ICT and the demand for energy : evidence from OECD countries

This paper analyzes the relationship between information and communication technology (ICT) and energy demand. We construct a comprehensive cross-country cross-industry panel data set covering 13 years, 10 OECD countries, and 27 industries. Using up to 2889 country-industry observations, we find that: (1) ICT capital is associated with a significant reduction in energy demand. (2) This relationship differs with regard to different types of energy. ICT use is not significantly correlated with electricity demand, but is significantly related to a reduction in non-electric energy demand. That is, ICT use comes with a reduction in total energy demand and an increase in the relative demand for electric over non-electric energy

Catechol-O-methyltransferase (COMT) Genotype Affects Age-Related Changes in Plasticity in Working Memory: A Pilot Study

Objectives. Recent work suggests that a genetic variation associated with increased dopamine metabolism in the prefrontal cortex (catechol-O-methyltransferase Val158Met; COMT) amplifies age-related changes in working memory performance. Research on younger adults indicates that the influence of dopamine-related genetic polymorphisms on working memory performance increases when testing the cognitive limits through training. To date, this has not been studied in older adults.Method. Here we investigate the effect of COMT genotype on plasticity in working memory in a sample of 14 younger (aged 24-30 years) and 25 older (aged 60-75 years) healthy adults. Participants underwent adaptive training in the -back working memory task over 12 sessions under increasing difficulty conditions. Results. Both younger and older adults exhibited sizeable behavioral plasticity through training ( < .001), which was larger in younger as compared to older adults ( < .001). Age-related differences were qualified by an interaction with COMT genotype ( < .001), and this interaction was due to decreased behavioral plasticity in older adults carrying the Val/Val genotype, while there was no effect of genotype in younger adults.Discussion. Our findings indicate that age-related changes in plasticity in working memory are critically affected by genetic variation in prefrontal dopamine metabolism

2001-GT-XXXX Boundary Layer Development in the BR710 and BR715 LP Turbines - The Implementation of High Lift and Ultra High Lift Concepts

ABSTRACT This paper describes a detailed study into the unsteady boundary layer behaviour in two high lift and one ultra high lift Rolls-Royce Deutschland LP turbines. The objectives of the paper are to show that high lift and ultra high-lift concepts have been successfully incorporated into the design of these new LP turbine profiles. Measurements from surface mounted hot film sensors were made in full size, cold flow test rigs at the altitude test facility at Stuttgart University. The LP turbine blade profiles are thought to be state of the art in terms of their lift and design philosophy. The two high lift profiles represent slightly different styles of velocity distribution. The first high-lift profile comes from a two stage LP turbine (the BR710 cold-flow, high-lift demonstrator rig). The second high-lift profile tested is from a three-stage machine (the BR715 LPT rig). The ultra-high lift profile measurements come from a redesign of the BR715 LP turbine: this is designated the BR715UHL LP turbine. This ultra high-lift profile represents a 12% reduction in blade numbers compared to the original BR715 turbine. The results from NGV2 on all of the turbines show "classical" unsteady boundary layer behaviour. The measurements from NGV3 (of both the BR715 and BR715UHL turbines) are more complicated, but can still be broken down into classical regions of wake-induced transition, natural transition and calming. The wakes from both upstream rotors and NGVs interact in a complicated manner, affecting the suction surface boundary layer of NGV3. This has important implications for the prediction of the flows on blade rows in multistage environments

A 2600-year history of floods in the Bernese Alps, Switzerland: frequencies, mechanisms and climate forcing

A 2600-yr long composite palaeoflood record is reconstructed from high-resolution delta plain sediments of the Hasli-Aare floodplain on the northern slope of the Swiss Alps. Natural proxies compiled from sedimentary, geochemical and geomorphological data were calibrated by textual and factual sources and instrumental data. No fewer than 12 of the 14 historically recorded extreme events between 1480 and the termination of the Hasli-Aare river channel correction in 1875 were also identified by coarse-grained flood layers, log(Zr/Ti) peaks and Factor 1 anomalies. Geomorphological, historical and instrumental data provide evidence for flood damage intensities and discharge estimations of severe and catastrophic historical floods. Spectral analysis of the geochemical and documentary flood series and several climate proxies (TSI, δ18O, tree-rings, NAO, SNAO) identify similar periodicities of around 60, 80, 100, 120 and 200 years during the last millennia, indicating the influence of the North Atlantic circulation and solar forcing on alpine flood dynamics. The composite floodplain record illustrates that periods of organic soil formation and deposition of phyllosilicates (from the medium high catchment area) match those of Total Solar Irradiance maxima, suggesting reduced flood activity during warmer climate pulses. Aggradation with multiple sets of flood layers with increased contribution of siliciclasts from the highest catchment area (plutonic bedrock) (e.g., 1300-1350, 1420-1480, 1550-1620, 1650-1720 and 1811-1851 cal yr AD) occurred predominantly during periods with reduced solar irradiance, lower δ18O anomalies, cooler summer temperatures and phases of drier spring climate in the Alps. Increased water storage by glaciers, snow cover and snow patches susceptible to melting processes associated with rainfall episodes and abrupt rises in temperature substantially increased surface run-off on slopes and discharges of alpine rivers. This interpretation is in agreement with the findings that the severe and catastrophic historical floods in the Aare since 1670 occurred mostly during positive SNAO pulses after years or even decades dominated by negative SNAO and cooler annual temperatures

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies

Objective: Utilize immune cell profiles in the cerebrospinal fluid (CSF) to advance the understanding and potentially support the diagnosis of inflammatory neuropathies.Methods: We analyzed CSF cell flow cytometry data of patients with definite Guillain-Barré syndrome (GBS, n = 26) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 32) based on established diagnostic criteria in comparison to controls with relapsing-remitting multiple sclerosis (RRMS, n = 49) and idiopathic intracranial hypertension (IIH, n = 63).Results: Flow cytometry revealed disease-specific changes of CSF cell composition with a significant increase of NKT cells and CD8+ T cells in CIDP, NK cells in GBS, and B cells and plasma cells in MS in comparison to IIH controls. Principal component analysis demonstrated distinct CSF immune cells pattern in inflammatory neuropathies vs. RRMS. Systematic receiver operator curve (ROC) analysis identified NKT cells as the best parameter to distinguish GBS from CIDP. Composite scores combing several of the CSF parameters differentiated inflammatory neuropathies from IIH and GBS from CIDP with high confidence. Applying a novel dimension reduction technique, we observed an intra-disease heterogeneity of inflammatory neuropathies.Conclusion: Inflammatory neuropathies display disease- and subtype-specific alterations of CSF cell composition. The increase of NKT cells and CD8+ T cells in CIDP and NK cells in GBS, suggests a central role of cytotoxic cell types in inflammatory neuropathies varying between acute and chronic subtypes. Composite scores constructed from multi-dimensional CSF parameters establish potential novel diagnostic tools. Intra-disease heterogeneity suggests distinct disease mechanisms in subgroups of inflammatory neuropathies

Inhalative Exposure to Vanadium Pentoxide Causes DNA Damage in Workers: Results of a Multiple End Point Study

BackgroundInhalative exposure to vanadium pentoxide (V(2)O(5)) causes lung cancer in rodents.ObjectiveThe aim of the study was to investigate the impact of V(2)O(5) on DNA stability in workers from a V(2)O(5) factory.MethodsWe determined DNA strand breaks in leukocytes of 52 workers and controls using the alkaline comet assay. We also investigated different parameters of chromosomal instability in lymphocytes of 23 workers and 24 controls using the cytokinesis-block micronucleus (MN) cytome method.ResultsSeven of eight biomarkers were increased in blood cells of the workers, and vanadium plasma concentrations in plasma were 7-fold higher than in the controls (0.31 microg/L). We observed no difference in DNA migration under standard conditions, but we found increased tail lengths due to formation of oxidized purines (7%) and pyrimidines (30%) with lesion-specific enzymes (formamidopyrimidine glycosylase and endonuclease III) in the workers. Bleomycin-induced DNA migration was higher in the exposed group (25%), whereas the repair of bleomycin-induced lesions was reduced. Workers had a 2.5-fold higher MN frequency, and nucleoplasmic bridges (NPBs) and nuclear buds (Nbuds) were increased 7-fold and 3-fold, respectively. Also, apoptosis and necrosis rates were higher, but only the latter parameter reached statistical significance.ConclusionsV(2)O(5) causes oxidation of DNA bases, affects DNA repair, and induces formation of MNs, NPBs, and Nbuds in blood cells, suggesting that the workers are at increased risk for cancer and other diseases that are related to DNA instability.Veronika A. Ehrlich, Armen K. Nersesyan, Kambis Atefie, Christine Hoelzl, Franziska Ferk, Julia Bichler, Eva Valic, Andreas Schaffer, Rolf Schulte‑Hermann, Michael Fenech, Karl‑Heinz Wagner and Siegfried Knasmüllerhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599764

Modeling neurocognitive and neurobiological recovery in addiction

This book focuses on "what to know" and "how to apply" information, prioritizing novel principles and delineating cutting-edge assessment, phenotyping and treatment tools

The use of adverse outcome pathways in the safety evaluation of food additives

Funder: ILSI EuropeAbstract: In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and cosmetics sectors has been well documented, their application in the food area remains largely unexplored. In this respect, an expert group of the International Life Sciences Institute Europe has recently explored the use of adverse outcome pathways in the safety evaluation of food additives. A key activity was the organization of a workshop, gathering delegates from the regulatory, industrial and academic areas, to discuss the potentials and challenges related to the application of adverse outcome pathways in the safety assessment of food additives. The present paper describes the outcome of this workshop followed by a number of critical considerations and perspectives defined by the International Life Sciences Institute Europe expert group

The use of adverse outcome pathways in the safety evaluation of food additives

Funder: ILSI EuropeAbstract: In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and cosmetics sectors has been well documented, their application in the food area remains largely unexplored. In this respect, an expert group of the International Life Sciences Institute Europe has recently explored the use of adverse outcome pathways in the safety evaluation of food additives. A key activity was the organization of a workshop, gathering delegates from the regulatory, industrial and academic areas, to discuss the potentials and challenges related to the application of adverse outcome pathways in the safety assessment of food additives. The present paper describes the outcome of this workshop followed by a number of critical considerations and perspectives defined by the International Life Sciences Institute Europe expert group

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Abstract: There is considerable interest in adverse outcome pathways (AOPs) as a means of organizing biological and toxicological information to assist in data interpretation and method development. While several chemical sectors have shown considerable progress in applying this approach, this has not been the case in the food sector. In the present study, safety evaluation reports of food additives listed in Annex II of Regulation (EC) No 1333/2008 of the European Union were screened to qualitatively and quantitatively characterize toxicity induced in laboratory animals. The resulting database was used to identify the critical adverse effects used for risk assessment and to investigate whether food additives share common AOPs. Analysis of the database revealed that often such scrutiny of AOPs was not possible or necessary. For 69% of the food additives, the report did not document any adverse effects in studies based on which the safety evaluation was performed. For the remaining 31% of the 326 investigated food additives, critical adverse effects and related points of departure for establishing health-based guidance values could be identified. These mainly involved effects on the liver, kidney, cardiovascular system, lymphatic system, central nervous system and reproductive system. AOPs are available for many of these apical endpoints, albeit to different degrees of maturity. For other adverse outcomes pertinent to food additives, including gastrointestinal irritation and corrosion, AOPs are lacking. Efforts should focus on developing AOPs for these particular endpoints