Optical scatter of quantum noise filter cavity optics

Optical cavities to filter squeezed light for quantum noise reduction require optics with very low scattering losses. We report on measured light scattering from two super-polished fused silica optics before and after applying highly-reflective ion-beam sputtered dielectric coatings. We used an imaging scatterometer that illuminates the sample with a linearly polarized 1064 nm wavelength laser at a fixed angle of incidence and records images of back scatter for azimuthal angles in the plane of the laser beam. We extract from these images the bidirectional reflectance distribution function (BRDF) of the optics with and without coating and estimate their integrated scatter. We find that application of these coatings led to a more than 50% increase of the integrated wide-angle scatter, to 5.00+/-0.30 and 3.38+/-0.20 ppm for the two coated samples. In addition, the BRDF function of the coated optics takes on a pattern of maxima versus azimuthal angle. We compare with a scattering model to show that this is qualitatively consistent with roughness scattering from the coating layer interfaces. These results are part of a broader study to understand and minimize optical loss in quantum noise filter cavities for interferometric gravitational-wave detectors. The scattering measured for these samples is acceptable for the 16 m long filter cavities envisioned for the Laser Interferometer Gravitational-wave Observatory (LIGO), though reducing the loss further would improve LIGO's quantum-noise limited performance.Comment: 10 pages, 3 figure

N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.

The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether N17 could be a molecular determinant of nuclear mHTT pathogenesis in vivo. BAC transgenic mice expressing mHTT lacking the N17 domain (BACHD-ΔN17) show dramatically accelerated mHTT pathology exclusively in the nucleus, which is associated with HD-like transcriptionopathy. Interestingly, BACHD-ΔN17 mice manifest more overt disease-like phenotypes than the original BACHD mice, including body weight loss, movement deficits, robust striatal neuron loss, and neuroinflammation. Mechanistically, N17 is necessary for nuclear exclusion of small mHTT fragments that are part of nuclear pathology in HD. Together, our study suggests that N17 modifies nuclear pathogenesis and disease severity in HD mice by regulating subcellular localization of known nuclear pathogenic mHTT species

Agile process systems engineering education:What to teach, and how to teach

peer reviewedThis paper investigates the current and future trends in the teaching of Process Systems Engineering (PSE) topics, addressing what should be taught and how these topics should be taught effectively in a classroom setting. It addresses which key PSE topics should constitute the core requirement of chemical engineering education and which application areas should be included. We surveyed existing courses on novel aspects of PSE applications, as well as polling PSE stakeholders to ascertain their opinion of what is taught and the degree to which graduates skills match their expectations. Existing gaps and interesting prospects have been revealed by the surveys leading to suggestions for the future. The second part of the contribution addresses how best the PSE content should be taught, so that our graduates are equipped to effectively apply their knowledge, given the availability of teaching technologies and the time available to effectively educate our students

Effects of biomechanical forces on signaling in the cortical collecting duct (CCD)

An increase in tubular fluid flow rate (TFF) stimulates Na reabsorption and K secretion in the cortical collecting duct (CCD) and subjects cells therein to biomechanical forces including fluid shear stress (FSS) and circumferential stretch (CS). Intracellular MAPK and extracellular autocrine/paracrine PGE2 signaling regulate cation transport in the CCD and, at least in other systems, are affected by biomechanical forces. We hypothesized that FSS and CS differentially affect MAPK signaling and PGE2 release to modulate cation transport in the CCD. To validate that CS is a physiological force in vivo, we applied the intravital microscopic approach to rodent kidneys in vivo to show that saline or furosemide injection led to a 46.5 ± 2.0 or 170 ± 32% increase, respectively, in distal tubular diameter. Next, murine CCD (mpkCCD) cells were grown on glass or silicone coated with collagen type IV and subjected to 0 or 0.4 dyne/cm2 of FSS or 10% CS, respectively, forces chosen based on prior biomechanical modeling of ex vivo microperfused CCDs. Cells exposed to FSS expressed an approximately twofold greater abundance of phospho(p)-ERK and p-p38 vs. static cells, while CS did not alter p-p38 and p-ERK expression compared with unstretched controls. FSS induced whereas CS reduced PGE2 release by ∼40%. In conclusion, FSS and CS differentially affect ERK and p38 activation and PGE2 release in a cell culture model of the CD. We speculate that TFF differentially regulates biomechanical signaling and, in turn, cation transport in the CCD

Imposition, resistance, and alternatives in the face of an interregional water crisis in Mexico: El Zapotillo project

En este dossier se analizan los complejos aspectos socio-políticos, económicos, hidrológicos, legales, entre otros, relacionados con la construcción del proyecto El Zapotillo, que incluye un trasvase del Río Verde entre los estados mexicanos de Jalisco y Guanajuato con consecuencias significativas paras las comunidades humanas y los ecosistemas. El Cuaderno de Trabajo presenta doce artículos escritos por especialistas en las diferentes dimensiones del proceso, e incluye el trabajo de estudiantes de doctorado, activistas, y miembros de las comunidades locales afecadas directamente por el proyecto. It is a dossier focused on the complex socio-political, economic, hydrological, legal and other aspects involving the construction of El Zapotillo project, which includes an inter-basin transfer of the Verde River between the Mexican states of Jalisco and Guanajuato with significant consequences for human communities and ecosystems. The Working Paper features twelve articles written by specialists in the different dimensions of the process, and includes the work of doctoral students, activists, and members of the local communities directly affected by the project.ITESO, A.C.Universidad de BernaEl Colegio de JaliscoUNAMUniversidad de GuanajuatoUniversidad de GuadalajaraCartocríticaIMDECCIDEComité Salvemos Temacapulín, Acasico y PalmarejoColectivo de Abogad@

A single dose of ChAdOx1 Chik vaccine induces neutralising antibodies against four chikungunya virus lineages in a phase 1 clinical trial

Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that causes swift outbreaks. Major concerns are the persistent and disabling polyarthralgia in infected individuals. Here we present the results from a first-in-human trial of the candidate simian adenovirus vectored vaccine ChAdOx1 Chik, expressing the CHIKV full-length structural polyprotein (Capsid, E3, E2, 6k and E1). 24 adult healthy volunteers aged 18–50 years, were recruited in a dose escalation, open-label, nonrandomized and uncontrolled phase 1 trial (registry NCT03590392). Participants received a single intramuscular injection of ChAdOx1 Chik at one of the three preestablished dosages and were followed-up for 6 months. The primary objective was to assess safety and tolerability of ChAdOx1 Chik. The secondary objective was to assess the humoral and cellular immunogenicity. ChAdOx1 Chik was safe at all doses tested with no serious adverse reactions reported. The vast majority of solicited adverse events were mild or moderate, and self-limiting in nature. A single dose induced IgG and Tcell responses against the CHIKV structural antigens. Broadly neutralizing antibodies against the four CHIKV lineages were found in all participants and as early as 2 weeks after vaccination. In summary, ChAdOx1 Chik showed excellent safety, tolerability and 100% PRNT50 seroconversion after a single dose

Herramienta de búsqueda en repositorios académicos basada en web semántica y sistemas NOSQL

Las instituciones académicas buscan exponer su producción científica/académica a través de repositorios digitales en Acceso Abierto. Sin embargo, presentan limitaciones para lograr los objetivos ya que los datos publicados pueden resultar insuficientes, o bien no se cuenta con términos adecuados que puedan ser relacionados para realizar búsquedas más integrales y eficaces de forma de obtener mejores resultados. Los metadatos empleados para la descripción de los datos publicados, al ser semiestructurados no permiten explotar la información de mejor manera porque hay conocimiento implícito que favorece la descripción de nuevas relaciones entre los datos explicitados que no está siendo usado. Actualmente el sistema de consultas provisto por SIBUNJU permite ver información de los trabajos finales de grados resumida por: Título, autor, idioma, editorial, ISBN y biblioteca depositaria. Este proyecto plantea la definición de una herramienta de búsqueda en un repositorio creado específicamente para la Facultad de Ingeniería, que facilite el acceso y la explotación de los datos residentes en el mismo a través de la incorporación de tecnologías de web semántica y sistemas NoSQL. Esta herramienta será útil tanto para alumnos, egresados, docentes, investigadores y la sociedad puesto que permite crear y compartir conocimiento, además de facilitar su transferencia al sector productivo.Eje: Ingeniería de Software.Red de Universidades con Carreras en Informátic

Active commuting to and from university, obesity and metabolic syndrome among Colombian university students

Background: There is limited evidence concerning how active commuting (AC) is associated with health benefits in young. The aim of the study was to analyze the relationship between AC to and from campus (walking) and obesity and metabolic syndrome (MetS) in a sample of Colombian university students. Methods: A total of 784 university students (78.6% women, mean age = 20.1 ± 2.6 years old) participated in the study. The exposure variable was categorized into AC (active walker to campus) and non-AC (non/infrequent active walker to campus: car, motorcycle, or bus) to and from the university on a typical day. MetS was defined in accordance with the updated harmonized criteria of the International Diabetes Federation criteria. Results: The overall prevalence of MetS was 8.7%, and it was higher in non-AC than AC to campus. The percentage of AC was 65.3%. The commuting distances in this AC from/to university were 83.1%, 13.4% and 3.5% for < 2 km, 2- 5 km and > 5 km, respectively. Multiple logistic regressions for predicting unhealthy profile showed that male walking commuters had a lower probability of having obesity [OR = 0.45 (CI 95% 0.25–0.93)], high blood pressure [OR = 0.26 (CI 95% 0.13–0.55)] and low HDL cholesterol [OR = 0.29 (CI 95% 0.14–0.59)] than did passive commuters. Conclusions: Our results suggest that in young adulthood, a key life-stage for the development of obesity and MetS, AC could be associated with and increasing of daily physical activity levels, thereby promoting better cardiometabolic health.This study was part of the project entitled “Body Adiposity Index and Biomarkers of Endothelial and Cardiovascular Health in Adults”, which was funded by Centre for Studies on Measurement of Physical Activity, School of Medicine and Health Sciences, Universidad del Rosario (Code N° FIUR DNBG001) and Universidad de Boyacá (Code N° RECT 60)

Hepatic Transcriptome Analysis of Hepatitis C Virus Infection in Chimpanzees Defines Unique Gene Expression Patterns Associated with Viral Clearance

Hepatitis C virus infection leads to a high rate of chronicity. Mechanisms of viral clearance and persistence are still poorly understood. In this study, hepatic gene expression analysis was performed to identify any molecular signature associated with the outcome of hepatitis C virus (HCV) infection in chimpanzees. Acutely HCV-infected chimpanzees with self-limited infection or progression to chronicity were studied. Interferon stimulated genes were induced irrespective of the outcome of infection. Early induction of a set of genes associated with cell proliferation and immune activation was associated with subsequent viral clearance. Specifically, two of the genes: interleukin binding factor 3 (ILF3) and cytotoxic granule-associated RNA binding protein (TIA1), associated with robust T-cell response, were highly induced early in chimpanzees with self-limited infection. Up-regulation of genes associated with CD8+ T cell response was evident only during the clearance phase of the acute self-limited infection. The induction of these genes may represent an initial response of cellular injury and proliferation that successfully translates to a “danger signal” leading to induction of adaptive immunity to control viral infection. This primary difference in hepatic gene expression between self-limited and chronic infections supports the concept that successful activation of HCV-specific T-cell response is critical in clearance of acute HCV infection

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.Instituto Multidisciplinario de Biología Celula