Traumatismo encéfalocraneano por agresión con objeto contundente sólido

Fil: Cutroni, Francisco. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: Santamarina, M.. Universidad Nacional de Cuyo. Facultad de Ciencias Médica

Dynamics of the Pionium with the Density Matrix Formalism

The evolution of pionium, the $\pi^+ \pi^-$ hydrogen-like atom, while passing through matter is solved within the density matrix formalism in the first Born approximation. We compare the influence on the pionium break-up probability between the standard probabilistic calculations and the more precise picture of the density matrix formalism accounting for interference effects. We focus our general result in the particular conditions of the DIRAC experiment at CERN.Comment: 14 pages, 2 figures, submitted to J. Phys. B: At. Mol. Phy

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study

Background Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data. Methods We used 1H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469). Metabolic phenotypes that reflected longitudinal intra- and inter-individual variation were used to predict measures of fetal growth and birth weight. Results A metabolic shift between the first and third trimesters of gestation was characterized by 1H NMR signals arising predominantly from steroid by-products. We identified 10 significant and reproducible metabolic associations in the third trimester with estimated fetal, birth, and placental weight in two independent subcohorts. These included branched-chain amino acids; isoleucine, valine, leucine, alanine and 3 hydroxyisobutyrate (metabolite of valine), which were associated with a significant fetal weight increase at week 34 of up to 2.4 % in Gipuzkoa (P < 0.005) and 1 % in Sabadell (P < 0.05). Other metabolites included pregnancy-related hormone by-products of estrogens and progesterone, and the methyl donor choline. We could explain a total of 48–53 % of the total variance in birth weight of which urine metabolites had an independent predictive power of 12 % adjusting for all other lifestyle/clinical factors. First trimester metabolic phenotypes could not predict reproducibly weight at later stages of development. Physical activity, as well as other modifiable lifestyle/clinical factors, such as coffee consumption, vitamin D intake, and smoking, were identified as potential sources of metabolic variation during pregnancy. Conclusions Significant reproducible maternal urinary metabolic signatures of fetal growth and birth weight are identified for the first time and linked to modifiable lifestyle factors. This novel approach to prenatal screening, combining multiple risk factors, present a great opportunity to personalize pregnancy management and reduce newborn disease risk in later life

Chemical composition of essential oils of three Mentha species and their antifungal activity against selected phytopathogenic and post-harvest fungi

This is an Accepted Manuscript of an article published by Taylor & Francis in All Life (Online) on 05 Jan 2022, available online: http://www.tandfonline.com/10.1080/26895293.2021.2022007[EN] The postharvest life of most fruit, vegetables and cereals is limited by fungal proliferation. The chemical composition of Mentha piperita, M. spicata and M. suaveolens essential oils (EO), and the antifungal activity against four pathogenic and post-harvest fungi isolated from food, were herein investigated to evaluate their potential as natural food preservatives. The EO were obtained by hydrodistillation of aerial parts leaves, stems and inflorescences (except for peppermint oil, which was purchased in a specialized store) and submitted to GC-MS and GC-FID analysis. Regarding the EO composition, carvone (41.1%) and limonene (14.1%) were the major compounds in M. spicata, menthol (47.0%) and menthone (23.1%), as well as other menthol derivatives (neomenthol -3.6%- and menthofurane -3.7%-) in M. piperita, and piperitone oxide (40.2%) and piperitenone oxide (31.4%) in M. suaveolens. Botryotinia fuckeliana was the most sensitive fungus. The three studied EO inhibited growth by 92¿100%. The highest dose of M. suaveolens EO, 400 ¿g/mL, produced 100% MGI in all the studied fungi, except Fusarium oxysporum with 94.21%. The M. suaveolens EO can be considered to develop a low-risk enviro-friendly botanical biofungicide.The authors also thank the Spanish Type Culture Collection (CECT) for providing the molecular strain identification equipment. This study has been financed by MINECO, Ministerio de Economía y competitividad `Materiales biodegradables multicapa de alta barrera para el envasado activo de alimentos¿ (AGL2016-76699-R).Santamarina Siurana, MP.; Llorens Molina, JA.; Sempere Ferre, F.; Santamarina Siurana, MC.; Rosello Caselles, J.; Giménez Santamarina, S. (2022). Chemical composition of essential oils of three Mentha species and their antifungal activity against selected phytopathogenic and post-harvest fungi. All Life (Online). 15(1):64-73. https://doi.org/10.1080/26895293.2021.2022007647315

Bioactive Botanics against Pathogenic and Mycotoxigenic Fungi Isolated from Rice

[EN] Cereal fungal contamination causes both economic and human health problems. In the present study, the chemical composition of commercial bay leaf, cinnamon, clove and oregano essential oils, and antifungal activity against three pathogenic fungi isolated from rice, were investigated. Essential oils presented a high percentage of oxygenated components: 78.8% in bay leaf (eucalyptol 52%); 90.5% in clove (eugenol 90%); 92% in cinnamon (eugenol 60% and eugenyl acetate 18.5%); 72% in oregano (carvacrol 50% and thymol 20%). Monoterpenes and sesquiterpenes were: 18% in bay leaf, 9% in clove, 5% in cinnamon, 25% in oregano. Cinnamon, and clove essential oils reduced fungal growth by 70%, 80% and almost 90%. Moreover, there was total inhibition using oregano until the seventeenth day. Oregano, clove and cinnamon oils could provide an alternative for controlling Bipolaris spicifer, Fusarium culmorum and Fusarium sambucinum in stored grains and seeds, so extending their shelf life.Giménez, S.; Rosello Caselles, J.; Santamarina Siurana, MP. (2019). Bioactive Botanics against Pathogenic and Mycotoxigenic Fungi Isolated from Rice. Agricultural Research & Technology. 23(3):00326-00331. http://hdl.handle.net/10251/153363S003260033123

Carney triad. Report of one case

Indexación: Scopus.Carney described a disorder characterized by the presence of several uncommon tumors which were pulmonary chondromas, gastric sarcomas and extra-adrenal paragangliomas. We report a 14 year-old girl in whom multiple gastric tumors were discovered during a study of an iron deficiency anemia and was subjected to a partial gastrectomy. At 25 years of age, she developed several pulmonary chondromas and at 33 years, a mediastinal tumor with features of an extra-adrenal paraganglioma was found. At 35 years of age, a total gastrectomy was performed to remove a gastrointestinal stromal tumor with excision of peritoneal and lymph node metastasis. One year later, the patient died due to liver failure secondary to liver metastases.http://ref.scielo.org/4jhgg

Direct calculation of the probability of pionium ionization in the target

We performed the first direct calculation of the probability of pionium (pi+pi- atom) ionization in the target. The dependence of the probability of pionium ionization in the target as a function of the pionium lifetime is established. These calculations are of interest of the DIRAC experiment at CERN, which aims to measure the pionium lifetime with high precision.Comment: 11 pages, 4 figures; submitted to "Physics of Atomic Nuclei" ("Yadernaya Fizika"

Stability assessment of a tailings storage facility using a non-local constitutive model accounting for anisotropic strain-softening

Recent failures of upstream-raised tailings storage facilities (TSF) raised con-cerns on the future use of these dams. While being cost-effective, they entail higher risks than conventional dams, as stability largely relies on the strength of tailings, which are loose and normally-consolidated materials that may exhibit strain-softening during un-drained loading. Current design practice involves limit equilibrium analyses adopting a fully-softened shear strength; while being conservative, this practice neglects the work input required to start the softening process that leads to progressive failure. This paper describes the calibration and application of the NGI-ADPSoft constitutive model to evaluate the potential of static liquefaction of an upstream-raised TSF and provides an indirect measure of resilience. The constitutive model incorporates undrained shear strength anisotropy and a mesh-independent anisotropic post-peak strain softening. The calibration is performed using laboratory testing, including anisotropically-consolidated triaxial compression tests and direct simple shear tests. The peak and residual undrained shear strengths are validated by statistical interpretation of the available CPTu data. It is shown that this numerical exercise is useful to verify the robustness of the TSF design.Comment: NGI-ADPSoft, Plaxis 2D, Strain-softening, Tailings, Static Liquefactio

Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway

[Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify and characterise potential molecular markers that appear during tumourigenesis and that might provide rapid and effective possibilities for the early detection of RCC. EGFR activation induces cell cycle progression, inhibition of apoptosis and angiogenesis, promotion of invasion/metastasis, and other tumour promoting activities. Over-expression of EGFR is thought to play an important role in tumour initiation and progression of RCC because up-regulation of EGFR has been associated with high grade cancers and a worse prognosis. Methods. Characterisation of the protein profile interacting with EGFR was performed using the following: an immunohistochemical (IHC) study of EGFR, a comprehensive computational study of EGFR protein-protein interactions, an analysis correlating the expression levels of EGFR with other significant markers in the tumourigenicity of RCC, and finally, an analysis of the utility of EGFR for prognosis in a cohort of patients with renal cell carcinoma. Results. The cases that showed a higher level of this protein fell within the clear cell histological subtype (p = 0.001). The EGFR significance statistic was found with respect to a worse prognosis. In vivo significant correlations were found with PDGFR-β, Flk-1, Hif1-α, proteins related to differentiation (such as DLL3 and DLL4 ligands), and certain metabolic proteins such as Glut5. In silico significant associations gave us a panel of 32 EGFR-interacting proteins (EIP) using the APID and STRING databases. Conclusions. This work summarises the multifaceted role of EGFR in the pathology of RCC, and it identifies EIPs that could help to provide mechanistic explanations for the different behaviours observed in tumours