1,180 research outputs found

    Anforderungsanalyse und -definition: Literaturwissenschaftliches und didaktisches Nutzungskonzept, GUI-Konzept, Such- und Findbarkeitskonzept

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    Das vorliegende Dokument enthĂ€lt die Anforderungsanalyse und -definition, das literaturwissenschaftliche und didaktisches Nutzungskonzept, sowie ein GUI-Konzept und ein Such- und Findbarkeitskonzept fĂŒr die im Rahmen des Projekts "GeoBib" entstehende Georeferenzierte Online-Bibliographie frĂŒher Holocaust- und Lagerliteratur. Das Dokument ist Teil der Schriftenreihe „GeoBib Dokumentation“, welche die im Laufe des Projekts "GeoBib" entstehenden internen Reports umfasst und somit die fortlaufenden Projektarbeiten dokumentiert. Ziel des Projekts GeoBib ist es, die frĂŒhen Texte der deutsch- bzw. polnischsprachigen Holocaust- und Lagerliteratur von 1933 bis 1949 zu erfassen und deren bibliographische Angaben (ohne Volltexte) in einer Online-Datenbank bereit zu stellen. So können diese frĂŒhen Texte, die in weiten Teilen aus dem kulturellen und kollektiven GedĂ€chtnis verdrĂ€ngt wurden, fĂŒr die öffentliche, wissenschaftliche und didaktische Wahrnehmung erschlossen und aufbereitet werden. Die systematische Erfassung der bis 1949 publizierten Texte sowie die Anreicherung durch exemplarische Informationen zu den Verfassern, zu gegebenenfalls erschienenen Rezensionen und SekundĂ€rliteratur orientieren sich dabei an internationalen Annotationsstandards. Metadaten und Textinhalte (Orte, Lager, Gettos etc.) werden georeferenziert, d.h. anhand von Kartenmaterial verortet und in einem geographischen Informationssystem erfasst und dargestellt. Das zu entwickelnde Web-Portal soll dabei – neben der bibliographischen Suche – auch ĂŒber geographische Karten gezielt Texte zu einer bestimmten Region auffindbar machen. Dabei sollen Abfragemöglichkeiten nach rĂ€umlichen Kriterien und bibliographischen Attributen kombinierbar sein

    Der große Sprung? Chinas ballistisches Raketenprogramm: Ein technischer Bericht

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    Seit seinen AnfĂ€ngen in den 1950er Jahren hat sich Chinas Raketenprogramm sehr stark entwickelt. Dieser Research Report zeigt auf, wie sich in einem Zeitraum von mehr 70 Jahren insbesondere die Entwicklung der ballistischen Raketen in China vollzogen hat. Dabei wertet der Autor insbesondere offene Quellen aus und nimmt eine technische Analyse dieser Daten vor. Er gibt außerdem einen kurzen Überblick ĂŒber die hierfĂŒr verantwortliche, bis heute sehr staatsnahe, chinesische Industrie sowie eine EinschĂ€tzung der aktuellen chinesischen RaketenstreitkrĂ€fte hinsichtlich operationeller Systeme, TruppenstĂ€rken und Stationierungsorten. Durch diesen Ansatz wird ersichtlich, dass China seit vielen Jahrzehnten - zunĂ€chst mit sowjetischer Hilfe, dann durch eigenstĂ€ndige Entwicklungen - weitreichende Raketensysteme als Werkzeug zur Erstellung von Bedrohungskulissen nutzt. Insbesondere in den vergangenen Jahren ist zu beobachten, dass China verstĂ€rkt in Forschung, Entwicklung und in die Produktion von Raketen investiert. Darauf weist ein signifikanter Anstieg bei Systemen mittlerer und großer Reichweite sowie eine weitreichende Modernisierung der vorhandenen Systeme hin. Dieser Report ist ein Nachschlagewerk zum aktuellen Stand des chinesischen Raketenprogrammes. Er soll dabei helfen, die technischen HintergrĂŒnde des chinesischen Raketenprogrammes zu verstehen und damit auch FĂ€higkeiten, Absichten und zugrundeliegende Strategien, kĂŒnftige Handlungsoptionen sowie Auswirkungen auf die internationale Staatengemeinschaft durch das chinesische Raketenprogramm besser einordnen zu können

    Towards a Swiss National Research Infrastructure

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    In this position paper we describe the current status and plans for a Swiss National Research Infrastructure. Swiss academic and research institutions are very autonomous. While being loosely coupled, they do not rely on any centralized management entities. Therefore, a coordinated national research infrastructure can only be established by federating the various resources available locally at the individual institutions. The Swiss Multi-Science Computing Grid and the Swiss Academic Compute Cloud projects serve already a large number of diverse user communities. These projects also allow us to test the operational setup of such a heterogeneous federated infrastructure

    The First Neocentric, Discontinuous, and Complex Small Supernumerary Marker Chromosome Composed of 7 Euchromatic Blocks Derived from 5 Different Chromosomes

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    Background: The majority of small supernumerary marker chromosomes (sSMCs) are derived from one single chromosome. Complex sSMCs instead consist of two to three genomic segments, originating from different chromosomes. Additionally, discontinuous sSMCs have been seen; however, all of them are derived from one single chromosome. Here, we reported a 41 year-old patient with infertility, hypothyroidism, rheumatism, and degenerative spine and schizoaffective disorder, being a carrier of a unique, complex, and discontinuous sSMC. Methods: The sSMC was characterized in detail by banding and molecular cytogenetics including fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (aCGH), as well as by optical genome mapping (OGM). Results: The neocentric sSMC characterized here contained seven portions of five different chromosomes and was present in ~50% of both peripheral blood cells and buccal mucosa cells. aCGH and OGM revealed gains of 8q12.3q12.3, 8q22.3–8q23.1, 9q33.3–9q34.11, 14q21.1–14q21.1, 14q21.1–14q21.2, 15q21.2–15q21.2, and 21q21.1–21q21.1. Furthermore, glass-needle based microdissection and reverse FISH, as well as FISH with locus-specific probes confirmed these results. The exact order of the involved euchromatic blocks could be decoded by OGM. Conclusions: Among the >7000 reported sSMCs in the literature, this is the only such complex, discontinuous, and neocentric marker with a centric minute shape

    Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.

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    Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, including the "CrossMab" format. CrossMabs contain a domain crossover in one of the antigen-binding (Fab) parts, together with the "knobs-and-holes" approach, to enforce the correct assembly of four different polypeptide chains into an IgG-like bispecific antibody. We determined the crystal structure of a hAng-2-binding Fab in its crossed and uncrossed form and show that CH1-CL-domain crossover does not induce significant perturbations of the structure and has no detectable influence on target binding

    Global reconstruction of language models with linguistic rules – Explainable AI for online consumer reviews

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    Analyzing textual data by means of AI models has been recognized as highly relevant in information systems research and practice, since a vast amount of data on eCommerce platforms, review portals or social media is given in textual form. Here, language models such as BERT, which are deep learning AI models, constitute a breakthrough and achieve leading-edge results in many applications of text analytics such as sentiment analysis in online consumer reviews. However, these language models are “black boxes”: It is unclear how they arrive at their predictions. Yet, applications of language models, for instance, in eCommerce require checks and justifications by means of global reconstruction of their predictions, since the decisions based thereon can have large impacts or are even mandatory due to regulations such as the GDPR. To this end, we propose a novel XAI approach for global reconstructions of language model predictions for token-level classifications (e.g., aspect term detection) by means of linguistic rules based on NLP building blocks (e.g., part-of-speech). The approach is analyzed on different datasets of online consumer reviews and NLP tasks. Since our approach allows for different setups, we further are the first to analyze the trade-off between comprehensibility and fidelity of global reconstructions of language model predictions. With respect to this trade-off, we find that our approach indeed allows for balanced setups for global reconstructions of BERT’s predictions. Thus, our approach paves the way for a thorough understanding of language model predictions in text analytics. In practice, our approach can assist businesses in their decision-making and supports compliance with regulatory requirements

    A fast and sensitive method for the continuous in situ determination of dissolved methane and its d13C-isotope ratio in surface waters

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    A fast and sensitive method for the continuous determination of methane (CH4) and its stable carbon isotopic values (d13C-CH4) in surface waters was developed by applying a vacuum to a gas/liquid exchange membrane and measuring the extracted gases by a portable cavity ring-down spectroscopy analyser (M-CRDS). The M-CRDS was calibrated and characterized for CH4 concentration and d13C-CH4 with synthetic water standards. The detection limit of the M-CRDS for the simultaneous determination of CH4 and d13CCH4 is 3.6 nmol L21 CH4. A measurement precision of CH4 concentrations and d13C-CH4 in the range of 1.1%, respectively, 1.7& (1r) and accuracy (1.3%, respectively, 0.8& [1r]) was achieved for single measurements and averaging times of 10 min. The response time s of 5765 s allow determination of d13C-CH4 values more than twice as fast than other methods. The demonstrated M-CRDS method was applied and tested for Lake Stechlin (Germany) and compared with the headspace-gas chromatography and fast membrane CH4 concentration methods. Maximum CH4 concentrations (577 nmol L21) and lightest d13C-CH4 (235.2&) were found around the thermocline in depth profile measurements. The M-CRDS-method was in good agreement with other methods. Temporal variations in CH4 concentration and d13C-CH4 obtained in 24 h measurements indicate either local methane production/oxidation or physical variations in the thermocline. Therefore, these results illustrate the need of fast and sensitive analyses to achieve a better understanding of different mechanisms and pathways of CH4 formation in aquatic environments

    Comparison of Several Methods for Determining the Internal Resistance of Lithium Ion Cells

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    The internal resistance is the key parameter for determining power, energy efficiency and lost heat of a lithium ion cell. Precise knowledge of this value is vital for designing battery systems for automotive applications. Internal resistance of a cell was determined by current step methods, AC (alternating current) methods, electrochemical impedance spectroscopy and thermal loss methods. The outcomes of these measurements have been compared with each other. If charge or discharge of the cell is limited, current step methods provide the same results as energy loss methods
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