36 research outputs found
Scattering theory for Klein-Gordon equations with non-positive energy
We study the scattering theory for charged Klein-Gordon equations:
\{{array}{l} (\p_{t}- \i v(x))^{2}\phi(t,x) \epsilon^{2}(x,
D_{x})\phi(t,x)=0,[2mm] \phi(0, x)= f_{0}, [2mm] \i^{-1} \p_{t}\phi(0, x)=
f_{1}, {array}. where: \epsilon^{2}(x, D_{x})= \sum_{1\leq j, k\leq
n}(\p_{x_{j}} \i b_{j}(x))A^{jk}(x)(\p_{x_{k}} \i b_{k}(x))+ m^{2}(x),
describing a Klein-Gordon field minimally coupled to an external
electromagnetic field described by the electric potential and magnetic
potential . The flow of the Klein-Gordon equation preserves the
energy: h[f, f]:= \int_{\rr^{n}}\bar{f}_{1}(x) f_{1}(x)+
\bar{f}_{0}(x)\epsilon^{2}(x, D_{x})f_{0}(x) - \bar{f}_{0}(x) v^{2}(x) f_{0}(x)
\d x. We consider the situation when the energy is not positive. In this
case the flow cannot be written as a unitary group on a Hilbert space, and the
Klein-Gordon equation may have complex eigenfrequencies. Using the theory of
definitizable operators on Krein spaces and time-dependent methods, we prove
the existence and completeness of wave operators, both in the short- and
long-range cases. The range of the wave operators are characterized in terms of
the spectral theory of the generator, as in the usual Hilbert space case
Hierarchical Neutrino Mass Matrices, CP violation and Leptogenesis
In this work we study examples of hierarchical neutrino mass matrices
inspired by family symmetries, compatible with experiments on neutrino
oscillations, and for which there is a connection among the low energy CP
violation phase associated to neutrino oscillations, the phases appearing in
the amplitude of neutrinoless double beta decay, and the phases relevant for
leptogenesis. In particular, we determine the predictions from a texture based
on an underlying SU(3) family symmetry together with a GUT symmetry, and a
strong hierarchy for the masses of the heavy right handed Majorana masses. We
also give some examples of inverted hierarchies of neutrino masses, which may
be motivated in the context of U(1) family symmetries.Comment: 34 pages. Replaced with published version -typos, corrections and
references adde
Chapter 9.: The complexity of open spaces at Çatalhöyük
FGW – Publications not associated with a particular research are
Gauge and Scheme Dependence of Mixing Matrix Renormalization
We revisit the issue of mixing matrix renormalization in theories that
include Dirac or Majorana fermions. We show how a gauge-variant on-shell
renormalized mixing matrix can be related to a manifestly gauge-independent one
within a generalized scheme of renormalization. This
scheme-dependent relation is a consequence of the fact that in any scheme of
renormalization, the gauge-dependent part of the mixing-matrix counterterm is
ultra-violet safe and has a pure dispersive form. Employing the unitarity
properties of the theory, we can successfully utilize the afore-mentioned
scheme-dependent relation to preserve basic global or local symmetries of the
bare Lagrangian through the entire process of renormalization. As an immediate
application of our study, we derive the gauge-independent renormalization-group
equations of mixing matrices in a minimal extension of the Standard Model with
isosinglet neutrinos.Comment: 31 pages, LaTeX, uses axodraw.st
Collider aspects of flavour physics at high Q
This review presents flavour related issues in the production and decays of
heavy states at LHC, both from the experimental side and from the theoretical
side. We review top quark physics and discuss flavour aspects of several
extensions of the Standard Model, such as supersymmetry, little Higgs model or
models with extra dimensions. This includes discovery aspects as well as
measurement of several properties of these heavy states. We also present public
available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era
of the LHC'', Geneva, Switzerland, November 2005 -- March 200
The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer s disease.
NoThe 5-HT1A receptor has been extensively studied over the last two decades. There is a plethora of information describing its anatomical, physiological and biochemical roles in the brain. In addition, the development of selective pharmacological tools coupled with our understanding of psychiatric pathology has lead to multiple hypotheses for the therapeutic utility of 5- and in particular 5-HT1A receptor antagonists. Over the last decade it has been suggested that 5-HT1A receptor antagonists may have therapeutic utility in such diseases as depression, anxiety, drug and nicotine withdrawal as well as schizophrenia. However, a very compelling rationale has been developed for the therapeutic potential of 5-HT1A receptor antagonists in Alzheimer s disease and potentially other diseases with associated cognitive dysfunction. Receptor blockade by a 5-HT1A receptor antagonist appears to enhance activation and signaling through heterosynaptic neuronal circuits known to be involved in cognitive processes and, as such, represents a novel therapeutic approach to the treatment of cognitive deficits associated with Alzheimer s disease and potentially other disorders with underlying cognitive dysfunction
WAY 405, a new silent 5-HT1A receptor antagonist with low affinity for vascular alpha1-adrenoceptors
Assessment of carotid artery dose in the treatment of nasopharyngeal cancer with IMRT versus conventional radiotherapy
Purpose: To determine the radiation dose to the carotid artery in nasopharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT) and to compare it to the dose delivered by a conventional three-field (3F) technique. Materials and methods: Sixteen patients with nasopharyngeal cancer who were treated at UCSF with IMRT were selected for this analysis. 3F plans were reconstructed for comparison. The carotid arteries were retrospectively contoured, and the dose received by each of the 32 carotid arteries was determined for both IMRT and 3F plans. A subset of 8 patients with N0/N1 nodal disease was selected for IMRT replanning using additional constraints to reduce the dose to the arteries. Results: Using the standard prescription doses for IMRT and 3F plans, the dose delivered to 95% of the tumor volume was significantly higher in the IMRT plans, reflecting the greater conformality of this technique. The median mean dose to the carotid arteries was 65.7 Gy with IMRT vs. 58.4 Gy with 3F (p < 0.001). After the application of dose constraints to the carotid arteries, it was possible to reduce the mean carotid dose to 54 Gy in the IMRT replans. Conclusions: IMRT achieves a higher tumoricidal dose and superior clinical target volume coverage, but results in an increase in the carotid artery dose as compared to conventional 3F technique. With careful IMRT planning, it is possible to constrain the carotid dose for a subset of patients with low-risk neck disease. Further study is necessary to quantify the long-term clinical impact of this intervention