Abgesicherte Fürsorge und fürsorgliche Absicherung in Gemeinschaft. Mehrgenerationenwohnprojekte als neue Formen der städtischen Reproduktion?

Mehrgenerationenwohnen (MGW) gewinnt vor dem Hintergrund des demografischen Wandels bei gleichzeitiger Individualisierung und Transformation von Familien- und Fürsorgestrukturen an gesellschaftlicher Relevanz. Aus einer feministischen Perspektive schaut der Aufsatz entlang dreier MGW-Projekte auf die intersubjektiven Beziehungen und geht den Fragen nach, wie Fürsorge in den Gruppen verhandelt wird und inwiefern sich dort neue Formen kollektiver städtischer Reproduktion ausbilden. Im Ergebnis zeigt sich, dass MGW-Projekte als selbst gewählte fürsorgliche Nachbarschaften fungieren, die in ihrem Verhältnis zwischen Nähe und Distanz, in der alltäglichen Lebensführung ihrer Bewohner_innen und der Organisation ihres Projektalltags sowie in ihren Aushandlungs- und Entscheidungsstrukturen zwischen Fürsorge und Absicherung changieren. Ausgehend vom empirischen Material schlagen wir daher vor, einen weiten Begriff von Fürsorge durch die Kategorie Absicherung zu konkretisieren

Abgesicherte Fürsorge und fürsorgliche Absicherung in Gemeinschaft. Mehrgenerationenwohnprojekte als neue Formen der städtischen Reproduktion?

Mehrgenerationenwohnen (MGW) gewinnt vor dem Hintergrund des demografischen Wandels bei gleichzeitiger Individualisierung und Transformation von Familien- und Fürsorgestrukturen an gesellschaftlicher Relevanz. Aus einer feministischen Perspektive schaut der Aufsatz entlang dreier MGW-Projekte auf die intersubjektiven Beziehungen und geht den Fragen nach, wie Fürsorge in den Gruppen verhandelt wird und inwiefern sich dort neue Formen kollektiver städtischer Reproduktion ausbilden. Im Ergebnis zeigt sich, dass MGW-Projekte als selbst gewählte fürsorgliche Nachbarschaften fungieren, die in ihrem Verhältnis zwischen Nähe und Distanz, in der alltäglichen Lebensführung ihrer Bewohner_innen und der Organisation ihres Projektalltags sowie in ihren Aushandlungs- und Entscheidungsstrukturen zwischen Fürsorge und Absicherung changieren. Ausgehend vom empirischen Material schlagen wir daher vor, einen weiten Begriff von Fürsorge durch die Kategorie Absicherung zu konkretisieren

Unique Co‐Catalytic Behavior of Protic Ionic Liquids as Multifunctional Electrolytes for Water Splitting

Hydrogen production from water splitting holds great promise for solving today’s energy crisis but it is challenging to have high efficiency and low cost. For the first time, a protic ionic liquid (PIL), diethylammonium formate (DEAF) was used as a multifunctional electrolyte in water splitting, demonstrating a unique role of co‐catalyst for the hydrogen evolution reaction (HER) with the highest current density (21 mA cm−2 at −0.5 V) and the most positive onset potential (−0.002 V) in comparison to aprotic ILs and commonly used inorganic salts. Moreover, the concentration of PIL and temperature of electrolyte solution were optimized. The possible mechanism for the multifunctionality and high performance for water splitting using this PIL was proposed using X‐ray photoelectron spectroscopy (XPS). The high performance for HER, simplicity and low cost for synthesis, and unique properties make DEAF highly promising as an electrolyte toward water splitting.DEAFening: For the first time, a protic ionic liquid, diethylammonium format, is used as a multifunctional electrolyte in a water‐splitting cell, demonstrating a unique role as co‐catalyst.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137194/1/celc201500458.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137194/2/celc201500458-sup-0001-misc_information.pd

A CX3CRI Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture

Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researchers to determine the most appropriate methodology for microglial studies. To establish a framework to facilitate future microglial studies, we first performed a comparative transcriptional analysis between iMGLs derived using three published datasets, which allowed us to establish the baseline protocol that is most representative of bona fide human microglia. Secondly, using CRISPR to tag the classic microglial marker CX3CR1 with nanoluciferase and tdTomato, we generated and functionally validated a reporter ESC line. Finally, using this cell line, we demonstrated that co-culture of iMGL precursors with human glia and neurons enhanced transcriptional resemblance of iMGLs to ex vivo microglia. Together, our comprehensive molecular analysis and reporter cell line are a useful resource for neurobiologists seeking to use iMGLs for disease modeling and drug screening studies.Peer reviewe

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition

Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study

The PRECISE study used convection enhanced delivery (CED) to infuse IL13-PE38QQR in patients with recurrent glioblastoma multiforme (GBM) and compared survival to Gliadel Wafers (GW). The objectives of this retrospective evaluation were to assess: (1) catheter positioning in relation to imaging features and (2) to examine the potential impact of catheter positioning, overall catheter placement and imaging features on long term clinical outcome in the PRECISE study. Catheter positioning and overall catheter placement were scored and used as a surrogate of adequate placement. Imaging studies obtained on day 43 and day 71 after resection were each retrospectively reviewed. Catheter positioning scores, catheter overall placement scores, local tumor control and imaging change scores were reviewed and correlated using Generalized Linear Mixed Models. Cox PH regression analysis was used to examine whether these imaging based variables predicted overall survival (OS) and progression free survival (PFS) after adjusting for age and KPS. Of 180 patients in the CED group, 20 patients did not undergo gross total resection. Of the remaining 160 patients only 53% of patients had fully conforming catheters in respect to overall placement and 51% had adequate catheter positioning scores. Better catheter positioning scores were not correlated with local tumor control (P = 0.61) or imaging change score (P = 0.86). OS and PFS were not correlated with catheter positioning score (OS: P = 0.53; PFS: P = 0.72 respectively), overall placement score (OS: P = 0.55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial