Estimación e imputación de datos faltantes en modelos longitudinales con variable respuesta tipo Poisson y Binomial Negativa con exceso de ceros

El objetivo de esta investigación es la estimación e imputación de datos faltantes en modelos longitudinales con variable respuesta tipo Poisson y Binomial Negativa cero inflada. Para responder al objetivo de está investigación, se propone una metodología que se basa en el uso de la máxima verosimilitud. Se supone que los datos son faltantes de forma aleatoria (FFA), en cada uno de los tiempos se hace uso del algoritmo EM: en el paso E se realiza una regresión ponderada, condicionada a los tiempo anteriores que son tomados como covariables, utilizando la propuesta de Ibrahim (1990). En el paso M se realiza la estimación e imputación de los datos faltantes utilizando la propuesta de Ayala y Melo (2007). La metodología propuesta es aplicada para el caso Poisson cero inflado en el estudio relacionado con el crecimiento del maíz presentado en Da Costa (2003). En el caso Binomial Negativa cero inflada, se aplica a un estudio del forrajeo del polen presentado en Rodríguez (2014).Abstract The objective of this research is the estimation and imputation of missing data in longitudinal models with variable response type Poisson and Negative Binomial Zero Inflated. In order to answer the objective of this study, a methodology is proposed base on the use of the maximum likelihood. The data is supposed to be missing at random (MAR) and in each time the algorithm EM is used. In step E a weighted regression is carried out, conditioned to the previous time that is taken as covariables using the proposal of Ibrahim’s (1990). In step M, the estimation and imputation of the missing data is carried out using the methodology of Ayala and Melo (2007). The proposed methodology is applied for the Poisson Zero Inflated Case in a study related to the growth of corn presented in Da Costa (2003). In the case Binomial Negative Zero Inflated, our strategy is applied to a study of the foraging of pollen presented in Rodriguez (2014).Maestrí

THE INFLUENCE OF VEGETATION TO INDOOR ILLUMINANCE, AIR TEMPERATURE AND RELATIVE HUMIDITY IN DESIGN STUDIO (Case Study: Architecture Department, Petra Christian University, Surabaya)

This research aimed to find the influence of vegetation outside the window to indoor light and thermal in Design studio, Architecture department of Petra Christian University, Surabaya. The vegetation was Shibataea kumasasa, cultivated in planter boxes, 90-100 centimeter high. The data was collected from the West and North window, for condition with and without vegetation outside the window. The measurement was taken on March until May 2019, using Hobo U12-012 data logger for measuring air temperature (�C), relative humidity (%) and illuminance (lux). Beside those physical measurement, the perception of 89 students as building user was also taken. The measurement result from windows facing West and North with the vegetation, the lowest indoor air temperature was 27�C with an average relative humidity of 70%. Meant its at the upper edge of the comfort zoneof Bioclimatic Chart from Olgyay and Canada�s National Occupational Health & Safety Resource (CCOHS), so the indoor space was still uncomfortable and cooling was required to get into the comfort zone at warm humid climate. Result from lighting measurements obtained for west-oriented windows with vegetation outside the window, the highest illuminance was 350 lux at 02:45 pm, as well as for windows facing North at 07.30 am - 04.45 pm in range of 105 - 155 lux (highest). So, if there are vegetation outside windows, it will require electric lighting addition, because the illuminance are below the SNI 03-6197-2011which recommends 750 lux for design studio. Whilst the user respond from the questionnaire taken, stated that aesthetic vegetation was expected for natural element, blocked the penetration of solar radiation into indoor, and reduce glare to increase visual comfort without reducing luminous sufficiency for the visual activities in the design studio

Isolation and molecular characterization of the Romaine lettuce phylloplane mycobiome

Romaine lettuce (Lactuca sativa) is an important staple of American agriculture. Unlike many vegetables, romaine lettuce is typically consumed raw. Phylloplane microbes occur naturally on plant leaves; consumption of uncooked leaves includes consumption of phylloplane microbes. Despite this fact, the microbes that naturally occur on produce such as romaine lettuce are for the most part uncharacterized. In this study, we conducted culture-based studies of the fungal romaine lettuce phylloplane community from organic and conventionally grown samples. In addition to an enumeration of all such microbes, we define and provide a discussion of the genera that form the “core” romaine lettuce mycobiome, which represent 85.5% of all obtained isolates: Alternaria, Aureobasidium, Cladosporium, Filobasidium, Naganishia, Papiliotrema, Rhodotorula, Sampaiozyma, Sporobolomyces, Symmetrospora and Vishniacozyma. We highlight the need for additional mycological expertise in that 23% of species in these core genera appear to be new to science and resolve some taxonomic issues we encountered during our work with new combinations for Aureobasidiumbupleuri and Curvibasidium nothofagi. Finally, our work lays the ground for future studies that seek to understand the effect these communities may have on preventing or facilitating establishment of exogenous microbes, such as food spoilage microbes and plant or human pathogens

SISTEM INFORMASI GEOGRAFIS UNTUK PERJALANAN WISATA DI KOTA SEMARANG

Tourist information system is an information system which built to fulfil the needs of information from tourists. This kind of information can be split into three major phases: pre-visiting information (before the trip), in site information and post-visiting (after the trip) information. A good tourist information system should support all of this phase. But in this case, the system will more concern to the second phase. In the second phase, the tourist already has a plan, what he wants to see, and what he wants to do and knows all the information required. Information from a guide book or map will help them find a location of a place or which way they should take and help them figured out the location of the places. To provide this kind of information, geographic information system (GIS) seems to be a good tool to handle this problem. GIS has capability to provide information and deliver them as guidance to user in a map form. The map consists of some space data and description about that space data. GIS could provide information such as a map of the important places like hotel, restaurant, tourist site, bank and the others, and about the street that pass all the places and providing some description about the places or street. This system will be applied to Semarang, with the searching tool as a major tools and information about all the tourism facilities in Semarang provided for the tourist with some pictures of them. With all the capability of GIS may tourist could have some guidance to help them along their trip in Semarang. Abstract in Bahasa Indonesia: Sistem informasi wisata adalah sistem informasi yang dibangun untuk memenuhi kebutuhan informasi wisatawan. Informasi dibedakan menjadi tiga bagian yaitu informasi sebelum perjalanan, informasi saat perjalanan dan informasi setelah perjalanan. Sebuah sistem informasi wisata yang baik harus dapat menyediakan informasi dari keseluruhan bagian tersebut. Penelitian ini menekankan pada bagian yang kedua. Dalam bagian kedua ini, wisatawan telah merencanakan perjalanan, tempat yang dikunjungi, apa yang ingin dilakukan, dan informasi yang ingin diperoleh. Informasi dari buku panduan dan peta membantu pencarian lokasi atau rute yang perlu ditempuh dan membantu mencari lokasi. Untuk penyediaan informasi, Sistem Informasi Geografis (SIG) merupakan alat bantu yang tepat untuk menangani masalah ini. SIG memiliki kemampuan untuk menyediakan informasi dan menampilkan dalam bentuk peta. Peta terdiri dari data dan deskripsi tentang data. SIG dapat menyediakan informasi seperti hotel, restoran, tempat wisata, bank dan lainnya, jalan yang menghubungkan tempat-tempat tersebut, maupun deskripsi tentang tempat dan jalan. Sistem diimplementasikan di kota Semarang, dengan menyediakan tools untuk searching dan informasi tentang fasilitas wisata beserta foto untuk wisatawan. Dengan kemampuan SIG, wisatawan mempunyai panduan untuk membantu perjalanan di Semarang. Kata kunci: perjalanan wisata, Sistem Informasi Geografis (SIG), Semaran

PENGEMBANGAN APLIKASI MOBILE PADA PELAYANAN PEMERINTAH KOTA YOGYAKARTA DALAM RANGKA TANGGAP RESPON INFORMASI DAN KELUHAN DARI MASYARAKAT

AbstractUnit Pelayanan Informasi dan Keluhan (UPIK) is an e-government application built by the Yogyakarta City Government in order. UPIK becomes a container of input information in the form of complaints, questions, information, suggestions, and suggestions from the community, as well as providing solutions response to information that entered the Yogyakarta City government. The goal is to accelerate the service of information and complaints to be conveyed by the public without the need for a convoluted procedure. In its implementation, UPIK has several limitations, such as: updating of news which is not fast, lack of responsiveness of community response or complaint, no coordinate location where community reporting, and delivery of complaints and suggestions from the public through opertator and to the office implemented manually. The methodology used in this study is GRAPPLE (Guidelines for Rapid APPlication Engineering) which is a method commonly used for the development of object-oriented applications. This Android-based application is built using java programming language by utilizing Brute Force method on the system, so that users easier to report complaints to the relevant offices. With this application can help the performance of related agencies responsible for making corrections of complaints that come in the Application Information Services and Complaints Yogyakarta-based mobile community.Keywords: Complaint, Community, Brute Force, Office, Response, Android.AbstrakUnit Pelayanan Informasi dan Keluhan (UPIK) adalah sebuah penerapan e-government yang dibangun oleh Pemerintah Kota Yogyakarta dalam rangka . UPIK menjadi wadah informasi masukan berupa keluhan, pertanyaan, informasi, usul, dan saran dari masyarakat, serta memberikan solusi respon atas informasi yang masuk kepemerintah Kota Yogyakarta. Tujuannya adalah untuk mempercepat pelayanan informasi dan keluhan yang ingin disampaikan masyarakat tanpa perlu prosedur yang berbelit belit. Dalam pelaksanaanya, UPIK memiliki beberapa keterbatasan, diantaranya adalah: pemutahiran berita yang tidak cepat, kurang tanggap penyelesaian tanggapan atau pengaduan masyarakat, tidak ada lokasi koordinat tempat pelaporan masyarakat, dan penyampaian keluhan dan saran dari masyarakat melalui opertator dan kepada  dinas dilaksanakan secara manual. Metodologi yang digunakan dalam penelitian ini adalah GRAPPLE (Guidelines for Rapid APPlication Engineering) yaitu suatu metode yang lazim digunakan untuk pengembangan aplikasi berorientasi objek. Aplikasi berbasis Android ini dibangun menggunakan bahasa pemprograman java dengan memanfaatkan metode Brute Force pada sistem, agar pengguna lebih mudah untuk melaporkan keluhan ke dinas yang terkait. Dengan aplikasi ini dapat membantu kinerja dinas-dinas terkait yang bertanggung jawab untuk melakukan pembenahan keluhan yang masuk di Aplikasi Pelayanan Informasi dan Pengaduan masyarakat Kota Yogyakarta berbasis mobile.Kata kunci: Keluhan, Masyarakat, Brute Force, Dinas, Respon, Android

PASTEUR4OA: : Revealing the true costs of Gold OA - towards a public data infrastructure of scholarly publishing costs

This briefing paper presents the current state of financial opacity in scholarly journal publishing. It describes what information is needed in order to obtain a bigger, more systemic picture of financial flows, and to understand how much money is going into the system, where this money comes from, and how these financial flows might be adjusted to support different kinds of publishing models. This document aims to shed light on following questions: What do we currently know about the costs of open access publishing? Which factors contribute to the current opacity in the market? Which approaches are taken to foster financial transparency of Gold OA? And what are recommendations to funders, institutions, researchers and publishers to increase transparency?Publisher PD

Analysis of Epigenetic Factors in Mouse Embryonic Neural Stem Cells Exposed to Hyperglycemia

BACKGROUND Maternal diabetes alters gene expression leading to neural tube defects (NTDs) in the developing brain. The mechanistic pathways that deregulate the gene expression remain unknown. It is hypothesized that exposure of neural stem cells (NSCs) to high glucose/hyperglycemia results in activation of epigenetic mechanisms which alter gene expression and cell fate during brain development. METHODS AND FINDINGS NSCs were isolated from normal pregnancy and streptozotocin induced-diabetic pregnancy and cultured in physiological glucose. In order to examine hyperglycemia induced epigenetic changes in NSCs, chromatin reorganization, global histone status at lysine 9 residue of histone H3 (acetylation and trimethylation) and global DNA methylation were examined and found to be altered by hyperglycemia. In NSCs, hyperglycemia increased the expression of Dcx (Doublecortin) and Pafah1b1 (Platelet activating factor acetyl hydrolase, isoform 1b, subunit 1) proteins concomitant with decreased expression of four microRNAs (mmu-miR-200a, mmu-miR-200b, mmu-miR-466a-3p and mmu-miR-466 d-3p) predicted to target these genes. Knockdown of specific microRNAs in NSCs resulted in increased expression of Dcx and Pafah1b1 proteins confirming target prediction and altered NSC fate by increasing the expression of neuronal and glial lineage markers. CONCLUSION/INTERPRETATION This study revealed that hyperglycemia alters the epigenetic mechanisms in NSCs, resulting in altered expression of some development control genes which may form the basis for the NTDs. Since epigenetic changes are reversible, they may be valuable therapeutic targets in order to improve fetal outcomes in diabetic pregnancy.This study is supported by the NUS bridging fund R-181-000-130-720. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

VizWiz

The lack of access to visual information like text labels, icons,and colors can cause frustration and decrease independence for blind people. Current access technology uses automatic approaches to address some problems in this space, but the technology is error-prone, limited in scope, and quite expensive. In this paper, we introduce VizWiz, a talking application for mobile phones that offers a new alternative to answering visual questions in nearly real-time—asking multiple people on the web. To support answering questions quickly, we introduce a general approach for intelligently recruiting human workers in advance called quikTurkit so that workers are available when new questions arrive. A field deployment with 11 blind participants illustrates that blind people can effectively use VizWiz to cheaply answer questions in their everyday lives, highlighting issues that automatic approaches will need to address to be useful. Finally, we illustrate the potential of using VizWiz as part of the participatory design of advanced tools by using it to build and evaluate VizWiz::LocateIt, an interactive mobile tool that helps blind people solve general visual search problems

Detailed simulation of electrical demands due to nationwide adoption of heat pumps, taking account of renewable generation and mitigation

This study quantifies the increase in the peak power demand, net of non-dispatchable generation, that may be required by widespread adoption of heat pumps. Electrification of heating could reduce emissions but also cause a challenging increase in peak power demand. This study expands on previous studies by quantifying the increase in greater detail; considering a wider range of scenarios, the characteristics of heat pumps and the interaction between wind generation and demand side management (DSM). A model was developed with dynamic simulations of individual heat pumps and dwellings. The increase in peak net-demand is highly sensitive to assumptions regarding the heat pumps, their installation, building fabric and the characteristics of the grid. If 80% of dwellings in the UK use heat pumps, peak net-demand could increase by around 100% (54 GW) but this increase could be mitigated to 30% (16 GW) by favourable conditions. DSM could reduce this increase to 20%, or 15% if used with extensive thermal storage. If 60% of dwellings use heat pumps, the increase in peak net-demand could be as low as 5.5 GW. High-performance heat pumps, appropriate installation and better insulated dwellings could make the increase in peak net-demand due to the electrification of heating more manageable

Cocina de Leña tipo Rocket de alta eficiencia y bajo impacto ambiental en comparación a la Cocina de Leña Convencional

El presente estudio pretende implementar la construcción de una cocina mejorada, utilizando los principios de diseño del Dr. Larry Winiarski quien desarrollo la Rocket Stoves (cocina cohete), además de evaluar los materiales que se usaran como aislantes mediante un análisis de transferencia de calor determinando la perdida de calor que podría tener la cocina a una determinada temperatura dentro de la cámara de combustión