Experimental and Numerical Investigation of Thermal Performance of a Crossed Compound Parabolic Concentrator with PV Cell

Crossed compound parabolic concentrator (CCPC) is a solar energy device used to increase the photovoltaic (PV) cell electrical power output. CCPC’s thermal and optical performance issues are equally important for a PV cell or module to work under a favourable operating condition. However, most work to-date is emphasised on its optical performance paying a little attention to the thermal characteristics. In this contribution, we investigate the thermal performance of a CCPC with PV cell at four different beam incidences (0o, 10o, 20o, 30o and 40o). Initially, experiment is performed in the indoor PV laboratory at the University of Exeter with 1kW/m2 radiation intensity. 3D simulations are carried out to first validate the predicted data and then to characterise the overall performance. Results show that the temperature in the PV silicon layer is the highest at 0o and 30o, with the top glass cover of CCPC having the lowest temperature at all the incidences. The temperature and optical efficiency profiles at the various incidences predicted by simulation show very good agreement with the measurements, especially at 0o incidence. This study provides useful information for understanding the coupled optical-thermal performance of the CCPC with PV cell working at various conditions

Experimental and Numerical Investigation of Thermal Performance of a Crossed Compound Parabolic Concentrator with PV Cell

Crossed compound parabolic concentrator (CCPC) is a solar energy device used to increase the photovoltaic (PV) cell electrical power output. CCPC’s thermal and optical performance issues are equally important for a PV cell or module to work under a favourable operating condition. However, most work to-date is emphasised on its optical performance paying a little attention to the thermal characteristics. In this contribution, we investigate the thermal performance of a CCPC with PV cell at four different beam incidences (0o, 10o, 20o, 30o and 40o). Initially, experiment is performed in the indoor PV laboratory at the University of Exeter with 1kW/m2 radiation intensity. 3D simulations are carried out to first validate the predicted data and then to characterise the overall performance. Results show that the temperature in the PV silicon layer is the highest at 0o and 30o, with the top glass cover of CCPC having the lowest temperature at all the incidences. The temperature and optical efficiency profiles at the various incidences predicted by simulation show very good agreement with the measurements, especially at 0o incidence. This study provides useful information for understanding the coupled optical-thermal performance of the CCPC with PV cell working at various conditions

and CREST

process and applications to optimal stopping problems under partial observatio

A coupled optical-thermal-electrical model to predict the performance of hybrid PV/T-CCPC roof-top systems

A crossed compound parabolic concentrator (CCPC) is applied into a photovoltaic/thermal (PV/T) hybrid solar collector, i.e. concentrating PV/T (CPV/T) collector, to develop new hybrid roof-top CPV/T systems. However, to optimise the system configuration and operational parameters as well as to predict their performances, a coupled optical, thermal and electrical model is essential. We establish this model by integrating a number of submodels sourced from literature as well as from our recent work on incidence-dependent optical efficiency, six-parameter electrical model and scaling law for outdoor conditions. With the model, electrical performance and cell temperature are predicted on specific days for the roof-top systems installed in Glasgow, Penryn and Jaen. Results obtained by the proposed model reasonably agree with monitored data and it is also clarified that the systems operate under off-optimal operating condition. Long-term electric performance of the CPV/T systems is estimated as well. In addition, effects of transient terms in heat transfer and diffuse solar irradiance on electric energy are identified and discussed

Restriction-based Fragmentation of Business Processes over the Cloud

Despite the elasticity and pay-per-use benefits of cloud computing (aka fifth utility computing), organizations adopting clouds could be locked-into single cloud providers, which is not always a “pleasant” experience when these providers stop operations. This is a serious concern for those organizations that who would like to deploy (core) business processes on the cloud along with tapping into these 2 benefits. To address the lock-into concern, this paper proposes an approach for decomposing business processes into fragments that would run over multiple clouds and hence, multiple providers. To develop fragments, the approach considers both restrictions over ownersof business processes and potential competition among cloud providers.Onthe one hand, restrictions apply to each task in a business process and are specialized into budget to allocate, deadline to meet, and exclusivity to request. On the other hand, competition leads cloud providers to offer flexible pricing policies that would cater to the needs and requirements of each process owner. A policy handles certain clouds’ properties referred to as limitedness, non-renewability, and nonshareability that impact the availability of cloud resources and hence, the whole fragmentation. For instance, a non- shareable resource could delay other processes, should the current process do not release this resource on time. During fragmentation interactions between owners of processes and providers of clouds happen according to 2 strategies referred to as global and partial. The former collects offers about cloud resources from all providers, while the latter collects such details from particular providers. To evaluate these strategies’ pros and cons, a system implementing them as well as demonstrating the technical feasibility of the fragmentation approach using credit-application case study, is also presented in the paper. The system extends BPMN2- modeler Eclipse plugin and supports interactions of processes’ owners with clouds’ providers that result to identifying the necessary fragments with focus on cost optimization

A Phase Ib, open-label, dose-finding study of alpelisib in combination with paclitaxel in patients with advanced solid tumors

Phosphatidylinositol 3-kinase (PI3K) pathway activation is associated with resistance to paclitaxel in solid tumors. We assessed the safety and activity of alpelisib, an oral, selective PI3K p110\u3b1 inhibitor, plus paclitaxel in patients with advanced solid tumors. This Phase Ib, multicenter, open-label, dose-finding study, with a planned dose-expansion phase of alpelisib once daily (QD) plus fixed-dose paclitaxel, recruited patients with advanced solid tumors. For the dose-finding phase, the primary objective was determination of maximum tolerated and/or recommended Phase II dose of alpelisib plus paclitaxel, and the secondary objectives included the assessment of safety for this combination. From March 2014 to August 2016, 19 patients with advanced solid tumors were treated with alpelisib QD (300 mg, n=6; 250 mg, n=4; 150 mg, n=9) plus paclitaxel (80 mg/m2, per standard of care). During dose finding, five of 12 (41.7%) evaluable patients for MTD determination experienced dose-limiting toxicities: alpelisib 300 mg, Grade 2 hyperglycemia (n=1); alpelisib 250 mg, Grade 2 hyperglycemia (n=1), Grade 4 hyperglycemia and Grade 3 acute kidney injury (n=1); and alpelisib 150 mg, Grade 2 hyperglycemia (n=1) and Grade 4 leukopenia (n=1). The MTD of alpelisib when administered with paclitaxel was 150 mg QD. Most frequent all-grade AEs were diarrhea (73.7%; Grade 3/4 10.5%) and hyperglycemia (57.9%; Grade 3/4 31.6%). The planned dose-expansion phase was not initiated. Alpelisib plus paclitaxel has a challenging safety profile in patients with advanced solid tumors. This study was closed following the completion of the dosefinding phase. Clinical trial registration: ClinicalTrials.gov NCT02051751

The global distribution of the Duffy blood group

Blood group variants are characteristic of population groups, and can show conspicuous geographic patterns. Interest in the global prevalence of the Duffy blood group variants is multidisciplinary, but of particular importance to malariologists due to the resistance generally conferred by the Duffy-negative phenotype against Plasmodium vivax infection. Here we collate an extensive geo-database of surveys, forming the evidence-base for a multi-locus Bayesian geostatistical model to generate global frequency maps of the common Duffy alleles to refine the global cartography of the common Duffy variants. We show that the most prevalent allele globally was FY*A, while across sub-Saharan Africa the predominant allele was the silent FY*BES variant, commonly reaching fixation across stretches of the continent. The maps presented not only represent the first spatially and genetically comprehensive description of variation at this locus, but also constitute an advance towards understanding the transmission patterns of the neglected P. vivax malaria parasite

The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila

Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are poorly understood. Several mechanisms controlling these processes are conserved in Drosophila, where homeostasis and energy mobilization are regulated by the glucagon-related adipokinetic hormone (AKH) and the Drosophila insulin-like peptides (DILPs). Here, we provide evidence that the Drosophila neuropeptide Allatostatin A (AstA) regulates AKH and DILP signaling. The AstA receptor gene, Dar-2, is expressed in both the insulin and AKH producing cells. Silencing of Dar-2 in these cells results in changes in gene expression and physiology associated with reduced DILP and AKH signaling and animals lacking AstA accumulate high lipid levels. This suggests that AstA is regulating the balance between DILP and AKH, believed to be important for the maintenance of nutrient homeostasis in response to changing ratios of dietary sugar and protein. Furthermore, AstA and Dar-2 are regulated differentially by dietary carbohydrates and protein and AstA-neuronal activity modulates feeding choices between these types of nutrients. Our results suggest that AstA is involved in assigning value to these nutrients to coordinate metabolic and feeding decisions, responses that are important to balance food intake according to metabolic needs

Vivax malaria in Mauritania includes infection of a Duffy-negative individual

<p>Abstract</p> <p>Background</p> <p>Duffy blood group polymorphisms are important in areas where <it>Plasmodium vivax </it>is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and <it>P. vivax</it>-infected patients living in the city of Nouakchott, Mauritania.</p> <p>Methods</p> <p><it>Plasmodium vivax </it>was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables.</p> <p>Results</p> <p>In the Moorish population, a high frequency of the <it>FYB^ES/FYB^ES</it>genotype was observed in uninfected individuals (27.8%), whereas no <it>P. vivax</it>-infected patient had this genotype. This was followed by a high level of <it>FYA/FYB</it>, <it>FYB/FYB</it>, <it>FYB/FYB^ES</it>and <it>FYA/FYB^ES</it>genotype frequencies, both in the <it>P. vivax</it>-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the <it>FYB^ES/FYB^ES</it>genotype was found in uninfected patients, whereas the <it>FYA/FYB^ES</it>genotype was observed in two <it>P. vivax</it>-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the <it>FYB^ES/FYB^ES</it>genotype and was infected by <it>P. vivax</it>.</p> <p>Conclusions</p> <p>This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, <it>P. vivax </it>is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent <it>P. vivax </it>invasion of human red blood cells.</p