Analysis of noncoherent orthogonal modulation for mobile computing

Wireless communication is employed to connect mobile computers in a networked environment for information exchange. In a tactical space, sensors and computers typically need to operate on-the-move while transmitting data over both short and long distances in different terrain and conditions. The wireless communication is thus susceptible to effects of Doppler shift and channel fading. In addition, when security and anti jamming features are required, such as frequency-hopping techniques, then coherent signal detection is difficult and noncoherent modulation is used instead. Our study will focus on the bit error rate (BER) performance analysis of noncoherent orthogonal modulation, specifically M-ary frequency-shift keying (MFSK) and code-shift keying (CSK) modulation, in both additive white Gaussian noise (AWGN) and for a Rayleigh fading channel with Doppler shift. The potential applications include communications between mobile computer-sensor devices, such as a mobile ground control station maintaining a datalink with UAV.http://archive.org/details/analysisofnoncoh1094555206CivilianApproved for public release; distribution is unlimited

NSCLC PATIENTS WITH BOTH WILDTYPE EGFR AND HIGH CD151 EXPRESSION HAVE POORER DISEASE OUTCOME

23rd Congress of the Asian Pacific Society of Respirology, 29 Nov - 2 Dec 20182320-2

Low-Distortion Surface Functionalization of Polymeric Microstructures

Polymeric microstructures can be immersed in an organic solution containing a reactive linker to functionalize the surface for attachment of nanoparticles, fluorescent dyes, proteins, DNA, and other species. However, organic media can swell and distort polymeric microstructures. Swelling and distortion can be irreversible when the linkers are themselves low-molecular-weight organics like ethylenediamine, which can bind to unreacted monomer groups or other functionalities within the polymer matrix. This work introduces an alternative approach for surface functionalization based on aqueous processing using higher-molecular-weight amines, which causes less distortion, but is comparably effective. The processes are compared by aminating crosslinked SU-8 thin films and 3D woodpile microstructures, electrolessly depositing copper onto these primed surfaces, and measuring the amount of copper deposited and the degree of distortion caused by amination. The method provides a new route to low-distortion SU-8 microstructures and identifies a path for improving related processing with other polymeric materials and structure types. Polymeric SU-8 microstructures can be surface-functionalized with minimal distortion using aqueous processing and multifunctional macromolecular amines. This approach minimizes swelling and chemical reactions within the polymeric matrix, which can lead to irreversible distortion when organic solvents and low-molecular-weight linkers are used to derivatize polymeric surfaces. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

An integrated command and control architecture concept for unmanned systems in the year 2030

U.S. Forces require an integrated Command and Control Architecture that enables operations of a dynamic mix of manned and unmanned systems. The level of autonomous behavior correlates to: 1) the amount of trust with the reporting vehicles, and 2) the multi-spectral perspective of the observations. The intent to illuminate the architectural issues for force protection in 2030 was based on a multi-phased analytical model of High Value Unit (HVU) defense. The results showed that autonomous unmanned aerial vehicles are required to defeat high-speed incoming missiles. To evaluate the level of autonomous behavior required for an integrated combat architecture, geometric distributions were modeled to determine force positioning, based on a scenario driven Detect-to-Engage timeline. Discrete event simulation was used to schedule operations, and a datalink budget assessment of communications to determine the critical failure paths in the the integrated combat architecture. The command and control principles used in the integrated combat architecture were based on Boyd's OODA (Obseve, Orient, Decide, and Act) Loop. A conservative fleet size estimate, given the uncertainties of the coverage overlap and radar detection range, a fleet size of 35 should be anticipated given an UAV detection range of 20km and radar coverage overlap of 4 seconds.http://archive.org/details/anintegratedcomm109455244US Navy (USN) authorsApproved for public release; distribution is unlimited

Laser/Electron Irradiation on Indium Phosphide (InP) Semiconductor: Promising Pathways to In Situ Formation of Indium Nanoparticles

In the current study, whether femtosecond laser and electron beam irradiation of indium phosphide (InP) are “green,” fast, and effective methods to produce metallic In nanoparticles is probed. High-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy are employed to investigate the formation and growth of In nanoparticles on InP. Density functional theory and quantum theory of atoms in molecules calculations are employed to reveal the nature of formation of In nanoparticles under electron beam irradiation. These results expand the fundamental understanding of the atomic processes underpinning the mechanism of In−P bond rupture during the transformation process induced by the electron irradiation of the InP crystal by increasing the total number of electrons in the bulk structure

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy

Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a fatal syndrome consisting of severe autoinflammation and progredient leukoencephalopathy with recurrent seizures; 12 of these subjects, whose DNA was available, segregated homozygous loss-of-function C2orf69 variants. C2ORF69 bears homology to esterase enzymes, and orthologs can be found in most eukaryotic genomes, including that of unicellular phytoplankton. We found that endogenous C2ORF69 (1) is loosely bound to mitochondria, (2) affects mitochondrial membrane potential and oxidative respiration in cultured neurons, and (3) controls the levels of the glycogen branching enzyme 1 (GBE1) consistent with a glycogen-storage-associated mitochondriopathy. We show that CRISPR-Cas9-mediated inactivation of zebrafish C2orf69 results in lethality by 8 months of age due to spontaneous epileptic seizures, which is preceded by persistent brain inflammation. Collectively, our results delineate an autoinflammatory Mendelian disorder of C2orf69 deficiency that disrupts the development/homeostasis of the immune and central nervous systems

The hierarchy quorum sensing network in Pseudomonas aeruginosa

10.1007/s13238-014-0100-xProtein and Cell6126-4