Prosodic modulation in the babble of cochlear implanted and normally hearing infants: a perceptual study using a visual analogue scale

This study investigates prosodic modulation in the spontaneous canonical babble of congenitally deaf infants with cochlear implants (CI) and normally hearing (NH) infants. Research has shown that the acoustic cues to prominence are less modulated in CI babble. However acoustic measurements of individual cues to prominence give incomplete information about prosodic modulation. In the present study, raters are asked to judge prominence since they simultaneously take into account all prosodic cues. Disyllabic utterances produced by CI and NH infants were presented to naive adult raters who had to indicate the degree and direction of prosodic modulation between syllables on a visual analogue scale. The results show that the babble of infants with CI is rated as having less prosodic modulation. Moreover, segmentally more variegated babble is rated as having more prosodic modulation. Raters do not perceive the babble to be predominantly trochaic, which indicates that the predominant stress pattern of Dutch is not yet apparent in the children’s productions

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Hearing impairment and vowel production. A comparison between normally hearing, hearing-aided and cochlear implanted Dutch children

This study investigated the acoustic characteristics of the Belgian Standard Dutch vowels in children with hearing impairment and in children with normal hearing. In a balanced experimental design, the 12 vowels of Belgian Standard Dutch were recorded in three groups of children: a group of children with normal hearing, a group with a conventional hearing aid and a group with a cochlear implant. The formants, the surface area of the vowel space and the acoustic differentiation between the vowels were determined. The analyses revealed that many of the vowels in hearing-impaired children showed a reduction of the formant values. This reduction was particularly significant with respect to F2. The size of the vowel space was significantly smaller in the hearing-impaired children. Finally, a smaller acoustic differentiation between the vowels was observed in children with hearing impairment. The results show that even after 5 years of device use, the acoustic characteristics of the vowels in hearing-assisted children remain significantly different as compared to their NH peers

Divergence in Ynone Reactivity: Atypical Cyclization by 3,4-Difunctionalization versus Rare Bis(cyclization)

Functionalized ynones can be activated by TfC=CH, which was generated in situ, to form zwitterionic species. These species were trapped in an intramolecular fashion by several nucleophiles to generate two major types of triflones in a divergent manner. Through fine-tuning of the reaction temperature, bis(triflyl)-6-membered- or (triflyl)-5-membered-fused-heterocycles were achieved in reasonable yields in a totally selective manner. In this way, bis(triflyl)flavones, bis(triflyl)thioflavones, bis(triflyl)selenoflavones, (triflyl)benzothienopyrans, (triflyl)benzoselenophenopyrans, (triflyl)vinyl aurones, and (triflyl)pyranoindoles were constructed. Conceivable mechanistic pathways were suggested on the basis of the isolation of several intermediates and the results from control experiments.Support for this work by the MINECO and FEDER (Projects CTQ2015-65060-C2-1-P and CTQ2015-65060-C2-2-P). C.L.-M. thanks MINECO for a predoctoral grant.Peer Reviewe