5,542 research outputs found
Influence of convective transport on tropospheric ozone and its precursors in a chemistry-climate model
The impact of convection on tropospheric O<sub>3</sub> and its precursors has been examined in a coupled chemistry-climate model. There are two ways that convection affects O<sub>3</sub>. First, convection affects O<sub>3</sub> by vertical mixing of O<sub>3</sub> itself. Convection lifts lower tropospheric air to regions where the O<sub>3</sub> lifetime is longer, whilst mass-balance subsidence mixes O<sub>3</sub>-rich upper tropospheric (UT) air downwards to regions where the O<sub>3</sub> lifetime is shorter. This tends to decrease UT O<sub>3</sub> and the overall tropospheric column of O<sub>3</sub>. Secondly, convection affects O<sub>3</sub> by vertical mixing of O<sub>3</sub> precursors. This affects O<sub>3</sub> chemical production and destruction. Convection transports isoprene and its degradation products to the UT where they interact with lightning NO<sub>x</sub> to produce PAN, at the expense of NO<sub>x</sub>. In our model, we find that convection reduces UT NO<sub>x</sub> through this mechanism; convective down-mixing also flattens our imposed profile of lightning emissions, further reducing UT NO<sub>x</sub>. Over tropical land, which has large lightning NO<sub>x</sub> emissions in the UT, we find convective lofting of NO<sub>x</sub> from surface sources appears relatively unimportant. Despite UT NO<sub>x</sub> decreases, UT O<sub>3</sub> production increases as a result of UT HO<sub>x</sub> increases driven by isoprene oxidation chemistry. However, UT O<sub>3</sub> tends to decrease, as the effect of convective overturning of O<sub>3</sub> itself dominates over changes in O<sub>3</sub> chemistry. Convective transport also reduces UT O<sub>3</sub> in the mid-latitudes resulting in a 13% decrease in the global tropospheric O<sub>3</sub> burden. These results contrast with an earlier study that uses a model of similar chemical complexity. Differences in convection schemes as well as chemistry schemes – in particular isoprene-driven changes are the most likely causes of such discrepancies. Further modelling studies are needed to constrain this uncertainty range
Critical Self-assembly Concentration of Bolaamphiphilic Peptides and Peptide Hybrids Determined by Fluorescence Measurements
The study of the self-assembly properties of peptides and proteins is important for the understanding of molecular recognition processes and for the rational design of functional biomaterials. Novel bolaamphiphilic peptides and peptide hybrids incorporating non-natural aminoacids were designed around a model lysine/leucine-rich peptide with the intention to study their selfassembly behaviour. Steady-state fluorescence measurements using pyrene as fluorescent probe were adapted to the determination of the critical self-assembly concentrations (CSACs) of these amphiphilic peptides and peptide hybrids. Different experimental conditions were studied. The morphology of the peptide aggregates was evaluated by scanning electron microscopy (SEM). Concentration andpHhave been revealed to play a key role in the control of the process. Peptides presented different three-dimensional supramolecular arrangements that were correlated with their aminoacid compositions (specifically considering the presence of tyrosine and proline) and CSAC values.Keywords: Peptide aggregation, self-assembly, critical self-assembly concentration, fluorescence, pyrenePDF and Supplementry file attache
Histidine nutrition and genotype affect cataract development in Atlantic salmon, Salmo salar L.
The aim of this study was to investigate effects of dietary levels of histidine (His) and iron (Fe) on cataract development in two strains of Atlantic salmon monitored through parr-smolt transformation. Three experimental diets were fed: (i) a control diet (CD) with 110 mg kg-1 Fe and 11.7 g kg-1 His; (ii) CD supplemented with crystalline His to a level of 18 g kg-1 (HD); and (iii) HD with added iron up to 220 mg kg-1 (HID). A cross-over design, with two feeding periods was used. A 6-week freshwater (FW) period was followed by a 20-week period, of which the first three were in FW and the following 17 weeks in sea water (SW). Fish were sampled for weighing, cataract assessment and tissue analysis at five time points. Cataracts developed in all groups in SW, but scores were lower in those fed high His diets (P < 0.05). This effect was most pronounced when HD or HID was given in SW, but was also observed when these diets were given in FW only. Histidine supplementation had a positive effect on growth performance and feed conversion ratio (P < 0.05), whereas this did not occur when iron was added. Groups fed HD or HID had higher lens levels of His and N-acetyl histidine (NAH), the latter showing a marked increase post-smoltification (P < 0.05). The HD or HID groups also showed higher muscle concentrations of the His dipeptide anserine (P < 0.05). There was a strong genetic influence on cataract development in the CD groups (P < 0.001), not associated with tissue levels of His or NAH. The role of His and His-related compounds in cataractogenesis is discussed in relation to tissue buffering, osmoregulation and antioxidation
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Remote detection and location of explosive volcanism in Alaska with the EarthScope Transportable Array
2MASS J06164006-6407194: The First Outer Halo L Subdwarf
We present the serendipitous discovery of an L subdwarf, 2MASS
J06164006-6407194, in a search of the Two Micron All Sky Survey for T dwarfs.
Its spectrum exhibits features indicative of both a cool and metal poor
atmosphere including a heavily pressured-broadened K I resonant doublet, Cs I
and Rb I lines, molecular bands of CaH, TiO, CrH, FeH, and H2O, and enhanced
collision induced absorption of H2. We assign 2MASS 0616-6407 a spectral type
of sdL5 based on a comparison of its red optical spectrum to that of near
solar-metallicity L dwarfs. Its high proper motion (mu =1.405+-0.008 arcsec
yr-1), large radial velocity (Vrad = 454+-15 km s-1), estimated uvw velocities
(94, -573, 125) km s-1 and Galactic orbit with an apogalacticon at ~29 kpc are
indicative of membership in the outer halo making 2MASS 0616-6407 the first
ultracool member of this population.Comment: Accepted for publication in Ap
A performance analysis method for distributed real-time robotic systems: A case study of remote teleoperation
Robot coordination and control systems for remote teleoperation applications are by necessity implemented on distributed computers. Modeling and performance analysis of these distributed robotic systems is difficult, but important for economic system design. Performance analysis methods originally developed for conventional distributed computer systems are often unsatisfactory for evaluating real-time systems. The paper introduces a formal model of distributed robotic control systems; and a performance analysis method, based on scheduling theory, which can handle concurrent hard-real-time response specifications. Use of the method is illustrated by a case of remote teleoperation which assesses the effect of communication delays and the allocation of robot control functions on control system hardware requirements
Infrasonic backpulsed membrane cleaning micro-and ultrafiltration membranes fouled with alumina and yeast
Membrane fouling is universally considered to be one of the most critical problems in the wider application of membrane filtration. In this research microfiltration membranes were fouled during a cross-flow filtration process, using yeast and alumina suspensions in a flat cell. Infrasonic backpulsing directly into the permeate space was then used to clean the membrane, using both permeate water and soap solutions. Ultrasonic time domain reflectometry (UTDR) was used to detect and measure the growth of fouling on membrane surfaces, during the filtration and cleaning processes. The objective of this work was to examine the efficiency of back-pulse cleaning, using different combinations of membrane materials and foulants, in flat cells. The results show that a flux value of between 60% and 95% of the clean water value can be recovered after cleaning, by using a sequence of three 6.7 Hz backpulses, each pulse being 35 s long with a peak amplitude of about 140 kPa
Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer
A small group of cell surface receptors are proteoglycans, possessing a core protein with one or more covalently attached glycosaminoglycan chains. They are virtually ubiquitous and their chains are major sites at which protein ligands of many types interact. These proteoglycans can signal and regulate important cell processes, such as adhesion, migration, proliferation, and differentiation. Since many protein ligands, such as growth factors, morphogens, and cytokines, are also implicated in tumour progression, it is increasingly apparent that cell surface proteoglycans impact tumour cell behaviour. Here, we review some recent advances, emphasising that many tumour-related functions of proteoglycans are revealed only after their modification in processes subsequent to synthesis and export to the cell surface. These include enzymes that modify heparan sulphate structure, recycling of whole or fragmented proteoglycans into exosomes that can be paracrine effectors or biomarkers, and lateral interactions between some proteoglycans and calcium channels that impact the actin cytoskeleton
Left out and invisible? : exploring social media representation of \u27left behind places\u27
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