Trace Metal Pollution in Narragansett Bay: A Case Study of the Rhode Island Quahog Fishery

This paper was written with two objectives in mind: to provide information relevant to the protection of the quahog fishery and the protection of human health. Both are threatened as hundreds of millions of gallons of industrial effluents and sewage treatment plant discharges enter Narragansett Bay daily. The implications of trace metal pollution with respect to the quahog fishery have received little attention to date. The purpose of this paper is to assemble scientific, legal, and socioeconomic information in a fashion which will direct future research and management attempts in an effective manner

Optimisation of diamond quantum processors

Diamond quantum processors consisting of a nitrogen-vacancy (NV) centre and surrounding nuclear spins have been the key to significant advancements in room-temperature quantum computing, quantum sensing and microscopy. The optimisation of these processors is crucial for the development of large-scale diamond quantum computers and the next generation of enhanced quantum sensors and microscopes. Here, we present a full model of multi-qubit diamond quantum processors and develop a semi-analytical method for designing gate pulses. This method optimises gate speed and fidelity in the presence of random control errors and is readily compatible with feedback optimisation routines. We theoretically demonstrate infidelities approaching $\sim 10^{-5}$ for single-qubit gates and established evidence that this can also be achieved for a two-qubit CZ gate. Consequently, our method reduces the effects of control errors below the errors introduced by hyperfine field misalignment and the unavoidable decoherence that is intrinsic to the processors. Having developed this optimal control, we simulated the performance of a diamond quantum processor by computing quantum Fourier transforms. We find that the simulated diamond quantum processor is able to achieve fast operations with low error probability.Comment: Published version. Updated references, additional analysis for the infidelities of CZ gate. Two new appendices on discussing the effects of time-ordering in the quantum evolution and examining the effects of the secular approximation and hyperfine field misalignments on gate fidelities. Adjusted the discussions and claims accordingl

Funk What You Heard: Hip Hop Is a Field of Study

“Funk What You Heard” is a beaconing call to all scholars who engage with Hip Hop studies. This article lays out the ways in which Hip Hop studies should properly respond to the wave of oppressions currently pounding the world. With several key date markers in place for Hip Hop studies, Tricia Rose’s Black Noise in 1994 and Murray Foreman and Mark Anthony Neal’s That’s the Joint in 2004, “Funk What You Heard” charts the path forward for the future of Hip Hop studies. Black Noise provided the original blueprint for studying Hip Hop and That’s the Joint! stamped “hip-hop studies” into history. Although we are close to thirty years since Black Noise, lyrical analysis is a dominant method for Hip Hop studies. Also, although we have a clearly identifiable field, academics still treat Hip Hop as an interesting topic they can write about without speaking to the field. “Funk What You Heard” calls for something more. We can no longer continue down this path of weak analysis and rewriting Hip Hop theories that have been discussed time and time again. Our contemporary waves of oppression have raised the stakes. With the path charted out, we ultimately call on Hip Hop scholars to answer their ancestral call. Answering this call pragmatically looks like building on the field, developing new and innovative research methods, and engaging with all the elements of Hip Hop. As far as the unseen, we will leave that up to your reflection with Hip Hop’s collective consciousness that is not bound by space and time

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

Copyright © 2015, The American Society for Biochemistry and Molecular Biology. Acknowledgements-We thank Drs Timo Rager and Rolf Hilfiker (Solvias, Switzerland) for polymorph analyses.Peer reviewedPublisher PD

Conceptual design of a two stage to orbit spacecraft

This project, undertaken through the Advanced Space Design Program, developed a 'Conceptual Design of a Two Stage To Orbit Spacecraft (TSTO).' The design developed utilizes a combination of air breathing and rocket propulsion systems and is fully reusable, with horizontal takeoff and landing capability. The orbiter is carried in an aerodynamically designed bay in the aft section of the booster vehicle to the staging altitude. This TSTO Spacecraft design meets the requirements of replacing the aging Space Shuttle system with a more easily maintained vehicle with more flexible mission capability

Intravaginal Practices, Vaginal Infections and HIV Acquisition: Systematic Review and Meta-Analysis

BACKGROUND: Intravaginal practices are commonly used by women to manage their vaginal health and sexual life. These practices could, however, affect intravaginal mucosal integrity. The objectives of this study were to examine evidence for associations between: intravaginal practices and acquisition of HIV infection; intravaginal practices and vaginal infections; and vaginal infections and HIV acquisition. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of prospective longitudinal studies, searching 15 electronic databases of journals and abstracts from two international conferences to 31(st) January 2008. Relevant articles were selected and data extracted in duplicate. Results were examined visually in forest plots and combined using random effects meta-analysis where appropriate. Of 2120 unique references we included 22 publications from 15 different studies in sub-Saharan Africa and the USA. Seven publications from five studies examined a range of intravaginal practices and HIV infection. No specific vaginal practices showed a protective effect against HIV or vaginal infections. Insertion of products for sex was associated with HIV in unadjusted analyses; only one study gave an adjusted estimate, which showed no association (hazard ratio 1.09, 95% confidence interval, CI 0.71, 1.67). HIV incidence was higher in women reporting intravaginal cleansing but confidence intervals were wide and heterogeneity high (adjusted hazard ratio 1.88, 95%CI 0.53, 6.69, I(2) 83.2%). HIV incidence was higher in women with bacterial vaginosis (adjusted effect 1.57, 95%CI 1.26, 1.94, I(2) 19.0%) and Trichomonas vaginalis (adjusted effect 1.64, 95%CI 1.28, 2.09, I(2) 0.0%). CONCLUSIONS/SIGNIFICANCE: A pathway linking intravaginal cleaning practices with vaginal infections that increase susceptibility to HIV infection is plausible but conclusive evidence is lacking. Intravaginal practices do not appear to protect women from vaginal infections or HIV and some might be harmful

Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis

OBJECTIVES: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. Granulomas are exclusively found in GPA and form around multinucleated giant cells (MGCs), at sites of microabscesses, containing apoptotic and necrotic neutrophils. Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. METHODS: We stimulated purified monocytes and whole peripheral blood mononuclear cells (PBMCs) from patients with GPA, patients with MPA or healthy controls with PR3 or MPO and visualised MGC and granuloma-like structure formation using light, confocal and electron microscopy, as well as measuring the cell cytokine production. We investigated the expression of PR3 binding partners on monocytes and tested the impact of their inhibition. Finally, we injected zebrafish with PR3 and characterised granuloma formation in a novel animal model. RESULTS: In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. PBMCs stimulated by PR3 formed granuloma-like structures with central MGC surrounded by T cells. This effect of PR3 was confirmed in vivo using zebrafish and was inhibited by niclosamide, a IL-6-STAT3 pathway inhibitor. CONCLUSIONS: These data provide a mechanistic basis for granuloma formation in GPA and a rationale for novel therapeutic approaches

Puzzling the Jesus of the Parables : a response to Ruben Zimmermann

Abstract: Ruben Zimmermann’s latest book, Puzzling the Parables of Jesus (2015), summarises much of his earlier research on the parables. It is one of the most thought-provoking and original books on the subject to appear in the last few decades. It not only challenges archaic ideas and methods, but also proposes an integrative approach of parable interpretation that combines historical, literary and reader-oriented approaches. His proposed definition of the parables of Jesus is well researched, and sure to influence future scholars. This article responds to Ruben Zimmermann’s work on the parables, focusing specifically on the abovementioned book. In particular, one aspect of his proposed method is challenged, namely his conscious attempt to do away with considerations of the pre-Easter context when interpreting the parables. The first section of the current article briefly considers key concepts in Zimmermann’s book that are relevant to the present discussion; the second section contains my response; and the third section proposes a variant methodology, featuring the parable of the Good Samaritan as a working example

Urinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms

BACKGROUND: Adenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary tract infection (UTI). The optimum clinical sampling method for ATP urinalysis has not been established. We tested the potential of urinary ATP in the assessment of lower urinary tract symptoms, infection and inflammation, and validated sampling methods for clinical practice. METHODS: A prospective, blinded, cross-sectional observational study of adult patients presenting with lower urinary tract symptoms (LUTS) and asymptomatic controls, was conducted between October 2009 and October 2012. Urinary ATP was assayed by a luciferin-luciferase method, pyuria counted by microscopy of fresh unspun urine and symptoms assessed using validated questionnaires. The sample collection, storage and processing methods were also validated. RESULTS: 75 controls and 340 patients with LUTS were grouped as without pyuria (n = 100), pyuria 1-9 wbc ?l(-1) (n = 120) and pyuria ?10 wbc ?l(-1) (n = 120). Urinary ATP was higher in association with female gender, voiding symptoms, pyuria greater than 10 wbc ?l(-1) and negative MSU culture. ROC curve analysis showed no evidence of diagnostic test potential. The urinary ATP signal decayed with storage at 23°C but was prevented by immediate freezing at ??-20°C, without boric acid preservative and without the need to centrifuge urine prior to freezing. CONCLUSIONS: Urinary ATP may have a role as a research tool but is unconvincing as a surrogate, clinical diagnostic marker

Changes in intraocular pressure in study and fellow eyes in the IVAN trial

PURPOSE: To describe changes in intraocular pressure (IOP) in the 'alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)' trial (registered as ISRCTN92166560). DESIGN: Randomised controlled clinical trial with factorial design. PARTICIPANTS: Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment. METHODS: At monthly visits, IOP was measured preinjection in both eyes, and postinjection in the study eye. OUTCOME MEASURES: The effects of 10 prespecified covariates on preinjection IOP, change in IOP (postinjection minus preinjection) and the difference in preinjection IOP between the two eyes were examined. RESULTS: For every month in trial, there was a statistically significant rise in both the preinjection IOP and the change in IOP postinjection during the time in the trial (estimate 0.02 mm Hg, 95% CI 0.01 to 0.03, p<0.001 and 0.03 mm Hg, 95% CI 0.01 to 0.04, p=0.002, respectively). There was also a small but significant increase during the time in trial in the difference in IOP between the two eyes (estimate 0.01 mm Hg, 95% CI 0.005 to 0.02, p<0.001). There were no differences between bevacizumab and ranibizumab for any of the three outcomes (p=0.93, p=0.22 and p=0.87, respectively). CONCLUSIONS: Anti-vascular endothelial growth factor agents induce increases in IOP of small and uncertain clinical significance