Os resíduos da construção em dois municípios do Litoral do Paraná

Orientador : Prof. Dr. Ednilson VianaDissertação (mestrado) - Universidade Federal do Paraná, Centro de Estudos do Mar, Programa de Pós-Graduação em Sistemas Costeiros e Oceânicos. Defesa : Pontal do Parana, 29/03/2011Bibliografia: fls. 11-12Resumo: O objetivo foi diagnosticar a geracao e o manejo dos Residuos da Construcao e Demolicao (RCD) em dois municipios do litoral do Parana. Alem de pesquisa bibliografica referente as caracteristicas fisico-territoriais e socioeconomicas, foram feitas entrevistas, mapeamentos, estimativa quantitativa e caracterizacao dos RCD atraves do monitoramento de empresas transportadoras. Os indices de geracao obtidos foram 327,4 Kg(ano).hab£¼1 em Matinhos e 190,6 Kg(ano).hab£¼1 em Pontal do Parana, o que equivale a respectivamente 51,9% e 37,8% do total dos residuos solidos em cada municipio. De modo geral, os agentes relacionados com a gestao e o manejo dos RCD nesses municipios nao estao adequadamente comprometidos, o que representa potencial risco de impacto negativo ao ambiente, a economia e a saude da populacao, evidenciando a necessidade da elaboracao de planos para esses residuos.Abstract: The aim was to detect the generation and management of Construction and Demolition Waste (CDW) in two coastal municipalities of Paran¨¢. In addition to literature regarding of physical-territorial and socio-economic, interviews, mappings, quantitative estimation and characterization of CDW by monitoring carriers were held. The generation rates obtained were 327.4 kg.(year).hab¡¥1 in Matinhos and 190.6 kg.(year).hab¡¥1 in Pontal do Paran¨¢, which is equivalent to respectively 51.9% and 37.8% of total solid waste in each municipality. In general, the agents related to the management and handling of RCD in these municipalities are not adequately engaged, which represents potential risk of negative impact to the environment, economy and population health, obviating the need for development of plans for these waste

Um santo entre os anticlericais: Francisco Ferrer nas p?ginas D?a lanterna (1909)

This work consists of the research carried out for the Trabalho de Conclus?o de Curso (TCC), a partial requirement for the graduation in the course. During this text we will develop about the source and the research problem of our TCC, whose purpose is to analyze the newspaper A Lanterna in the year 1909, seeking to perceive the anticlerical manifestations present throughout the publications of the same, with emphasis on the use of news involving Francisco Ferrer and his figure. In a first moment we will contextualize the studied period, the First Republic, and begin a historiographic discussion on the anticlericalism in the working press of the time. Already in the second chapter the analysis itself will be done, using the source to discuss the use of the figure of Ferrer as propaganda of anticlericalism, mainly through the Escola Moderna project.Este trabalho consiste na pesquisa realizada para o Trabalho de Conclus?o de Curso (TCC), requisito parcial para a gradua??o no curso. Durante este texto desenvolvemos sobre a fonte e o problema de pesquisa de nosso TCC, que tem o prop?sito de analisar o jornal A Lanterna no ano de 1909, buscando perceber as manifesta??es anticlericais presentes ao longo das publica??es do mesmo, com ?nfase na utiliza??o de not?cias envolvendo Francisco Ferrer e sua figura. Num primeiro momento contextualizamos o per?odo estudado, a Primeira Rep?blica, e iniciar uma discuss?o historiogr?fica sobre o anticlericalismo na imprensa oper?ria da ?poca. J? durante o segundo cap?tulo foi feita a an?lise em si, utilizando a fonte para discutir o uso da figura de Ferrer como propaganda do anticlericalismo, principalmente atrav?s do projeto da Escola Moderna

"Swiss Business Culture" : wie Führung in der Schweiz funktioniert

Die Zusammenarbeit zwischen Mitarbeitern aus verschiedenen Kulturen gilt als erfolgskritischer Faktor in global agierenden Unternehmen. Im International Headquarters der Building Technologies Division von Siemens in Zug werden deshalb neue ausländische Führungskräfte im Rahmen ihrer Integration mit der Schweizer Geschäftskultur vertraut gemacht. Der dafür entwickelte «Swiss Business Culture Day» bietet den Führungskräften aus dem Ausland Orientierungshilfen für das Verständnis von Führung und Zusammenarbeit in der Schweiz. Zugleich werden die teilnehmenden Schweizer Führungskräfte für kulturell bedingte Verhaltensmuster und Wertvorstellungen ihrer ausländischen Kollegen sensibilisiert

Monogenetic near-island seamounts in the Galapagos Archipelago

Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 21(12), (2020): e2020GC008914, https://doi.org/10.1029/2020GC008914.Rarely have small seamounts on the flanks of hotspot derived ocean‐island volcanoes been the targets of sampling, due to sparse high‐resolution mapping near ocean islands. In the Galápagos Archipelago, for instance, sampling has primarily targeted the subaerial volcanic edifices, with only a few studies focusing on large‐volume submarine features. Sampling restricted to these large volcanic features may present a selection bias, potentially resulting in a skewed view of magmatic and source processes because mature magmatic systems support mixing and volcanic accretion that overprints early magmatic stages. We demonstrate how finer‐scale sampling of satellite seamounts surrounding the volcanic islands in the Galápagos can be used to lessen this bias and thus, better constrain the evolution of these volcanoes. Seamounts were targeted in the vicinity of Floreana and Fernandina Islands, and between Santiago and Santa Cruz. In all regions, individual seamounts are typically monogenetic, but each seamount field requires multigenerational magmatic episodes to account for their geochemical variability. This study demonstrates that in the southern and eastern regions the seamounts are characterized by greater geochemical variability than the islands they surround but all three regions have (Sr‐Nd‐He) isotopic signatures that resemble neighboring islands. Variations in seamount chemistry from alkalic to tholeiitic near Fernandina support the concept that islands along the center of the hotspot track undergo greater mean depths of melting, as predicted by plume theory. Patterns of geochemical and isotopic enrichment of seamounts within each region support fine‐scale mantle heterogeneities in the mantle plume sourcing the Galápagos hotspot.This work was carried out with funding from National Science Foundation Division of Ocean Sciences (OCE‐1634952 to V. D. Wanless, OCE‐1634685 to S. A. Soule). The authors have no competing interests to declare. We thank Sally Gibson and three anonymous reviewers for providing detailed and critical feedback on this manuscript.2021-05-0

Rosetta:MSF: a modular framework for multi-state computational protein design

Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties. Rosetta is a software suite including algorithms for computational modeling and analysis of protein structures and offers many elaborate protocols created to solve highly specific tasks of protein engineering. Most of Rosetta's protocols optimize sequences based on a single conformation (i.e. design state). However, challenging CPD objectives like multi-specificity design or the concurrent consideration of positive and negative design goals demand the simultaneous assessment of multiple states. This is why we have developed the multi-state framework MSF that facilitates the implementation of Rosetta's single-state protocols in a multi-state environment and made available two frequently used protocols. Utilizing MSF, we demonstrated for one of these protocols that multi-state design yields a 15% higher performance than single-state design on a ligand-binding benchmark consisting of structural conformations. With this protocol, we designed de novo nine retro-aldolases on a conformational ensemble deduced from a (beta alpha)(8)-barrel protein. All variants displayed measurable catalytic activity, testifying to a high success rate for this concept of multi-state enzyme design

The treatment of cutaneous abscesses: Comparison of emergency medicine providers\u27 practice patterns

INTRODUCTION: Cutaneous abscesses are commonly treated in the emergency department (ED). Although incision and drainage (I&D) remains the standard treatment, there is little high-quality evidence to support additional interventions such as pain control, type of incision, and use of irrigation, wound cultures, and packing. Although guidelines exist to support clinician management of abscesses, they do not clearly specify these additional interventions. This study sought to describe the ED treatments administered to adults with uncomplicated superficial cutaneous abscesses, defined as purulent lesions requiring incision and drainage that could be managed in an ED or outpatient setting. METHODS: Four hundred and seventy-four surveys were distributed to 15 EDs across the United States. Participants were queried about their level of training and practice environment as well as specific questions regarding their management of cutaneous abscesses in the ED. RESULTS: In total, 350 providers responded to the survey (74%). One hundred eighty-nine respondents (54%) were attending physicians, 135 (39%) were residents, and 26 (7%) were midlevel providers. Most providers (76%) used narcotics for pain management, 71% used local anesthetic over the roof of the abscess, and 60% used local anesthetic in a field block for pain control. More than 48% of responders routinely used irrigation after (I&D). Eighty-five percent of responders used a linear incision to drain the abscess and 91% used packing in the wound cavity. Thirty-two percent routinely sent wound cultures and 17% of providers routinely prescribed antibiotics. Most providers (73%) only prescribed antibiotics if certain historical factors or physical findings were present on examination. Antibiotic treatment, if used, favored a combination of 2 or more drugs to cover both Streptococcus and methicillin-resistant Staphylococcus aureus (47%). Follow-up visits were most frequently recommended at 48 hours unless wound was concerning and required closer evaluation. CONCLUSION: Variability exists in the treatment strategies for abscess care. Most providers used narcotic analgesics in addition to local anesthetic, linear incisions, and packing. Most providers did not irrigate, order wound cultures, or routinely prescribe oral antibiotics unless specific risk factors or physical signs were present. Limited evidence is available at this time to guide these treatment strategies

Analytical Fiber ODF Reconstruction in 3D Polarized Light Imaging: Performance Assessment

International audienceThree dimensional Polarized Light Imaging (3D-PLI) allows to map the spatial fiber structure of postmortem tissue at a sub-millimeter resolution, thanks to its birefringence property. Different methods have been recently proposed to reconstruct the fiber orientation distribution function (fODF) from high-resolution vector data provided by 3D-PLI. Here, we focus on the analytical fODF computation approach, which uses the spherical harmonics to represent the fODF and analytically computes the spherical harmonics coefficients via the spherical Fourier transform. This work deals with the assessment of the performance of this approach on rich synthetic data which simulates the geometry of the neuronal fibers and on human brain dataset. A computational complexity and robustness to noise analysis demonstrate the interest and great potential of the approach

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying obesity-induced IR in skeletal muscle remains controversial; reduced post-receptor signalling of the insulin receptor substrate 1 (IRS1) adaptor protein and downstream effectors such as protein kinase B (PKB) have previously been implicated. We examined expression and/or activation of a number of components of the insulin-signalling cascade in skeletal muscle of 22 healthy young men (with body mass index (BMI) range, 20–37 kg/m2). Whole body insulin sensitivity (M value) and body composition was determined by the hyperinsulinaemic (40 mU. min−1.m−2.), euglycaemic clamp and by dual energy X-ray absorptiometry (DEXA) respectively. Skeletal muscle (vastus lateralis) biopsies were taken before and after one hour of hyperinsulinaemia and the muscle insulin signalling proteins examined by western blot and immunoprecipitation assay. There was a strong inverse relationship between M-value and BMI. The most striking abnormality was significantly reduced insulin-induced activation of p42/44 MAP kinase, measured by specific assay, in the volunteers with poor insulin sensitivity. However, there was no relationship between individuals' BMI or M-value and protein expression/phosphorylation of IRS1, PKB, or p42/44 MAP kinase protein, under basal or hyperinsulinaemic conditions. In the few individuals with poor insulin sensitivity but preserved p42/44 MAP kinase activation, other signalling defects were evident. These findings implicate defective p42/44 MAP kinase signalling as a potential contributor to obesity-related IR in a non-diabetic population, although clearly multiple signalling defects underlie obesity associated IR

Health-industry linkages for local health: reframing policies for African health system strengthening

The benefits of local production of pharmaceuticals in Africa for local access to medicines and to effective treatment remain contested. There is scepticism among health systems experts internationally that production of pharmaceuticals in sub-Saharan Africa (SSA) can provide competitive prices, quality and reliability of supply. Meanwhile low-income African populations continue to suffer poor access to a broad range of medicines, despite major international funding efforts. A current wave of pharmaceutical industry investment in SSA is associated with active African government promotion of pharmaceuticals as a key sector in industrialization strategies. We present evidence from interviews in 2013–15 and 2017 in East Africa that health system actors perceive these investments in local production as an opportunity to improve access to medicines and supplies. We then identify key policies that can ensure that local health systems benefit from the investments. We argue for a ‘local health’ policy perspective, framed by concepts of proximity and positionality, which works with local priorities and distinct policy time scales and identifies scope for incentive alignment to generate mutually beneficial health–industry linkages and strengthening of both sectors. We argue that this local health perspective represents a distinctive shift in policy framing: it is not necessarily in conflict with ‘global health’ frameworks but poses a challenge to some of its underlying assumptions

The Influence of Feedback on Task-Switching Performance:A Drift Diffusion Modeling Account

Task-switching is an important cognitive skill that facilitates our ability to choose appropriate behavior in a varied and changing environment. Task-switching training studies have sought to improve this ability by practicing switching between multiple tasks. However, an efficacious training paradigm has been difficult to develop in part due to findings that small differences in task parameters influence switching behavior in a non-trivial manner. Here, for the first time we employ the Drift Diffusion Model (DDM) to understand the influence of feedback on task-switching and investigate how drift diffusion parameters change over the course of task switch training. We trained 316 participants on a simple task where they alternated sorting stimuli by color or by shape. Feedback differed in six different ways between subjects groups, ranging from No Feedback (NFB) to a variety of manipulations addressing trial-wise vs. Block Feedback (BFB), rewards vs. punishments, payment bonuses and different payouts depending upon the trial type (switch/non-switch). While overall performance was found to be affected by feedback, no effect of feedback was found on task-switching learning. Drift Diffusion Modeling revealed that the reductions in reaction time (RT) switch cost over the course of training were driven by a continually decreasing decision boundary. Furthermore, feedback effects on RT switch cost were also driven by differences in decision boundary, but not in drift rate. These results reveal that participants systematically modified their task-switching performance without yielding an overall gain in performance