Audience Prospecting for Dynamic-Product-Ads in Native Advertising

With yearly revenue exceeding one billion USD, Yahoo Gemini native advertising marketplace serves more than two billion impressions daily to hundreds of millions of unique users. One of the fastest growing segments of Gemini native is dynamic-product-ads (DPA), where major advertisers, such as Amazon and Walmart, provide catalogs with millions of products for the system to choose from and present to users. The subject of this work is finding and expanding the right audience for each DPA ad, which is one of the many challenges DPA presents. Approaches such as targeting various user groups, e.g., users who already visited the advertisers' websites (Retargeting), users that searched for certain products (Search-Prospecting), or users that reside in preferred locations (Location-Prospecting), have limited audience expansion capabilities. In this work we present two new approaches for audience expansion that also maintain predefined performance goals. The Conversion-Prospecting approach predicts DPA conversion rates based on Gemini native logged data, and calculates the expected cost-per-action (CPA) for determining users' eligibility to products and optimizing DPA bids in Gemini native auctions. To support new advertisers and products, the Trending-Prospecting approach matches trending products to users by learning their tendency towards products from advertisers' sites logged events. The tendency scores indicate the popularity of the product and the similarity of the user to those who have previously engaged with this product. The two new prospecting approaches were tested online, serving real Gemini native traffic, demonstrating impressive DPA delivery and DPA revenue lifts while maintaining most traffic within the acceptable CPA range (i.e., performance goal). After a successful testing phase, the proposed approaches are currently in production and serve all Gemini native traffic.Comment: In Proc. IeeeBigData'2023 (Industry and Government Program

Functional Characterization of Transcription Factor Motifs Using Cross-species Comparison across Large Evolutionary Distances

We address the problem of finding statistically significant associations between cis-regulatory motifs and functional gene sets, in order to understand the biological roles of transcription factors. We develop a computational framework for this task, whose features include a new statistical score for motif scanning, the use of different scores for predicting targets of different motifs, and new ways to deal with redundancies among significant motif–function associations. This framework is applied to the recently sequenced genome of the jewel wasp, Nasonia vitripennis, making use of the existing knowledge of motifs and gene annotations in another insect genome, that of the fruitfly. The framework uses cross-species comparison to improve the specificity of its predictions, and does so without relying upon non-coding sequence alignment. It is therefore well suited for comparative genomics across large evolutionary divergences, where existing alignment-based methods are not applicable. We also apply the framework to find motifs associated with socially regulated gene sets in the honeybee, Apis mellifera, using comparisons with Nasonia, a solitary species, to identify honeybee-specific associations

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Second-harmonic-generation enhancement in cavity resonator integrated grating filters

International audienceWe demonstrate numerically and experimentally second-harmonic generation (SHG) in a cavity resonator integrated grating filter (CRIGF, a planar cavity resonator made of Bragg grating reflectors) around 1550 nm. SHG is modeled numerically for several different systems, including a thin plane layer of LiNbO3 without and with a grating coupler to excite a waveguide mode. We demonstrate that when the waveguide mode is confined to a CRIGF, designed to work with focused incident beams, the SHG power is increased more than 30 times, compared to the case of a single grating coupler used with an almost collimated pump beam

Sensitive detection and quantification of SARS-CoV-2 in saliva

Abstract Saliva has significant advantages as a test medium for detection of SARS-CoV-2 infection in patients, such as ease of collection, minimal requirement of supplies and trained personnel, and safety. Comprehensive validation in a large cohort of prospectively collected specimens with unknown SARS-CoV-2 status should be performed to evaluate the potential and limitations of saliva-based testing. We developed a saliva-based testing pipeline for detection of SARS-CoV-2 nucleic acids using real-time reverse transcription PCR (RT-PCR) and droplet digital PCR (ddPCR) readouts, and measured samples from 137 outpatients tested at a curbside testing facility and 29 inpatients hospitalized for COVID-19. These measurements were compared to the nasal swab results for each patient performed by a certified microbiology laboratory. We found that our saliva testing positively detects 100% (RT-PCR) and 93.75% (ddPCR) of curbside patients that were identified as SARS-CoV-2 positive by the Emergency Use Authorization (EUA) certified nasal swab testing assay. Quantification of viral loads by ddPCR revealed an extremely wide range, with 1 million-fold difference between individual patients. Our results demonstrate for both community screening and hospital settings that saliva testing reliability is on par with that of the nasal swabs in detecting infected cases, and has potential for higher sensitivity when combined with ddPCR in detecting low-abundance viral loads that evade traditional testing methods