Highly variable upper and abyssal overturning cells in the South Atlantic

The Meridional Overturning Circulation (MOC) is a primary mechanism driving oceanic heat redistribution on Earth, thereby affecting Earth’s climate and weather. However, the full-depth structure and variability of the MOC are still poorly understood, particularly in the South Atlantic. This study presents unique multiyear records of the oceanic volume transport of both the upper (~3100 meters) overturning cells based on daily moored measurements in the South Atlantic at 34.5°S. The vertical structure of the time-mean flows is consistent with the limited historical observations. Both the upper and abyssal cells exhibit a high degree of variability relative to the temporal means at time scales, ranging from a few days to a few weeks. Observed variations in the abyssal flow appear to be largely independent of the flow in the overlying upper cell. No meaningful trends are detected in either cell.Fil: Kersalé, Marion. National Ocean And Atmospheric Administration; Estados Unidos. University of Miami; Estados UnidosFil: Meinen, Christopher S.. National Ocean And Atmospheric Administration; Estados UnidosFil: Perez, Renellys C.. National Ocean And Atmospheric Administration; Estados UnidosFil: Le Hénaff, Matthieu. National Ocean And Atmospheric Administration; Estados Unidos. University of Miami; Estados UnidosFil: Valla, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; ArgentinaFil: Lamont, Tarron. University of Cape Town; SudáfricaFil: Sato, Olga T.. Universidade de Sao Paulo; BrasilFil: Dong, Shenfu. National Ocean And Atmospheric Administration; Estados UnidosFil: Terre, T.. University of Brest; Francia. Centre National de la Recherche Scientifique; FranciaFil: van Caspel, M.. Universidade de Sao Paulo; BrasilFil: Chidichimo, María Paz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; ArgentinaFil: van den Berg, Marcel Alexander. Department of Environmental Affairs; SudáfricaFil: Speich, Sabrina. University Of Cape Town; SudáfricaFil: Piola, Alberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ecole Normale Superieure. Laboratoire de Meteorologie Dynamique; Francia. Ministerio de Defensa. Armada Argentina. Servicio de Hidrografía Naval. Departamento Oceanografía; Argentina. Instituto Franco-Argentino sobre Estudios del Clima y sus Impactos; Argentina. Universidad de Buenos Aires; ArgentinaFil: Campos, Edmo. Universidade de Sao Paulo; Brasil. American University Of Sharjah.; Emiratos Árabes UnidosFil: Ansorge, Isabelle. University of Cape Town; SudáfricaFil: Volkov, Denis L.. University of Miami; Estados Unidos. National Ocean And Atmospheric Administration; Estados UnidosFil: Lumpkin, Rick. National Ocean And Atmospheric Administration; Estados UnidosFil: Garzoli, S. L.. University of Miami; Estados Unidos. National Ocean And Atmospheric Administration; Estados Unido

Hydrogen sensors based on electrophoretically deposited Pd nanoparticles onto InP

Electrophoretic deposition of palladium nanoparticles prepared by the reverse micelle technique onto InP substrates is addressed. We demonstrate that the substrate pre-deposition treatment and the deposition conditions can extensively influence the morphology of the deposited palladium nanoparticle films. Schottky diodes based on these films show notably high values of the barrier height and of the rectification ratio giving evidence of a small degree of the Fermi level pinning. Moreover, electrical characteristics of these diodes are exceptionally sensitive to the exposure to gas mixtures with small hydrogen content

Warming Trend in Antarctic Bottom Water in the Vema Channel in the South Atlantic

The excess heat absorbed from the atmosphere has increased the temperature in the upper layers of the ocean (<2,000 m). In the abyss, infrequently repeated ship sections, deep Argo float measurements, and sparse moored observations have found signs of warming in the Southwest Atlantic, possibly linked to changes in the Weddell Sea. We present a new moored temperature time series sampled near the bottom in the Vema Channel, from February 2019 to August 2020. Together with historical data, the combined record confirms the warming of the abyssal waters, with an increase of 0.059°C in potential temperature between January 1991 and August 2020, embedded within intense high-frequency variability. Moreover, the data suggest the possibility of an accelerated warming, with a change in the temperature trend from 0.0016°C yr−1, between the early 1990s and 2005, to 0.0026°C yr−1 afterwards

Antiretroviral activity of 5-azacytidine during treatment of a HTLV-1 positive myelodysplastic syndrome with autoimmune manifestations

Myelodysplastic syndromes (MDS) are often accompanied by autoimmune phenomena. The underlying mechanisms for these associations remain uncertain, although T cell activation seems to be important. Human T-lymphotropic virus (HTLV-1) has been detected in patients with myelodysplastic syndromes, mostly in regions of the world which are endemic for the virus, and where association of HTLV-1 with rheumatological manifestation is not rare. We present here the case of a 58 year old man who presented with cytopenias, leukocytoclastic vasculitis of the skin and glomerulopathy, and was diagnosed as MDS (refractory anemia with excess blasts - RAEB 1). The patient also tested positive for HTLV-1 by PCR. After 8 monthly cycles of 5-azacytidine he achieved a complete hematologic remission. Following treatment, a second PCR for HTLV-1 was carried out and found to be negative. This is the first report in the literature of a HTLV-1-positive MDS with severe autoimmune manifestations, which was treated with the hypomethylating factor 5-azacitidine, achieving cytogenetic remission with concomitant resolution of the autoimmune manifestations, as well as HTLV-1-PCR negativity. HTLV-1-PCR negativity may be due to either immune mediated clearance of the virus, or a potential antiretroviral effect of 5-azacytidine. 5-azacytidine is known for its antiretroviral effects, although there is no proof of its activity against HTLV-1 infection in vivo

Seamount Observatory and SAMOC Overturning, Cruise No. MSM60, January 04 - February 01, 2017, Cape Town (South Africa) - Montevideo (Uruguay)

The scientific program of the MARIA S. MERIAN MSM60 expedition was the first basin-wide section across the South Atlantic following the SAMBA/SAMOC line at 34°30'S. The scientific program consisted of full water depth sampling (up to 5300m) using the CTD/O2/lADCP rosette system. The water samples have been analysed on board for oxygen, dissolved inorganic carbon, alkalinity, salinity, CFC12, and SF6. In addition samples have been taken for later analysis of nutrients, chlorophyll structure (HPLC), POC, and nitrogen isotope analysis. The sampling and measurements where performed against highest standards defined in the GO-SHIP cruise recommendations (http://www.go-ship.org/). An Underwater Vision Profiler (UVP) was mounted on the CTD for full depth particle photography. Underway measurements included hull mounted ADCPs (75kHz and 38kHz) and high resolution (11nm) XBT probes. The data will be analysed for multiple purposes including calculation of the meridional volume, heat, and freshwater transport across the SAMBA/SAMOC line. The biogeochemical data will be compared to historical data acquired at neighbouring sections, e.g. along the WOCE/GO-SHIP A10 section (30°S) occupied by RV Meteor in 1993 as part of the WOCE program. The MSM60 expedition is a contribution to the EU H-2020 AtlantOS project

Diffusion of MMPs on the Surface of Collagen Fibrils: The Mobile Cell Surface – Collagen Substratum Interface

Remodeling of the extracellular matrix catalyzed by MMPs is central to morphogenetic phenomena during development and wound healing as well as in numerous pathologic conditions such as fibrosis and cancer. We have previously demonstrated that secreted MMP-2 is tethered to the cell surface and activated by MT1-MMP/TIMP-2-dependent mechanism. The resulting cell-surface collagenolytic complex (MT1-MMP)2/TIMP-2/MMP-2 can initiate (MT1-MMP) and complete (MMP-2) degradation of an underlying collagen fibril. The following question remained: What is the mechanism of substrate recognition involving the two structures of relatively restricted mobility, the cell surface enzymatic complex and a collagen fibril embedded in the ECM? Here we demonstrate that all the components of the complex are capable of processive movement on a surface of the collagen fibril. The mechanism of MT1-MMP movement is a biased diffusion with the bias component dependent on the proteolysis of its substrate, not adenosine triphosphate (ATP) hydrolysis. It is similar to that of the MMP-1 Brownian ratchet we described earlier. In addition, both MMP-2 and MMP-9 as well as their respective complexes with TIMP-1 and -2 are capable of Brownian diffusion on the surface of native collagen fibrils without noticeable dissociation while the dimerization of MMP-9 renders the enzyme immobile. Most instructive is the finding that the inactivation of the enzymatic activity of MT1-MMP has a detectable negative effect on the cell force developed in miniaturized 3D tissue constructs. We propose that the collagenolytic complex (MT1-MMP)2/TIMP-2/MMP-2 represents a Mobile Cell Surface – Collagen Substratum Interface. The biological implications of MT1-MMP acting as a molecular ratchet tethered to the cell surface in complex with MMP-2 suggest a new mechanism for the role of spatially regulated peri-cellular proteolysis in cell-matrix interactions

Movements and Population Structure of Humpback Whales in the North Pacific

Despite the extensive use of photographic identification methods to investigate humpback whales in the North Pacific, few quantitative analyses have been conducted. We report on a comprehensive analysis of interchange in the North Pacific among three wintering regions (Mexico, Hawaii, and Japan) each with two to three subareas, and feeding areas that extended from southern California to the Aleutian Islands. Of the 6,413 identification photographs of humpback whales obtained by 16 independent research groups between 1990 and 1993 and examined for this study, 3,650 photographs were determined to be of suitable quality. A total of 1,241 matches was found by two independent matching teams, identifying 2,712 unique whales in the sample (seen one to five times). Site fidelity was greatest at feeding areas where there was a high rate of resightings in the same area in different years and a low rate of interchange among different areas. Migrations between winter regions and feeding areas did not follow a simple pattern, although highest match rates were found for whales that moved between Hawaii and southeastern Alaska, and between mainland and Baja Mexico and California. Interchange among subareas of the three primary wintering regions was extensive for Hawaii, variable (depending on subareas) for Mexico, and low for Japan and reflected the relative distances among subareas. Interchange among these primary wintering regions was rare. This study provides the first quantitative assessment of the migratory structure of humpback whales in the entire North Pacific basin

Search for large extra dimensions in the production of jets and missing transverse energy in p(p)over-bar collisions at root s=1.96 TeV

We present the results of a search for new physics in the jets plus missing transverse energy data sample collected from 368 pb(-1) of p (p) over bar collisions at root s = 1.96 TeV recorded by the Collider Detector at Fermilab. We compare the number of events observed in the data with a data-based estimate of the standard model backgrounds contributing to this signature. We observe no significant excess of events, and we interpret this null result in terms of lower limits on the fundamental Planck scale for a large extra dimensions scenario

Search for long-lived doubly charged Higgs bosons in p(p)over-bar collisions at root s=1.96 TeV

We present a search for long-lived doubly charged Higgs bosons (H+/-+/-), with signatures of high ionization energy loss and muonlike penetration. We use 292 pb(-1) of data collected in p (p) over bar collisions at root s=1.96 TeV by the CDF II detector at the Fermilab Tevatron. Observing no evidence of long-lived doubly charged particle production, we exclude H-L(+/-+/-) and H-R(+/-+/-) bosons with masses below 133 GeV/c(2) and 109 GeV/c(2), respectively. In the degenerate case we exclude H+/-+/- mass below 146 GeV/c(2). All limits are quoted at the 95% confidence level