Neural networks in football

[EN] Machine learning provides the ability to examine massive datasets and discover patterns within the data without relying on a priori assumptions. Its application to the field of sport (which is experiencing rapid growth) is divided into predictive (training programmes, results...) and explanatory (injuries) models. In this report, which is part of a final project for a master’s degree course, we use unsupervised learning techniques (self-organised maps and clustering) to group players according to different statistics (passes, goals, fouls, etc.) and compare the results with their real playing positions. We also describe the tools used to implement and visualise the results, so that a reader can be inspired to carry out their own project.[ES] El aprendizaje automático brinda la capacidad de examinar conjuntos de datos masivos y descubrir patrones dentro de los datos sin depender de suposiciones a priori. Su aplicación al ámbito del deporte, que está experimentando un rápido crecimiento, se divide en modelos predictivos (programas de entrenamiento, resultados...) y explicativos (lesiones). En esta memoria, que forma parte de un proyecto final para una asignatura de máster, empleamos técnicas de aprendizaje no supervisado (mapas autoorganizados y clústering) para agrupar jugadores en función de diferentes estadísticas (pases, goles, faltas, etc) y comparamos los resultados con sus posiciones reales de juego. Asimismo, se describen las herramientas utilizadas para implementar y visualizar los resultados, con el objetivo de que un lector pueda inspirarse para realizar su propio proyecto.Sancho Barrios, L.; Sanmartin Vich, O.; Roger De La Resurreccion, C. (2021). Redes neuronales en el fútbol. Modelling in Science Education and Learning. 14(1):15-32. https://doi.org/10.4995/msel.2021.15023OJS1532141Calabuig, J. M. and García Raffi, L. M. and Sánchez Pérez, E. A. (2021). Aprender como una máquina: Introduciendo la inteligencia artificial en la enseñanza secundaria. Modelling in Science, Education and Learning, v. 14, n. 1, p. 45-52.Fausett, L. (1994). Fundamentals of Neural Networks: Architectures, Algorithms, and Applications. Prentice-Hall international editions. Prentice-Hall.Haykin, S. (1999). Neural Networks: A Comprehensive Foundation. International Edition. Prentice Hall.Kohonen, T. (1982). Self-organized formation of topologically correct featuremaps. Biological Cybernetics 43, 59-69. https://doi.org/10.1007/BF00337288Murtagh, F. hclust package. https://www.rdocumentation.org/packages/stats/versions/3.6.2/ topics/hclustWehrens, R. and Kruisselbrink, J. Supervised and unsupervised self-organising maps. https://github.com/cran/kohone

Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million single nucleotide polymorphisms (SNPs) and small indels identified through whole-genome sequencing of 2230 Icelanders. We imputed genotypes for 4208 BCC patients and 109 408 controls using Illumina SNP chip typing data, carried out association tests and replicated the findings in independent population samples. We found new BCC susceptibility loci at TGM3 (rs214782[G], P = 5.5 × 10(-17), OR = 1.29) and RGS22 (rs7006527[C], P = 8.7 × 10(-13), OR = 0.77). TGM3 encodes transglutaminase type 3, which plays a key role in production of the cornified envelope during epidermal differentiation.Red Tematica de Investigacion Cooperative en Cancer RD06/0020/1054 Danish Cancer Society "Europe Against Cancer": European Prospective Investigation into Cancer and Nutrition (EPIC) deCODE Genetics/AMGE

New basal cell carcinoma susceptibility loci.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 SNPs and small indels detected through whole-genome sequencing of 2,636 Icelanders and imputed into 4,572 BCC patients and 266,358 controls. Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76, P=4.7 × 10(-12)), 2q33 CASP8-ALS2CR12 (rs13014235[C], OR=1.15, P=1.5 × 10(-9)), 8q21 ZFHX4 (rs28727938[G], OR=0.70, P=3.5 × 10(-12)) and 10p14 GATA3 (rs73635312[A], OR=0.74, P=2.4 × 10(-16)). Fine mapping reveals that two variants correlated with rs73635312[A] occur in conserved binding sites for the GATA3 transcription factor. In addition, expression microarrays and RNA-seq show that rs13014235[C] and a related SNP rs700635[C] are associated with expression of CASP8 splice variants in which sequences from intron 8 are retained.NCI\SAIC-Frederick, Inc. (SAIC-F) 10XS170 Roswell Park Cancer Institute 10XS171 Science Care Inc. X10S172 Laboratory, Data Analysis and Coordinating Center (LDACC) HHSN268201000029C SAIC-F 10ST1035 HHSN261200800001E Brain Bank DA006227 DA033684 N01MH000028 University of Geneva MH090941 MH101814 University of Chicago MH090951 MH090937 MH101820 MH101825 University of North Carolina-Chapel Hill MH090936 MH101819 Harvard University MH090948 Stanford University MH101782 Washington University St Louis MH101810 University of Pennsylvania MH10182

Procedimiento de trabajo en vías públicas Ajuntament de Quart de Poblet

El Trabajo de Fin de Máster PROCEDIMIENTO DE TRABAJO EN VÍAS PÚBLICAS en el Ajuntament de Quart de Poblet, pretende paliar una serie de carencias que pueden observarse dentro del área de mantenimiento de dicho municipio. Los servicios municipales, las brigadas de obras, o servicios o cualesquiera de los nombres asignados a los equipos de trabajadores que realizan tareas de mantenimiento en la vía pública en un organismo público o incluso privado realizan pequeñas reparaciones en espacios públicos, muchas veces transitados por los peatones o por el tráfico rodado y en general no existen unos procedimientos de actuación previstos documentalmente para mejorar la seguridad y la salud laboral del trabajador y la de terceros: peatones, vehículos etc. Por tanto este trabajo pretende aportar una base documentada de acciones básicas de actuación cuando se realicen trabajos en vías públicas, una documentación que a la vez sirva como línea de formación inicial o continua de los trabajadores del servicio

Sonidegib para el tratamiento del carcinoma basocelular avanzado en práctica clínica real: estudio nacional multicéntrico

Article disponible en anglès: http://hdl.handle.net/10230/59174Antecedentes: El carcinoma de células basales (CBC) es el cáncer más prevalente. Una minoría de CBC tiene un comportamiento agresivo (CBCla) y puede requerir inhibidores de la vía hedgehog, como sonidegib como tratamiento. Objetivo: Describir el uso de sonidegib en un gran número de pacientes y aportar más datos sobre su perfil de eficacia y seguridad en la vida real. Métodos: Realizamos un estudio retrospectivo y multicéntrico que incluyó pacientes tratados con sonidegib. Se recogieron datos epidemiológicos, de eficacia y de seguridad. Resultados: Se incluyeron un total de 82 pacientes con una edad media de 73,9 años. Diez pacientes tenían síndrome de Gorlin. La mediana de duración del tratamiento fue de seis meses. La mediana de duración del seguimiento fue de 34,2 meses. Globalmente, 81,7% de los pacientes mostró mejoría clínica (52,4% respuesta parcial y 29,3% respuesta completa), 12,2% estabilidad clínica y 6,1% progresión de la enfermedad. No hubo diferencias estadísticamente significativas en la mejoría clínica entre la posología de sonidegib de 24 h y de 48 h. Después de seis meses de tratamiento, 48,8% de los pacientes suspendió sonidegib. El tratamiento previo con vismodegib y el CBC primario recurrente se asociaron con una peor respuesta a sonidegib. A los seis meses de tratamiento, 68,3% de los pacientes experimentó al menos un efecto adverso. Conclusión: Sonidegib muestra un perfil de eficacia y seguridad mejor de lo esperado en la práctica clínica habitual

Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis

Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue to rise. Apart from visible hyperkeratotic, hyperplastic lesions, AK is also associated with the presence of subclinical lesions adjacent to tumor tissue, which has led to the use of the concept "cancerization field". Although lesion- and field-targeting treatments are currently available, many are associated with local side effects and recurrence of new lesions. This review provides information on AK pathophysiology and treatment options and summarizes the available clinical evidence supporting the use of Eryfotona AK-NMSC, a film-forming medical device with SPF 100+ containing the DNA repair enzyme photolyase, for managing AK, based on the analysis of the results of 228 patients treated with the product. FUNDING: ISDIN funded the Article Processing Charges

Frequent DPH3 promoter mutations in skin cancers.

Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at sites adjacent and within a binding motif for E-twenty six/ternary complex factors (Ets/TCF), at -8 and -9 bp from DPH3 transcription start site. Follow up screening of 586 different skin lesions showed that the DPH3 promoter mutations were present in melanocytic nevi (2/114; 2%), melanoma (30/304; 10%), basal cell carcinoma of skin (BCC; 57/137; 42%) and squamous cell carcinoma of skin (SCC; 12/31; 39%). Reporter assays carried out in one melanoma cell line for DPH3 and OXNAD1 orientations showed statistically significant increased promoter activity due to -8/-9CC > TT tandem mutations; although, no effect of the mutations on DPH3 and OXNAD1 transcription in tumors was observed. The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. The detected mutations displayed typical UV signature; however, the functionality of the mutations remains to be determined

Effects of COVID-19 Lockdown on Tumour Burden of Melanoma and Cutaneous Squamous Cell Carcinoma.

The aim of this study was to compare tumour burden in patients who underwent surgery for melanoma and cutaneous squamous cell carcinoma during nationwide lockdown in Spain due to COVID-19 (for the period 14 March to 13 June 2020) and during the same dates in 2019 before the COVID-19 pandemic. In addition, associations between median tumour burden (Breslow thickness for melanoma and maximum clinical diameter for cutaneous squamous cell carcinoma) and demographic, clinical, and medical factors were analysed, building a multivariate linear regression model. During the 3 months of lockdown, there was a significant decrease in skin tumours operated on (41% decrease for melanoma (n = 352 vs n = 207) and 44% decrease for cutaneous squamous cell carcinoma (n = 770 vs n = 429)) compared with the previous year. The proportion of large skin tumours operated on increased. Fear of SARS-CoV-2 infection, with respect to family member/close contact, and detection of the lesion by the patient or doctor, were related to thicker melanomas; and fear of being diagnosed with cancer, and detection of the lesion by the patient or relatives, were related to larger size cutaneous squamous cell carcinoma. In conclusion, lockdown due to COVID-19 has resulted in a reduction in treatment of skin cancer