Integrable Theory of the Perturbation Equations

An integrable theory is developed for the perturbation equations engendered from small disturbances of solutions. It includes various integrable properties of the perturbation equations: hereditary recursion operators, master symmetries, linear representations (Lax and zero curvature representations) and Hamiltonian structures etc. and provides us a method to generate hereditary operators, Hamiltonian operators and symplectic operators starting from the known ones. The resulting perturbation equations give rise to a sort of integrable coupling of soliton equations. Two examples (MKdV hierarchy and KP equation) are carefully carried out.Comment: 27 pages, latex, to appear in Chaos, Soliton & Fractal

Structure of the clean Ta(100) surface

The clean Ta(100) surface and some aspects of hydrogen adsorption have been studied by LEED and AES. The thorough examination of LEED patterns did not provide any evidence for an atomic reconstruction of the clean surface over the entire temperature range investigated, 150–600 K. The r-factor analysis used for comparison between measured and calculated I–V spectra yields a contraction of the topmost layer spacing of about 11% and an expansion of the second layer spacing of about 1% compared to the bulk value. The hydrogen adsorption does not induce any superstructures, but small hydrogen exposures lass then 1 L influence I–V spectra substantially

ResQbot: a mobile rescue robot with immersive teleperception for casualty extraction

In this work, we propose a novel mobile rescue robot equipped with an immersive stereoscopic teleperception and a teleoperation control. This robot is designed with the capability to perform safely a casualty-extraction procedure. We have built a proof-of-concept mobile rescue robot called ResQbot for the experimental platform. An approach called “loco-manipulation” is used to perform the casualty-extraction procedure using the platform. The performance of this robot is evaluated in terms of task accomplishment and safety by conducting a mock rescue experiment. We use a custom-made human-sized dummy that has been sensorised to be used as the casualty. In terms of safety, we observe several parameters during the experiment including impact force, acceleration, speed and displacement of the dummy’s head. We also compare the performance of the proposed immersive stereoscopic teleperception to conventional monocular teleperception. The results of the experiments show that the observed safety parameters are below key safety thresholds which could possibly lead to head or neck injuries. Moreover, the teleperception comparison results demonstrate an improvement in task-accomplishment performance when the operator is using the immersive teleperception

Drug-eluting Bead Chemoembolization for the Treatment of Nonresectable Hepatic Carcinoma in Dogs: A Prospective Clinical Trial

Abstract Background Effective treatment options for nonresectable hepatic carcinoma (HC) in dogs are limited. Hypothesis/Objective Objectives were to report outcomes, complications, and tumor responses via computed tomography (CT) assessment after drug‐eluting bead transarterial chemoembolization (DEB‐TACE) for nonresectable HC in dogs. The authors hypothesized that major complications would be uncommon and short‐term CT assessment would demonstrate stable disease or partial response. Animals Client‐owned dogs (n = 16) with nonresectable HC. Methods Prospective, single‐arm clinical trial. Drug‐eluting bead transarterial chemoembolization was performed to varying levels of blood flow stasis. Computed tomography imaging was compared before and approximately 12 weeks after initial treatment. Results Drug‐eluting bead transarterial chemoembolization was successfully administered in all attempts. Based on percent change in elliptical tumor volume response (mL), stable disease (8/13; 62%) was the most common outcome followed by partial response (3/13; 23%) and progressive disease (2/13; 15%) with a median of 74 days (range, 39‐125) after initial treatment. Median tumor volume (mL) after DEB‐TACE decreased in volume by 13% (range, 56% decrease to 77% increase). Mild complications consistent with postembolization syndrome occurred after 7/27 (26%) treatments. Major complications occurred after 3/27 (11%) treatments: hepatic abscess/septicemia (2) and cholecystitis/death (1), resulting in treatment‐induced death after 2/27 (7%) treatments. Median survival time after treatment was 337 days (range, 22‐1061). Dogs with a presenting complaint of weight loss (P = .02) had a significantly shorter median survival time (126 days; range, 46‐337) than those dogs without prior history of weight loss (582 days; range, 22‐1061). Conclusions Drug‐eluting bead transarterial chemoembolization for nonresectable HC is a feasible procedure, which promoted stable disease or partial response in 85% of dogs in this study sample

Terahertz generation in Czochralski grown periodically poled Mg:Y:LiNbO3 via optical rectification

Using a canonical pump-probe experimental technique, we studied the terahertz (THz) waves generation and detection via optical rectification and mixing in Czochralski-grown periodically poled Mg:Y:LiNbO3 (PPLN) crystals. THz waves with frequencies at 1.37 THz and 0.68 THz as well as 1.8 THz were obtained for PPLN with nonlinear grating periods of 0.03 and 0.06 mm, respectively. A general theoretical model was developed by considering the dispersion and damping of low frequency phonon-polariton mode. Our results show that THz waves are generated in forward and backward directions via pumping pulse rectification. The generated THz waves depend on the spectral shape of the laser pulses, quasi-phase mismatches and dispersion characteristics of a crystal.Comment: 25 pages, 4 figure

A bi-dimensional finite mixture model for longitudinal data subject to dropout

In longitudinal studies, subjects may be lost to follow-up, or miss some of the planned visits, leading to incomplete response sequences. When the probability of non-response, conditional on the available covariates and the observed responses, still depends on unobserved outcomes, the dropout mechanism is said to be non ignorable. A common objective is to build a reliable association structure to account for dependence between the longitudinal and the dropout processes. Starting from the existing literature, we introduce a random coefficient based dropout model where the association between outcomes is modeled through discrete latent effects. These effects are outcome-specific and account for heterogeneity in the univariate profiles. Dependence between profiles is introduced by using a bi-dimensional representation for the corresponding distribution. In this way, we define a flexible latent class structure which allows to efficiently describe both dependence within the two margins of interest and dependence between them. By using this representation we show that, unlike standard (unidimensional) finite mixture models, the non ignorable dropout model properly nests its ignorable counterpart. We detail the proposed modeling approach by analyzing data from a longitudinal study on the dynamics of cognitive functioning in the elderly. Further, the effects of assumptions about non ignorability of the dropout process on model parameter estimates are (locally) investigated using the index of (local) sensitivity to non-ignorability

Photoacid behaviour in a fluorinated green fluorescent protein chromophore:Ultrafast formation of anion and zwitterion states

The photophysics of the chromophore of the green fluorescent protein in Aequorea victoria (avGFP) are dominated by an excited state proton transfer reaction. In contrast the photophysics of the same chromophore in solution are dominated by radiationless decay, and photoacid behaviour is not observed. Here we show that modification of the pKa of the chromophore by fluorination leads to an excited state proton transfer on an extremely fast (50 fs) time scale. Such a fast rate suggests a barrierless proton transfer and the existence of a pre-formed acceptor site in the aqueous solution, which is supported by solvent and deuterium isotope effects. In addition, at lower pH, photochemical formation of the elusive zwitterion of the GFP chromophore is observed by means of an equally fast excited state proton transfer from the cation. The significance of these results for understanding and modifying the properties of fluorescent proteins are discusse

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5

Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development. In a genetic approach to study functions of Pax5 in GABAergic neurons, Pax5 was specifically deleted in GABAergic neurons from Pax5 floxed mice using a novel Gad1-Cre transgenic mouse line expressing Cre recombinase in Gad1-positive, i.e. GABAergic neurons. Surprisingly, these mice developed a marked enlargement of the lateral ventricles at approximately seven weeks of age, which was lethal within 1–2 weeks of its appearance. This hydrocephalus phenotype was observed in mice homozygous or heterozygous for the Pax5 conditional knockout, with a gene dosage-dependent penetrance. By QTL (quantitative trait loci) mapping, a 3.5 Mb segment on mouse chromosome 4 flanked by markers D4Mit237 and D4Mit214 containing approximately 92 genes including Pax5 has previously been linked to differences in lateral ventricular size. Our findings are consistent with Pax5 being a relevant gene underlying this QTL phenotype and demonstrate that Pax5 in GABAergic neurons is essential for normal ventricular development

The local stellar population of nova regions in the Large Magellanic Cloud

This study aims at identifying and understanding the parent population of novae in the Large Magellanic Cloud (LMC) by studying the local, projected, stellar population. The star formation history of the local environment around novae is studied based on photometric data of stars and star clusters in the nova neighbourhood, available in the OGLE II survey and star cluster catalogues. The ages of stellar population within a few arcmin around novae regions are estimated using isochrone fits to the V vs (V-I) colour-magnitude diagrams. The fraction of stars in various evolutionary states are compared using luminosity functions of the main-sequence stars and the red giant stars. The age, density and luminosity function of the stellar population are estimated around 15 novae. The upper limit of the age of the intermediate stellar population is found to be 4 Gyr in all the regions, excepting the region around the slow nova LMC 1948. Star formation in these regions is found to have started between 4 - 2.0 Gyr, with a majority of the regions starting the star formation at 3.2 Gyr. This star formation event lasted until 1.6 - 0.8 Gyr The star formation history of the underlying population of both the fast and moderately fast novae indicate their parent population to be similar and likely to be in the age range 3.2 - 1.0 Gyr. This is in good agreement with the theoretical age estimates for Galactic cataclysmic variables. The region around the slow nova shows a stellar population in the age range 1 - 10 Gyr, with a good fraction belonging to an older population, consistent with the idea that the progenitors of slow novae belong to older population.Comment: to appear in A&A (final version - error analysis included, typos corrected, figures 17 and 18 changed