598 research outputs found
Computer vision-based analytical chemistry applied to determining iron in commercial pharmaceutical formulations
[EN] Two different computer vision-based analytical chemistry (CVAC) methods were developed to quantify iron in the commercial pharmaceutical formulations Ferbisol (R) and Ferro sanol (R). The methods involve using a digital camera or a desktop scanner to capture a digital image of a series of Fe2+ standard solutions and the unknown sample upon reaction with o-phenanthroline. The images are processed with appropriate software (e.g., the public domain programme ImageJ, from NIH) to obtain a numerical value (analytical signal) based on colour intensity. The fact that such a value is proportional to the analyte concentration allows one to construct a calibration graph from the standards and interpolate the value for the sample in order to determine its concentration. The results thus obtained were compared with those provided by a spectrophotometric method and the US Pharmacopoeia's recommended method. The differences never exceeded 2%. The two proposed methods are simple and inexpensive; also, they provide an effective instrumental alternative to spectrophotometric methods which can be especially beneficial in those cases where purchasing and maintaining a spectrophotometer is unaffordable.Solana-Altabella, A.; Sanchez-Iranzo, M.; Bueso-Bordils, J.; Lahuerta-Zamora, L.; Mellado Romero, AM. (2018). Computer vision-based analytical chemistry applied to determining iron in commercial pharmaceutical formulations. Talanta. 188:349-355. https://doi.org/10.1016/j.talanta.2018.06.008S34935518
Combination of polymeric superplasticizers, water repellents and pozzolanic agents to improve air lime-based grouts for historic masonry repair
This paper presents the experimental procedure to develop air lime-based injection grouts including polymeric superplasticizers, a water repellent agent and pozzolanic agents as additives. Research focuses on the development of grouts to improve various characteristics simultaneously combining different additions and admixtures. Aiming to improve the injectability of the grouts, in this study different polymeric superplasticizers were added, namely polycarboxylated-ether derivative (PCE), polynaphthalene sulfonate (PNS) and condensate of melamine-formaldehyde sulfonate (SMFC). Sodium oleate was also used as a water repellent agent to reduce the water absorption. The enhancement of the strength and setting time was intended by using microsilica and metakaolin as pozzolanic mineral additions. Compatibility between the different admixtures and action mechanism of the different polymers were studied by means of zeta potential and adsorption isotherms measurements. Diverse grout mixtures were produced and investigated assessing their injectability, fluidity, stability, compressive strength, hydrophobicity and durability. This research leads to several suitable mixtures produced by using more than one component to enhance efficiency and to provide better performance of grouts. According to the results, the grout composed of air lime, metakaolin, sodium oleate and PCE was found the most effective composition improving the mechanical strength, injectability and hydrophobicity
Time-dependent density-functional and reduced density-matrix methods for few electrons: Exact versus adiabatic approximations
To address the impact of electron correlations in the linear and non-linear
response regimes of interacting many-electron systems exposed to time-dependent
external fields, we study one-dimensional (1D) systems where the interacting
problem is solved exactly by exploiting the mapping of the 1D -electron
problem onto an -dimensional single electron problem. We analyze the
performance of the recently derived 1D local density approximation as well as
the exact-exchange orbital functional for those systems. We show that the
interaction with an external resonant laser field shows Rabi oscillations which
are detuned due to the lack of memory in adiabatic approximations. To
investigate situations where static correlations play a role, we consider the
time-evolution of the natural occupation numbers associated to the reduced
one-body density matrix. Those studies shed light on the non-locality and
time-dependence of the exchange and correlation functionals in time-dependent
density and density-matrix functional theories.Comment: 19 pages, 13 figures, version as published apart from layou
Galaxy rotation curves: the effect of j x B force
Using the Galaxy as an example, we study the effect of j x B force on the
rotational curves of gas and plasma in galaxies. Acceptable model for the
galactic magnetic field and plausible physical parameters are used to fit the
flat rotational curve for gas and plasma based on the observed baryonic
(visible) matter distribution and j x B force term in the static MHD equation
of motion. We also study the effects of varied strength of the magnetic field,
its pitch angle and length scale on the rotational curves. We show that j x B
force does not play an important role on the plasma dynamics in the
intermediate range of distances 6-12 kpc from the centre, whilst the effect is
sizable for larger r (r > 15 kpc), where it is the most crucial.Comment: Accepted for publication in Astrophysics & Space Science (final
printed version, typos in proofs corrected
EVIDENT 3 Study: A randomized, controlled clinical trial to reduce inactivity and caloric intake in sedentary and overweight or obese people using a smartphone application: Study protocol
Introduction: Mobile technology, when included within multicomponent interventions, could contribute to more effective weight loss. The objective of this project is to assess the impact of adding the use of the EVIDENT 3 application, designed to promote healthy living habits, to traditional modification strategies employed for weight loss. Other targeted behaviors (walking, caloric-intake, sitting time) and outcomes (quality of life, inflammatory markers, measurements of arterial aging) will also be evaluated. Methods: Randomized, multicentre clinical trial with 2 parallel groups. The study will be conducted in the primary care setting and will include 700 subjects 20 to 65 years, with a body mass index (27.5-40kg/m2), who are clinically classified as sedentary. The primary outcome will be weight loss. Secondary outcomes will include change in walking (steps/d), sitting time (min/wk), caloric intake (kcal/d), quality of life, arterial aging (augmentation index), and pro-inflammatory marker levels. Outcomes will be measured at baseline, after 3 months, and after 1 year. Participants will be randomly assigned to either the intervention group (IG) or the control group (CG). Both groups will receive the traditional primary care lifestyle counseling prior to randomization. The subjects in the IG will be lent a smartphone and a smartband for a 3-month period, corresponding to the length of the intervention. The EVIDENT 3 application integrates the information collected by the smartband on physical activity and the self-reported information by participants on daily food intake. Using this information, the application generates recommendations and personalized goals for weight loss. Discussion: There is a great diversity in the applications used obtaining different results on lifestyle improvement and weight loss. The populations studied are not homogeneous and generate different results. The results of this study will help our understanding of the efficacy of new technologies, combined with traditional counseling, towards reducing obesity and enabling healthier lifestyles. Ethicsanddissemination: The study was approved by the Clinical Research Ethics Committee of the Health Area of Salamanca ("CREC of Health Area of Salamanca") on April 2016. A SPIRIT checklist is available for this protocol. The trial was registered in ClinicalTrials.gov provided by the US National Library of Medicine-number NCT03175614
Pentagonal nanowires: a first-principles study of atomic and electronic structure
We performed an extensive first-principles study of nanowires in various
pentagonal structures by using pseudopotential plane wave method within the
density functional theory. Our results show that nanowires of different types
of elements, such as alkali, simple, transition and noble metals and inert gas
atoms, have a stable structure made from staggered pentagons with a linear
chain perpendicular to the planes of the pentagons and passing through their
centers. This structure exhibits bond angles close to those in the icosahedral
structure. However, silicon is found to be energetically more favorable in the
eclipsed pentagonal structure. These quasi one dimensional pentagonal nanowires
have higher cohesive energies than many other one dimensional structures and
hence may be realized experimentally. The effect of magnetic state are examined
by spin-polarized calculations. The origin of the stability are discussed by
examining optimized structural parameters, charge density and electronic band
structure, and by using analysis based on the empirical Lennard-Jones type
interaction. Electronic band structure of pentagonal wires of different
elements are discussed and their effects on quantum ballistic conductance are
mentioned. It is found that the pentagonal wire of silicon exhibits metallic
band structure.Comment: 4 figures, accepted for publication in Phys. Rev.
The relationship of the atlantic diet with cardiovascular risk factors and markers of arterial stiffness in adults without cardiovascular disease
Background: Studying the adherence of the population to the Atlantic Diet (AD) could be simplified by an easy and quickly applied dietary index. The aim of this study is to analyse the relationship of an index measuring compliance with recommendations regarding the Atlantic diet and physical activity with cardiovascular disease risk factors, cardiovascular risk factors, obesity indexes and arterial stiffness markers.
Methods: We included 791 individuals from the EVIDENT study (lifestyles and arterial ageing), (52.3 ± 12 years, 61.7% women) without cardiovascular disease. Compliance with recommendations on AD was collected through the responses to a food frequency questionnaire, while physical activity was measured by accelerometer. The number of recommendations being met was estimated using a global scale between 0 and 14 points (a higher score representing greater adherence). Blood pressure, plasma lipid and glucose values and obesity rates were measured. Cardiovascular risk was estimated with the Framingham equation.
Results: In the overall sample, 184 individuals (23.3%) scored between 0–3 on the 14-point index we created, 308 (38.9%) between 4 and 5 points, and 299 (37.8%) 6 or more points. The results of multivariate analysis yield a common tendency in which the group with an adherence score of at least 6 points shows lower figures for total cholesterol (p = 0.007) and triglycerides (p = 0.002). Similarly, overall cardiovascular risk in this group is the lowest (p < 0.001), as is pulse wave velocity (p = 0.050) and the mean values of the obesity indexes studied (p < 0.05 in all cases).
Conclusion: The rate of compliance with the Atlantic diet and physical activity shows that greater adherence to these recommendations is linked to lower cardiovascular risk, lower total cholesterol and triglycerides, lower rates of obesity and lower pulse wave velocity values
Fluid geochemistry of the Los Humeros geothermal field (LHGF - Puebla, Mexico): New constraints for the conceptual model
Geothermal power in Mexico is mainly produced in four geothermal fields operated by the Comision Federal de Electricidad (CFE): Cerro Prieto, Los Azufres, Los Humeros, and Las Tres Virgenes. The Los Humeros Geothermal Field (LHGF) is ranked third in terms of generated capacity, and in the last decade its installed capacity has doubled (up to 95.0 MW). Further increases in the geothermal power generation capacity in Mexico are planned, and thus the LHGF warrants further examination. The development and growth phases of any geothermal project must start from an awareness of the conceptual model of the natural system studied. The recharge mechanism, feeding zones, and fluid flow-path must be identified, along with the estimation of the temperature at the productive level and of phase separation (liquid - steam). To accomplish this, detailed fluid geochemical surveys were carried out in June 2017 and March 2018, in which 57 and 87 samples were collected, respectively, from cold and thermal springs, water wells and maar lakes located around and inside the LHGF. Samples from fumaroles inside the producing area were also collected for the first time, together with fluid from re-injection wells. The presence of a meteoric component, which plays an important role at the regional scale, is confirmed by the chemical and isotope data, and its contribution in terms of recharge may be higher than previously assumed. The Sierra Madre Oriental, on the west side of the LHGF, is characterized by widespread outcrops of limestone belonging to the same geological formation as those at the bottom of the LHGF. The isotope composition (delta D and delta O-18, respectively -77.3 parts per thousand and -10.50 parts per thousand for the hypothetical Infiltration Water IW) is similar to that observed in cold springs located in the Sierra Madre Oriental, and from this the evolution of isotopes in the liquid-rock-steam system during water-rock interaction and phase separation processes can be modelled. Thus, the experimental data obtained for natural gas emissions (fumarolic condensates) and for geothermal fluids can be reproduced. These findings suggest that geothermal fluids in the LHGF are likely to be derived from meteoric water infiltrating (IW) the limestone outcrops of the Sierra Madre Oriental. During their flow-path, the infiltrating waters exchange isotopes at a high temperature with the crustal rocks, which have a much higher O-18/O-16 ratio, resulting in a shift towards higher delta O-18 (-4.35 parts per thousand +/- 1) as the water O exchanges with rock O. The vapor phase can be separated from this deep water (DW) and it is discharged from the fumarolic effluents of Loma Blanca. Single Step Vapor Separation (SSVS) and Continuous Steam Separation processes (CSS) were modelled using stable isotopes of water. The results of geochemical modeling agree with available data for geothermal liquids discharged from several geothermal wells, suggesting that steam separation may be interpreted either as SSVS or CSS. Other processes can affect the chemistry and isotope composition of geothermal fluids (e.g. phase segregation, gas exchange, contributions from magmatic-volcanic deep fluids and re-injection fluids). The proposed conceptual model is consistent with both the geochemical data and the geological setting, and provides a useful point of reference for examining the fluid flow-path and geochemical processes active in the LHGF, at least at a general level. An involvement of magmatic-volcanic deep fluids in the feeding mechanism of the geothermal system cannot be excluded at priori, but the regional meteoric end-member is supported by the data and it seems the most important component
Liver transplantation in cirrhotic patients with diabetes mellitus: Midterm results, survival, and adverse events
Liver cirrhosis is frequently associated with diabetes mellitus (DM), and this
metabolic complication is also frequent after orthotopic liver transplantation
(OLT). The aim of our study is to investigate which factors are associated with
DM before and after OLT and their impact on post-OLT evolution. We evaluated the
prevalence of DM among 115 liver transplant candidates with cirrhosis and
assessed their evolution after OLT (median follow-up, 41 months). Sixteen
candidates had DM requiring pharmacological therapy (group A), 45 candidates had
DM controlled with diet (group B), and 54 candidates did not have DM (group C).
One-year and 3-year actuarial survival rates were 100% and 100% for group A, 91%
and 85% for group B, and 77% and 74% for group C, respectively (P <.03). Post-OLT
DM was more frequent in group A. The incidence of other metabolic complications,
major infections, rejection, and arterial hypertension; the need for
hospitalization; and renal and graft function of patients in groups A, B, and C
were similar. The only risk factor for DM 1 year after OLT on multivariate
analysis was pre-OLT DM requiring pharmacological treatment. The incidence of
complications, need for hospitalization, and renal and graft function 1 year
after OLT for patients with post-OLT DM were similar to those of patients without
post-OLT DM. In conclusion, patients with cirrhosis who have DM have a greater
risk for post-OLT DM, but their midterm survival is not worse than the survival
of those without DM
Sterile neutrino production via active-sterile oscillations: the quantum Zeno effect
We study several aspects of the kinetic approach to sterile neutrino
production via active-sterile mixing. We obtain the neutrino propagator in the
medium including self-energy corrections up to , from which
we extract the dispersion relations and damping rates of the propagating modes.
The dispersion relations are the usual ones in terms of the index of refraction
in the medium, and the damping rates are where
is the active neutrino scattering rate and
is the mixing angle in the medium. We provide a generalization of
the transition probability in the \emph{medium from expectation values in the
density matrix}: and
study the conditions for its quantum Zeno suppression directly in real time. We
find the general conditions for quantum Zeno suppression, which for sterile neutrinos with \emph{may
only be} fulfilled near an MSW resonance. We discuss the implications for
sterile neutrino production and argue that in the early Universe the wide
separation of relaxation scales far away from MSW resonances suggests the
breakdown of the current kinetic approach.Comment: version to appear in JHE
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