic blight, vacancy and declining population, the city wants to research and exploit the potential of arts and culture as means to a physical, social and economic revivification of its downtown. A key aim of this study is to formulate a set of best practices and recommendation based on relevant literature and case studies. These evaluations and recommendations would assists the city of Chicopee to craft policies, as they would find appropriate, to help increasing the downtown area economic performance and at large the city economic growth. The recommendations could also serve to the community groups, such as artists, entrepreneurs, students and young professional that want to join their forces to promote community values and redevelopment

Creating Livable Neighborhoods in Old Hill and Six Corners, Springfield, Massachusetts

This report documents the work of the Graduate Urban Design Studio in Springfield’s Old Hill and Six Corners neighborhoods with 12,000 inhabitants. Both neighborhoods are challenged by a very low average household income, housing foreclosures, lot vacancies, lack of substantial home ownership, high traffic volumes and poor quality of open space. The primary goal of the project was to develop a vision to renew Old Hill and Six Corners to improve livability for their residents and create new opportunities for housing, recreation, working and commercial activities. Crucial keys to attaining this goal will be creating a stronger sense of place throughout the neighborhood and improved connectivity to the existing public open spaces like the Watershops Pond and the proposed recreational trail “Arc of Recreation”. Four physical design objectives were explored: Creating a vision for livable streets - a more livable streetscape improves walkability, urban ecology, commercial activities and provides an enriching sensual experience. Creating a better physical environment for commercial and business activities – attractive streets create a new identity and support existing businesses. Creating and improving a pedestrian and bicycle oriented circulation and coherent public open space system. Exploring new housing opportunities - new sites for housing integrate the student population in the neighborhoods. We are proud that our proposals were recognized after a tornado hit Springfield in June 2011. REBUILDSPRINGFIELD targeted the tornado-impacted neighborhoods in a collaborative effort with engaged citizens and community groups. Our plans created a valuable planning and design framework to rebuild the City

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Cortometraje de ficción NEFELIBATA

Treball Final de Grau en Comunicació Audiovisual. Codi: CA0932. Curs acadèmic: 2017-2018Este trabajo de final de grado ha tenido como objetivo la realización de una pieza audiovisual, en este caso, un cortometraje titulado Nefelibata. Para ello se ha desarrollado el proyecto desde la concepción de la idea hasta su realización, siguiendo las fases habituales para la creación de un producto audiovisual: la pre-producción, la producción y la post-producción. En este trabajo se puede encontrar en primer lugar la justificación de la elección del tema y los objetivos que se pretenden alcanzar con el mismo, además de documentos que detallan el proyecto. En segundo lugar se profundizará en la trama argumental y la elaboración del cortometraje a través diferentes dossieres en los que se se encontrarán los documentos que se han requerido para la realización de la pieza audiovisual, tales como, guiones, desgloses, material ilustrado, entre otros. Seguidamente, encontraremos una memoria que relata todo el procedimiento que ha sido llevado a cabo por el equipo, además de las conclusiones y resultados obtenidos tras las finalización del proyecto. Finalmente en los anexos se ha incluido material adicional como: el making off, el vídeo de casting, la banda sonora, el script y la foto fija.This finaldegree project had an audio-visual piece as a target, in this case, a short film called Nefelibata. The work has been developed from the idea’s conception up to its accomplishment, by following the usual steps for the creation of an audio-visual product: the pre-production, the production and the post-production. In this work, in addition the documents that detail the project, you can find first of all the reason for the choice of this subject and what aimes are intended to be achieved with it. Secondly , we will go deep in the storyline and the elaboration of the short film through different dossiers, where some documents that have been required for the realization of the audiovisual piece, are found. Such as scripts, disaggregation, illustrated material, among others. Next, we will find a report that relates the entire procedure that has been carried out by the team, and also the conclusions and results obtained after the end of the project. Finally, additional material has been included in the annexes such as: the making off, the casting video, the soundtrack, the script and the still photo

Low correlation between Ki67 assessed by qRT-PCR in Oncotype Dx score and Ki67 assessed by Immunohistochemistry

International audienceAbstract Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX test was designed for ER+/HER2− early-stage breast cancers to help adjuvant chemotherapy decision by providing a Recurrent Score (RS). RS measures the expression of 21 specific genes from tumor tissue, including Ki67 . The primary aim of this study was to assess the agreement between Ki67 RNA obtained with Oncotype DX RS and Ki67 IHC . Other objectives were to analyze the association between the event free survival (EFS) and the expression level of Ki67 RNA ; and association between RS and Ki67 RNA . Herein, we report a low agreement of 0.288 by Pearson correlation coefficient test between Ki67 IHC and Ki67 RNA in a cohort of 98 patients with early ER+/HER2− breast cancers. Moreover, Ki67 RNA high tumors were significantly associated with the occurrence of events ( p = 0.03). On the other hand, we did not find any association between Ki67 IHC and EFS ( p = 0.26). We observed a low agreement between expression level of Ki67 RNA and Ki67 protein labelling by IHC. Unlike Ki67 IHC and independently of the RS, Ki67 RNA could have a prognostic value. It would be interesting to better assess the prognosis and predictive value of Ki67 RNA measured by qRT-PCR. The Ki67 RNA in medical routine could be a good support in countries where Oncotype DX is not accessible

Characterization of human umbilical cord lining-derived epithelial cells and transplantation potential

10.3727/096368910X564085Cell Transplantation2011-121827-1841CTRA

Development of a prediction model for postoperative pneumonia A multicentre prospective observational study

BACKGROUND Postoperative pneumonia is associated with increased morbidity, mortality and costs. Prediction models of pneumonia that are currently available are based on retrospectively collected data and administrative coding systems. OBJECTIVE To identify independent variables associated with the occurrence of postoperative pneumonia. DESIGN A prospective observational study of a multicentre cohort (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe database). SETTING Sixty-three hospitals in Europe. PATIENTS Patients undergoing surgery under general and/or regional anaesthesia during a 7-day recruitment period. MAIN OUTCOME MEASURE The primary outcome was postoperative pneumonia. Definition: the need for treatment with antibiotics for a respiratory infection and at least one of the following criteria: new or changed sputum; new or changed lung opacities on a clinically indicated chest radiograph; temperature more than 38.3 degrees C; leucocyte count more than 12 000 mu l(-1). RESULTS Postoperative pneumonia occurred in 120 out of 5094 patients (2.4%). Eighty-two of the 120 (68.3%) patients with pneumonia required ICU admission, compared with 399 of the 4974 (8.0%) without pneumonia (P < 0.001). We identified five variables independently associated with postoperative pneumonia: functional status [odds ratio (OR) 2.28, 95% confidence interval (CI) 1.58 to 3.12], pre-operative SpO(2) values while breathing room air (OR 0.83, 95% CI 0.78 to 0.84), intra-operative colloid administration (OR 2.97, 95% CI 1.94 to 3.99), intra-operative blood transfusion (OR 2.19, 95% CI 1.41 to 4.71) and surgical site (open upper abdominal surgery OR 3.98, 95% CI 2.19 to 7.59). The model had good discrimination (c-statistic 0.89) and calibration (Hosmer-Lemeshow P = 0.572). CONCLUSION We identified five variables independently associated with postoperative pneumonia. The model performed well and after external validation may be used for risk stratification and management of patients at risk of postoperative pneumonia

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.The aim of this study was to inform vaccination prioritization by modelling the impact of vaccination on elective inpatient surgery. The study found that patients aged at least 70 years needing elective surgery should be prioritized alongside other high-risk groups during early vaccination programmes. Once vaccines are rolled out to younger populations, prioritizing surgical patients is advantageous