The Alpine-Carpathian-Dinaridic orogenic system: correlation and evolution of tectonic units

A correlation of tectonic units of the Alpine-Carpathian-Dinaridic system of orogens, including the substrate of the Pannonian and Transylvanian basins, is presented in the form of a map. Combined with a series of crustal-scale cross sections this correlation of tectonic units yields a clearer picture of the three-dimensional architecture of this system of orogens that owes its considerable complexity to multiple overprinting of earlier by younger deformations. The synthesis advanced here indicates that none of the branches of the Alpine Tethys and Neotethys extended eastward into the Dobrogea Orogen. Instead, the main branch of the Alpine Tethys linked up with the Meliata-Maliac-Vardar branch of the Neotethys into the area of the present-day Inner Dinarides. More easterly and subsidiary branches of the Alpine Tethys separated Tisza completely, and Dacia partially, from the European continent. Remnants of the Triassic parts of Neotethys (Meliata-Maliac) are preserved only as ophiolitic mélanges present below obducted Jurassic Neotethyan (Vardar) ophiolites. The opening of the Alpine Tethys was largely contemporaneous with the Latest Jurassic to Early Cretaceous obduction of parts of the Jurassic Vardar ophiolites. Closure of the Meliata-Maliac Ocean in the Alps and West Carpathians led to Cretaceous-age orogeny associated with an eclogitic overprint of the adjacent continental margin. The Triassic Meliata-Maliac and Jurassic Western and Eastern Vardar ophiolites were derived from one single branch of Neotethys: the Meliata-Maliac-Vardar Ocean. Complex geometries resulting from out-of-sequence thrusting during Cretaceous and Cenozoic orogenic phases underlay a variety of multi-ocean hypotheses, that were advanced in the literature and that we regard as incompatible with the field evidence. The present-day configuration of tectonic units suggests that a former connection between ophiolitic units in West Carpathians and Dinarides was disrupted by substantial Miocene-age dislocations along the Mid-Hungarian Fault Zone, hiding a former lateral change in subduction polarity between West Carpathians and Dinarides. The SW-facing Dinaridic Orogen, mainly structured in Cretaceous and Palaeogene times, was juxtaposed with the Tisza and Dacia Mega-Units along a NW-dipping suture (Sava Zone) in latest Cretaceous to Palaeogene times. The Dacia Mega-Unit (East and South Carpathian Orogen, including the Carpatho-Balkan Orogen and the Biharia nappe system of the Apuseni Mountains), was essentially consolidated by E-facing nappe stacking during an Early Cretaceous orogeny, while the adjacent Tisza Mega-Unit formed by NW-directed thrusting (in present-day coordinates) in Late Cretaceous times. The polyphase and multi-directional Cretaceous to Neogene deformation history of the Dinarides was preceded by the obduction of Vardar ophiolites onto to the Adriatic margin (Western Vardar Ophiolitic Unit) and parts of the European margin (Eastern Vardar Ophiolitic Unit) during Late Jurassic to Early Cretaceous time

Participatory Research as a Path to Community-Informed, Gender-Fair Machine Translation

Recent years have seen a strongly increased visibility of non-binary people in public discourse. Accordingly, considerations of gender-fair language go beyond a binary conception of male/female. However, language technology, especially machine translation (MT), still suffers from binary gender bias. Proposing a solution for gender-fair MT beyond the binary from a purely technological perspective might fall short to accommodate different target user groups and in the worst case might lead to misgendering. To address this challenge, we propose a method and case study building on participatory action research to include experiential experts, i.e., queer and non-binary people, translators, and MT experts, in the MT design process. The case study focuses on German, where central findings are the importance of context dependency to avoid identity invalidation and a desire for customizable MT solutions.Comment: 11 pages, 4 figure

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an ex vivo 3D platform that accurately captured the genomic diversity of MPNST and could be utilized in a medium-throughput manner for drug screening studies to be validated in vivo using patient-derived xenografts (PDX). METHODS: Genomic analysis was performed on all PDX-tumor pairs. Selected PDX were harvested for assembly into 3D microtissues. Based on prior work in our labs, we evaluated drugs (trabectedin, olaparib, and mirdametinib) ex vivo and in vivo. For 3D microtissue studies, cell viability was the endpoint as assessed by Zeiss Axio Observer. For PDX drug studies, tumor volume was measured twice weekly. Bulk RNA sequencing was performed to identify pathways enriched in cells. RESULTS: We developed 13 NF1-associated MPNST-PDX and identified mutations or structural abnormalities in NF1 (100%), SUZ12 (85%), EED (15%), TP53 (15%), CDKN2A (85%), and chromosome 8 gain (77%). We successfully assembled PDX into 3D microtissues, categorized as robust (\u3e90% viability at 48 h), good (\u3e50%), or unusable (\u3c50%). We evaluated drug response to robust or good microtissues, namely MN-2, JH-2-002, JH-2-079-c, and WU-225. Drug response ex vivo predicted drug response in vivo, and enhanced drug effects were observed in select models. CONCLUSIONS: These data support the successful establishment of a novel 3D platform for drug discovery and MPNST biology exploration in a system representative of the human condition

Gestão humanizada aplicada aos princípios e práticas cooperativistas: estudo de caso em uma agência SICREDI

Cooperativism is relevant for the promotion and transformation of territorial socioeconomic development. Parallel to this, some principles of cooperativism are based on the assumptions of humanized management, which has increasingly been constituted as a value and competitive differential for organizations. Considering these aspects, this study proposed to identify the interrelationships and applications of humanized management assumptions regarding the principles and practices of cooperativism, with a view to contributing to their development and to the development of credit cooperativism. The methodology used was bibliographic research, documentary research and interviews, from a case study in an agency of the Sicredi das Culturas RS/MG cooperative, located in the northwest region of Rio Grande do Sul. The results allowed to identify interrelationships of the cooperative strategies and practices with the assumptions of humanized management; similarities between the very assumptions of humanized management, allowing its segmentation into three essential purposes (well-being, productivity and integral performance); and proximity to these assumptions and their purposes with cooperative principles. Thus, it is concluded that humanized management has a significant interrelationship with cooperative principles and practices, contributing to the optimization of the fundamentals and actions that permeate the internal and external processes implemented in this scenario, constituting a differential value and competitiveness for the Sicredi agency considered in this study, for its respective cooperative and for the Sicredi system, in the cooperative and credit cooperative market, and society. Keywords: Humanized Management Cooperative Principles. Credit Cooperativism.O cooperativismo é relevante para a promoção e transformação do desenvolvimento socioeconômico territorial. Paralelo a isto, alguns princípios do cooperativismo estão alicerçados nos pressupostos da gestão humanizada, que cada vez mais tem se constituído como um diferencial valorativo e competitivo para as organizações. Considerando tais aspectos, este estudo propôs identificar as inter-relações e aplicações dos pressupostos da gestão humanizada quanto aos princípios e práticas do cooperativismo, com vistas a contribuir para seu desenvolvimento e para o desenvolvimento do cooperativismo de crédito. Utilizou-se como metodologia pesquisa bibliográfica, pesquisa documental e entrevistas, a partir de um estudo de caso em uma agência da cooperativa Sicredi das Culturas RS/MG, localizada na região noroeste do Rio Grande do Sul. Os resultados permitiram identificar inter-relações das estratégias e práticas cooperativistas com os pressupostos da gestão humanizada; similaridades entre os próprios pressupostos da gestão humanizada, permitindo sua segmentação em três finalidades essenciais (bem-estar, produtividade e atuação integral); e proximidades destes pressupostos e de suas finalidades com os princípios cooperativistas. Desta forma, concluiu-se que a gestão humanizada tem uma significativa inter-relação com os princípios e com práticas cooperativistas, contribuindo para a otimização dos fundamentos e das ações que permeiam os processos internos e externos implementados neste cenário, constituindo-se como um diferencial valorativo e competitivo para a agência Sicredi considerada neste estudo, para a sua respectiva cooperativa e para o sistema Sicredi, perante o mercado do cooperativismo e do cooperativismo de crédito, e a sociedade. Palavras-chave: Gestão Humanizada. Princípios Cooperativistas. Cooperativismo de Crédito

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use

Bedeutung der sozialen Kompetenzen für die Berufswahl und Übungsmöglichkeiten bereits in der Primarschule

Die Sozialkompetenz wurde in den letzten Jahren zum Modewort schlechthin. In dieser Arbeit wird zum einen der Sammelbegriff „Sozialkompetenz“ theoriebasiert umrissen und zum andern der Stellenwert der sozialen Kompetenzen im Schulunterricht und in den Anfängen der Berufsausbildung anhand einer Umfrage beleuchtet. Da ein Grossteil der Probanden die sozialen Kompetenzen als äusserst wichtig bezeichneten, zeigt der Autor Möglichkeiten auf, wie die sozialen Kompetenzen als Lerninhalt den Weg in die Schulzimmer finden können. Damit die Übungen kindergerecht ausgeführt werden können, wurde im Rahmen dieser Arbeit eine Übungseinheit in einer 3. Klasse durchgeführt. Die daraus gewonnen Erkenntnisse und Beobachtungen werden beschrieben und flossen in die entworfenen Übungsbeispiele ein

El nuevo contexto hidrológico del área agrícola de Bandera, Santiago del Estero, interpretado a partir de datos de nivel freático

Los cambios de uso de la tierra pueden afectar el balance hídrico de los ecosistemas generando condiciones hidrológicas muy diferentes a las originales. El desmonte y agriculturización de Bandera, uno de los focos agrícolas más activos del Chaco semiárido, ha generado ascensos en el nivel freático regional producto de la percolación profunda de excedentes hídricos. A fin de entender el contexto hidrológico actual, este trabajo reúne datos de nivel freático medidos en campos agrícolas entre 2012 y 2019. Los niveles registrados entre 2012 y 2014 varían entre 4 y 8 m de profundidad dependiendo, en parte, de la posición de los lotes en la topografía regional. Entre diciembre de 2014 y febrero de 2015 ocurre un período de altas precipitaciones que desencadena importantes ascensos freáticos y anegamientos. Los registros de nivel posteriores a 2015, sugieren que se ha alcanzado una nueva condición hidrológica en la cual gran parte del área estudiada presenta niveles freáticos que fluctúan dentro de los primeros 3m de profundidad. Esta condición de napa cercana, sumada a la baja porosidad efectiva del suelo, genera rápida respuesta de ascensos de nivel ante lluvias extremas, determinando un aumento en la vulnerabilidad al anegamiento ante periodos de abundante pluviosidad.Fil: Schefer, Eliana Cintia. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucumán-Santiago del Estero. Estación Experimental Agropecuaria Quimilí; ArgentinaFil: Mercau, Jorge Luis. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Nosetto, Marcelo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Jobbagy Gampel, Esteban Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Houspanossian, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; ArgentinaFil: Marano, Roberto. Universidad Nacional del Litoral; ArgentinaFil: Giménez, Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina3° Congreso Internacional del Gran Chaco AmericanoArgentinaUniversidad Nacional de Santiago del EsteroInstituto Nacional de Tecnología Agropecuari

Late cretaceous intra-oceanic magmatism in the internal Dinarides (northern Bosnia and Herzegovina) : implications for the collision of the Adriatic and European plates

The Kozara Mountains of northern Bosnia and Hercegovina form part of the internal Dinarides and host two tectonically juxtaposed ophiolitic successions of different age. The southern part of the Kozara Mountains exposes the Western Vardar Ophiolitic Unit, which was obducted onto the Adriatic margin in the Late Jurassic. The northern part exposes a bimodal igneous succession that was thrust onto the Western Vardar Ophiolitic Unit during the latest Cretaceous to Early Paleogene. This bimodal igneous succession comprises isotropic gabbros, doleritic dikes, basaltic pillow lavas and rhyolites. Pelagic limestones, intercalated with pillow lavas, yielded a Campanian globotruncanid association, consistent with concordant U-Pb ages on zircons from dolerites and rhyolites of 81.39+/-0.11 and 81.6+/-0.12 Ma, respectively. Chondrite-normalised rare earth element patterns of the bimodal igneous rocks show enrichment of LREE over HREE. Primitive mantle-normalised multi-element diagrams do not reveal significant depletion of HFSE. The epsilon Nd(T) and initial (87)Sr/(86)Sr isotopic values range from +4.4 to +6.3 and from 0.70346 to 0.70507 respectively, suggesting an intraoceanic origin. The bimodal igneous succession is unconformably overlain by Maastrichtian to Paleocene siliciclastics that contain abundant ophiolitic detritus, suggesting reworking of the Campanian magmatics. An Eocene turbiditic sandstone succession unconformably covers both the Western Vardar Ophiolitic Unit and the Late Cretaceous bimodal igneous successions. These observations suggest that the Adriatic Plate and the Europe-derived Tisza and Dacia Mega-Units were still separated by a deep basin floored by oceanic lithosphere until the Campanian and that its closure did not occur before the Maastrichtian to earliest Paleogene. This Late Cretaceous oceanic domain probably represented a remnant of the Vardar Ocean, or alternatively, the Alpine Tethys; possibly the traces of both oceanic domains were connected in the are

Arts et sciences du romantisme allemand

L’interprétation communément reçue du romantisme est de considérer qu’il est un phénomène exclusivement esthétique et artistique. Or il n’en est rien. D’un côté, l’esthétique y est adossée à la science dans trois domaines tout particulièrement : en mathématiques, l’idée combinatoire ne manque pas de retentir sur la poétique ; en physique, la théorie des champs permet d’introduire une philosophie romantique de la nature ; en biologie, la théorie de la forme permet de penser une morphologie naissante. D’un autre côté et inversement, les idées esthétiques débordent sur la science comme le montre l’approche goethéenne des phénomènes naturels. Au centre de cet espace théorique et du débat qu’il engendre, il faut placer la pensée de Kant comme le point focal de l’ouvrage. Aller de la science vers l’art ou de l’art vers la science afin de faire valoir leur unité qui est celle de l’esthétique et de l’épistémologie, telle est l’ambition du romantisme allemand. Telle est aussi l’ambition des études réunies ici