Understanding the Science of Climate Change \u3ci\u3eTalking Points – Impacts to Alaska Maritime and Transitional\u3c/i\u3e

Alaska is a huge state spanning 375 million acres and occupying nearly one-fifth of the land area for the contiguous 48 states. More than half of the coastline of the entire United States is in Alaska. Due to the great size and geographically diverse nature of Alaska, two bioregional documents were produced: “Boreal and Arctic” and “Alaska Maritime and Transitional.” In Alaska, the vast majority of the land is public; with approximately 222 million acres (approximately 60%) designated federal lands and another 90 million acres (approximately 24%) in state ownership. There are 17 National Park Service (NPS) areas in Alaska covering over 54 million acres; this represents two-thirds of the land in the entire National Park system. Wrangell-St. Elias is the largest NPS unit at over 13 million acres in size. There are 16 National Wildlife Refuges in Alaska totaling over 76 million acres, representing approximately 80% of the entire National Wildlife Refuge system. The two national forests in Alaska encompass nearly 22 million acres; Tongass National Forest is the largest United States Forest Service unit, with nearly 17 million acres. The Bureau of Land Management manages almost 78 million acres in Alaska. Climate changes in the Alaska Maritime and Transitional bioregion include increased mean, minimum, and maximum annual temperatures, and increasing spring and wintertime temperatures that have resulted in a longer growing growing season and shifting plant distributions. Regional models project a wintertime shift in temperatures from below to above freezing by the mid to late 21st century, a decrease in the annual number of snow-free and frost-free days, and a mean increase in annual air temperatures. Observed hydrologic changes within the bioregion are profound, including significant decreases in the number, mass, and volume of glaciers; increased rates of glacial retreat and thinning; increased volume of glacial runoff; and increasing stream temperatures. Projections for the coming century include further changes in seasonal and annual precipitation patterns (both snow and rainfall), continued drying of existing wetlands, and sea level rise resulting from continued melting and retreat of glaciers. Observed and predicted bioregional changes in temperature and hydrology affect vegetation and wildlife through altered seasonality of runoff, increased wildfire and insect activity, movement of forests and shrublands into wetlands and recently deglaciated areas, phenological shifts (altered timing of reproductive events such as fish spawning and bud burst), and major directional and elevational shifts in plant distributions and community assemblages. Direct effects of bioregional climate changes on human populations and infrastructure are structure damage from thawing permafrost, altered soil conditions, and shifts in water and plant communities, which may, in turn, affect animal communities and alter fire regimes. Changes in terrestrial and marine wildlife distributions may affect visitor viewing opportunities and complicate subsistence hunting throughout the region

Do your words portray or betray your values? The rhetorical choices we make every time we speak

Dr. Beth Patrick-Trippel presents the theoretical constructs used by all four students as well as a brief explanation of the nature of the research being done. Rachel Schramm: Picturing Race and Sports on the Big Screen. What can we learn from “Remember the Titans” and “Glory Road” using Richard Weaver’s Ideas of the Ideal? Jazmin Rangle: Instagram, social media and the Rhetoric of Kim Kardashian-West. Can the rhetoric of Richard Weaver keep up with the Kardashians? Becca Williams: What value messages cause us to laugh at Dwight’s awkwardness in “The Office?” Can we understand our own rhetorical choices by examining the choices in one of America’s most loved sit-coms? Kaitlyn Altmann: Richard Weaver’s Metaphysical Dream as seen through Dystopian Movie Characters in The Hunger Games and Mockingjay

Protocol for a multicentre randomised controlled trial of STeroid Administration Routes For Idiopathic Sudden sensorineural Hearing loss:The STARFISH trial

Idiopathic sudden sensorineural hearing loss (ISSNHL) is the rapid onset of reduced hearing due to loss of function of the inner ear or hearing nerve of unknown aetiology. Evidence supports improved hearing recovery with early steroid treatment, via oral, intravenous, intratympanic or a combination of routes. The STARFISH trial aims to identify the most clinically and cost-effective route of administration of steroids as first-line treatment for ISSNHL. STARFISH is a pragmatic, multicentre, assessor-blinded, three-arm intervention, superiority randomised controlled trial (1:1:1) with an internal pilot (ISRCTN10535105, IRAS 1004878). 525 participants with ISSNHL will be recruited from approximately 75 UK Ear, Nose and Throat units. STARFISH will recruit adults with sensorineural hearing loss averaging 30dBHL or greater across three contiguous frequencies (confirmed via pure tone audiogram), with onset over a ≤3-day period, within four weeks of randomisation. Participants will be randomised to 1) oral prednisolone 1mg/Kg/day up to 60mg/day for 7 days; 2) intratympanic dexamethasone: three intratympanic injections 3.3mg/ml or 3.8mg/ml spaced 7±2 days apart; or 3) combined oral and intratympanic steroids. The primary outcome will be absolute improvement in pure tone audiogram average at 12-weeks following randomisation (0.5, 1.0, 2.0 and 4.0kHz). Secondary outcomes at 6 and 12 weeks will include: Speech, Spatial and Qualities of hearing scale, high frequency pure tone average thresholds (4.0, 6.0 and 8.0kHz), Arthur Boothroyd speech test, Vestibular Rehabilitation Benefit Questionnaire, Tinnitus Functional Index, adverse events and optional weekly online speech and pure tone hearing tests. A health economic assessment will be performed, and presented in terms of incremental cost effectiveness ratios, and cost per quality-adjusted life-year. Primary analyses will be by intention-to-treat. Oral prednisolone will be the reference. For the primary outcome, the difference between group means and 97.5% confidence intervals at each time-point will be estimated via a repeated measures mixed-effects linear regression model

On the evolution of the intrinsic scatter in black hole versus galaxy mass relations

We present results on the evolution of the intrinsic scatter of black hole masses considering different implementations of a model in which black holes only grow via mergers. We demonstrate how merger driven growth affects the correlations between black hole mass and host bulge mass. The simple case of an initially log-normal distributed scatter in black hole and bulge masses combined with random merging within the galaxy population results in a decreasing scatter with merging generation/number as predicted by the Central-limit theorem. In general we find that the decrease in scatter {\sigma} is well approximated by {\sigma}merg(m) = {\sigma}ini \times (m + 1)^(-a/2) with a = 0.42 for a range of mean number of mergers m < 50. For a large mean number of mergers (m > 100) we find a convergence to a = 0.61. This is valid for a wide range of different initial distributions, refill-scenarios or merger mass-ratios. Growth scenarios based on halo merger trees of a (100 Mpc)^3 dark matter LambdaCDM-simulation show a similar behaviour with a scatter decrease of a = 0.30 with typical number of mergers m < 50 consistent with random merging (best matching model: a = 0.34). Assuming a present day scatter of 0.3 dex in black hole mass and a mean number of mergers not exceeding m = 50 our results imply a scatter of 0.6 dex at z = 3 and thus a possible scenario in which overmassive (and undermassive) black holes at high redshift are a consequence of a larger intrinsic scatter in black hole mass. A simple toy model connecting the growth of black holes to the growth of LambdaCDM dark matter halos via mergers, neglecting any contribution from accretion, yields a consistent M\cdot -MBulge relation at z = 0 - if we assume the correct initial relation.Comment: 19 pages, 21 figures, accepted for publication in MNRA

Galaxy density profiles and shapes -- I. simulation pipeline for lensing by realistic galaxy models

Studies of strong gravitational lensing in current and upcoming wide and deep photometric surveys, and of stellar kinematics from (integral-field) spectroscopy at increasing redshifts, promise to provide valuable constraints on galaxy density profiles and shapes. However, both methods are affected by various selection and modelling biases, whch we aim to investigate in a consistent way. In this first paper in a series we develop a flexible but efficient pipeline to simulate lensing by realistic galaxy models. These galaxy models have separate stellar and dark matter components, each with a range of density profiles and shapes representative of early-type, central galaxies without significant contributions from other nearby galaxies. We use Fourier methods to calculate the lensing properties of galaxies with arbitrary surface density distributions, and Monte Carlo methods to compute lensing statistics such as point-source lensing cross-sections. Incorporating a variety of magnification bias modes lets us examine different survey limitations in image resolution and flux. We rigorously test the numerical methods for systematic errors and sensitivity to basic assumptions. We also determine the minimum number of viewing angles that must be sampled in order to recover accurate orientation-averaged lensing quantities. We find that for a range of non-isothermal stellar and dark matter density profiles typical of elliptical galaxies, the combined density profile and corresponding lensing properties are surprisingly close to isothermal around the Einstein radius. The converse implication is that constraints from strong lensing and/or stellar kinematics, which are indeed consistent with isothermal models near the Einstein radius, cannot trivially be extrapolated to smaller and larger radii.Comment: 31 pages, 15 figures; paper II at arXiv:0808.2497; accepted for publication in MNRAS; PDF file with full resolution figures at http://www.sns.ias.edu/~glenn/paper1.pd

Introductory programming: a systematic literature review

As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming. This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research

Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells

In utero hematopoietic cell transplantation (IUHCT) is a potential therapy for the treatment of numerous genetic diseases such as hemoglobinopathies, immunodeficiencies, and inborn errors of metabolism.1 In utero therapy offers the benefit of avoiding host myeloablation and immunosuppression and has been shown to be successful in multiple animal models, including mice,2-5 dogs,6,7 pigs,8,9 and sheep.10-12 The timing of IUHCT exposes the transplanted human cells to the normal fetal migratory and developmental cues that facilitate proper stem cell distribution and differentiation.11,12 Clinically, IUHCT has been successful for fetuses with severe combined immunodeficiency (SCID),13,14 but therapeutic uses for other diseases, including hemoglobinopathies, have seen limited success.15 Further investigations identified multiple barriers to successful engraftment, including lack of space within the hematopoietic niche16,17 and the maternal immune system.2,18 Among available animal models of IUHCT, the fetal mouse remains an efficient and reproducible model to study the differentiation of stem cells in a nonirradiated host. NSG (NOD-SCID IL2Rg-null) mice, which are developed with SCID and IL-2Rg-null chain mutations, are a robust platform for the engraftment of human hematopoietic cells because they have no endogenous T, B, or natural killer cells.19-22 In this study, we used IUHCT of human CD341 cells in NSG mice to create a reproducible mouse model to study stem cell engraftment, differentiation, and systemic repopulation after IUHCT

A Single Peroxisomal Targeting Signal Mediates Matrix Protein Import in Diatoms

Peroxisomes are single membrane bound compartments. They are thought to be present in almost all eukaryotic cells, although the bulk of our knowledge about peroxisomes has been generated from only a handful of model organisms. Peroxisomal matrix proteins are synthesized cytosolically and posttranslationally imported into the peroxisomal matrix. The import is generally thought to be mediated by two different targeting signals. These are respectively recognized by the two import receptor proteins Pex5 and Pex7, which facilitate transport across the peroxisomal membrane. Here, we show the first in vivo localization studies of peroxisomes in a representative organism of the ecologically relevant group of diatoms using fluorescence and transmission electron microscopy. By expression of various homologous and heterologous fusion proteins we demonstrate that targeting of Phaeodactylum tricornutum peroxisomal matrix proteins is mediated only by PTS1 targeting signals, also for proteins that are in other systems imported via a PTS2 mode of action. Additional in silico analyses suggest this surprising finding may also apply to further diatoms. Our data suggest that loss of the PTS2 peroxisomal import signal is not reserved to Caenorhabditis elegans as a single exception, but has also occurred in evolutionary divergent organisms. Obviously, targeting switching from PTS2 to PTS1 across different major eukaryotic groups might have occurred for different reasons. Thus, our findings question the widespread assumption that import of peroxisomal matrix proteins is generally mediated by two different targeting signals. Our results implicate that there apparently must have been an event causing the loss of one targeting signal even in the group of diatoms. Different possibilities are discussed that indicate multiple reasons for the detected targeting switching from PTS2 to PTS1

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies