Damping of differential rotation in neutron stars

We derive the transport relaxation times for quasiparticle-vortex scattering processes via nuclear force, relevant for the damping of differential rotation of superfluids in the quantum liquid core of a neutron star. The proton scattering off the neutron vortices provides the dominant resistive force on the vortex lattice at all relevant temperatures in the phase where neutrons only are in the paired state. If protons are superconducting, a small fraction of hyperons and resonances in the normal state would be the dominant source of friction on neutron and proton vortex lattices at the core temperatures $T\ge 10^{7}$ K.Comment: 5 pages, Revtex, Phys. Rev. D 58, Rapid Communication, in pres

Syntaxin of Plant Proteins SYP123 and SYP132 Mediate Root Hair Tip Growth in Arabidopsis thaliana

Root hairs are fast-growing tubular protrusions on root epidermal cells that play important roles in water and nutrient uptake in plants. The tip-focused polarized growth of root hairs is accomplished by the secretion of newly synthesized materials to the tip via the polarized membrane trafficking mechanism. Here, we report the function of two different types of plasma membrane (PM) Qa-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), SYP123 and SYP132, in the growth of root hair in Arabidopsis. We found that SYP123, but not SYP132, localizes in the tip region of root hairs by recycling between the brefeldin A (BFA)-sensitive endosomes and the PM of the expanding tip in an F-actin-dependent manner. The vesicle-associated membrane proteins VAMP721/722/724 also exhibited tip-focused localization in root hairs and formed ternary SNARE complexes with both SYP123 and SYP132. These results demonstrate that SYP123 and SYP132 act in a coordinated fashion to mediate tip-focused membrane trafficking for root hair tip growth. © 2014 The Author

Католицька концепція міжрелігійного діалогу: зміна акцентів

In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process involved in both iron acquisition and ISR signaling. Here, we show that volatile compounds (VOCs) from ISR-inducing Pseudomonas bacteria are important elicitors of MYB72. VOCs-induced MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent manner, indicating that MYB72 is an intrinsic part of the plants’ iron acquisition response that is typically activated upon iron starvation. However, VOCs-induced MYB72 is activated independently of the iron availability in the root vicinity. Moreover, rhizobacterial VOCs-mediated induction of MYB72 requires photosynthesis-related signals, while iron deficiency in the rhizosphere can activate MYB72 in the absence of shoot-derived signals. Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and can enhance the iron acquisition capacity of roots independently of the iron availability in the rhizosphere. This work highlights the role of MYB72 in plant processes by which root microbiota simultaneously stimulate systemic immunity and activate the iron uptake machinery in their host plants

Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures

Background: Mental health disorders in the child and adolescent population are a pressing public health concern. Despite the high prevalence of psychopathology in this vulnerable population, the transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) has many obstacles such as deficiencies in planning, organisational readiness and policy gaps. All these factors contribute to an inadequate and suboptimal transition process. A suite of measures is required that would allow young people to be assessed in a structured and standardised way to determine the on-going need for care and to improve communication across clinicians at CAMHS and AMHS. This will have the potential to reduce the overall health economic burden and could also improve the quality of life for patients travelling across the transition boundary. The MILESTONE (Managing the Link and Strengthening Transition from Child to Adult Mental Health Care) project aims to address the significant socioeconomic and societal challenge related to the transition process. This protocol paper describes the development of two MILESTONE transition-related measures: The Transition Readiness and Appropriateness Measure (TRAM), designed to be a decision-making aide for clinicians, and the Transition Related Outcome Measure (TROM), for examining the outcome of transition. Methods: The TRAM and TROM have been developed and were validated following the US FDA Guidance for Patient-reported Outcome Measures which follows an incremental stepwise framework. The study gathers information from service users, parents, families and mental health care professionals who have experience working with young people undergoing the transition process from eight European countries. Discussion: There is an urgent need for comprehensive measures that can assess transition across the CAMHS/AMHS boundary. This study protocol describes the process of development of two new transition measures: the TRAM and TROM. The TRAM has the potential to nurture better transitions as the findings can be summarised and provided to clinicians as a clinician-decision making support tool for identifying cases who need to transition and the TROM can be used to examine the outcomes of the transition process. Trial registration: MILESTONE study registration: ISRCTN83240263 Registered 23-July-2015 - ClinicalTrials.gov NCT03013595 Registered 6 January 2017

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases. We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation. This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT). Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1. Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc. Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells. We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp. In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants

The FMOS-COSMOS survey of star-forming galaxies at z~1.6 III. Survey design, performance, and sample characteristics

We present a spectroscopic survey of galaxies in the COSMOS field using the Fiber Multi-Object Spectrograph (FMOS), a near-infrared instrument on the Subaru Telescope. Our survey is specifically designed to detect the Halpha emission line that falls within the H-band (1.6-1.8 um) spectroscopic window from star-forming galaxies with 1.4 ~10^10 Msolar. With the high multiplex capability of FMOS, it is now feasible to construct samples of over one thousand galaxies having spectroscopic redshifts at epochs that were previously challenging. The high-resolution mode (R~2600) effectively separates Halpha and [NII]6585 thus enabling studies of the gas-phase metallicity and photoionization state of the interstellar medium. The primary aim of our program is to establish how star formation depends on stellar mass and environment, both recognized as drivers of galaxy evolution at lower redshifts. In addition to the main galaxy sample, our target selection places priority on those detected in the far-infrared by Herschel/PACS to assess the level of obscured star formation and investigate, in detail, outliers from the star formation rate - stellar mass relation. Galaxies with Halpha detections are followed up with FMOS observations at shorter wavelengths using the J-long (1.11-1.35 um) grating to detect Hbeta and [OIII]5008 that provides an assessment of extinction required to measure star formation rates not hampered by dust, and an indication of embedded Active Galactic Nuclei. With 460 redshifts measured from 1153 spectra, we assess the performance of the instrument with respect to achieving our goals, discuss inherent biases in the sample, and detail the emission-line properties. Our higher-level data products, including catalogs and spectra, are available to the community.Comment: 26 pages, Updated version resubmitted to ApJSS; Data products and catalogs are now available at http://member.ipmu.jp/fmos-cosmos