Does ict resources improve the sport teaching processes in handball?

La motivación (M) y la capacidad de percepción-análisis (PA) del juego, variables del proceso de enseñanza-aprendizaje, fueron evaluadas tras utilizar diferentes recursos durante las explicaciones del entrenador. 71 jugadores(Sub-18) fueron divididos en dos grupos: G1 (n=35): recursos tradicionales; G2 (n=36): recursos multimedia. Se evaluó el nivel inicial (i) y final (f), tras 10 sesiones de entrenamiento. Ambas variables mejoraron significativamente en ambos grupos. Fueron mayores las mejoras del G2 en ambas variables (p<.001). Se hallaron únicamente diferencias intergrupales en la evaluación final en M y PA (p<.001), mostrando el Grupo 2 mejores resultados. Se concluye que la utilización de recursos multimedia posee un efecto positivo mayor que los recursos tradicionales sobre M y PA en jugadores de balonmano (Sub-18).Motivation (M) and game perception-analysis ability (PA), variables in the teaching-learning process, were evaluated after using different resources during the coach’s explanations. Seventy-one players (Under-18) were divided into 2 groups: G1 (n = 35) traditional resources; G2 (n = 36) multimedia resources. Initial (i) and final (f) levels of both variables were evaluated after 10 training sessions. Both variables showed a significant improvement in both groups. The improvements shown in G2 were greater in both variables (p<0.001). Intergroup differences were only found in the final evaluation in M and PA (p<0,001), where G2 obtained better results. It was concluded that using multimedia resources has a greater positive effect than traditional resources on M and PA in under-18 handball players

Marginal Damage of Methane Emissions: Ozone Impacts on Agriculture

Methane directly contributes to air pollution, as an ozone precursor, and to climate change, generating physical and economic damages to different systems, namely agriculture, vegetation, energy, human health, or biodiversity. The methane-related damages to climate, measured as the Social Cost of Methane, and to human health have been analyzed by different studies and considered by government rulemaking in the last decades, but the ozone-related damages to crop revenues associated to methane emissions have not been incorporated to policy agenda. Using a combination of the Global Change Analysis Model and the TM5-FASST Scenario Screening Tool, we estimate that global marginal agricultural damages range from ~ 423 to 556 $2010/t-CH4, of which 98$2010/t-CH4 occur in the USA, which is the most affected region due to its role as a major crop producer, followed by China, EU-15, and India. These damages would represent 39–59% of the climate damages and 28–64% of the human health damages associated with methane emissions by previous studies. The marginal damages to crop revenues calculated in this study complement the damages from methane to climate and human health, and provides valuable information to be considered in future cost-benefits analyses. © 2023, The Author(s).JS and SW were supported by the U.S. Environmental Protection Agency, under Interagency Agreement DW-089-92459801. The views expressed in this article are purely those of the authors and do not, under any circumstances, represent the views or policies of the U.S. Environmental Protection Agency or the European Commission. JS and SW were supported by the U.S. Environmental Protection Agency, under Interagency Agreement DW-089-92459801. The views expressed in this article are purely those of the authors and do not, under any circumstances, represent the views or policies of the U.S. Environmental Protection Agency or the European Commission

The Gaia-ESO Survey: pre-main-sequence stars in the young open cluster NGC 3293

Delgado, Antonio J. et. al.The young open cluster NGC3293 is included in the observing program of the Gaia-ESO survey (GES). The radial velocity values provided have been used to assign cluster membership probabilities by means of a single-variable parametric analysis. These membership probabilities are compared to the results of the photometric membership assignment of NGC3293, based on UBVRI photometry. The agreement of the photometric and kinematic member samples amounts to 65 per cent, and could increase to 70 per cent as suggested by the analysis of the differences between both samples. A number of photometric PMS candidate members of spectral type F are found, which are confirmed by the results from VPHAS photometry and SED fitting for the stars in common with VPHAS and GES data sets. Excesses at mid- and near-infrared wavelengths, and signs of H alpha emission, are investigated for them. Marginal presence of H alpha emission or infilling is detected for the candidate members. Several of them exhibit moderate signs of U excess and weak excesses at mid-IR wavelengths. We suggest that these features originate from accretion discs in their last stages of evolution.This work was partly supported by the European Union FP7 programme through ERC grant number 320360 and by the Leverhulme Trust through grant RPG-2012-541. We acknowledge the support from INAF and Ministero dell' Istruzione, dell' Universita' e della Ricerca (MIUR) in the form of the grant 'Premiale VLT 2012'. The results presented here benefit from discussions held during the Gaia-ESO workshops and conferences supported by the ESF (European Science Foundation) through the GREAT Research Network Programme. AJD, LS, EJA and MTC acknowledge financial support from the Spanish Ministerio de Economia y Competitividad, through grant AYA2013-40611-P. JLY acknowledges support from FCT (SFRH/BSAB/1423/2014 and UID/FIS/04434/2013). TM acknowledges financial support from Belspo for contract PRODEX GAIA-DPAC.Peer reviewe

Obtaining the basic response pattern of physiological time series data : a comparison of methods

An understanding of the kinetics of physiological variables such as the heart rate or the rate of change of volume of oxygen uptake is fundamental not only to training methodology and competitive success in sport and exercise, but also to our knowledge of cardiovascular health. A correct and efficient means of interpreting and analyzing the data obtained is of vast importance, as exercise testing is routinely used in both of these areas

Assessing synergies and trade-offs of diverging Paris-compliant mitigation strategies with long-term SDG objectives

The Sustainable Development Goals (SDGs) and the Paris Agreement are the two transformative agendas, which set the benchmarks for nations to address urgent social, economic and environmental challenges. Aside from setting long-term goals, the pathways followed by nations will involve a series of synergies and trade-offs both between and within these agendas. Since it will not be possible to optimise across the 17 SDGs while simultaneously transitioning to low-carbon societies, it will be necessary to implement policies to address the most critical aspects of the agendas and understand the implications for the other dimensions. Here, we rely on a modelling exercise to analyse the long-term implications of a variety of Paris-compliant mitigation strategies suggested in the recent scientific literature on multiple dimensions of the SDG Agenda. The strategies included rely on technological solutions such as renewable energy deployment or carbon capture and storage, nature-based solutions such as afforestation and behavioural changes in the demand side. Results for a selection of energy-environment SDGs suggest that some mitigation pathways could have negative implications on food and water prices, forest cover and increase pressure on water resources depending on the strategy followed, while renewable energy shares, household energy costs, ambient air pollution and yield impacts could be improved simultaneously while reducing greenhouse gas emissions. Overall, results indicate that promoting changes in the demand side could be beneficial to limit potential trade-offs

The toxicity and intraspecific variability of Alexandrium andersonii Balech

The toxicity of Alexandrium andersonii Balech is unclear and its intraspecific variability has yet to be studied. To address these gaps in our knowledge, in the present work five strains of A. andersonii from four different localities were characterized. The results showed that despite genetic homogeneity in the 5.8-ITS (internal transcribed spacer) and large subunit (LSU) regions and similar growth rates, strains originating from different locations varied with respect to cell size, the ratios of certain pigments, and their growth patterns. Cultures of the strains grown at 20 8C were analyzed for toxicity using four different methodologies. The two officially established methods, mouse bioassay and high-performance liquid chromatography with fluorescence detection (HPLC-FLD) and post-column reaction analysis of PSP toxins, failed to show the toxicity of any strain. Strains grown at 14 8C were also negative for PSP toxins by HPLC-FLD. However, strains grown at 20 8C exhibited both a response characteristic of the presence of toxin-inhibiting voltage-gated sodium channels, as demonstrated in a neuroblastoma neuro- 2a cell-based assay, as well as hemolytic activity in a sheep red blood cell assay

Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy

OBJECTIVE: Mutations in KCNC1 can cause severe neurological dysfunction, including intellectual disability, epilepsy, and ataxia. The Arg320His variant, which occurs in the voltage-sensing domain of the channel, causes a highly penetrant and specific form of progressive myoclonus epilepsy with severe ataxia, designated myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). KCNC1 encodes the voltage-gated potassium channel KV 3.1, a channel that is important for enabling high-frequency firing in interneurons, raising the possibility that MEAK is associated with reduced interneuronal function. METHODS: To determine how this variant triggers MEAK, we expressed KV 3.1bR320H in cortical interneurons in vitro and investigated the effects on neuronal function and morphology. We also performed electrophysiological recordings of oocytes expressing KV 3.1b to determine whether the mutation introduces gating pore currents. RESULTS: Expression of the KV 3.1bR320H variant profoundly reduced excitability of mature cortical interneurons, and cells expressing these channels were unable to support high-frequency firing. The mutant channel also had an unexpected effect on morphology, severely impairing neurite development and interneuron viability, an effect that could not be rescued by blocking KV 3 channels. Oocyte recordings confirmed that in the adult KV 3.1b isoform, R320H confers a dominant negative loss-of-function effect by slowing channel activation, but does not introduce potentially toxic gating pore currents. SIGNIFICANCE: Overall, our data suggest that, in addition to the regulation of high-frequency firing, KV 3.1 channels play a hitherto unrecognized role in neuronal development. MEAK may be described as a developmental dendritopathy

Neuroimagen del linfoma primario del sistema nervioso central en pacientes inmunodeprimidos

ResumenObjetivosEl linfoma primario del sistema nervioso central (LPSNC) es una entidad rara con un pronóstico fatal. Dado el aumento en el número de casos con inmunosupresión adquirida, nuestros objetivos son estudiar las características epidemiológicas y neurorradiológicas de aquellos pacientes inmunodeprimidos con diagnóstico de LPSNC con afectación cerebral e investigar si existen diferencias entre los pacientes con el virus de la inmunodeficiencia humana (VIH) positivo y negativo.Materiales y métodosSe realizó un estudio descriptivo y retrospectivo de los pacientes inmunodeprimidos con afectación cerebral por LPSNC, diagnosticados durante los últimos 13 años en 2 hospitales de referencia. Se evaluaron múltiples variables. El nivel de significación estadística utilizado fue p<0,05.ResultadosEl grupo VIH-positivo tenía una media de edad de 36,82±5,4 años, frente a los 55,60 ± 21,43 años de los pacientes VIH-negativo (p<0,022). Los pacientes VIH-positivo tuvieron una media de 1,27 ± 0,65 lesiones por paciente, mientras que en el grupo VIH-negativo fue de 2,60 ± 1,78 (p<0,039). El 18,2% (n=2) del grupo VIH-positivo y el 80% (n=8) del grupo VIH-negativo presentaron lesiones homogéneas (p<0,005). Ningún paciente VIH-positivo tuvo afectación del cuerpo calloso, pero el grupo VIH-negativo presentó un 50% (n=5) de afectación (p<0,012).ConclusionesEl LPSNC en pacientes inmunodeprimidos puede presentar múltiples características en las imágenes. Existen diferencias entre los pacientes VIH positivo y negativo, por lo que es importante reconocerlas para establecer un manejo y tratamiento diferente entre ambos grupos.AbstractPurposesPrimary central nervous system lymphoma (PCNSL) is a rare tumour with poor prognosis. Due to the increased number of patients with acquired immunodeficiency, our purposes are to describe epidemiological and imaging findings in immunodeficient patients with PCNSL of the brain and to study the differences between HIV-positive and HIV-negative patients with PCNSL.Materials and methodsA retrospective, descriptive study was performed with immunodeficient patients diagnosed of PCNSL of the brain during the last 13 years in two reference hospitals. Twenty-one patients fulfilled the inclusion criteria. Multiple variables were evaluated. Significance was defined as p<0.05.ResultsHIV-positive group was a mean age of 36,82±5,4 years and the mean age in HIV-negative group was 55,60±21,43 years (p<0,022). The mean number of lesions was 1,27±0,65 in HIV-positive group and 2,60±1,78 in HIV-negative group (p<0,039). The lesions were homogeneous in 18,2% (n=2) HIV-positive group and 80% (n=8) in HIV-negative group (p<0,005). No HIV-positive patient and 50% (n=5) of HIV-negative patients showed corpus callosum involvement (p<0,012).ConclusionsPCNSL in immunodeficient patients is associated with a large spectrum of radiological findings. There were differences between HIV-positive and HIV-negative patients, is important recognize these differences as the therapeutic management of these two groups vary