Review of Feminist Bioethics At the Center, On the Margins, edited by Jackie Leach Scully, Laurel E. Baldwin-Ragaven, Petya Fitzpatrick

The anthology, Feminist Bioethics, edited by Jackie Leach Scully, Laurel E. Baldwin-Ragaven, and Petya Fitzpatrick, examines how feminist bioethics theoretically and methodologically challenges mainstream bioethics, and whether these approaches are useful for exploring difference in other contexts. It offers critical conceptual analyses of "autonomy", "universality", and "trust", and covers topics such as testing for hereditary cancer, prenatal selection for sexual orientation, midwifery, public health, disability, Indigenous research reform in Australia, and China's one child policy

Care Ethics, Religion, and Spiritual Traditions

Care Ethics, Religion, and Spiritual Traditions is a collection of original essays that address the intersection between contemporary feminist care ethics and religious morality. Feminist care ethics is one of the most dynamic areas in modern theory. This relational approach to morality emphasizes context, emotion, and imagination over consequences, rules, and rights has only been around for about four decades, with its definition still being negotiated. Still, the respect for this approach is demonstrated by its widespread inclusion in moral discourse. Historically, care has been an overlooked concept in philosophy, but religion\u27s ambivalence toward care ethics is even more pronounced. On the one hand, caring is a fundamental value espoused by virtually all religions and spiritual traditions. Yet, on the other hand, deontological principles so essential to many religious moralities create clear categories of adjudication antithetical to feminist care ethics. Care Ethics, Religion, and Spiritual Traditions engages theorists from various disciplines in discussing the continuities, discontinuities, and applications of feminist care ethics, spiritual traditions, and religion. This collection includes contributions from Ruth E. Groenhout, Maurice Hamington, Adriana Jesenková, Luigina Mortari, Sarah Munawar, Inge van Nistelrooij, Kimberley D. Parzuchowski, Jamie Pitts, Martin Robb, Jason Rubenstein, Robert Michael Ruehl, Maureen Sander-Staudt, Steven Steyl, and Sarah Zager. The volume also includes a foreword by Catherine Keller

Global care, local configurations - challenges to conceptualizations of care

Migration, along with the implied geographies of the ethics of care literature and policy initiatives vis-à-vis care have increasingly led to the adoption of the ‘global’ as the most appropriate level for analysing care. Much of the empirical work underpinning analyses of care, however, was done at particular sites and had specific emphases that are now being adopted in the analysis of care globally. In this article, I suggest the need for empirical research from other parts of the world to inform, build on and challenge the existing theorizations of transnational care. Using examples from India, I highlight some ways in which (a) recognizing the varied genealogies of care in different places, (b) bringing together the literature on care diamonds with that on care chains, and (c) recognizing the diversity of family forms and the increasing transnationalization of markets, the state and civil society may enrich existing care chain analysis. I thus suggest that we need to explore what differences in the infrastructural architecture of care means for how we theorize care in the context of migration. I outline some elements of a new research agenda, not only for research on India but also for recognizing the importance of heterogeneous care arrangements in a globalizing world of care

Functional loss of IKBE leads to NF-KB deregulation in aggressive chronic lymphocytic leukemia

NF-?B is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-?B pathway in a discovery and validation CLL cohort totaling 315 cases. The most frequently mutated gene was NFKBIE (21/315 cases; 7%), which encodes I?B?, a negative regulator of NF-?B in normal B cells. Strikingly, 13 of these cases carried an identical 4-bp frameshift deletion, resulting in a truncated protein. Screening of an additional 377 CLL cases revealed that NFKBIE aberrations predominated in poor-prognostic patients and were associated with inferior outcome. Minor subclones and/or clonal evolution were also observed, thus potentially linking this recurrent event to disease progression. Compared with wild-type patients, NFKBIE-deleted cases showed reduced I?B? protein levels and decreased p65 inhibition, along with increased phosphorylation and nuclear translocation of p65. Considering the central role of B cell receptor (BcR) signaling in CLL pathobiology, it is notable that I?B? loss was enriched in aggressive cases with distinctive stereotyped BcR, likely contributing to their poor prognosis, and leading to an altered response to BcR inhibitors. Because NFKBIE deletions were observed in several other B cell lymphomas, our findings suggest a novel common mechanism of NF-?B deregulation during lymphomagenesis. <br/

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Since the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy.

Loss of cell cycle controls is a hallmark of cancer and has a well-established role in aggressive B cell malignancies. However, the role of such lesions in indolent follicular lymphoma (FL) is unclear and individual lesions have been observed with low frequency. By analyzing genomic data from two large cohorts of indolent FLs, we identify a pattern of mutually exclusive (P = 0.003) genomic lesions that impair the retinoblastoma (RB) pathway in nearly 50% of FLs. These alterations include homozygous and heterozygous deletions of the p16/CDKN2a/b (7%) and RB1 (12%) loci, and more frequent gains of chromosome 12 that include CDK4 (29%). These aberrations are associated with high-risk disease by the FL prognostic index (FLIPI), and studies in a murine FL model confirm their pathogenic role in indolent FL. Increased CDK4 kinase activity toward RB1 is readily measured in tumor samples and indicates an opportunity for CDK4 inhibition. We find that dual CDK4 and BCL2 inhibitor treatment is safe and effective against available models of FL. In summary, frequent RB pathway lesions in indolent, high-risk FLs indicate an untapped therapeutic opportunity