Strategy of textile design: Use of design methodology tools in the creative process

This paper is based on the study of the application of the tools of design methodology in technological textile products also called smart fabrics. The application of the design methodology in the creative process took place in a textile factory by checking the contributions to the creativity, innovation, and quality. The purpose of studying the design practices in the use of resources and methods of the textile contributes to the development of the product and also meets the needs of customers. In this context, modifications were necessary to the development tools in the creative process that may cause the best use, reduction and cost containment improving the overall quality and meeting customers’ needs. There is much talk about making products, refining and improving, but there is hardly any detailed application on how to carry it out, what parameters are used to such an achievement and what solutions are applied to the design process. The application in creative processes and product design follows parameters that are often provided by customers. The concepts that are linked to these product development processes, and the understanding of their purpose helps reveal the customers’ needs.Keywords: design methodology, creative process, textile design

Strategy of textile design: Use of design methodology tools in the creative process

This paper is based on the study of the application of the tools of design methodology in technological textile products also called smart fabrics. The application of the design methodology in the creative process took place in a textile factory by checking the contributions to the creativity, innovation, and quality. The purpose of studying the design practices in the use of resources and methods of the textile contributes to the development of the product and also meets the needs of customers. In this context, modifications were necessary to the development tools in the creative process that may cause the best use, reduction and cost containment improving the overall quality and meeting customers’ needs. There is much talk about making products, refining and improving, but there is hardly any detailed application on how to carry it out, what parameters are used to such an achievement and what solutions are applied to the design process. The application in creative processes and product design follows parameters that are often provided by customers. The concepts that are linked to these product development processes, and the understanding of their purpose helps reveal the customers’ needs.Keywords: design methodology, creative process, textile design

Origem do plexo braquial do macaco Cebus apella

O Cebus apella, animal das matas do continente Sul-americano, distribui-se geograficamente por quase todo o Brasil. Apresenta satisfatória adaptação ao cativeiro, condição em que se reproduz com facilidade. Assim, focalizamos o Cebus apella, na origem de seu plexo braquial. Nosso objetivo é dar seqüência ao conhecimento de sua anatomia, visando também ao fornecimento de subsídios para interpretações anátomo-funcionais, comparativamente ao homem e aos animais domésticos. Foram utilizados 20 animais, sendo 10 machos e 10 fêmeas, adultos, pertencentes ao acervo de pesquisas da Universidade Federal de Uberlândia, Uberlândia - MG. Preparamos as peças anatômicas segundo a metodologia usual em estudos anatômicos. Dos espécimes dissecados, o plexo braquial do Cebus apella está constituído por raízes de C5 a T1 em 55,00 ±± 11,12%, de C5 a T2 em 25,00 ±± 9,68%, de C4 a T1 em 15,00 ±± 7,98% e de C4 a T2 em 5,00 ±± 4,87%. Observou-se a ocorrência de pré e de pós-fixação do plexo, bem como o seu deslocamento cranial e caudal. Em conclusão, o plexo braquial do Cebus apella está constituído por raízes de C5 a T1.The monkey Cebus apella, native to South American forests, is geographically distributed through the Brazilian land and presents satisfactory adaptation to the captive life showing great capacity of reproduction. Thus, we have described the origin of the brachial plexus in the monkey Cebus apella. The aim of this study was to add information for morphofunctional and comparative studies focusing on Cebus apella, humans and domestic animals. Twenty adult animals, 10 males and 10 females, belonging to the collection of Anatomy Laboratory of the Federal University of Uberlândia were obtained and prepared through fixation and dissection. In the dissected specimens, the brachial plexus of Cebus apella was comprised of nerve roots from C5 to T1 (55,00 ±± 11,12%), from C5 to T2 (25,00 ±± 9,68%), from C4 to T1 (15,00 ±± 7,98%) and from C4 to T2 (5,00 ±± 4,87%). In addition, the occurrence of pre- and post- fixation of the plexus as well as its cranial and caudal extent have been discussed. In conclusion, the brachial plexus of Cebus apella is constituted by nerve roots from C5 to T1

Origem do plexo braquial do macaco Cebus apella

O Cebus apella, animal das matas do continente Sul-americano, distribui-se geograficamente por quase todo o Brasil. Apresenta satisfatória adaptação ao cativeiro, condição em que se reproduz com facilidade. Assim, focalizamos o Cebus apella, na origem de seu plexo braquial. Nosso objetivo é dar seqüência ao conhecimento de sua anatomia, visando também ao fornecimento de subsídios para interpretações anátomo-funcionais, comparativamente ao homem e aos animais domésticos. Foram utilizados 20 animais, sendo 10 machos e 10 fêmeas, adultos, pertencentes ao acervo de pesquisas da Universidade Federal de Uberlândia, Uberlândia - MG. Preparamos as peças anatômicas segundo a metodologia usual em estudos anatômicos. Dos espécimes dissecados, o plexo braquial do Cebus apella está constituído por raízes de C5 a T1 em 55,00 ±± 11,12%, de C5 a T2 em 25,00 ±± 9,68%, de C4 a T1 em 15,00 ±± 7,98% e de C4 a T2 em 5,00 ±± 4,87%. Observou-se a ocorrência de pré e de pós-fixação do plexo, bem como o seu deslocamento cranial e caudal. Em conclusão, o plexo braquial do Cebus apella está constituído por raízes de C5 a T1

Constituição do plexo lombar do macaco Cebus apella

Os primatas não-humanos têm se constituído em importante grupo dentre os animais submetidos a estudos diversos, o que se reveste de suma importância até para o entendimento de sua própria evolução, somando-se ao fato de que o conhecimento pormenorizado de sua Anatomia pode representar fator importante para sua preservação e proteção. Por outro lado, dentro do sistema neural, mostra particular interesse o estudo comparativo da composição do plexo lombar, representativo da origem dos nervos que se destinam aos membros pélvicos, segmento anatômico este de considerável importância, relativamente aos aspectos evolutivos de postura e locomoção. O objetivo deste trabalho é conhecer a origem, a composição do plexo lombar do Cebus apella, visando um melhor entendimento da Anatomia deste animal. A literatura ao nosso alcance não revelou citação alguma específica sobre o tema, para essa espécie. Utilizamos 20 animais, sendo 10 machos e 10 fêmeas. A preparação das peças anatômicas seguiu metodologia usual empregada em estudos anatômicos. Após análise cuidadosa das peças, verificou-se que o plexo lombar do Cebus apella, está quase sempre separado dos plexos lombar, sacral e coccígeo. Há consideráveis variações entre espécimes e entre antímeros de um mesmo animal. Há participação na formação do plexo lombar, de raízes L2 a L5, com maior freqüência de L3 e L4. Em 75,00% dos casos, o plexo lombar direito está formado por L2, L3 e L4, em 55,00%, apenas por L3 e L4, em 20,00% por L2, L3, L4 e em 5,00%, L5 contribui, enquanto que no antímero esquerdo em 80,00% houve participação de L2, L3 e L4; sendo que, em 50,00% de L3 e L4, em 30,00% de L2, L3, L4 e L5 e em 15,00%, L5 está presente e em 5,00% apenas L2 e L3. O número de anastomoses é variável.The non-human primates have been considered an important group among the diverse studied animals, having a great interest not only for the understanding of its own evolution, but also due to the fact that the detailed knowledge of its Anatomy can represent a relevant factor for its preservation and protection. In addition, concerning the neural system, the comparative study on the composition of the lumbo-sacral plexus representing the origin of the nerves that are destined to the pelvic members, shows a particular interest for being an anatomical segment involved in evolutionary aspects of posture and locomotion. The aim of this work was to study the origin, composition of the lumbar plexus in monkey Cebus apella in order to obtain a better comprehension of the Anatomy in this animal. Previous studies have not demonstrated any findings on the topic in this species. Twenty animals, 10 male and 10 female, were obtained from the conserved anatomical piece collection of the Anatomy Laboratory of the Federal University of Uberlândia. The preparation of the specimens consisted of fixation and dissection according to the routine procedures used in anatomical studies. After a detailed analysis of the specimens, it was verified that the lumbar plexus of Cebus apella is almost always separated in lumbar, sacral and coccygeal segments. There were considerable variations among the specimens and between the sides. The roots L2-L5 participated in the formation of the lumbar plexus, with higher frequency of L3 and L4, while the roots L4-S4. The right lumbar plexus was formed by L2, L3, and L4 (75.00% of cases), L3 and L4 (55.00%), L2, L3, L4 (20.00%), and L2, L3, L4 and L5 (5.00%), while on the left side there was participation of L2, L3, and L4 (80.00%), being that L3 and L4 (50.00%) and L2, L3, L4 and L5 (30.00%), and L5 is present in 15.00% and L2 and L3 in 5.00%. The number of anastomoses is variable

Excisão cirúrgica de um osteocondroma de raiz nervosa da cauda equina de cão

Background: Spinal neoplasms are classified into extradural, intradural/extramedullary or intramedullary. Intradural/extramedullary tumors include meningiomas and nerve sheath tumors, which arise from meninges or peripheral nerves around the spinal cord. Clinical signs are related to dysfunction of the involved nerve and include pain, nerve root signature and atrophy. Osteochondromas are benign tumors located within the bone, on its surface or in extra-osseous regions, when they are classified as soft tissue osteochondoma. The aim of this study is to describe a case of an osteochondroma in a nervous root of the cauda equina in a dog, whose surgical resection allowed the resolution of the clinical signs.Case: A 12-year-old, male, Labrador Retriever dog, was presented with a 40-day history of progressive, painful, pelvic limb paresis, with no improvement when treated with analgesics and acupuncture. Neurological abnormalities included paraparesis, sometimes worse in the left pelvic limb, that was carried flexed at the level of the stifle, hindlimb atrophy, decreased interdigital reflexes and pain in the lumbar spinal region, mainly over L6 vertebra. Results of blood count and serum biochemical analysis were unremarkable. Computed tomography (CT) of the lumbosacral area was performed and the evaluation of images in transverse and reconstructed dorsal and sagittal planes allowed the visualization of a hyperattenuating and calcified round structure with 8 mm x 6 mm, in the left side of vertebral canal, at the level of caudal epiphysis of L6. Lumbosacral (L7-S1) CT abnormalities, as subchondral sclerosis, mild disc margin bulging, spondylosis deformans and foraminal proliferation were also observed but were considered clinically insignificant. Then, a dorsal L6 laminectomy was performed and after opening of the vertebral canal it was observed the presence of an ovoid mass, in the left side of the medullary cone, measuring approximately 0.9 cm in length, originating from a sacral nerve root. This structure was excised and submitted to histopathological evaluation. The dog improved after surgery without any complications, and neurological functions were gradually recovered. The histopathology of the mass was confirmed as an osteochondroma.Discussion: The history and neurologic examination findings as well the improvement after surgery were compatible with the lesion visualized by TC in L6, rather than the degenerative changes in L7-S1. Regarding the position of the mass, the main differential would be nerve sheath tumor, one of the most common types of primary neoplasia of the peripheral nervous system, however in a CT study in dogs with brachial plexus and nerve roots neoplasms, calcification of the tumor was not observed. Most of benign cartilaginous tumors of soft tissue are chondromas/osteochondromas, and this lesion should not be confused with multiple osteochondroma or multiple cartilaginous exostoses, which have been reported as multifocal, proliferative lesions involving the surface of ribs, vertebrae and pelvis of young dogs. If this lesion is unique, it is called osteochondroma. There are two reports of chondromas into the first lumbar vertebrae of dogs, with adherence to the floor of the vertebral canal and one report of an osteochondroma originated from the left pedicle of T11 in a cat. Radiculopathy and myelopathy caused by osteochondromas inside the spine are rare in humans and description of this tumor arising from nerve roots were not found in the veterinary literature. Probably the origin of the mass was metaplasia of the meninges surrounding the nervous root. In conclusion, neurological examination, CT and surgical exploration allowed the diagnosis and removal of a soft tissue osteochondroma, a rare benign tumor, with good patient recovery

In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity

Tetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin which has shown significant activity on trypomastigote forms of Trypanosoma cruzi. In this work, the in vitro metabolism of grandisin was studied in the pig cecum model and by biomimetic phase I reactions, aiming at an ensuing a preclinical pharmacokinetic investigation. Although grandisin exhibited no metabolization by the pig microbiota, one putative metabolite was formed in a biomimetic model using Jacobsen catalyst. The putative metabolite was tested against T. cruzi revealing loss of activity in comparison to grandisin.FINEPFINEPFAPESPFAPESPCAPESCAPESCNPqCNP

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality

Studies of new Higgs boson interactions through nonresonant HH production in the b¯bγγ fnal state in pp collisions at √s = 13 TeV with the ATLAS detector

A search for nonresonant Higgs boson pair production in the b ¯bγγ fnal state is performed using 140 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. This analysis supersedes and expands upon the previous nonresonant ATLAS results in this fnal state based on the same data sample. The analysis strategy is optimised to probe anomalous values not only of the Higgs (H) boson self-coupling modifer κλ but also of the quartic HHV V (V = W, Z) coupling modifer κ2V . No signifcant excess above the expected background from Standard Model processes is observed. An observed upper limit µHH < 4.0 is set at 95% confdence level on the Higgs boson pair production cross-section normalised to its Standard Model prediction. The 95% confdence intervals for the coupling modifers are −1.4 < κλ < 6.9 and −0.5 < κ2V < 2.7, assuming all other Higgs boson couplings except the one under study are fxed to the Standard Model predictions. The results are interpreted in the Standard Model efective feld theory and Higgs efective feld theory frameworks in terms of constraints on the couplings of anomalous Higgs boson (self-)interactions