Statistical evaluation of the geochemical data for prospecting polymetallic mineralization in the Suoi Thau – Sang Than region, Northeast Vietnam

In Northeast Vietnam, Suoi Thau-Sang Than is considered as a high potential area of polymetallic deposits. 1,720 geochemical samples were used to investigate polymetallic mineralization; thereby polymetallic ore occurrences in this study region were discovered and the statistical and multivariate analysis helps to define geochemical anomalies in some northeastern regions, namely Suoi Thau, Sang Than, and Ban Kep. The statistical method and cluster analysis of geochemical data indicate that the Cu, Pb, and Zn elements are good indicators, and most of them comply with the lognormal or gamma distribution. Based on the third-order threshold, the geochemical anomalies of the content of the Cu, Pb, and Zn elements reflect the concentration of copper forming ore bodies in the mineralized zone, and clearly show the concentration in three distinct zones. The trend surface analysis which was employed to determine spatial variations and relationships among these good indicator elements and anomalous areas revealed relative changes in the content of the indicator elements, and they can be considered as regular. Moreover, the goodness of fit obtained trend functions of Pb and Zn, and Cu elements is a third-degree trend surface model. These results indicate that the models can be useful in studying geochemical anomalies and analyzing the tendency of the concentration of indicator elements in the Suoi Thau-Sang Than region. Additionally, it is suggested that the statistical analysis shows a remarkable potential to use the bottom river sediments in the region to investigate polymetallic mineralization. Moreover, geochemical data can help to evaluate geochemical anomalies of the pathfinder elements and potential mineral mapping of the Suoi Thau-Sang Than region in Northeast Vietnam

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Ocena zasobów konkrecji polimetalicznych w rejonie Suoi Thau-Sang Than, północno-wschodnim Wietnamie

1,720 chemical, mineral, and petrography samples in the Suoi Thau-Sang Than area, northeastern Vietnam were collected to investigate polymetallic nodules resource. The similarity-analogy in ore geology, direct calculation method for metallization parameters, and mineral resource estimation based on cutoff grade change methods are employed to estimate polymetallic nodules resource from the Suoi Thau, Sang Than, and Ban Kep areas in northeastern Vietnam. The similarity-analogy in ore geology indicates 1,785,000 tons Cu, 12,005,000 tons Pb+Zn, and 195 kg Au in total. The direct calculation method for metallization parameters shows 2,060,000 tons Cu, 13,648,000 tons Pb+Zn, and 224 kg Au in total. These methods display that the Sang Than area contains mainly polymetallic nodules in the studied area. Following the mineral resource estimation based on cutoff grade changes, estimation results indicate potential Pb-Zn nodules resource in the Ban Kep and Cu nodules resource in the Sang Than, while no potential Au nodules resource in the Suoi Thau and the Sang Than as well as the Ban Kep. The estimation results obtained from mineral resource estimation based on cutoff grade changes are suitable with the results from the traditional geometric block methods. Our study suggests that the Sang Than area can be considered as a potential Cu nodules resource, and the Ban Kep area is potential Pb-Zn nodules resource in northeastern Vietnam for future exploitation, while there is no potential polymetallic nodules resource in the Suoi Thau area. Furthermore, the one resource estimation based on cutoff grade changes method displays an overview of the prospect on polymetallic nodules resources, indicating that this method can serve as a basis for the proposed selection of the prospective areas for effective Cu, Pb-Zn, and Au mineral exploration in the Suoi Thau-Sang Than area, northeastern Vietnam.W celu zbadania zasobów konkrecji polimetalicznych zebrano 1,720 próbek substancji chemicznych, minerałów i petrografii z obszaru Suoi Thau-Sang Than w północno-wschodnim Wietnamie. Podobieństwo-analogia w geolo-gii rudy, metoda bezpośredniego obliczania parametrów metalizacji i szacowania zasobów mineralnych w opar-ciu o metody zmian zawartości granicznej są wykorzystywane do szacowania zasobów konkrecji polimetalicz-nych w obszarze Suoi Thau, Sang Than i Ban Kep w północno-wschodnim Wietnamie. Podobieństwo-analogia w geologii rudy wskazuje łącznie na 1,785,000 ton Miedzi, 12,005,000 ton Ołowiu + Cynków i 195 kg Żłota. Meto-da bezpośredniego obliczania parametrów metalizacji pokazuje łącznie 2 060 000 ton Miedzi, 13,648,000 ton Ołowiu + Cynków i 224 kg Żłota. Te metody pokazują, że obszar Sang Than zawiera głównie konkrecje polimeta-liczne na badanym obszarze. Po oszacowaniu zasobów mineralnych na podstawie zmian zawartości granicznej, wyniki oszacowań wskazują na potencjalny zasobów konkrecji Ołowiu - Cynków w Ban Kep i Miedzi w Sang Than, natomiast nie ma potencjalnego zasobu konkrecji Żłota w Suoi Thau i Sang Than, a także w Ban Kep. Wy-niki uzyskane z szacowania zasobów mineralnych na podstawie zmian zawartości granicznej są zgodne z wyni-kami tradycyjnymi metodami bloków geometrycznych. Nasze badanie sugeruje, że obszar Sang Than można uznać za potencjalny zasób konkrecji Miedzi, a obszar Ban Kep jest potencjalnym zasobem konkrecji Ołowiu + Cynków w północno-wschodnim Wietnamie do przyszłej eksploatacji, natomiast w obszarze Suoi Thau nie ma potencjalnego zasobu konkrecji polimetalicznych. Co więcej, oszacowanie zasobu w oparciu o metody zmian zawartości granicznej przedstawia przegląd perspektyw dotyczących zasobów konkrecji polimetalicznych, wska-zując, że metoda ta może służyć jako podstawa do proponowanego wyboru perspektywicznych obszarów efek-tywnych Miedzi, Ołowiu-Cynków i Żłota poszukiwanie minerałów w obszarze Suoi Thau-Sang Than w północno-wschodnim Wietnamie

Simultaneous enhancement of specific capacitance and potential window of graphene-based electric double-layer capacitors using ferroelectric polymers

© 2021 Elsevier B.V.Despite their high power density, aqueous-based electric double-layer capacitors (EDLCs) possess relatively low energy density due to the limitation of potential window (~1.0 V) and low specific capacitance of active materials. To increase the energy density without sacrificing the power density, it is highly desired to achieve a simultaneous improvement of both specific capacitance and potential window of EDLCs. However, this remains a major challenge that is not been solved up to date. This work demonstrates that by inserting a polarized-polyvinylidene fluoride (PVDF) ferroelectric layer underneath the graphene, a simultaneous enhancement of both areal capacitance and potential window is achieved, in which the areal capacitance increases from 5.5 to 7.5 μF/cm2 (i.e., 36%) (or 55 F/cm3 to 75 F/cm3 in terms of volumetric capacitance), and the potential window expands from 1.0 V to 1.5 V. This results in a threefold increase in the areal energy density of the capacitor. The enhancement in capacitance can be explained by the Gouy–Chapman–Stern model. The widening of potential window is due to the shift of the Fermi level of graphene caused by the doping effect of the polarized-PVDF layer.11Nsciescopu

Response surface modeling and optimizing conditions for anthocyanins extraction from Hibiscussabdariffa L. (Roselle) grown in Lam Dong, Vietnam

Hibiscus sabdariffa L. (Hs, roselle; Malvaceae) is a common ingredient used in the food and pharmaceutical industries for color and health benefits. Anthocyanins along with protocatechuic acid and quercetin have been recognized as bioactive compounds in Hibiscussabdariffa L. aqueous extracts. In this work, Response Surface Methodology was implemented together with Box-Behnken experimental design to investigate the impacts of process variables on anthocyanin extraction yields from Hibiscus sabdariffa L. (Roselle) grown in Lam Dong, Vietnam. The effects of three independent variables; namely the extraction temperatures of solvent ethanol (X1); the duration of extraction (X2); solid-liquid ratios (X3) on the total anthocyanins content (Y1) were explored. The optimization model showed that with the solid liquid ratio 7.7:1, extraction time 33.29 min, and temperature 56.9°C, the highest anthocyanin concentration of 186.006 mg/L was obtained. Hibiscussabdariffa L. anthocyanin yield detailed significant correlation with high F values, low P values (<0.0001), and desirable determination coefficient (R2 = 0.9770). The resulting quadratic model could be used to predict yields with given conditions. Actual experimental verification and residual testing revealed that the actual anthocyanin yields could be accurately predicted by the model

Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration

Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and seizures. After trial medication was ceased at 6 months, survivors were followed to 12 months post-randomization. This preplanned secondary analysis aimed to determine any sustained or delayed effects of fluoxetine at 12 months post-randomization. Methods: AFFINITY was a randomized, parallel-group, double-blind, placebo-controlled trial in adults (n=1280) with a clinical diagnosis of stroke in the previous 2 to 15 days and persisting neurological deficit who were recruited at 43 hospital stroke units in Australia (n=29), New Zealand (4), and Vietnam (10) between 2013 and 2019. Participants were randomized to oral fluoxetine 20 mg once daily (n=642) or matching placebo (n=638) for 6 months and followed until 12 months after randomization. The primary outcome was function, measured by the modified Rankin Scale, at 6 months. Secondary outcomes for these analyses included measures of the modified Rankin Scale, mood, cognition, overall health status, fatigue, health-related quality of life, and safety at 12 months. Results: Adherence to trial medication was for a mean 167 (SD 48) days and similar between randomized groups. At 12 months, the distribution of modified Rankin Scale categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio, 0.93 [95% CI, 0.76–1.14]; P =0.46). Compared with placebo, patients allocated fluoxetine had fewer recurrent ischemic strokes (14 [2.18%] versus 29 [4.55%]; P =0.02), and no longer had significantly more falls (27 [4.21%] versus 15 [2.35%]; P =0.08), bone fractures (23 [3.58%] versus 11 [1.72%]; P =0.05), or seizures (11 [1.71%] versus 8 [1.25%]; P =0.64) at 12 months. Conclusions: Fluoxetine 20 mg daily for 6 months after acute stroke had no delayed or sustained effect on functional outcome, falls, bone fractures, or seizures at 12 months poststroke. The lower rate of recurrent ischemic stroke in the fluoxetine group is most likely a chance finding. REGISTRATION: URL: http://www.anzctr.org.au/ ; Unique identifier: ACTRN12611000774921