Ecological-transaction model approach of adolescents’ parental maltreatment and peer-bullying: the moderating role of bullying at the classroom

INTRODUCTION: The present study examined the ecological-transactional model delineated by Cicchetti and Lynch (1993) and the nature of the association between adolescents’ parental maltreatment and victimization and bullying at school. METHOD: Multivariate multilevel regression analyses were conducted on a sample of 2.852 adolescents between the ages of 12 and 17 from 25 secondary schools. Data was nested across 133 classrooms. Classrooms level variables and individual variables in relationship to parental maltreatment, behavioural disorders, sex, and bullying and victimization were included in the analysis. RESULTS: Results indicated that adolescents who reported suffering violence at home, showed more vulnerability to becoming victims of bullying at school, with the relationship being moderated by the level of bullying in the classroom. It was also examined the role of behavioural disorders and a relation between these factors was found amongst the bullies but not the victims. DISCUSSION AND CONCLUSION: This study uses the systemic perspective of ecological-transactional model on child maltreatment to show the importance between the school and home microsystems in the perpetuation of victimization. The results imply that what children experience at home might cause emotional and behavioural differences in varying classroom climates at school. Therefore, understanding the interactions between systems’ transaction of socialisation mechanisms might contribute for effective anti-bullying programs

Workforce capacity planning for proactive troubleshooting in the Network Operations Center

Modern data centers require that a Network Operations Center is continuously monitoring network health, desirably in order to take proactive action before potential trouble occurs. In this paper, we contribute to the capacity planning of the workforce in charge. To this end, we have extensively analyzed, with real-world data, behavioral changes in a large server population in a data center. Our findings allow classifying such behavioral changes, which may be indicative of potential trouble, into relevance regions using a ranking mechanism. Then, the proposed methodology allows, together with an estimation of the time to analyze, assessing the workforce necessary to proactively tackle the behavioral changes observed. We conclude with a case study from a working data center, including a hands-on implementation of a traffic analysis solution to detect such behavioral changes and an estimation of the needed workforce to analyze them. Our results show that between 4 and 5 network managers are an adequate number for handling behavioral-changes analysis in a large enterprise data centerThis research has been partially funded the Ministry of Science and Innovation of Spain through Project AGILEMON under Grant AEI PID2019-104451RB-C21 and by Naudit High Performance Computing and Networking under art. 83. project

Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer.

Background. The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). Patients and methods. We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. Results. Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm3 were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm3 (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm3 (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. Conclusions. MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm3 was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer.post-print403 K

A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana

Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and synchronize plant growth and development with environmental changes. Transcription and alternative splicing are thought to be tightly linked and coordinated, at least in part, through a network of transcriptional and splicing regulatory factors that interact with the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II. One of the proteins that has been shown to play such a role in yeast and mammals is pre-mRNA-PROCESSING PROTEIN 40 (PRP40, also known as CA150, or TCERG1). In plants, members of the PRP40 family have been identified and shown to interact with the CTD of RNA Pol II, but their biological functions remain unknown. Here, we studied the role of AtPRP40C, in Arabidopsis thaliana growth, development and stress tolerance, as well as its impact on the global regulation of gene expression programs. We found that the prp40c knockout mutants display a late-flowering phenotype under long day conditions, associated with minor alterations in red light signaling. An RNA-seq based transcriptome analysis revealed differentially expressed genes related to biotic stress responses and also differentially expressed as well as differentially spliced genes associated with abiotic stress responses. Indeed, the characterization of stress responses in prp40c mutants revealed an increased sensitivity to salt stress and an enhanced tolerance to Pseudomonas syringae pv. maculicola (Psm) infections. This constitutes the most thorough analysis of the transcriptome of a prp40 mutant in any organism, as well as the first characterization of the molecular and physiological roles of a member of the PRP40 protein family in plants. Our results suggest that PRP40C is an important factor linking the regulation of gene expression programs to the modulation of plant growth, development, and stress responses.Fil: Hernando, Carlos Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: García Hourquet, Mariano. Fundación Instituto Leloir; ArgentinaFil: de Leone, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Careno, Daniel Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

High Performance Algorithms and Implementations Using Sparse and Parallelization Techniques on MBS

In this paper we will see how the efficiency of the MBS simulations can be improved in two different ways, by considering both an explicit and implicit semi-recursive formulation. The explicit method is based on a double velocity transformation that involves the solution of a redundant but compatible system of equations. The high computational cost of this operation has been drastically reduced by taking into account the sparsity pattern of the system. Regarding this, the goal of this method is the introduction of MA48, a high performance mathematical library provided by Harwell Subroutine Library. The second method proposed in this paper has the particularity that, depending on the case, between 70 and 85% of the computation time is devoted to the evaluation of forces derivatives with respect to the relative position and velocity vectors. Keeping in mind that evaluating these derivatives can be decomposed into concurrent tasks, the main goal of this paper lies on a successful and straightforward parallel implementation that have led to a substantial improvement with a speedup of 3.2 by keeping all the cores busy in a quad-core processor and distributing the workload between them, achieving on this way a huge time reduction by doing an ideal CPU usag

Assessment of satisfaction in patients after hysterectomy by myomatous uterus

Objetivo: el objetivo de este estudio es evaluar los resultados, en cuanto a calidad de vida, de aquellas pacientes que han sido sometidas a una histerectomía por útero miomatoso. Material y métodos: se realiza una encuesta sobre calidad de vida a todas las pacientes sometidas a histerectomía con indicación de útero miomatoso, en un hospital de tercer nivel dentro de la red de hospitales del servicio de salud de la Comunidad de Madrid, en el año 2010. Resultados: Se identificaron un total de 152 pacientes a las que se les había realizado una histerectomía por útero miomatoso, de las cuales contestaron la encuesta un total de 112 (74%) pacientes. Cuando se les preguntó a las pacientes si había mejorado su calidad de vida tras la realización de la histerectomía, un 78’6% (88/112) respondió afirmativamente, un 17% (19/112) refirió tener la misma calidad de vida, y un 4’4% (5/112) respondió que su calidad de vida había empeorado tras la intervención. Conclusiones: las pacientes sometidas a una histerectomía por útero miomatoso presentan un alto grado de satisfacción tras la cirugía, comunicando en su mayoría una mejora en cuanto al dolor pélvico previo a la cirugía, y una mejor calidad de vida tras la intervenciónObjective: the objective of this study is to evaluate the results, in terms of quality of life of those patients who have undergone hysterectomy for fibroid uterus. Material and methods: we performed a survey on quality of life for all patients undergoing hysterectomy with uterine fibroid indication in a tertiary care hospital within the hospital network of the health service of the Community of Madrid, in the year 2010. Results: a total of 152 patients which had undergone a hysterectomy for uterine myoma, which answered the survey a total of 112 (74%) patients. When asked patients if they had improved their quality of life after performing a hysterectomy, a 78’6% (88/112) responded affirmatively, 17% (19/112) reported having the same quality of life, and 4.4% (5/112) responded that their quality of life had worsened after surgery. Conclusions: patients undergoing a hysterectomy for uterine fibroids have a high degree of satisfaction after the surgery, communicating mostly an improvement in pelvic pain prior to surgery, and improved quality of life after surger

Management of borderline ovarian tumours: A comprehensive review of the literature

Borderline ovarian tumours differ from epithelial ovarian cancer by their low incidence, frequent association with infertility, low association with mutations in BCRA genes, different percentages of the most common histological types, early stage diagnosis, and high survival rate, even when associated with peritoneal involvement. They occur in younger women, which is why one of the objectives in these patients will be the preservation of fertility. The management of these tumours has been widely discussed and still continues to be controversial. The latest findings underscore the importance of full staging in both radical and conservative surgery, to choose the most comprehensive treatment and obtain an accurate prognosis. One of the objectives of this article shall be the in-depth review of the indications, benefits, and disadvantages of each type of surgery, as well as the usefulness of the medical treatment. In addition, the article aims to review follow-up guidelines and to clarify the main prognostic factors that affect recurrence and survival of these patients

Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma

Adenocarcinoma of the cervix is a rare condition that has shown an increase in incidence, especially in the 20- to 34-year-old group. Adenocarcinoma represents about 5–10% of all tumours in this area, and, among these, the clear cell type accounts for 4–9%. This type of tumour affects mainly postmenopausal women but also occurs in young women with a history of prenatal exposure to diethylstilbestrol (DES). The prognosis for adenocarcinoma of the cervix is poor overall and worse for the clear cell variety. This article discusses a case of clear cell adenocarcinoma of the cervix, unrelated to intrauterine exposure to DES, in a woman of childbearing age who wished to preserve her fertility and was therefore treated by radical vaginal trachelectomy and pelvic lymphadenectomy

Real-time tool detection for workflow identification in open cranial vault remodeling

Deep learning is a recent technology that has shown excellent capabilities for recognition and identification tasks. This study applies these techniques in open cranial vault remodeling surgeries performed to correct craniosynostosis. The objective was to automatically recognize surgical tools in real-time and estimate the surgical phase based on those predictions. For this purpose, we implemented, trained, and tested three algorithms based on previously proposed Convolutional Neural Network architectures (VGG16, MobileNetV2, and InceptionV3) and one new architecture with fewer parameters (CranioNet). A novel 3D Slicer module was specifically developed to implement these networks and recognize surgical tools in real time via video streaming. The training and test data were acquired during a surgical simulation using a 3D printed patientbased realistic phantom of an infant’s head. The results showed that CranioNet presents the lowest accuracy for tool recognition (93.4%), while the highest accuracy is achieved by the MobileNetV2 model (99.6%), followed by VGG16 and InceptionV3 (98.8% and 97.2%, respectively). Regarding phase detection, InceptionV3 and VGG16 obtained the best results (94.5% and 94.4%), whereas MobileNetV2 and CranioNet presented worse values (91.1% and 89.8%). Our results prove the feasibility of applying deep learning architectures for real-time tool detection and phase estimation in craniosynostosis surgeries.This work was supported by projects PI18/01625 (Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III and European Regional Development Fund “Una manera de hacer Europa”). Luis Hernández Álvarez was supported by CSIC Project 202050E304 (CASDiM)