Negative Interactions in Irreversible Self-Assembly

This paper explores the use of negative (i.e., repulsive) interaction the abstract Tile Assembly Model defined by Winfree. Winfree postulated negative interactions to be physically plausible in his Ph.D. thesis, and Reif, Sahu, and Yin explored their power in the context of reversible attachment operations. We explore the power of negative interactions with irreversible attachments, and we achieve two main results. Our first result is an impossibility theorem: after t steps of assembly, Omega(t) tiles will be forever bound to an assembly, unable to detach. Thus negative glue strengths do not afford unlimited power to reuse tiles. Our second result is a positive one: we construct a set of tiles that can simulate a Turing machine with space bound s and time bound t, while ensuring that no intermediate assembly grows larger than O(s), rather than O(s * t) as required by the standard Turing machine simulation with tiles

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice

Mathematical-Physical reappraisal of Archie's first equation on the basis of a statistical network model

Knowledge of the geometrical properties of porous rocks is crucial for the evaluation of their hydrocarbon potential. A major problem in quantitative formation evaluation is to provide a physical basis of Archie's equations first published in 1942, which are widely used in formation evaluation and are believed to reflect this knowledge empirically. Our study, a theoretical model-based approach, provides a physical basis of Archie's first equation (Archie I) and puts it up for scientific discussion. We employ the statistical network model theory of Schopper, and take sedimentation and favorable diagenetic conditions restricted to compaction into account. We find that compaction is a prominent geological feature that needs to be considered and quantified in order to establish a physical basis of Archie I. Our interpretation of Archie I – that it measures in relative terms – is in agreement with this finding, but not in line with the mainstream view, which interprets Archie I in absolute terms. Evidence suggests that compaction may also provide the overarching physical basis to address within-well integration of borehole–geophysical data (including resistivity data) as well as their integration across spatial scales from well-to-well and beyond. Although our more consistent understanding of Archie's first equation clearly helps to advance today's evaluation of resistivity logs, the gain in evaluating these logs is still not satisfactory

PROLOGUE Deliverable 2.2 Methodological and organizational issues and requirements for ND studies

Naturalistic driving observation is a relatively new method for studying road safety issues, a method by which one can objectively observe various driver- and accident related behaviour. Typically, participants get their own vehicles equipped with some sort of data logging device that can record various driving behaviours such as speed, braking, lane keeping/variations, acceleration, deceleration etc., as well as one or more video cameras. In this way normal drivers are observed in their normal driving context while driving their own vehicles. Optimally, this allows for observation of the driver, vehicle, road and traffic environments and interaction between these factors. The main objective of PROLOGUE is to demonstrate the usefulness, value, and feasibility of conducting naturalistic driving observation studies in a European context in order to investigate traffic safety of road users, as well as other traffic related issues such as eco-driving and traffic flow/traffic management. The current deliverable describes the methodological issues related to naturalistic driving studies. It describes the experimental procedures, variables to be measured, experimental design, statistical analysis methods, organizational issues and legal and ethical issues for naturalistic studies. Maximal use is made of the extensive knowledge and experience that comes from the EU projects FESTA and EuroFOT, the 100car study and the SHRP2 preparatory safety studies

Küçülme Stratejisinin Çalişanların Örgüte Bağlılıkları Üzerindeki Etkileri Kayseri İli nde Bir Araştırma

This paper investigates a global search optimisation technique, referred to as the repeated weighted boosting search. The proposed optimisation algorithm is extremely simple and easy to implement. Heuristic explanation is given for the global search capability of this technique. Comparison is made with the two better known and widely used global search techniques, known as the genetic algorithm and adaptive simulated annealing. The effectiveness of the proposed algorithm as a global optimiser is investigated through several examples