Neurocognitive Function in Children with Primary Hypertension

To compare neurocognitive test performance of children with primary hypertension to that of normotensive controls

An assessment of the Arctic Ocean in a suite of interannual CORE-II simulations. Part III: Hydrography and fluxes

In this paper we compare the simulated Arctic Ocean in 15 global ocean–sea ice models in the framework of the Coordinated Ocean-ice Reference Experiments, phase II (CORE-II). Most of these models are the ocean and sea-ice components of the coupled climate models used in the Coupled Model Intercomparison Project Phase 5 (CMIP5) experiments. We mainly focus on the hydrography of the Arctic interior, the state of Atlantic Water layer and heat and volume transports at the gateways of the Davis Strait, the Bering Strait, the Fram Strait and the Barents Sea Opening. We found that there is a large spread in temperature in the Arctic Ocean between the models, and generally large differences compared to the observed temperature at intermediate depths. Warm bias models have a strong temperature anomaly of inflow of the Atlantic Water entering the Arctic Ocean through the Fram Strait. Another process that is not represented accurately in the CORE-II models is the formation of cold and dense water, originating on the eastern shelves. In the cold bias models, excessive cold water forms in the Barents Sea and spreads into the Arctic Ocean through the St. Anna Through. There is a large spread in the simulated mean heat and volume transports through the Fram Strait and the Barents Sea Opening. The models agree more on the decadal variability, to a large degree dictated by the common atmospheric forcing. We conclude that the CORE-II model study helps us to understand the crucial biases in the Arctic Ocean. The current coarse resolution state-of-the-art ocean models need to be improved in accurate representation of the Atlantic Water inflow into the Arctic and density currents coming from the shelves

North Atlantic simulations in Coordinated Ocean-ice Reference Experiments phase II (CORE-II). Part I: Mean states

Simulation characteristics from eighteen global ocean–sea-ice coupled models are presented with a focus on the mean Atlantic meridional overturning circulation (AMOC) and other related fields in the North Atlantic. These experiments use inter-annually varying atmospheric forcing data sets for the 60-year period from 1948 to 2007 and are performed as contributions to the second phase of the Coordinated Ocean-ice Reference Experiments (CORE-II). The protocol for conducting such CORE-II experiments is summarized. Despite using the same atmospheric forcing, the solutions show significant differences. As most models also differ from available observations, biases in the Labrador Sea region in upper-ocean potential temperature and salinity distributions, mixed layer depths, and sea-ice cover are identified as contributors to differences in AMOC. These differences in the solutions do not suggest an obvious grouping of the models based on their ocean model lineage, their vertical coordinate representations, or surface salinity restoring strengths. Thus, the solution differences among the models are attributed primarily to use of different subgrid scale parameterizations and parameter choices as well as to differences in vertical and horizontal grid resolutions in the ocean models. Use of a wide variety of sea-ice models with diverse snow and sea-ice albedo treatments also contributes to these differences. Based on the diagnostics considered, the majority of the models appear suitable for use in studies involving the North Atlantic, but some models require dedicated development effort

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

The transient response of Southern Ocean circulation to geothermal heating in a global climate model

Model and observational studies have concluded that geothermal heating significantly alters the global overturning circulation and the properties of the widely-distributed Antarctic Bottom Waters. Here we test two distinct geothermal heat flux datasets under different experimental designs in a fully coupled model that mimics the control run of a typical Coupled Model Intercomparison Project (CMIP) climate model. Our regional analysis reveals that bottom temperature and transport changes, due to the inclusion of geothermal heating, are propagated throughout the water column, most prominently in the Southern Ocean, with the background density structure and major circulation pathways acting as drivers of these changes. Whilst geothermal heating enhances Southern Ocean abyssal overturning circulation by 20-50%, upwelling of warmer deep waters and cooling of upper ocean waters within the Antarctic Circumpolar Current (ACC) region decrease its transport by 3 to 5 Sv. The transient responses in regional bottom temperature increases exceed 0.1°C. The combination of large scale features that we show act to transport anomalies far from their geothermal source all exist in the Southern Ocean. Such features include steeply sloping isopycnals, weak abyssal stratification, voluminous southward flowing deep waters and exported bottom waters, the ACC, and the polar gyres. Recently the Southern Ocean has been identified as a prime region for deep ocean warming; geothermal heating should be included in climate models to ensure accurate representation of these abyssal temperature changes

Connecting Changing Ocean Circulation with Changing Climate

The influence of changing ocean currents on climate change is evaluated by comparing an earth system model’s response to increased CO2 with and without an ocean circulation response. Inhibiting the ocean circulation response, by specifying a seasonally varying preindustrial climatology of currents, has a much larger influence on the heat storage pattern than on the carbon storage pattern. The heat storage pattern without circulation changes resembles carbon storage (either with or without circulation changes) more than it resembles the heat storage when currents are allowed to respond. This is shown to be due to the larger magnitude of the redistribution transport—the change in transport due to circulation anomalies acting on control climate gradients—for heat than for carbon. The net ocean heat and carbon uptake are slightly reduced when currents are allowed to respond. Hence, ocean circulation changes potentially act to warm the surface climate. However, the impact of the reduced carbon uptake on radiative forcing is estimated to be small while the redistribution heat transport shifts ocean heat uptake from low to high latitudes, increasing its cooling power. Consequently, global surface warming is significantly reduced by circulation changes. Circulation changes also shift the pattern of warming from broad Northern Hemisphere amplification to a more structured pattern with reduced warming at subpolar latitudes in both hemispheres and enhanced warming near the equator

The deep ocean buoyancy budget and its temporal variability

Despite slow rates of ocean mixing, observational and modeling studies suggest that buoyancy is redistributed to all depths of the ocean on surprisingly short interannual to decadal time scales. The mechanisms responsible for this redistribution remain p

Role of Ocean Model Formulation in Climate Response Uncertainty

Oceanic heat uptake (OHU) is a significant source of uncertainty in both the transient and equilibrium responses to increasing the planetary radiative forcing. OHU differs among climate models and is related in part to their representation of vertical and lateral mixing. This study examines the role of ocean model formulation-specifically the choice of the vertical coordinate and the strength of the background diapycnal diffusivity K-d-in the millennial-scale near-equilibrium climate response to a quadrupling of atmospheric CO2. Using two fully coupled Earth system models (ESMs) with nearly identical atmosphere, land, sea ice, and biogeochemical components, it is possible to independently configure their ocean model components with different formulations and produce similar near-equilibrium climate responses. The SST responses are similar between the two models (r(2) = 0.75, global average similar to 4.3 degrees C) despite their initial preindustrial climate mean states differing by 0.4 degrees C globally. The surface and interior responses of temperature and salinity are also similar between the two models. However, the Atlantic meridional overturning circulation (AMOC) responses are different between the two models, and the associated differences in ventilation and deep-water formation have an impact on the accumulation of dissolved inorganic carbon in the ocean interior. A parameter sensitivity analysis demonstrates that increasing the amount of K-d produces very different near-equilibrium climate responses within a given model. These results suggest that the impact of the ocean vertical coordinate on the climate response is small relative to the representation of subgrid-scale mixing.6 month embargo; published online: 29 October 2018This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]