620 research outputs found

    Psychological Safety and Norm Clarity in Software Engineering Teams

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    In the software engineering industry today, companies primarily conduct their work in teams. To increase organizational productivity, it is thus crucial to know the factors that affect team effectiveness. Two team-related concepts that have gained prominence lately are psychological safety and team norms. Still, few studies exist that explore these in a software engineering context. Therefore, with the aim of extending the knowledge of these concepts, we examined if psychological safety and team norm clarity associate positively with software developers' self-assessed team performance and job satisfaction, two important elements of effectiveness. We collected industry survey data from practitioners (N = 217) in 38 development teams working for five different organizations. The result of multiple linear regression analyses indicates that both psychological safety and team norm clarity predict team members' self-assessed performance and job satisfaction. The findings also suggest that clarity of norms is a stronger (30\% and 71\% stronger, respectively) predictor than psychological safety. This research highlights the need to examine, in more detail, the relationship between social norms and software development. The findings of this study could serve as an empirical baseline for such, future work.Comment: Submitted to CHASE'201

    Velocity Dispersion of Dissolving OB Associations Affected by External Pressure of Formation Environment

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    This paper presents a possible way to understand dissolution of OB associations (or groups). Assuming rapid escape of parental cloud gas from associations, we show that the shadow of the formation environment for associations can be partially imprinted on the velocity dispersion at their dissolution. This conclusion is not surprising as long as associations are formed in a multiphase interstellar medium, because the external pressure should suppress expansion caused by the internal motion of the parental clouds. Our model predicts a few km s−1^{-1} as the internal velocity dispersion. Observationally, the internal velocity dispersion is ∌1\sim 1 km s−1^{-1} which is smaller than our prediction. This suggests that the dissipation of internal energy happens before the formation of OB associations.Comment: 6 pages. AJ accepte

    MEME Suite: tools for motif discovery and searching

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    The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and protein interaction domains. The popular MEME motif discovery algorithm is now complemented by the GLAM2 algorithm which allows discovery of motifs containing gaps. Three sequence scanning algorithms—MAST, FIMO and GLAM2SCAN—allow scanning numerous DNA and protein sequence databases for motifs discovered by MEME and GLAM2. Transcription factor motifs (including those discovered using MEME) can be compared with motifs in many popular motif databases using the motif database scanning algorithm Tomtom. Transcription factor motifs can be further analyzed for putative function by association with Gene Ontology (GO) terms using the motif-GO term association tool GOMO. MEME output now contains sequence LOGOS for each discovered motif, as well as buttons to allow motifs to be conveniently submitted to the sequence and motif database scanning algorithms (MAST, FIMO and Tomtom), or to GOMO, for further analysis. GLAM2 output similarly contains buttons for further analysis using GLAM2SCAN and for rerunning GLAM2 with different parameters. All of the motif-based tools are now implemented as web services via Opal. Source code, binaries and a web server are freely available for noncommercial use at http://meme.nbcr.net

    Fifty Years of IMF Variation: The Intermediate-Mass Stars

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    I track the history of star count estimates of the Milky Way field star and open cluster IMFs, concentrating on the neglected mass range from 1 to 15 M⊙{_\odot}. The prevalent belief in a universal IMF appears to be without basis for this mass range. Two recent estimates of the field star IMF using different methods and samples give values of the average logarithmic slope Γ\Gamma between -1.7 and -2.1 in the mass range 1.1 to 4 M⊙{_\odot}. Two older estimates between 2 and 15 M⊙{_\odot} disagree severely; the field IMF in this range is essentially unknown from star counts. Variations in Γ\Gamma among open cluster IMFs in this mass range have not decreased despite numerous detailed studies, even for studies using homogeneous data and reduction procedures and including only clusters with a significant mass range. These cluster variations \textit{might} be due to the combined effects of sampling, systematic errors, stellar evolution uncertainties, dynamical evolution, and unresolved binaries. If so, then the cluster data are consistent with a universal IMF, but are also consistent with sizeable variations. The cluster data do not allow an estimate of an average IMF or Γ\Gamma because the average depends on the choice of weighting procedure and other effects. If the spread in cluster IMFs is in excess of the effects listed above, real IMF variations must occur that do not depend much on physical conditions explored so far. The complexity of the star formation process seen in observations and simulations suggests that large realization-to-realization differences might be expected, in which case an individual cluster IMF would be in part the product of evolutionary contingency in star formation, and the function of interest is the probability distribution of IMF parameters.Comment: 18 pages, including 4 figures: invited talk presented at the conference on "IMF@50: The Stellar Initial Mass Function Fifty Years Later" held at Abbazia di Spineto, Siena, Italy, May 2004; to be published by Kluwer Academic Publishers, edited by E. Corbelli, F. Palla, and H. Zinnecke

    Identification of red high proper-motion objects in Tycho-2 and 2MASS catalogues using Virtual Observatory tools

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    Aims: With available Virtual Observatory tools, we looked for new M dwarfs in the solar neighbourhood and M giants with high tangential velocities. Methods: From an all-sky cross-match between the optical Tycho-2 and the near-infrared 2MASS catalogues, we selected objects with proper motions >50mas/yr and very red V-Ks colours. For the most interesting targets, we collected multi-wavelength photometry, constructed spectral energy distributions, estimated effective temperatures and surface gravities from fits to atmospheric models, performed time-series analysis of ASAS V-band light curves, and assigned spectral types from low-resolution spectroscopy obtained with CAFOS at the 2.2m Calar Alto telescope. Results: We got a sample of 59 bright red high proper-motion objects, including fifty red giants, four red dwarfs, and five objects reported in this work for the first time. The five new stars have magnitudes V~10.8-11.3mag, reduced proper motions midway between known dwarfs and giants, near-infrared colours typical of giants, and effective temperatures Teff~2900-3400K. From our time-series analysis, we discovered a long secondary period in Ruber 4 and an extremely long primary period in Ruber 6. With the CAFOS spectra, we confirmed the red giant nature of Ruber 7 and 8, the last of which seems to be one of the brightest metal-poor M giants ever identified.Comment: Accepted in Astronomy & Astrophysic

    Optical clock intercomparison with 6×10−196\times 10^{-19} precision in one hour

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    Improvements in atom-light coherence are foundational to progress in quantum information science, quantum optics, and precision metrology. Optical atomic clocks require local oscillators with exceptional optical coherence due to the challenge of performing spectroscopy on their ultra-narrow linewidth clock transitions. Advances in laser stabilization have thus enabled rapid progress in clock precision. A new class of ultrastable lasers based on cryogenic silicon reference cavities has recently demonstrated the longest optical coherence times to date. In this work we utilize such a local oscillator, along with a state-of-the-art frequency comb for coherence transfer, with two Sr optical lattice clocks to achieve an unprecedented level of clock stability. Through an anti-synchronous comparison, the fractional instability of both clocks is assessed to be 4.8×10−17/τ4.8\times 10^{-17}/\sqrt{\tau} for an averaging time τ\tau in seconds. Synchronous interrogation reveals a quantum projection noise dominated instability of 3.5(2)×10−17/τ3.5(2)\times10^{-17}/\sqrt{\tau}, resulting in a precision of 5.8(3)×10−195.8(3)\times 10^{-19} after a single hour of averaging. The ability to measure sub-10−1810^{-18} level frequency shifts in such short timescales will impact a wide range of applications for clocks in quantum sensing and fundamental physics. For example, this precision allows one to resolve the gravitational red shift from a 1 cm elevation change in only 20 minutes

    OP0164 LONG-TERM SAFETY OF ANAKINRA IN PATIENTS WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS FROM THE PHARMACHILD REGISTRY

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    Background:Systemic juvenile idiopathic arthritis (SJIA) is characterized by extra-articular manifestations, as fever and rash, and rarely associated by a potentially lethal complication as macrophage activation syndrome (MAS). Anakinra is a recombinant human interleukin (IL)-1 receptor antagonist whose efficacy and safety profile has been studied for patients with SJIA.Objectives:To evaluate the long-term safety profile of anakinra in patients with SJIA.Methods:Data from patients with SJIA enrolled in the Pharmachild registry before 30 September 2018 and treated with anakinra were analyzed. The study endpoints were the occurrence of non-serious adverse events (AEs) of at least moderate severity and serious AEs (SAEs), including macrophage activation syndrome (MAS), and the duration of anakinra treatment with reasons for discontinuation. All endpoints were analyzed overall, by 6 month-time windows and in different treatment sets represented by those patients continuously treated with anakinra for at least 12, 18 and 24 months (set-12, -18, -24, respectively).Results:306 patients were enrolled. 46%, 34% and 28% of them had been treated for at least 12, 18 and 24 months, respectively. 201 AEs, mostly represented by infections, were reported for 509.3 patient-years (py) with an overall incidence rate (IR) of 39.5/100 py. Among 56 SAEs (IR 11.0/100 py), (Table 1) 23.2% were infections and 19.6% MAS episodes. The IR of AEs was higher during the first 6 months of anakinra, followed by decreasing IR in the different long-term treatment sets. Treatment discontinuation occurred in 76% of patients, most in the first 6 months, due to inefficacy (43%), remission (31%) or AEs/intolerance (15%). No deaths or malignancies occurred during anakinra treatment.Table 1.Number of SAEs and incidence rates (95% CI) by overall PT decreasing order and time window in the complete set (events with a frequency >1 by overall SOC and >1 by overall PT were reported) Only time windows 10.000 USD each) from the following industries in the last 3 years: BMS, Eli-Lilly, GlaxoSmithKline, F Hoffmann-La Roche, Janssen, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties
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