Interstellar helium in interplanetary space

The velocity distribution function of He(+) in the solar wind at 1 AU is calculated with the assumption that the source is photoionization of a cold (T = 100 K), neutral interstellar wind. If the spiral magnetic field is noise free, the velocity distribution is diffuse and would not produce a peak at 4(E over Q) sub H in an E over Q particle spectrum. If the velocity of the interstellar wind with respect to the sun lies in the ecliptic, a large variation of the He(+) number density with respect to ecliptic longitude is expected

Diagnosis of venous incompetence inerectile dysfunction

In 26 of 214 patients with erectile dysfunction and proved venous incompetence by cavernosography, an additional bidirectional Doppler ultrasound was performed also to demonstrate venous outflow disturbances. All except one leakage in the superficial and deep dorsal veins could be demonstrated as well as 4 of 6 cavernosum-glandular shunts. Bidirectional Doppler ultrasound visualized a continuous retrograde blood flow from the sulcus coronarius to the root of the penis in superficial and deep dorsal penile veins as well as in ectopic penile veins, an orthograde blood flow in the sulcus coronarius in cavernosum-glandular shunt

Low scale type II seesaw: present constraints and prospects for displaced vertex searches

The type II seesaw mechanism is an attractive way to generate the observed light neutrino masses. It postulates a SU(2)L-triplet scalar field, which develops an induced vacuum expectation value after electroweak symmetry breaking, giving masses to the neutrinos via its couplings to the lepton SU(2)L-doublets. When the components of the triplet field have masses around the electroweak scale, the model features a rich phenomenology. We discuss the currently allowed parameter space of the minimal low scale type II seesaw model, taking into account all relevant constraints, including charged lepton flavour violation as well as collider searches. We point out that the symmetry protected low scale type II seesaw scenario, where an approximate “lepton number”-like symmetry suppresses the Yukawa couplings of the triplet to the lepton doublets, is still largely untested by the current LHC results. In part of this parameter space the triplet components can be long-lived, potentially leading to a characteristic displaced vertex signature where the doubly-charged component decays into same-sign charged leptons. By performing a detailed analysis at the reconstructed level we find that already at the current run of the LHC a discovery would be possible for the considered parameter point, via dedicated searches for displaced vertex signatures. The discovery prospects are further improved at the HL-LHC and the FCC-hh/SppC

Experimental evaluation of three leak detection and location concepts for space stations

Three leak (or precursor damage modes) detection and location concepts for space station overboard leakage were evaluated experimentally. The techniques are: (1) static and dynamic seal leak detector sensing of moisture or all gases in space cabin atmosphere, (2) active ultrasonic Lamb-wave detection of flaws or cracks in cabin wall, and (3) impact gage detection of stress waves induced in cabin pressure wall by meteoroid or orbital impact. The experimental results obtained in the program demonstrated that all three leak detection and location concepts are feasible. With further development, the methods can be integrated into an effective damage control system for advanced manned earth-orbital systems

Study of damage control systems for space station

Damage control systems for detecting and locating overboard and onboard leak and damage modes on space station

Impairment of germline transmission after blastocyst injection with murine embryonic stem cells cultured with mouse hepatitis virus and mouse minute virus

The aim of this study was to determine the susceptibility of murine embryonic stem (mESCs) to mouse hepatitis virus (MHV-A59) and mouse minute virus (MMVp) and the effect of these viruses on germline transmission (GLT) and the serological status of recipients and pups. When recipients received 10 blastocysts, each injected with 100 TCID50 MHV-A59, three out of five recipients and four out of 14 pups from three litters became seropositive. When blastocysts were injected with 10−5 TCID50 MMVp, all four recipients and 14 pups from four litters remained seronegative. The mESCs replicated MHV-A59 but not MMVp, MHV-A59 being cytolytic for mESCs. Exposure of mESCs to the viruses over four to five passages but not for 6 h affected GLT. Recipients were seropositive for MHV-A59 but not for MMVp when mESCs were cultured with the virus over four or five passages. The data show that GLT is affected by virus-contaminated mESCs

The Forward Physics Facility: Sites, Experiments, and Physics Potential

The Forward Physics Facility (FPF) is a proposal to create a cavern with thespace and infrastructure to support a suite of far-forward experiments at theLarge Hadron Collider during the High Luminosity era. Located along the beamcollision axis and shielded from the interaction point by at least 100 m ofconcrete and rock, the FPF will house experiments that will detect particlesoutside the acceptance of the existing large LHC experiments and will observerare and exotic processes in an extremely low-background environment. In thiswork, we summarize the current status of plans for the FPF, including recentprogress in civil engineering in identifying promising sites for the FPF andthe experiments currently envisioned to realize the FPF's physics potential. Wethen review the many Standard Model and new physics topics that will beadvanced by the FPF, including searches for long-lived particles, probes ofdark matter and dark sectors, high-statistics studies of TeV neutrinos of allthree flavors, aspects of perturbative and non-perturbative QCD, andhigh-energy astroparticle physics.<br

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer : development of a prognostic model through a crowdsourced challenge with open clinical trial data

Background Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease. Methods Data from the comparator arms of four phase 3 clinical trials in first-line metastatic castration-resistant prostate cancer were obtained from Project Data Sphere, comprising 476 patients treated with docetaxel and prednisone from the ASCENT2 trial, 526 patients treated with docetaxel, prednisone, and placebo in the MAINSAIL trial, 598 patients treated with docetaxel, prednisone or prednisolone, and placebo in the VENICE trial, and 470 patients treated with docetaxel and placebo in the ENTHUSE 33 trial. Datasets consisting of more than 150 clinical variables were curated centrally, including demographics, laboratory values, medical history, lesion sites, and previous treatments. Data from ASCENT2, MAINSAIL, and VENICE were released publicly to be used as training data to predict the outcome of interest-namely, overall survival. Clinical data were also released for ENTHUSE 33, but data for outcome variables (overall survival and event status) were hidden from the challenge participants so that ENTHUSE 33 could be used for independent validation. Methods were evaluated using the integrated time-dependent area under the curve (iAUC). The reference model, based on eight clinical variables and a penalised Cox proportional-hazards model, was used to compare method performance. Further validation was done using data from a fifth trial-ENTHUSE M1-in which 266 patients with metastatic castration-resistant prostate cancer were treated with placebo alone. Findings 50 independent methods were developed to predict overall survival and were evaluated through the DREAM challenge. The top performer was based on an ensemble of penalised Cox regression models (ePCR), which uniquely identified predictive interaction effects with immune biomarkers and markers of hepatic and renal function. Overall, ePCR outperformed all other methods (iAUC 0.791; Bayes factor >5) and surpassed the reference model (iAUC 0.743; Bayes factor >20). Both the ePCR model and reference models stratified patients in the ENTHUSE 33 trial into high-risk and low-risk groups with significantly different overall survival (ePCR: hazard ratio 3.32, 95% CI 2.39-4.62, p Interpretation Novel prognostic factors were delineated, and the assessment of 50 methods developed by independent international teams establishes a benchmark for development of methods in the future. The results of this effort show that data-sharing, when combined with a crowdsourced challenge, is a robust and powerful framework to develop new prognostic models in advanced prostate cancer.Peer reviewe