281 research outputs found
CD8+ T-cell specificity is compromised at a defined major histocompatibility complex class I/CD8 affinity threshold
The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of the pMHCI/CD8 interaction (~1.5-fold) can disproportionately amplify this effect, boosting antigen sensitivity by up to two orders of magnitude. However, recognition specificity is lost altogether with more substantial increases in pMHCI/CD8 affinity (~10-fold). In this study, we used a panel of MHCI mutants with altered CD8-binding properties to show that TCR-mediated antigen specificity is delimited by a pMHCI/CD8 affinity threshold. Our findings suggest that CD8 can be engineered within certain biophysical parameters to enhance the therapeutic efficacy of adoptive T-cell transfer irrespective of antigen specificity
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold
The CD8 co-receptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR)-binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of the pMHCI/CD8 interaction (~1.5-fold) can disproportionately amplify this effect, boosting antigen sensitivity by up to two orders of magnitude. However, recognition specificity is lost altogether with more substantial increases in pMHCI/CD8 affinity (~10-fold). In this study, we used a panel of MHCI mutants with altered CD8-binding properties to show that TCR-mediated antigen specificity is delimited by a pMHCI/CD8 affinity threshold. Our findings suggest that CD8 can be engineered within certain biophysical parameters to enhance the therapeutic efficacy of adoptive T-cell transfer irrespective of antigen specificity
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold
The CD8 coreceptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR) binding platform and enhances the sensitivity of antigen-driven activation to promote effective CD8+ T-cell immunity. A small increase in the strength of the pMHCI/CD8 interaction (~ 1.5-fold) can disproportionately amplify this effect, boosting antigen sensitivity by up to two orders of magnitude. However, recognition specificity is lost altogether with more substantial increases in pMHCI/CD8 affinity (~ 10-fold). In this study, we used a panel of MHCI mutants with altered CD8 binding properties to show that TCR-mediated antigen specificity is delimited by a pMHCI/CD8 affinity threshold. Our findings suggest that CD8 can be engineered within certain biophysical parameters to enhance the therapeutic efficacy of adoptive T-cell transfer irrespective of antigen specificity.
The pMHCI/CD8 interaction controls specificit
Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV
We search for the standard model Higgs boson produced in association with an
electroweak vector boson in events with no identified charged leptons, large
imbalance in transverse momentum, and two jets where at least one contains a
secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1
integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV
recorded by the CDF II experiment at the Tevatron. We find 268 (16) single
(double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are
expected from standard model background processes. We place 95% confidence
level upper limits on the Higgs boson production cross section for several
Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115
GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model
prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let
Observation of Orbitally Excited B_s Mesons
We report the first observation of two narrow resonances consistent with
states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar
collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the
Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed
as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+,
\bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1})
= 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let
Forward-Backward Asymmetry in Top Quark Production in ppbar Collisions at sqrt{s}=1.96 TeV
Reconstructable final state kinematics and charge assignment in the reaction
ppbar->ttbar allows tests of discrete strong interaction symmetries at high
energy. We define frame dependent forward-backward asymmetries for the outgoing
top quark in both the ppbar and ttbar rest frames, correct for experimental
distortions, and derive values at the parton-level. Using 1.9/fb of ppbar
collisions at sqrt{s}=1.96 TeV recorded with the CDF II detector at the
Fermilab Tevatron, we measure forward-backward top quark production asymmetries
in the ppbar and ttbar rest frames of A_{FB,pp} = 0.17 +- 0.08 and A_{FB,tt} =
0.24 +- 0.14.Comment: 7 pages, 2 figures, submitted to Phys.Rev.Lett, corrected references
and change of tex
Search for Pair Production of Scalar Top Quarks Decaying to a tau Lepton and a b Quark in ppbar Collisions at sqrt{s}=1.96 TeV
We search for pair production of supersymmetric top quarks (~t_1), followed
by R-parity violating decay ~t_1 -> tau b with a branching ratio beta, using
322 pb^-1 of ppbar collisions at sqrt{s}=1.96 TeV collected by the CDF II
detector at Fermilab. Two candidate events pass our final selection criteria,
consistent with the standard model expectation. We set upper limits on the
cross section sigma(~t_1 ~tbar_1)*beta^2 as a function of the stop mass
m(~t_1). Assuming beta=1, we set a 95% confidence level limit m(~t_1)>153
GeV/c^2. The limits are also applicable to the case of a third generation
scalar leptoquark (LQ_3) decaying LQ_3 -> tau b.Comment: 7 pages, 2 eps figure
Measurement of Ratios of Fragmentation Fractions for Bottom Hadrons in p-pbar Collisions at sqrt{s}=1.96 TeV
This paper describes the first measurement of b-quark fragmentation fractions
into bottom hadrons in Run II of the Tevatron Collider at Fermilab. The result
is based on a 360 pb-1 sample of data collected with the CDF II detector in
p-pbar collisions at sqrt{s}=1.96 TeV. Semileptonic decays of B0, B+, and B_s
mesons, as well as Lambda_b baryons, are reconstructed. For an effective bottom
hadron p_T threshold of 7 GeV/c, the fragmentation fractions are measured to be
f_u/f_d=1.054 +/- 0.018 (stat) +0.025-0.045(sys) +/- 0.058 (Br),
f_s/(f_u+f_d)=0.160 +/- 0.005 (stat) +0.011-0.010 (sys) +0.057-0.034 (Br), and
f_{Lambda_b}/(f_u+f_d)=0.281\pm0.012 (stat) +0.058-0.056 (sys) +0.128-0.086
(Br), where the uncertainty (Br) is due to uncertainties on measured branching
ratios. The value of f_s/(f_u+f_d) agrees within one standard deviation with
previous CDF measurements and the world average of this quantity, which is
dominated by LEP measurements. However, the ratio f_{Lambda_b}/(f_u+f_d) is
approximately twice the value previously measured at LEP. The approximately 2
sigma discrepancy is examined in terms of kinematic differences between the two
production environments.Comment: Submitted to PRD, 54 pages, 53 plot
Measurement of the fraction of t-tbar production via gluon-gluon fusion in p-pbar collisions at sqrt(s)=1.96 TeV
We present a measurement of the ratio of t-tbar production cross section via
gluon-gluon fusion to the total t-tbar production cross section in p-pbar
collisions at sqrt{s}=1.96 TeV at the Tevatron. Using a data sample with an
integrated luminosity of 955/pb recorded by the CDF II detector at Fermilab, we
select events based on the t-tbar decay to lepton+jets. Using an artificial
neural network technique we discriminate between t-tbar events produced via
q-qbar annihilation and gluon-gluon fusion, and find
Cf=(gg->ttbar)/(pp->ttbar)<0.33 at the 68% confidence level. This result is
combined with a previous measurement to obtain the most precise measurement of
this quantity, Cf=0.07+0.15-0.07.Comment: submitted to Phys. Rev.
Two-Particle Momentum Correlations in Jets Produced in ppbar Collisions at s**(1/2) = 1.96-TeV
We present the first measurement of two-particle momentum correlations in
jets produced in collisions at TeV. Results are
obtained for charged particles within a restricted cone with an opening angle
of 0.5 radians around the jet axis and for events with dijet masses between 66
and 563 GeV/c. A comparison of the experimental data to theoretical
predictions obtained for partons within the framework of resummed perturbative
QCD in the next-to-leading log approximation (NLLA) shows that the parton
momentum correlations survive the hadronization stage of jet fragmentation,
giving further support to the hypothesis of local parton-hadron duality. The
extracted value of the NLLA parton shower cutoff scale set
equal to is found to be
MeV.Comment: Submitted to Phys.Rev.
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